LOCUS       NM_152807               2772 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil domain containing 137 (Ccdc137),
            transcript variant 1, mRNA.
ACCESSION   NM_152807
VERSION     NM_152807.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Tao,S., Xie,S.J., Diao,L.T., Lv,G., Hou,Y.R., Hu,Y.X., Xu,W.Y.,
            Du,B. and Xiao,Z.D.
  TITLE     RNA-binding protein CCDC137 activates AKT signaling and promotes
            hepatocellular carcinoma through a novel non-canonical role of
            DGCR8 in mRNA localization
  JOURNAL   J Exp Clin Cancer Res 42 (1), 194 (2023)
   PUBMED   37542342
  REMARK    GeneRIF: RNA-binding protein CCDC137 activates AKT signaling and
            promotes hepatocellular carcinoma through a novel non-canonical
            role of DGCR8 in mRNA localization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669855.20.
            
            On Mar 10, 2023 this sequence version replaced NM_152807.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156682.1, BC026662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL669855.20        119926-120083
            159-292             AL669855.20        120417-120550
            293-515             AL669855.20        121847-122069
            516-598             AL669855.20        123521-123603
            599-678             AL669855.20        123811-123890
            679-2772            AL669855.20        124070-126163
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.15 cM"
     gene            1..2772
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /note="coiled-coil domain containing 137"
                     /db_xref="GeneID:67291"
                     /db_xref="MGI:MGI:1914541"
     exon            1..158
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..897
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 137"
                     /protein_id="NP_690020.1"
                     /db_xref="CCDS:CCDS25736.1"
                     /db_xref="GeneID:67291"
                     /db_xref="MGI:MGI:1914541"
                     /translation="MARPGNIALVTARSAGLRGSGQPQGRRQQQAQGQQRSASLPGQR
                     SKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKKTLSNKKRKKEAQVAFKKTLEKEA
                     KGEEPDIAVPKFKQRKGESDVAYVQRMEQEAQHVLFLSKNQAPRQPEVQAAPKKEKSE
                     RKKAFQKRRLEKAQRKREARAVDRLEQELLKDTVKFGEVVLQPPELTVQPRRSTSRDA
                     PGKKSLMLKKMLLGPGGGSPAPATSLARQRILGEERERAVQAYRALKKLHRQEMTPAQ
                     PPGSSFQRQGHACL"
     exon            159..292
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            293..515
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            516..598
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..678
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            679..2772
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2168
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2772
                     /gene="Ccdc137"
                     /gene_synonym="3110023B02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgcaggacg cgcctggggt agtcatggcg aggcctggga acatagcact ggttactgcg
       61 cggtcggccg gtcttagagg ctcgggacag ccgcaggggc ggcggcagca gcaggctcaa
      121 ggacagcagc gctcggcctc actgcccgga cagcgcagca aagaaaagaa gaaagtgaat
