LOCUS       NM_001347071            3887 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 136 (Ccdc136),
            transcript variant 3, mRNA.
ACCESSION   NM_001347071 XM_006505046
VERSION     NM_001347071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3887)
  AUTHORS   Gurdita,A., Nickerson,P.E.B., Pokrajac,N.T., Ortin-Martinez,A.,
            Samuel Tsai,E.L., Comanita,L., Yan,N.E., Dolati,P., Tachibana,N.,
            Liu,Z.C., Pearson,J.D., Chen,D., Bremner,R. and Wallace,V.A.
  TITLE     InVision: An optimized tissue clearing approach for
            three-dimensional imaging and analysis of intact rodent eyes
  JOURNAL   iScience 24 (8), 102905 (2021)
   PUBMED   34430805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3887)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3887)
  AUTHORS   Tsai,E.L.S., Ortin-Martinez,A., Gurdita,A., Comanita,L., Yan,N.,
            Smiley,S., Delplace,V., Shoichet,M.S., Nickerson,P.E.B. and
            Wallace,V.A.
  TITLE     Modeling of Photoreceptor Donor-Host Interaction Following
            Transplantation Reveals a Role for Crx, Muller Glia, and Rho/ROCK
            Signaling in Neurite Outgrowth
  JOURNAL   Stem Cells 37 (4), 529-541 (2019)
   PUBMED   30715780
REFERENCE   6  (bases 1 to 3887)
  AUTHORS   Geng,Q., Ni,L., Ouyang,B., Hu,Y., Zhao,Y. and Guo,J.
  TITLE     A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome
            Formation and Fertilization in Mice
  JOURNAL   Reprod Sci 23 (10), 1387-1396 (2016)
   PUBMED   27076447
  REMARK    GeneRIF: Study demonstrates the essential role of CCDC136-mediated
            acrosome formation in spermatogenesis and fertilization, which
            might also provide new insight into the genetic causes of human
            infertility.
REFERENCE   7  (bases 1 to 3887)
  AUTHORS   Smiley,S., Nickerson,P.E., Comanita,L., Daftarian,N., El-Sehemy,A.,
            Tsai,E.L., Matan-Lithwick,S., Yan,K., Thurig,S., Touahri,Y.,
            Dixit,R., Aavani,T., De Repentingy,Y., Baker,A., Tsilfidis,C.,
            Biernaskie,J., Sauve,Y., Schuurmans,C., Kothary,R., Mears,A.J. and
            Wallace,V.A.
  TITLE     Establishment of a cone photoreceptor transplantation platform
            based on a novel cone-GFP reporter mouse line
  JOURNAL   Sci Rep 6, 22867 (2016)
   PUBMED   26965927
  REMARK    Erratum:[Sci Rep. 2016 Apr 22;6:24012. doi: 10.1038/srep24012.. De
            Repentigny, Yves [corrected to De Repentingy, Yves]. PMID:
            27102716]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3887)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC044807.4.
            
            On Apr 28, 2022 this sequence version replaced NM_001347071.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC044807.4         116277-116436
            161-268             AC044807.4         117173-117280
            269-517             AC044807.4         118895-119143
            518-592             AC044807.4         119229-119303
            593-913             AC044807.4         125565-125885
            914-1025            AC044807.4         128919-129030
            1026-1194           AC044807.4         129768-129936
            1195-1332           AC044807.4         130942-131079
            1333-1491           AC044807.4         131404-131562
            1492-1662           AC044807.4         132058-132228
            1663-1848           AC044807.4         132596-132781
            1849-2043           AC044807.4         134480-134674
            2044-2268           AC044807.4         135125-135349
            2269-2775           AC044807.4         136766-137272
            2776-2997           AC044807.4         137626-137847
            2998-3279           AC044807.4         138796-139077
            3280-3558           AC044807.4         139681-139959
            3559-3887           AC044807.4         146319-146647
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..3887
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /note="coiled-coil domain containing 136"
                     /db_xref="GeneID:232664"
