LOCUS       NM_146055               3705 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cell cycle activator and apoptosis regulator 2
            (Ccar2), mRNA.
ACCESSION   NM_146055 XM_001001452 XM_985344
VERSION     NM_146055.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Liang,N., He,J., Yan,J., Han,X., Zhang,X., Niu,Y., Sha,W. and Li,J.
  TITLE     DBC1 maintains skeletal muscle integrity by enhancing myogenesis
            and preventing myofibre wasting
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (1), 255-269 (2024)
   PUBMED   38062876
  REMARK    GeneRIF: DBC1 maintains skeletal muscle integrity by enhancing
            myogenesis and preventing myofibre wasting.
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Wang,Y., Wang,J.M., Xiao,Y., Hu,X.B., Zheng,S.Y., Fu,J.L.,
            Zhang,L., Gan,Y.W., Liang,X.M. and Li,D.W.
  TITLE     SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells
  JOURNAL   Aging (Albany NY) 15 (17), 8812-8832 (2023)
   PUBMED   37683133
  REMARK    GeneRIF: SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells.
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Niri,F., Terpstra,A.N., Lim,K.R.Q. and McDermid,H.E.
  TITLE     Chromatin remodeling factor CECR2 forms tissue-specific complexes
            with CCAR2 and LUZP1
  JOURNAL   Biochem Cell Biol 99 (6), 759-765 (2021)
   PUBMED   34197713
  REMARK    GeneRIF: Chromatin remodeling factor CECR2 forms tissue-specific
            complexes with CCAR2 and LUZP1.
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Colman,L., Caggiani,M., Leyva,A., Bresque,M., Liechocki,S.,
            Maya-Monteiro,C.M., Mazal,D., Batthyany,C., Calliari,A.,
            Contreras,P. and Escande,C.
  TITLE     The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular
            response and formation of aortic dissection during Angiotensin II
            infusion
  JOURNAL   Sci Rep 10 (1), 6772 (2020)
   PUBMED   32317757
  REMARK    GeneRIF: The protein Deleted in Breast Cancer-1 (DBC1) regulates
            vascular response and formation of aortic dissection during
            Angiotensin II infusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Santos,L., Colman,L., Contreras,P., Chini,C.C., Carlomagno,A.,
            Leyva,A., Bresque,M., Marmisolle,I., Quijano,C., Duran,R.,
            Irigoin,F., Prieto-Echague,V., Vendelbo,M.H., Sotelo-Silveira,J.R.,
            Chini,E.N., Badano,J.L., Calliari,A.J. and Escande,C.
  TITLE     A novel form of Deleted in breast cancer 1 (DBC1) lacking the
            N-terminal domain does not bind SIRT1 and is dynamically regulated
            in vivo
  JOURNAL   Sci Rep 9 (1), 14381 (2019)
   PUBMED   31591441
  REMARK    GeneRIF: A novel form of Deleted in breast cancer 1 (DBC1) lacking
            the N-terminal domain does not bind SIRT1 and is dynamically
            regulated in vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Li,Z., Chen,L., Kabra,N., Wang,C., Fang,J. and Chen,J.
  TITLE     Inhibition of SUV39H1 methyltransferase activity by DBC1
  JOURNAL   J Biol Chem 284 (16), 10361-10366 (2009)
   PUBMED   19218236
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151836.3.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_985344.2, XM_001001452.2, NM_146055.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038346.1, AK028194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC151836.3         151594-151758       c
            166-259             AC151836.3         150631-150724       c
            260-351             AC151836.3         150340-150431       c
            352-443             AC151836.3         149847-149938       c
            444-558             AC151836.3         149528-149642       c
            559-688             AC151836.3         149241-149370       c
            689-785             AC151836.3         148979-149075       c
            786-905             AC151836.3         143810-143929       c
            906-1128            AC151836.3         141555-141777       c
            1129-1242           AC151836.3         141366-141479       c
            1243-1406           AC151836.3         140892-141055       c
            1407-1578           AC151836.3         140327-140498       c
