LOCUS       NM_178793               5742 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus collagen and calcium binding EGF domains 1 (Ccbe1),
            mRNA.
ACCESSION   NM_178793
VERSION     NM_178793.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5742)
  AUTHORS   Ocskay,Z., Balint,L., Christ,C., Kahn,M.L. and Jakus,Z.
  TITLE     CCBE1 regulates the development and prevents the age-dependent
            regression of meningeal lymphatics
  JOURNAL   Biomed Pharmacother 170, 116032 (2024)
   PUBMED   38141283
  REMARK    GeneRIF: CCBE1 regulates the development and prevents the
            age-dependent regression of meningeal lymphatics.
REFERENCE   3  (bases 1 to 5742)
  AUTHORS   Bonet,F., Anez,S.B., Inacio,J.M., Futschik,M.E. and Belo,J.A.
  TITLE     CCBE1 Is Essential for Epicardial Function during Myocardium
            Development
  JOURNAL   Int J Mol Sci 23 (20), 12642 (2022)
   PUBMED   36293499
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5742)
  AUTHORS   Gur-Cohen,S., Yang,H., Baksh,S.C., Miao,Y., Levorse,J.,
            Kataru,R.P., Liu,X., de la Cruz-Racelis,J., Mehrara,B.J. and
            Fuchs,E.
  TITLE     Stem cell-driven lymphatic remodeling coordinates tissue
            regeneration
  JOURNAL   Science 366 (6470), 1218-1225 (2019)
   PUBMED   31672914
REFERENCE   5  (bases 1 to 5742)
  AUTHORS   Gancz,D., Raftrey,B.C., Perlmoter,G., Marin-Juez,R., Semo,J.,
            Matsuoka,R.L., Karra,R., Raviv,H., Moshe,N., Addadi,Y., Golani,O.,
            Poss,K.D., Red-Horse,K., Stainier,D.Y. and Yaniv,K.
  TITLE     Distinct origins and molecular mechanisms contribute to lymphatic
            formation during cardiac growth and regeneration
  JOURNAL   Elife 8, e44153 (2019)
   PUBMED   31702554
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5742)
  AUTHORS   Zou,Z., Enis,D.R., Bui,H., Khandros,E., Kumar,V., Jakus,Z.,
            Thom,C., Yang,Y., Dhillon,V., Chen,M., Lu,M., Weiss,M.J. and
            Kahn,M.L.
  TITLE     The secreted lymphangiogenic factor CCBE1 is essential for fetal
            liver erythropoiesis
  JOURNAL   Blood 121 (16), 3228-3236 (2013)
   PUBMED   23426945
  REMARK    GeneRIF: The secreted lymphangiogenic protein CCBE1 is essential
            for fetal but not postnatal erythropoiesis.
REFERENCE   7  (bases 1 to 5742)
  AUTHORS   Hagerling,R., Pollmann,C., Andreas,M., Schmidt,C., Nurmi,H.,
            Adams,R.H., Alitalo,K., Andresen,V., Schulte-Merker,S. and
            Kiefer,F.
  TITLE     A novel multistep mechanism for initial lymphangiogenesis in mouse
            embryos based on ultramicroscopy
  JOURNAL   EMBO J 32 (5), 629-644 (2013)
   PUBMED   23299940
REFERENCE   8  (bases 1 to 5742)
  AUTHORS   Bos,F.L., Caunt,M., Peterson-Maduro,J., Planas-Paz,L., Kowalski,J.,
            Karpanen,T., van Impel,A., Tong,R., Ernst,J.A., Korving,J., van
            Es,J.H., Lammert,E., Duckers,H.J. and Schulte-Merker,S.
  TITLE     CCBE1 is essential for mammalian lymphatic vascular development and
            enhances the lymphangiogenic effect of vascular endothelial growth
            factor-C in vivo
  JOURNAL   Circ Res 109 (5), 486-491 (2011)
   PUBMED   21778431
  REMARK    GeneRIF: Phenotypic analysis of murine Ccbe1 mutant embryos show a
            complete lack of definitive lymphatic structures, even though
            lymphatic endothelial cells are specified within the cardinal vein
REFERENCE   9  (bases 1 to 5742)
  AUTHORS   Facucho-Oliveira,J., Bento,M. and Belo,J.A.