                     /db_xref="MGI:MGI:1918128"
     exon            1..160
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3666
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 136; taraco"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 136
                     isoform 3"
                     /protein_id="NP_001334000.1"
                     /db_xref="CCDS:CCDS85019.1"
                     /db_xref="GeneID:232664"
                     /db_xref="MGI:MGI:1918128"
                     /translation="MEAGGGAGAGAAGWSCPGPGPTVTTLGSYEVSEGCERKKGQRWG
                     SLERRGMQAMDGEVLLPALYEEEEEEEEEEEEVEEEQVEKGGSLGSLSMGKHRGLSLT
                     ETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ
                     QLQGELQHLREEISLLEHEKESELKEMEQELHLAQAEIQNLRQAAADSATEHESDIAS
                     LQDDLCRLQNDLDDMERIRGDYEMEIASLRAEMELKTSEPSNLSISDFSGIQDELHHL
                     RERYNLLNEEYQALRESNSSLTGQLAELESDRTRRATERWLESHLLRSTMSSESQTSE
                     LDFPEPDPVMQLLRQQLLGAEEQMQDMQDKCKNLYCELEELQHHRRTSEEEQKRLQRE
                     LKCAQNEVLRFQTSHSTQHEELKSRLCTLQQKYDASQDEHSELLKVQMQLETELQQLR
                     LLRCTPVESQSEKELMCRLQKLQAQHQCSVNEKEQLLEVQHHLHDKLRCHESEVHRLR
                     SMVDCLREKNEKNSGIHLQLQEMKGLYQFSRDELERQKHMYDQLEQDFLLCQQELTEL
                     KSSQSLCEENGNCSNKCDALLARLTELQDKFKASQEEIGHLQMEQCELLEDQRRLQEE
                     QGQLQEELHRLTFPQPKCGILQKSQELLSKLQDLCEMQLLYQNMQEQQRKLTQNQECV
                     LKEQLEAHKHLRGFKESHFQEVLANPQDARGPKSSSCENKFKVLMDQLQALQVLYDTS
                     QKQQEVLQREHGRLMEERKRLQAELQLCMEEMQVLQTQSPMIKRSFEYCGKNSGSRAP
                     STENFHRSYESSIDENEGYQKSYVSSQPSTETFLKSYDSSTSANEAFEKSYCSSSTSV
                     SYKKSYGSVSSGETLHRSYASSSTDEDPAEPEDLEHFEETVAKVLTKLQAVKALYQVS
                     QEEHCQLQQRMHRLLAKQKELTEELQCCEKELRECMESLGKPLPPQSDKCEIKELQTK
                     LRELQLQYQASMDEQGRLLAVQEQLEGQLQCCQEELRQLKENRPSISSEARGKNVNKN
                     MNKNANGVRNKKLSMACSEDLENGFENEKNLEVMLYYKASQRRLDELMKEEKEIEEAR
                     KKEREKKAKKDLCKLATNPAADPRAEPEPTEDEEENFEEYREGEDESCEAAEEGNPLK
                     LSESKKNMFGMWKPMVFLAIAAVALYVLPNMRPQESEYYMK"
     exon            161..268
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..517
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..592
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            593..913
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1025
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1194
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1332
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1491
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1662
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1848
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2043
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2268
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2775
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2997
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3279
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3558
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3887
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3887
                     /gene="Ccdc136"
                     /gene_synonym="4921511K06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggccc gccctctctc ctccctgcgc accgggctcc cggtccccgg cccggaggct
       61 gcggcttctg ctcgggaggc ggcggcggcg gcgggagcag ccatggaggc aggcggcggg
      121 gccggcgcgg gagccgcggg ctggagctgc cctggcccag gacccacagt aaccacttta
      181 ggctcctatg aggtatctga gggttgtgag aggaagaaag gccaacgctg ggggtctctg
      241 gagcgccgtg ggatgcaagc tatggacggg gaggtgttac ttccagctct atatgaggaa
      301 gaggaggagg aagaggagga agaggaagag gtcgaagaag agcaagtaga gaaaggaggc
      361 agtttgggct ccctttcaat gggcaagcat cggggcctga gcctgacaga gacagagctg
      421 gaggagctga gggcccaggt gctgcagctg gtggcagagc tggaggagac ccgtgagctt
      481 gctgggcagc atgaagatga ctccctggag cttcaggggc tcctggagga tgagcggctg
      541 gccagtgccc agcaagcaga agtattcacc aagcagattc agcagctcca aggtgagctg
      601 caacatctac gggaggagat ttccctgtta gagcatgaga aggaaagcga acttaaagaa