            1579-1806           AC151836.3         139910-140137       c
            1807-2043           AC151836.3         139578-139814       c
            2044-2188           AC151836.3         138835-138979       c
            2189-2271           AC151836.3         138432-138514       c
            2272-2418           AC151836.3         137954-138100       c
            2419-2530           AC151836.3         137727-137838       c
            2531-2719           AC151836.3         137459-137647       c
            2720-2925           AC151836.3         137137-137342       c
            2926-3705           AC151836.3         136135-136914       c
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.24 cM"
     gene            1..3705
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /note="cell cycle activator and apoptosis regulator 2"
                     /db_xref="GeneID:219158"
                     /db_xref="MGI:MGI:2444228"
     exon            1..165
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            166..259
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2970
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /note="cell division cycle and apoptosis regulator protein
                     2"
                     /codon_start=1
                     /product="cell cycle and apoptosis regulator protein 2"
                     /protein_id="NP_666167.3"
                     /db_xref="CCDS:CCDS49534.1"
                     /db_xref="GeneID:219158"
                     /db_xref="MGI:MGI:2444228"
                     /translation="MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQ
                     NARHLQSGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNP
                     GQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFP
                     QKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPR
                     HDLSPYRVHLTPYTVDSPTCDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLGQPFSLH
                     HPSRIQVSSEKEAAPDTGAEPSPEDSDPTYSSKVLLLSSPGLEEFYRCCMLFVDDMAE
                     PRETPEHPLKQLKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQT
                     GIDLSTCTKWWRFAEFQYLQPGPPRQLHTVVVYLPDVWTIMPTLEEWEALCQQKATEA
                     APQPHEASGEAEATEQAPDVSEQADTSKQNTETMEATTQQDVDTDLPEAPPPPLEPAV
                     MARPRCVNLSLYGIVEDRRPKERISFEVVVLAELFVEMLQRDFGYRIYKTLLSLPEKV
                     VSPPEPEKEEAAKEDAVKEEEAVKEEAVKVSKDEVQNEGTAAESDSPLKEDGLLPKRP
                     SSGGEEEEKARGEAAEDLCEMALDPDLLLLRDDGEDEFAGAKLEETEVRSVASNQSEM
                     EYSSLQDMPKELDPSTVLPLDCLLAFVFFDANWCGYLHRRDLERVLLTLGIRLSAEQA
                     KQLVSRVVAQNICQYRSLQYSRAEVLDDGLPEDVLFGNLDLLPPSGKSTKPGAAPTEH
                     KGLVPHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTL
                     AAEMQELRARLAEAEETARTAERQKNQLQRQMQDFRRRLTPLHLEMQRIVEKADSWVE
                     KEEPTPSN"
     exon            260..351
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            352..443
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            444..558
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            559..688
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            689..785
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            786..905
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1128
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1242
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1406
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1578
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1806
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2043
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2188
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2271
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2418
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2530
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2719
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2925
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3705
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3173..3178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /note="hexamer: AATACA"
     polyA_site      3196
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="Ccar2"
