LOCUS       NP_997085                629 aa            linear   ROD 28-APR-2025
DEFINITION  coiled-coil domain-containing protein 120 [Mus musculus].
ACCESSION   NP_997085 XP_620948
VERSION     NP_997085.2
DBSOURCE    REFSEQ: accession NM_207202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 629)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 629)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (residues 1 to 629)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (residues 1 to 629)
  AUTHORS   Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B.,
            Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and
            Ramsdell,F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
REFERENCE   5  (residues 1 to 629)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY023242.1, BC053918.1, BU505792.1 and AL671995.4.
            
            On or before May 25, 2005 this sequence version replaced
            XP_620948.1, NP_997085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.48 cM"
     Protein         1..629
                     /product="coiled-coil domain-containing protein 120"
                     /calculated_mol_wt=67277
     Region          2..>82
                     /region_name="CUPID"
                     /note="Cytohesin Ubiquitin Protein Inducing Domain;
                     pfam11819"
                     /db_xref="CDD:463360"
     Region          31..70
                     /region_name="Involved in CYTH2-binding.
                     /evidence=ECO:0000250|UniProtKB:Q96HB5"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AEV7.1)"
     Region          209..356
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AEV7.1)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HB5; propagated from
                     UniProtKB/Swiss-Prot (A2AEV7.1)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AEV7.1)"
     Region          399..432
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AEV7.1)"
     Site            432
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (A2AEV7.1)"
     Region          602..629
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AEV7.1)"
     CDS             1..629
                     /gene="Ccdc120"
                     /gene_synonym="DXImx50e; Jm11; Sfc25"
                     /coded_by="NM_207202.2:310..2199"
                     /db_xref="CCDS:CCDS29972.1"
                     /db_xref="GeneID:54648"
                     /db_xref="MGI:MGI:1859619"
ORIGIN      
        1 mevkgqliss ptftapaalf geaaplvksd rlrglldrqr alqealsvkl qelrkvclqe
       61 aeltgqlppe cplepgerpq lvrrrppaar ayppphpnpa hhslcpaeel alealerevs
      121 vqqqiaaaar rlalapdlng eqrrrrrqvq vdalrrlhel eeqlrdfrar lglpvlqplp
      181 lsagalvnaq gvclgtrlaq lsqedvvlhs essslsesga shdneephsc fplterpspp
      241 kawdqfravs ggsperrapw kpppsdiygd lksrrnsvas ptsptrslpr sassfegrsv
      301 patpvltrgs gprlckpegl hsrqwsgsqd sqmgfprpdp asdraslfaa rtrrsnssea
      361 llvdraaagg agsppaplap paagppvcks sevlyerpqp vpsfssrttg ppdppraarp
      421 ssaapasrga prlptvcgdf lldypldrgl prgsggagwg ellpapevpg plsrrdglla
      481 mlpgpppiya adgsspllrs kdpntrairs kpsglppeav eglevhpnpl lwmppptrip
      541 pagergghkn laleglrdwy irnsglavgp qrrpmlphvg pthtpflhar cyevgqslyg
      601 ppsqaplphs rsftappvsg ryggaftdg
//
