LOCUS       NM_001168659            3436 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 127 (Ccdc127),
            transcript variant 1, mRNA.
ACCESSION   NM_001168659
VERSION     NM_001168659.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164539.1, AK002564.1 and CT009486.7.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.335037.1,
                                           SRR7345562.1660959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK164539.1         2-37
            37-1443             AK002564.1         19-1425
            1444-3436           CT009486.7         122988-124980
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.17 cM"
     gene            1..3436
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /note="coiled-coil domain containing 127"
                     /db_xref="GeneID:67433"
                     /db_xref="MGI:MGI:1914683"
     exon            1..92
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /inference="alignment:Splign:2.1.0"
     exon            93..223
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..885
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 127"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 127
                     isoform 1"
                     /protein_id="NP_001162130.1"
                     /db_xref="CCDS:CCDS26644.1"
                     /db_xref="GeneID:67433"
                     /db_xref="MGI:MGI:1914683"
                     /translation="MNNLNDPPNWNIRPNARADGGDGSKWNYALLVPMLGLAAFRWIW
                     SRESQKEIEKARKAYHQRTAAFQQDLEAKYHAVISEHRRAVAQLSLELEKEQNRTSSF
                     REALISQGRKLAEEKKLLEQERAQIKQEKSRLQPLRNVYLSCLQEEDDWQRRAQHVLK
                     EVGEALEERQNIYCSLIIPRSARLELEKSLLVRTSVDPVAADLEMAAGLSDIFKHDKH
                     CGDVWNTNKRQNGKLMWMYLKYWELLVELKKFKKVEKVILEK"
     exon            224..3436
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /note="hexamer: AATAAT"
     polyA_site      1445
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /note="major polyA site"
     regulatory      3411..3416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="Ccdc127"
                     /gene_synonym="0610011N22Rik; 5430420E17Rik; A430066A18;
                     C130002N06"
ORIGIN      
        1 gtgagtggtg gtgcgcctgc gccctgtaaa cgcggcggtg gcaacacgtc tgaggtaggg
       61 tggcagcaac gctgatgggc tctgctccag gggtatagct ccatgaataa cttaaacgac
      121 cccccaaatt ggaatatcag gcccaatgcc agggctgatg ggggtgatgg aagcaagtgg
      181 aattatgccc tattggtgcc aatgctcgga ttggcagcat ttcgttggat ttggtctagg
      241 gaatcccaaa aagagataga aaaagccaga aaagcatatc atcagagaac agctgctttc
      301 caacaggatc ttgaagccaa ataccatgct gtgatctcag aacaccggcg cgctgtggct
      361 cagctgtctt tggaactgga aaaagagcaa aatagaacaa gtagttttcg agaagccctc
      421 atctcgcagg ggcgtaagtt ggcagaagaa aagaaacttc tcgaacagga acgggctcag
      481 ataaagcaag aaaaaagccg gctccagcct ctgagaaatg tctatttgag ctgcctgcaa
      541 gaagaggatg actggcagag gagagcccag catgtgctga aagaggtggg agaagctctc
      601 gaggaacgcc aaaatatcta ttgtagcctg atcatccccc gtagtgcacg actagagctg
      661 gagaagagct tactggtgcg cacatctgtt gatccagtgg ctgctgacct agaaatggca
      721 gctggcttgt ctgacatatt taagcatgat aagcattgtg gagatgtctg gaacaccaac
      781 aaacgtcaaa atgggaagct catgtggatg tatctcaaat actgggaact acttgtcgaa
