LOCUS       NM_183115               2705 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled-coil domain containing 125 (Ccdc125),
            transcript variant A, mRNA.
ACCESSION   NM_183115 XM_979245 XM_979291
VERSION     NM_183115.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Araya,N., Arimura,H., Kawahara,K., Yagishita,N., Ishida,J.,
            Fujii,R., Aratani,S., Fujita,H., Sato,T., Yamano,Y., Higuchi,I.,
            Osame,M., Nishioka,K., Fukamizu,A., Arimura,K., Maruyama,I. and
            Nakajima,T.
  TITLE     Role of Kenae/CCDC125 in cell motility through the deregulation of
            RhoGTPase
  JOURNAL   Int J Mol Med 24 (5), 605-611 (2009)
   PUBMED   19787194
  REMARK    GeneRIF: These results suggest that the novel gene, Kenae/CCDC125,
            acts as a regulator of cell motility through RhoA, Rac1 and cdc42.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165159.2.
            
            On Sep 1, 2010 this sequence version replaced NM_183115.4.
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085249.1, SRR7652917.260013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               AC165159.2         126575-126945
            372-670             AC165159.2         134998-135296
            671-729             AC165159.2         136411-136469
            730-816             AC165159.2         138875-138961
            817-894             AC165159.2         139861-139938
            895-980             AC165159.2         141380-141465
            981-1063            AC165159.2         144203-144285
            1064-1164           AC165159.2         147413-147513
            1165-1272           AC165159.2         149389-149496
            1273-1444           AC165159.2         150631-150802
            1445-1575           AC165159.2         151464-151594
            1576-2705           AC165159.2         153205-154334
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..2705
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /note="coiled-coil domain containing 125"
                     /db_xref="GeneID:76041"
                     /db_xref="MGI:MGI:1923291"
     exon            1..371
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            372..670
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1884
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /note="isoform A is encoded by transcript variant A;
                     coiled-coil domain-containing protein 125"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 125
                     isoform A"
                     /protein_id="NP_898938.4"
                     /db_xref="CCDS:CCDS26736.1"
                     /db_xref="GeneID:76041"
                     /db_xref="MGI:MGI:1923291"
                     /translation="MSKVPRSSSEAEDIWETEDDMTEGDLGYGLGRKPGGIYEVPCSI
                     TSKKRSDGKNSSPPPFPRKGEERSETSFQYSRRKGFQDTSAEGYRASRLSSTDSNSEL
                     SDEQLRRRLHEALEDVEILKTELEASQRQLEGKEEALKILQSMAMLGKATSHTQTMLQ
                     KTIEQKRSLEKEINALQWEMEFDQDRFKNIEESWIQKCDRLNCDNAVLRENLKLRTEE
                     IKMLKSKNAVLNQRYLEALAMLDIKEQKMGQEESGFTDVSGLELAVLGACLCHGPGGS
                     PCSCAKMAASTRKLVLQLRHELETLQKSKEEAHITADAFRIAFEQQLMRKNEQALRLA
                     GGDLCKRAATWINRQHQADDGYPAQRRKKTLGQRLLGILPSENSSKGAEDQDNMQEVF
                     KMLVDLLNDKEEALAHQRKVSYMLARALEDKDTASERNKEKIPMSQTFPFKTAWHDAS
                     ELCGLRDPVQSNHVSEPMACICSIQHPPKVSDCPRTLKRSCSLPSTLFYK"
     exon            671..729
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            730..816
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..894
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            895..980
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1063
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1164