      181 tgcaagccta agaaccagga tgagcaagaa atcccttttc ggctccgaga aattatgagg
      241 agccgacagg agatgaaaaa gacgctaagt aacaagaaga gaaaaaagga ggcccaggtg
      301 gctttcaaga agacgttgga aaaggaagcg aagggggagg agccagacat cgctgtcccc
      361 aagttcaagc aaaggaaggg ggagtctgat gtggcctacg tccagcgcat ggagcaggag
      421 gcccagcacg tgctgtttct tagcaagaac caggcccctc ggcagccaga ggtgcaggca
      481 gctcccaaga aggagaagtc tgagcgcaag aaagcgttcc agaagcgacg actggaaaag
      541 gcccagagga aaagggaagc aagagccgtg gacagattgg agcaggagct actgaaagat
      601 actgtgaagt ttggagaagt tgtgttgcag cccccagagc tgacagttca gcccaggagg
      661 agcacaagca gagatgctcc tggcaagaaa tcactaatgc tgaagaagat gctgttgggt
      721 cctggtggcg ggtccccggc tccagccacc tcactggccc gccagcggat cctgggggaa
      781 gagcgggaac gggctgtgca ggcttacaga gccctgaaga agctgcatag acaggaaatg
      841 acacctgcac agccaccagg cagctctttc cagaggcagg gccacgcttg tctgtgatgc
      901 agagacccag gggcctgatc ccctggaaac tggtctggga gctgctagac ctgggtaagg
      961 gagaggcagc ggatgctctc cttgcatagg gtcctgagag taagctttca ggtttggaag
     1021 agtgcttttc cttcctctga aggttgtcct tataagagtg accaccatgg tatcccatct
     1081 catacagggc aaacccccgc atcccagcac ttgcctgaga cacagctgga agggctggta
     1141 ttttccttga gcctaagttc attctgaaac aagtctcggc tgagacaagc caggaccact
     1201 gtagaatgga ctcaatccct taatccagcc aattactgaa gctgctggtg taggtcagcc
     1261 tacaccaatg ttttaagaag ctcccatggg cttactgcaa cctttggaag gcagggacag
     1321 acagcaaagc aggttagtgg gctggtggaa gggcaagtgg gggcggcaat cagcactttt
     1381 tttttatttg cctgcagggt tctgtacaaa tgaccagaac tcccagccca ctcttggttt
     1441 ggatagagag ggggtttcag tactgactga gtgccttgag gtatacacat gaaaaccagg
     1501 tttcaatggt tgacagagta gagtatttat accaagaggg tagaggcgaa agaattgggt
     1561 gttcaaagcc agtcttgact tgaagcaaat gtatggcctg cctgaacagg ttgagagagt
     1621 ctcaaaaacc ttacttagac atcaaaagag cgaagcttgg accctgctgg ggaagcccac
     1681 agtcctctag cagacctagg agcctccgtc cagcaaagct ggtcctggag cctagtggag
     1741 tgctccaaat gtgcattttc cagagtgaag tttattaaag ttttgctctt tgaagtctgg
     1801 gccgttgctc tccaacatgc ttatccacgg ccctagtcaa tgcgtgtcaa tgtgacaaga
     1861 tgagtgagtg tgcagacaca cacccaacag tagcaagggc cagaatagag cagggtgcat
     1921 cggccacttg actttccact gcacatcagg actagggcca gggcccagga gccaccatta
     1981 tcagagtatg taggcttctg agttctttag aagcaatgtg gccacacatc caaagctcaa
     2041 ctgtgcgcta catcaaatga ctctgggtaa ttatccctca gagcccatgc ctatatgtgc
     2101 ctgtgcctat atgtgcttga ctcctcccac tttctgtaat gtttattaaa gatgcccaca
     2161 cccatgcatt cagggattgt tttctgagtg ctgctttttc acaaaatatc ccagctaaat
     2221 ggatgttttc ctgctgtgct taagccatct cagattgacc ttggccagaa cgatgtgtgg
     2281 agccacctgt ctggcttccc cattcctcac ttctggtatg gaagatgtgg ctgctcttgt
     2341 tccctgccca ctccaaggtc aggtctggtc tctgctgcca tcttggagtc ctgaccctca
     2401 gaacactaaa tattggcagg taagctggag cctgtccacc attatatcat tactgaataa
     2461 ttggtgattc atatagacac ataggtacat atatgtcttc atgtgtgtaa aggtcttcat
     2521 ggtgtaaggg gcaggagaca taagggcttc cccagccctc tccactttgt cctggttgaa
     2581 aatcaggcac cctgatgtac tgctctgctg caggtttttc ctcagcagat gagcctagaa
     2641 gattatcatg ctgatgcacc tgacaagcta tcccagtaga atgttaccac ctcctgtgtg
     2701 ccttctcttg tccacttgtg ggacctcata tacccctgta catgagaaat aaaagtttat
     2761 tgaataaatc ca
//