  TITLE     Ccbe1 expression marks the cardiac and lymphatic progenitor
            lineages during early stages of mouse development
  JOURNAL   Int J Dev Biol 55 (10-12), 1007-1014 (2011)
   PUBMED   22252499
  REMARK    GeneRIF: Ccbe1 expression marks the cardiac and lymphatic
            progenitor lineages during early stages of mouse development
REFERENCE   10 (bases 1 to 5742)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ179960.1, AK035153.1, AC102243.14 and AV264768.2.
            
            On Feb 2, 2007 this sequence version replaced NM_178793.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.17526.1, AK035153.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CJ179960.1         1-6
            7-1613              AK035153.1         2-1608
            1614-5593           AC102243.14        78274-82253         c
            5594-5742           AV264768.2         584-732
FEATURES             Location/Qualifiers
     source          1..5742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.13 cM"
     gene            1..5742
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /note="collagen and calcium binding EGF domains 1"
                     /db_xref="GeneID:320924"
                     /db_xref="MGI:MGI:2445053"
     exon            1..218
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1311
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /note="collagen and calcium-binding EGF domain-containing
                     protein 1; full of fluid protein homolog"
                     /codon_start=1
                     /product="collagen and calcium-binding EGF
                     domain-containing protein 1 precursor"
                     /protein_id="NP_848908.1"
                     /db_xref="CCDS:CCDS29314.1"
                     /db_xref="GeneID:320924"
                     /db_xref="MGI:MGI:2445053"
                     /translation="MVPPPLPSRGGAAKRQLGKSLGPLLLLLALGHTWTYREEPEDRD
                     REVCSENKITTTKYPCLKSSGELTTCFRKKCCKGYKFVLGQCIPEDYDICAQAPCEQQ
                     CTDNFGRVLCTCYPGYRYDRERHQKRERPYCLDIDECATSNTTLCAHICINTMGSYHC
                     ECREGYILEDDGRTCTRGDKYPNDTGHEEKSENEVKAGTCCATCKEFSQMKQTVLQLK
                     QKMALLPNNAAELGKYVNGDKVLASNAYLPGPPGLPGGQGPPGSPGPKGSPGFPGMPG
                     PPGQPGPRGSMGPMGPSPDLSHIKQGRRGPVGPPGAPGRHGSKGERGAPGPPGSPGPP
                     GSFDFLLLVLADIRNDIAELQEKVFGHRTHSSAEDFPLPQEFSSYPETLDFGSGDDYS
                     RRTEARDPEAPRNFYP"
     exon            219..299
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            300..352
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            353..487
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            488..640
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            641..744
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            745..865
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1005
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1041
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1077
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..5742
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1505
                     /gene="Ccbe1"
                     /gene_synonym="4933426F18Rik; 9430093N24Rik; mKIAA1983"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcggct gcggccgcgg agcctccctg ggcacagcgc agggagagag ctcgggcgcc
       61 gagaagaagc cgcgagcttc cccgatggtg ccgccgcctc ttccgagccg gggaggagca
      121 gccaagaggc agctgggcaa gagcctgggg ccgctgctgc tactcctggc gctgggacac
