LOCUS       NM_001373948            2366 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 116 (Ccdc116),
            transcript variant 4, mRNA.
ACCESSION   NM_001373948 XM_006522707
VERSION     NM_001373948.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154667.2.
            
            On Sep 5, 2019 this sequence version replaced XM_006522707.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.118011.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC154667.2         113994-114063       c
            71-208              AC154667.2         113628-113765       c
            209-757             AC154667.2         111948-112496       c
            758-1360            AC154667.2         111217-111819       c
            1361-2366           AC154667.2         108681-109686       c
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.62 cM"
     gene            1..2366
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /note="coiled-coil domain containing 116"
                     /db_xref="GeneID:76872"
                     /db_xref="MGI:MGI:1924122"
     exon            1..70
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            71..208
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2197
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /note="isoform 2 is encoded by transcript variant 4;
                     coiled-coil domain-containing protein 116"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 116
                     isoform 2"
                     /protein_id="NP_001360877.1"
                     /db_xref="CCDS:CCDS88887.1"
                     /db_xref="GeneID:76872"
                     /db_xref="MGI:MGI:1924122"
                     /translation="MARCRHHSGYLADDEAAHSTYVAPLPKKHLLPEMRPTCKLGRVP
                     HLPSMNQYSEHQSHQQNFRHPLAFGGFLDFLTEGQVLDSLQTVVEQATERLAAMKTEA
                     GVPLVDIQDPVEVPSSRHRSRARPSIDTVHRHRARPTLCAGRPNNYPSCSSSMSDSHS
                     SITAGWLGSHSQDSDLGARGIGSLPPMRDKLLLEKNLKRLLRLENKGKILNQSCSQRD
                     SLLWDSLGSQTSSQWTREQPLSWFSGLLGSSPATPETSELGLGEQEMIFLKQKLNKEM
                     KSLLNQPRPFNLPTYCPLREPHHTLDFLAKHRLFPALQRVVSQAVDKLSHACRHNGFP
                     LFPVTSETIPDLPGNSDLLQPSSKASIPTNREARGEPCDSLTTAYSPKTSHRKSKGRR
                     GSPPNAVQMATRFRLKSPNTKFSKKKPLPAISSVSSLSYISNPWFEELTNFLVEQAVS
                     LLICKYKFEESLNKQLGFISFPITEVLMDIFLGFKKVKGTHIRLSSDINWTCLLRKLE
                     EAELSQQALRHASRSGTSPRSVSRIGTTQHSTEPSSMQPELTGDTDQDQSPESYLSLH
                     PELPIHQLLNSQDPGTGQEQTPNMNLSEAKHSIISNASIGSRSSKTKKVENTEEGENG
                     EEEEEEEEEEEEEEEEEEEDRGSKEDDTKDFFEGEHTPPSPPLHELENFMNTTTVMSP
                     NNSP"
     exon            209..757
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1360
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2366
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2366
                     /gene="Ccdc116"
                     /gene_synonym="4930432J16Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttctctgt gcggtagagc tttaaagggt gctgagtgag cgaaccccta gaagcacagc
       61 agagactctg aggagtctgc atctgtgctg tgggacctga aaaaggaagc agaaaacaaa
      121 tttaattatc ctcatcatgg cgaggtgccg ccaccactca ggatatctgg ctgacgacga
      181 ggctgctcac agcacctatg tggccccgct gcccaagaag cacctgttgc cagaaatgag
      241 gccaacctgc aagcttgggc gtgtaccaca cctaccatca atgaaccaat actcagagca
      301 ccaaagccac cagcaaaact ttaggcaccc tctggcattt ggtggcttcc tggatttcct
      361 cacggagggt caggtactgg acagcttgca gacagttgtg gagcaggcaa cagaacgttt
      421 ggctgccatg aagacagagg ctggcgtgcc actggtggat attcaagacc ccgtggaggt
      481 gccaagtagt aggcatcgat ctcgagccag acccagcatc gacactgtgc accggcaccg
      541 tgctcggccc accctgtgtg ctggacgccc aaacaattac ccatcttgct ccagttccat
      601 gtctgattcc catagcagca tcacagctgg atggctgggg tcccacagcc aagacagtga
      661 cctgggtgcc agaggcatag gctcactgcc acctatgagg gacaaactcc tgcttgagaa
      721 aaacctcaag aggctactcc gactggaaaa caaagggaaa atcctgaatc aatcctgctc
      781 ccagagggat tccctgctgt gggactcact gggcagccaa accagcagtc agtggacccg
      841 ggagcagccc ctgtcttggt tctctgggct attgggctcc agtccagcca cccctgaaac
      901 ttcagagttg ggacttggag aacaggagat gattttcctc aaacaaaagt taaacaagga
      961 gatgaagtca ctgctgaacc agccaagacc cttcaacctg cctacctatt gtccactcag
     1021 ggaaccccat cataccctgg acttcctagc taagcatcgt ctctttcctg ccctgcagcg
     1081 tgtggtcagc caggctgtag acaagctcag ccatgcctgc cgtcacaatg gcttccccct
     1141 cttcccagtt acctcagaga ccattccaga tctgcctgga aactccgatc ttctgcagcc
     1201 cagctctaag gcttccatac ccaccaacag ggaggctagg ggagagcctt gtgattctct
     1261 caccacagcc tacagcccta agacatctca cagaaaaagc aagggcagaa ggggctcccc
     1321 acctaatgca gtccagatgg ctaccagatt caggctcaag agccccaaca ccaagttttc
     1381 gaagaagaag cctctgcccg ccatctcatc tgtttccagc ttgtcctaca tctctaaccc
     1441 ctggtttgag gaactcacta acttcttggt tgagcaggca gtctccttgc ttatctgcaa
     1501 gtacaagttt gaggaaagcc tcaataagca acttggcttc atctcttttc ctatcactga
     1561 ggttctcatg gacatctttc tgggcttcaa gaaggtgaag ggtacccaca tccgcctgtc
     1621 ctcagacatc aactggacct gtcttcttcg taagttggaa gaagctgagt tgtcacagca
     1681 ggccctaaga catgcctcca ggtcaggaac ctctccacgt agtgtctccc gtattggcac
     1741 cacccagcat agcacagaac cctcctccat gcaaccggag cttactggtg acacagacca
     1801 ggaccagtct ccagagtcct acctctccct ccaccctgag ttgccaatcc accagctgct
     1861 caactctcag gatcctggaa caggccagga acagacacct aacatgaacc tgtcagaggc
     1921 caagcactct ataatctcca atgctagtat cggctctaga tcttccaaga ccaagaaagt
     1981 ggaaaacact gaagagggtg agaacggtga ggaggaggaa gaagaggagg aggaagaaga
     2041 ggaggaagag gaggaggaag aggaggacag aggaagtaag gaggatgaca ccaaagattt
     2101 ttttgagggt gagcacacac ctcctagccc gcctttgcat gagttggaga actttatgaa
     2161 tacaaccact gtaatgagcc caaataactc cccatgaggc ctctgtgagc cacaaagagt
     2221 actcctgtcc tatcctaata gctggccact cagccagccc tgttctgagt gaaggtcagg
     2281 atgactgggt gctcaggagg agctctgcta gtattatcaa gggagccaaa gagccaaatg
     2341 gaaataaata catgttggtg gacaca
//