      661 atggagcagg agttgcattt ggcccaagca gagatccaaa atctacggca agctgcggca
      721 gactctgcca ctgaacatga gagtgacata gcgtccttgc aggatgatct ctgccggttg
      781 cagaatgatc tcgatgacat ggagcgcatt cgaggggact atgagatgga gattgcctcg
      841 ctccgggcag aaatggaatt gaagacttct gaaccatcta atctaagcat ctccgacttc
      901 tctgggatac aagatgaact acaccatctt cgggagcgct acaacttact gaatgaggag
      961 tatcaggcct tgcgggagag caacagcagc ctcacagggc agcttgctga gctggagagt
     1021 gataggacac ggagagcaac agagcgatgg ttggaatctc acctgctacg gagtacgatg
     1081 tcctccgagt ctcagacgtc agaactggat ttcccagagc ctgaccctgt gatgcagctt
     1141 ttgcgccagc agctgctggg agctgaggaa cagatgcagg acatgcagga caagtgtaag
     1201 aacttgtatt gtgaattgga agagctacag catcaccgca gaaccagtga ggaggagcag
     1261 aagcggctgc agagggagct caagtgtgcc cagaatgagg tgctccggtt tcagacctcc
     1321 cacagcaccc agcatgagga gctgaagagc aggctctgta ccctgcagca gaagtatgac
     1381 gctagccagg acgagcacag tgagcttctg aaggtgcaga tgcagctcga gactgagctc
     1441 cagcagctca gactcctcag atgcactcct gtagagagcc agagtgagaa ggagttgatg
     1501 tgccggctcc agaagctgca ggcccagcac cagtgcagtg tgaatgagaa agagcagctt
     1561 ctagaagtcc agcatcacct gcacgacaag ctgcggtgcc acgagtcaga ggtgcatcgg
     1621 ctccgaagca tggtggactg cttgcgagag aaaaatgaga agaattcagg gatacacctc
     1681 cagcttcagg agatgaaggg attgtatcag ttcagcaggg atgagctgga gcgccagaag
     1741 cacatgtatg accagctgga gcaggacttc ctgctctgcc agcaggagct gacagagctc
     1801 aagtccagcc agtccctctg tgaagagaat ggaaactgct caaacaagtg tgatgctctg
     1861 ctggccagac tgacagaatt gcaggacaag ttcaaagcca gccaggagga gattgggcac
     1921 ctgcagatgg aacagtgtga gctcctggag gaccagagga ggctgcagga ggagcagggc
     1981 cagctgcagg aagagctgca caggctcaca ttcccacagc ccaaatgtgg catcttgcag
     2041 aagagtcagg agctgctttc aaagctgcaa gatctgtgtg aaatgcagct gctctaccaa
     2101 aacatgcagg agcaacagcg aaagctgaca caaaaccagg agtgtgtact gaaggagcag
     2161 ctagaggcac acaagcatct tcgaggtttc aaagagtctc atttccagga agtgttggcg
     2221 aaccctcaag atgctagagg gcctaagtcc tccagttgtg agaataagtt caaggtgctt
     2281 atggaccagc tgcaggctct gcaggtgcta tatgacacca gtcagaaaca gcaggaggta
     2341 ctgcagcggg agcatgggcg gctcatggag gagcggaaga ggctgcaggc tgagctacag
     2401 ctctgcatgg aagaaatgca ggtgctccaa actcagtccc ccatgataaa aaggagtttt
     2461 gagtactgcg ggaagaactc aggcagcagg gcccccagca ctgagaactt ccacaggagt
     2521 tacgagagct ccattgatga aaatgagggc tatcagaaga gttatgtgag ctcccagccc
     2581 agcactgaaa ccttcctcaa gagctatgac agtagcacca gtgccaacga ggcctttgag
     2641 aagagttact gctccagcag cacaagtgtg agctataaga agagttatgg ctctgtcagt
     2701 agtggtgaga cccttcacag gagctatgcc agcagcagta ctgatgagga cccagctgag
     2761 cctgaagact tggagcactt tgaggaaaca gtggccaagg tgctgaccaa gttgcaggca
     2821 gtgaaggccc tgtaccaagt gagccaggaa gagcactgcc agctgcagca acggatgcac
     2881 aggctgctgg ccaagcagaa ggagctcaca gaggagctgc agtgctgcga gaaggagctg
     2941 agggagtgca tggagagcct ggggaagccc ctgcctcccc agagtgacaa gtgcgagatc
     3001 aaagaactgc aaactaagct gcgggagctg cagctgcagt accaggctag catggatgag
     3061 caggggcggc ttctggccgt gcaggagcag ctggaggggc agctgcagtg ctgccaggaa
     3121 gaactccgcc agctcaaaga aaacaggccc tctattagct cagaagccag gggcaagaat
     3181 gtcaataaga atatgaacaa gaatgccaat ggagttagaa ataagaagct gagcatggcg
     3241 tgctcagagg atttggagaa cggttttgag aatgaaaaga atctggaggt gatgctatac
     3301 tacaaggcca gccagaggag attagatgag ctaatgaaag aagaaaaaga gatcgaagag
     3361 gcaagaaaga aagaaagaga gaaaaaagcc aagaaagact tgtgtaaact agctactaat
     3421 ccagcagcag atcctagggc agagcctgag ccgacagaag atgaggagga aaactttgaa
     3481 gagtacagag aaggggagga tgaatcttgt gaggctgccg aggaaggcaa cccccttaag
     3541 ctttctgaga gcaaaaagaa catgtttggg atgtggaagc ctatggtttt cttggctatt
     3601 gcagcagtag ctctgtatgt gttacccaat atgcgaccgc aggaatcaga atactacatg
     3661 aagtgatggc agacctggac cagcccagag ggcagatccc cagaggctac caccctcacc
     3721 tttgggcaga atacactgtg ccagagcccc aacccaccta tgtttctcca tctcctttgc
     3781 ctcagccact cagactggaa aggcttatgg gagttgctgg ctctcaacct cctgccttgt
     3841 gtaagaacct gggttccttg taattaaatg tcagcctaat tacacga
//