      181 acgtggacct accgagagga acccgaggac cgcgacagag aagtgtgctc tgaaaacaag
      241 atcaccacga ccaaataccc atgtctgaag tcttcgggcg agctcaccac gtgcttcagg
      301 aaaaaatgct gcaaaggata taaatttgtt cttggacagt gtattccaga agattatgac
      361 atttgtgccc aagctccctg tgaacagcag tgcacggata acttcggccg tgtgctgtgc
      421 acgtgctacc cgggataccg atatgaccgc gagagacacc aaaagcggga gagaccgtac
      481 tgtctggata tcgatgaatg tgccaccagc aataccactc tctgtgcaca tatctgcatc
      541 aacaccatgg gcagctacca ctgtgagtgt cgggagggct acatccttga ggacgatggg
      601 aggacctgca caaggggaga caaatacccc aatgacactg ggcatgaaga gaagtccgag
      661 aatgaggtga aagccgggac ctgctgcgcc acatgcaaag agttctccca gatgaagcag
      721 accgtgctgc agctgaaaca gaagatggcg ctgctcccca acaatgccgc tgaactgggc
      781 aagtatgtca atggtgacaa ggtactggcc tcaaacgcct accttccagg acctcctggc
      841 ctgcctgggg gacagggccc accaggctca ccaggaccca aggggagccc tggattcccc
      901 ggtatgccag gccctcctgg acagccaggc ccacggggct caatgggacc tatgggacct
      961 tcccctgacc tgtctcatat taagcaaggc cggaggggcc ccgtgggccc accaggagca
     1021 ccaggaagac acggctccaa gggggagaga ggagcacccg gacccccggg gtctccggga
     1081 cccccaggtt ctttcgactt cctgctgctt gtgctggcgg acattcgaaa tgacatcgca
     1141 gagctgcagg agaaggtgtt tggacaccgg actcactctt ccgccgagga cttcccccta
     1201 cctcaggaat tctccagcta cccagagacg ctggactttg gctctggaga tgactactcc
     1261 agaagaactg aagcaaggga ccccgaggcc ccaagaaatt tttatccata gcacatccca
     1321 tatcctcacg ccaccagaag agaagcatgc cttcgacctt ccccttactc tgtttccaaa
     1381 cccggttttc caagtttcct gtgcatcaca ctagcaacag gaagatgtga tgggttaacg
     1441 tgctgttctt gaagagccaa tgggtggttg acatcaagac tttcttcaac gtccgatttt
     1501 ttcaagagct tttgggtttc tgagttcatc attccacaga atcttcaact ttggcagagt
     1561 gcaaaagagg ggaaaatggc accgtgggtt cttaggagtg taaggttcct tctaaaaaga
     1621 aaataatgtt caaatgcttg actattcatt ccctactgtc aggagtaagg cttttagggt
     1681 gggggtgggg gtggaggggc atggaaggag caaccatgga gaataacatt gatagaaaat
     1741 gattttcctt agcaatatcc cagatttcaa attctgcatc ctattttcca acttgatggg
     1801 ggtttttttt tgtttgtttg ttttggtttg gttttttgtt ttttgggggt gtttgtttgt
     1861 ttgtttgtct ttaaatttgg ttacagaaac aagagattgg aaagaatgtg ttcagagaga
     1921 tagagaatta gccttatatt tcctgtctca taggttgccg aatttagaat tcagatacga
     1981 cagtcattga ttcgtgcaaa tcctatgtgg aggagggagt ttgtttgtaa gggcttgatc
     2041 atgttttcta gggagcttgg ggtgaggaaa cactctgtgc atactagaac agagggctcc
     2101 tggagaccag gacgattgaa gactacatgg tcaaaagcat tgtcctgctc catacatgtt
     2161 gatgatttgt gaaataagat ggctgacatt taagaagaag tacaagatgc cctggcactg
     2221 acagggttgc cagatgtgcc agcaaggcct gatccaggct gaatcaaggc tggagggaaa
     2281 tcactgccct ggaatcttag ccaaggatgt caaggggaca ttgagaagtg cttcactaaa
     2341 atcagattaa tcagaagcag attaatctac tcttaagaga tttgaagttc tcaccagggc
     2401 acacttggaa cagcatacag ctgagaggtc tctgagatag agaaggagga ggagtttttg
     2461 ataaattgga ataattttcc actatttgcc ccctgatttg gttagaatcc ctgttgttct
     2521 gggtgtcctt gactttttgt cctgggccac aaggaaacgg cttggaggcc agcacatttc
     2581 ccaatgtctc cctaagtccc ttcttggagt atgtctagat ccccagggaa tcatgttccc
     2641 agaaaggagc aagaggccag caggttcctt cttggtatct ctgggttctt gtttcaggga
     2701 tctgcttccg ggctccttag tgaacacttt ctccttgggt gtgcagcagg ctccgtgatc
     2761 ttgctcacat ggttgcccac accagggtcc cagtttgcta tcctgcagtg cccccttata
     2821 tttctaagaa gtttgagatt gcattgatct tttccctata tcacttaagc ctccatcgtc
     2881 ttcccacacc tactgtgaca gcttgttgga ggaaacagct attggtttgc atgacactgc