      841 cttaaaaaat ttaagaaagt agagaaggtc atattagaaa aataagaatg taatgaaact
      901 caaggccaga gggagtctct ccccatggca gtctgcagtc tggggtctct tgatattttt
      961 actctgttcc tttgccacca aaagtggccc agtagagcta ctcgttgtga gaactcaagt
     1021 ctttccaccc tttgagcagt gcagtggggc cttagcagat aatgtttttc tacgatgcta
     1081 tgcagctatt agagatactt tttttgaaac atttttgagc tgctaatatt tagcaaaaca
     1141 agtacaacta tatattttag ttctaagggg aaaaaaatac aatattctta ctctaagaaa
     1201 tgttttctca gtttttacct ctactccctt tcctgatttc atgtaagagt tgttgagtaa
     1261 tatagtagtt atattaccaa aatttatctt gtttggaaca ccccaccacc accaaaaaac
     1321 caaatatttc ttatgcccag ccggtacccc agtgaatatt tagaattgag ctggtcctgt
     1381 attcaataag catgttattt attagcaatg atatgcagtc aataatattt gtcatttaaa
     1441 agtaatggtg ttgctttttt ttttttttta aatggttttt caagacaggg tttctctgta
     1501 tagccctggc tgtcctggaa ctcactttgt agaccaggct ggcctcgaac tcagaaatcc
     1561 acctgcctct gcctcccaag tgttgggatt aaaggcatac aaccaccacg ccgggcatgg
     1621 tattactttt tgtgtgactt ttactatttt ttttttgaga caatcttact acatagccca
     1681 ggtggacagt cttcctgcct caggctccca catgctgtga ttacaagtgt gtattacatt
     1741 cttgggttga taattttgca tgtattgata agtacttata actcatttac atacagctta
     1801 tatgagttga ccctttgtac ataacttaca taatccttac tctggtttta tgagctaagt
     1861 acttgtaaat ggtaatttct caagataccc aggttctgtg acttgccata gtttctaata
     1921 ctcaacctat ggttgccctc aggactaaga tttgtgttag caagaaagat aaaatcagca
     1981 gagaacaggc atgtagaaga atctagaggg agccagatgg agccaccagg ggttacactg
     2041 tggaatccca gggagcattg tttagtttag gggtataact agaaacacaa caaattccca
     2101 ggaaagctca ctggagacta tcaagatttt gatagagtga gatctattca tgtgaccttt
     2161 cacagcagtt ccattcccac aggaaggcaa gtggtagaag tcactcatag tctgtaagca
     2221 gtttaggtat ggtgaatcac tcttgctagt taccagcact gggaactccc agcatctaga
     2281 cacctattag ggactagcct tgtgtgagga tgcactatga agtctgttaa gtgagctttc
     2341 ccacatagcc ttattttaca gaggatgggg atagagagcc ttaatatgga gaaagcaatc
     2401 tgtctaggtc ataggtagta ttttgtggag tggatctgag ttgggtgttt gatttacaga
     2461 cattggaacc tgtgtgtggt tatttgtcag tagccatgca ggaagtgaac aaagtagtca
     2521 gtttgtgttc agatcctata ttctaccctg tgcatatctt tctgtgtaga gagatggcaa
     2581 acttgaaaat acttacccag aaaacagttc agttatagaa tggttaagga gcacttggcc
     2641 cgcttcctat tccacattta gttttcagaa ctaccttgac agagctgata gcaggcactc
     2701 tgagcagaag ccaggtaatt ccaccttcag ataaagctct tgtccgtagc tatttaccat
     2761 gtctttctgc tgtattacca gtcttttgag aagttatttt tttctagtac atctaagaaa
     2821 cagtttttta agattgtgtt tcctaattca ttagaccatt gaaggaagcc acataggctc
     2881 tagttttctg ttactccact ggtttgccca tgtgatcttg gacagaccac ctcatggctt
     2941 tctctaagat ttatctttta aaatgacaca ttttccaggg gaatcacatc actgtttgag
     3001 tctgtggcat gcccgccttc catcctaagt atgctttctg tctttttcaa ctgaaaatgt
     3061 tagtagcata ttttattgct gttcggggtc aagtggaagt agacagacct tgggggtaga
     3121 gacagcacag gaggatctgg aatggtttac ctgtgagagg aggtcctgaa atggggaggt
     3181 acctgagaag ggtcacatgg agaaggacta caagtgggag tcaagtccct tggttggcac
     3241 acggatggtt atagagctaa gttttttact tcagtcacaa aagaattatt ttcacactct
     3301 taagttttaa agtttagatt attacgtaaa taaactgtac atgagtttag ccacactcct
     3361 attttattag catttcatta cagtagtact ttggcaaagc aaatactgga aataaagtct
     3421 aaacgagtct ttctta
//