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1272
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1444
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1575
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..2705
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2705
                     /gene="Ccdc125"
                     /gene_synonym="5830436D01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttcctaaccg ggctttctaa tgccgaaagc cggtgttccg agatctacct ctccgggaac
       61 cccagctccg gcacactttt ctcttagggg gttcctgaag tcccaaggtt gggactcata
      121 attttccatg tattgacgct caccttgccc cagtctgttc taaatctcag acttttattt
      181 gcccgtcggt ttgtccatcc ggctttggag ctgaagttgg aggagggcag ctaacatccg
      241 gttgcacgga ggcacggata ctgggctcag gagagctgaa gcgccgctgg cccacccgga
      301 cctggcgatc ctttcgggtc ccctgcggtg gtcgtgcagt cacgtggccc gaggacgcgt
      361 ggcggagtgg gcatttggct aatgagcaaa gtgccgaggt catcgagcga ggcagaggac
      421 atctgggaaa cagaggatga catgaccgaa ggtgacctag gctatggcct cggaagaaaa
      481 cccggtggta tttatgaagt tccgtgttcg attacatcta agaaaaggtc agatggaaag
      541 aactcaagcc ctcctccgtt tccaagaaag ggagaagaaa gaagcgaaac cagtttccag
      601 tattccagga ggaagggctt tcaagataca agcgctgagg gataccgagc atccagactg
      661 agcagcacag attctaactc agaattgtcg gatgagcagt taaggcgacg tcttcatgaa
      721 gccttagagg acgtagagat tttaaaaacg gaacttgaag cgtctcaaag acaacttgaa
      781 ggtaaagagg aagcattgaa aatcctccaa agcatggcaa tgcttggcaa agccacaagc
      841 cacacacaga caatgcttca aaaaactata gaacaaaaga gatctctgga gaaggaaata
      901 aatgccttgc agtgggaaat ggaatttgat caggatagat ttaaaaatat agaagaatct
      961 tggatccaga aatgtgacag gctaaactgt gacaatgcag tcctcagaga gaatctgaag
     1021 ttgagaacag aggaaataaa gatgctaaag tctaagaatg ctgttttgaa tcagcggtac
     1081 ttggaggccc tcgccatgct tgatatcaag gagcagaaga tgggtcagga ggagagtggc
     1141 tttacagatg tatcaggtct cgagcttgca gtccttggag cctgcctgtg tcatggtcct
     1201 ggagggagcc cctgttcttg tgccaaaatg gcagcatcca ctcggaaact ggttcttcag
     1261 ctcagacatg agttggaaac tctgcagaag agtaaggaag aggcgcacat aacggcagat
     1321 gcattcagga ttgcttttga gcaacagtta atgaggaaaa atgagcaggc actgagactg
     1381 gctggagggg acctgtgtaa aagagcggca acgtggatca acagacaaca ccaggcagac
     1441 gatggatatc cggcacaaag gagaaagaag accttagggc aaagattact ggggatactc
     1501 ccttcggaaa acagctccaa gggcgctgaa gaccaagaca atatgcaaga ggtctttaag
     1561 atgctggtag atttgttgaa tgacaaagaa gaagcccttg cacatcagag aaaggttagt
     1621 tacatgctcg ctcgggcgct ggaagacaaa gacacggcct cagaaaggaa taaagaaaaa
     1681 atccccatga gccagacctt cccattcaaa acggcctggc acgacgcttc agagctctgt
     1741 ggtctgcgtg atccagtaca gtcaaaccat gtttctgaac ccatggcttg catctgttca
     1801 atacagcatc ctccaaaagt ttcagactgc ccaagaactc ttaaaagatc ctgttctttg
     1861 ccatcaactt tattttacaa gtaaaccact tgaagttaga attaagagat tcttaaaagt
     1921 cagatgttgg agctggaaac ggagctcaga ggtagacatt tggttagcgt gcctgaggcc
     1981 tggggtcagt ccatggtggc gcacgccttt aaccctggca ctcaggaaag cagaggcagg
     2041 cgatctctga ctttgaggcc agtctggtct acagagtgag ttccagcaca aatgcttcat
     2101 aaggcaatcc tgtcgtggga gaatacaaaa cgggccttgg gtctgatgtt cagcactgca
     2161 aagactgtct ggaagctcag gcctggaaat cccagcacgt gggaggctga ggcaggacaa
     2221 ctactgtaag tttgagggat aactagatta cattaagact gttgctaaag ccgggcgtgg
     2281 tagcacacac acacacactc aggaggcaga ggcaggcgga tttctaagtt cgagaccagc
     2341 ctggtctaca aagtgagttc caggacagcc agggctacac agagaaaccc tgtctcgaaa
     2401 aaataaaata aaattaaaaa aaaaaaaaaa gactgttgcc aaaacagaag aacaactata
     2461 taaatgtcaa tatgaagacg ctgtaggctt tcaaggtgtt ttaaaaattt attagcatag
     2521 taatttacaa agttgtaagt ttcattatga tatcttaata cacatattaa tacatgtgtt
     2581 ttgatgacat tcctcccttt taattttagg atgcagctta agcaagcgaa cccttatcac
     2641 atgtcctcca agaaatgtct taatatttgt gttgacattt tttataaact aatttccata
     2701 tttta
//