     2941 atccaccatc cactcttctt tctgagcaat aagaaggggc tctgtctaca gagccagcca
     3001 gagcctcgtg ggctttcact tcccctctcc cacctcccta ccctcatccc tctctcctgg
     3061 ttctcttcct tttccttttt tttctctctt cctctcctcc tcttttgctc cttctctcct
     3121 tcatttcctc tacccctatc ctagcttccc tgcctttcca cctctccttt cttacttgct
     3181 tccttcctcc ctccttccct ccctcccttt ctccttctct ccctccatct ttcttccttt
     3241 ctactccctc cctcccttcc tacctaccta cttccttcct tccctttttt cttccttagt
     3301 tccctctctc tgctccctcc ctccttccct ccatgcttgc ctgcctatct tcctacccag
     3361 ttagaaaggc aggattccca cacactccca cccaaatccc cagtggctgt ccatcagcag
     3421 tcctgatgaa ggcaagcaca cacttgcatc gcttgcttgc tgtctcaccc tccttccccc
     3481 ttcagtctct cctgaacctg tgcatcacca cagatagcct tgtcaactgt ggcttcctga
     3541 agagatggat gcaaccgcag tcaagtgcca cctggaatct atttagtgct tgcctgctta
     3601 tagaacccat cttttaaagg gtgtggatgg atgaattctc aaaactatgc acaggctctg
     3661 tgagcaataa ttatgtccat ctttttttat gaggaatttt ataactactt tttatgtcta
     3721 ctttttttag acagtgaaat gtatgtagaa atataatctt tattgccaaa tgctggtaaa
     3781 acgcgagcac actccatgct tggctggagg ccaggataat gtactgaaag aatgaagaga
     3841 aagtcataat atctgggatt catgagtctg tctagataat tacctccagg aaaacataat
     3901 agcctatatt ttgtgatctc aatatgccat gtcaatttag ataatcgtta ctcctcagat
     3961 tttcaaaaca tggaatacta actaactaca agaccaacgc atgtcctcta cttattcaaa
     4021 tcatggattt ttagtgataa agcattattg ctcccatatc ttttagttgt ggacagaaaa
     4081 aaaaatcaaa gcttttctgt ctaaacaaat ttctgctcaa aatatcatag gaaggccttt
     4141 gggaggaagg acagttcaga acaaatttac cgagtcactt catatctcac agggaaaata
     4201 ttttagtttt ttatacgccc ttcaacactt tagtagaaat ggtcaacttt tctaatattt
     4261 ccactggtta agacttggtt atgaattgcc tctgtgttta taaagcaatg agaataaaat
     4321 ttcactgaaa ataatataaa gaagactttc attttagttt aggaaaactg aattttccaa
     4381 ttccagaagg aaaaaaataa ccagttttcc tgtgccagtt aagtgttagg agctaggtgt
     4441 gatggtggac acctgtaatc ccagcacctg agaagcacag ctaggcagat caggagttca
     4501 aggtcagcct cagctacata acaagtgtga ggccagcctg ggctatctga gagtctatct
     4561 caaaataata atgatgatga tgataatgtg atgataataa agaataataa ttagcagagg
     4621 actaaagaga tggctcagag gttaaggatt cttgctgctc ttccagagat acagagctca
     4681 gtttccagct cttgcacagg cagctcacaa catctgtaaa cacaggtcca ggtgatctgg
     4741 cgccctcttc tggcttccat agtacctgca ctcacatgca cacacacaca tagatataca
     4801 aacacataat tacaaataaa gtctttttta aaggagtggg tacaaagagg atgctgcctt
     4861 ttcttgcttt ctatgttact ttccaatact tgctacggaa ttaactaaag tcatattgct
     4921 gtgtggagcc aggccactat ccagcaggaa aattataagt gcccagtgat cttggaagaa
     4981 gttttggccc atcaaaggcc aggtgcagag caccctggta gacccaggta agtcatgttc
     5041 cctttccaag gttctgaaca tccttggcct tggaagtacc actatcaggc acattggcac
     5101 aaaacttctt catgaccatc catcaaactt taccttgagg tctcaggaag ccacccccct
     5161 atcttatttt gagcatcatt tttcattttc ctcctcttcc aaattcaaac agacagcctc
     5221 aggagcctcc ttctgcaagc ttatcttcca gacaactgtt ctaaaaggga aagctattgg
     5281 ctggaatctg agccatacaa ttagtaatat agaggcttct gttctattca gggaaataca
     5341 tgggtcattt cctgatgcag caatcatgta tgtttcacaa catgtcaaaa ataattttct
     5401 ctttggattt ttcaagggcc gtcattgtta aagctgaaat ggtgtgcttt atatactctt
     5461 cctacaaatg ttaccatcag agaggaacca tgaaaaagga catatgggct atccatccct
     5521 cagagagctc agtatgtttt gtccgattcc cagagcttga tccctgagtg gttcttgagt
     5581 ctgtttttat ttctcagtca ctggtcatat atttcagtat ctctgtgcat tatttatatc
     5641 agatcttgta acagtcaaac tgatattcca acagtcatgg atgtaatact aggaagtgcg
     5701 tttgtatgac tgtatatgct taataacaaa gttatttttc tt
//