                     /gene_synonym="2610301G19Rik; Dbc1; mKIAA1967"
                     /note="major polyA site"
ORIGIN      
        1 gaagggagag gtcgatggag aagagggagg taccatatcc gggagagtgg cagcttccga
       61 ccagtggtct ctcttccgga gaggcgtttc cggtggtggt ggcagcggcg gctgcggtgg
      121 ttccgggtgt ctttgtcccc ctggtgtcgt ggccctggcc cgcaggtttc cccccaagac
      181 cttgaaagga cagtattcca aatgtcccag tttaagcggc agaggatcaa cccacttcca
      241 gggggacgca acttctcagg cgcagcttca acatctcttt tgggccctcc ccctggtcta
      301 cttactcctc ctgtggccac agacctgtcc caaaatgcca ggcaccttca gagtggggaa
      361 aagcagcgag tcttcacagg cattgttacc agcttgcatg actactttgg ggtggtagat
      421 gaagaagtct tttttcagct aagtgtggtg aagggtcgac tgccccagct gggggagaag
      481 gtgctggtga aggccgcata caacccaggc caggccgtgc cctggaatgc tgtcaaggtg
      541 cagacgctct ccaaccagcc cttactgaag tctccagcgc ctccccttct gcacgtggca
      601 gctctgggcc agaagcaagg gatcctggga gctcagcccc agctgatctt tcagcctcac
      661 cgaattcccc cccttttccc tcagaagcct ctgagtctct tccagacatc ccacacactt
      721 cacctgagcc acctgaacag atttcctgct cggggtcctc atggaaggct ggaccagggc
      781 cgaagtgatg actatgactc gaagaaacgc aaacagcggg ctggcggaga gccttggggt
      841 gctaagaaac ctaggcatga cctgtctcct taccgggttc atctcactcc ctatactgtg
      901 gacagtccca cctgtgactt cctagaactg cagcgacgtt accgcagcct gttggtcccc
      961 tcagatttcc tttccgttca cttgagctgg ctgtcagcct tccctctggg ccagcccttt
     1021 tccctccacc acccaagtcg gatccaggtc tcttcagaga aggaggcagc tccagacact
     1081 ggtgctgagc ccagccctga ggacagtgac cccacttaca gttccaaggt gctgctgctc
     1141 tcctccccag gcctggagga gttctatcgt tgctgcatgc tgtttgtgga tgacatggct
     1201 gagccaaggg agacaccaga gcatcctctg aagcagctaa agtttttgct gggccggaaa
     1261 gaagaagagg cagtgctggt tgggggtgag tggtctcctt ccctggatgg cctcgacccc
     1321 caggcagacc cgcaggtgct ggtgcgcaca gccatccgct gtgcacaagc ccagactggc
     1381 attgacttga gcacctgcac caaatggtgg cgctttgctg agtttcagta cttacagccg
     1441 gggccgcccc ggcagttaca cacagtagtg gtgtacctgc cagacgtgtg gaccatcatg
     1501 cccactttgg aggagtggga ggcactgtgc caacagaaag ccacggaggc agctccccaa
     1561 ccacatgagg catcagggga agcagaggct actgaacagg ctcctgatgt gtcagagcaa
     1621 gcagacactt ctaaacagaa cacagagaca atggaggcca ccacacagca agatgtggac
     1681 actgatctcc cagaggcccc tccgcctcct ctagaacctg ctgtgatggc ccgtcctcgc
     1741 tgtgtcaacc tgtctcttta tggaattgtg gaggatcgga ggccaaaaga aaggatctct
     1801 tttgaggtag tggtgctggc tgagctgttt gtagagatgc tgcagaggga ttttggctat
     1861 agaatttata agacgctgct gagccttcca gaaaaagttg tgtctcctcc tgaacctgag
     1921 aaggaggagg cagccaaaga agatgcggtc aaagaggagg aggctgtcaa agaggaggca
     1981 gtgaaggtgt ccaaggatga ggtacagaat gagggcacag ctgccgagtc agacagccca
     2041 ctgaaggagg atgggcttct gcccaaacgg ccctcttcag ggggagaaga ggaggaaaag
     2101 gcccggggcg aggcggctga ggacctctgt gagatggcct tggacccaga cctgctgctg
     2161 ctgcgggatg atggagagga cgaatttgca ggagcaaagc tagaggaaac agaggttcgt
     2221 tctgttgcct caaaccagtc agagatggaa tattcttctc ttcaggacat gcctaaggag
     2281 ctggatccct caactgtgct ccccctggac tgtcttttgg cttttgtgtt ttttgatgcc
     2341 aactggtgtg gctacttgca caggcgagac ttggagaggg tcctcctcac actagggatc
     2401 cggctcagtg cagagcaggc caaacagttg gttagtagag tggtggcaca gaacatctgc
     2461 cagtaccgga gccttcagta cagccgtgct gaagtgctgg acgatggcct tcctgaagac
     2521 gtgctcttcg gaaacctgga tctactgcct ccttcaggga agagcacaaa gccaggtgct
     2581 gcccccacag agcacaaagg cctggtgccc cacaatggta gcctcatcaa tgtgggaagc
     2641 ctgttacagc gtgcagagca gcaagacagt ggccgcctat acctggagaa caagattcac
     2701 acactggaac tgaagcttga ggagagccat aaccgcttct cagccactga ggtgacaaat
     2761 aagacactgg cagcagagat gcaggagctg cgggcccggc tggccgaggc agaggagacg
     2821 gcccggacag cagagcgaca gaagaaccag ctccagcgac agatgcagga cttccgcagg
     2881 cgcctgaccc cactgcacct tgagatgcag cggattgttg agaaggctga cagctgggta
     2941 gagaaagaag agccaacgcc tagcaactga gtggctgcct agtgaggtct gcgatggagc
     3001 ctgatgacat tagagccctt ttggtaccag aaggcagctg gagcagggcc tgggagccac
     3061 agcaggggta gcttgagttc tgtgctcagc ctctgcaggg gatgtcaaac tcagtatggg
     3121 gtttgtgcta tgtggatgga tatgtaagga actccagttc cagctacaac taaatacaac
     3181 gtcctttgca cccctagaat gtcattttgc cctcaatctt ggaatttctc ccagggccct
     3241 tgtagtcttg tgctgtctcc tgtcctcgtc cattttagag caagacggga ggaaaaggca
     3301 tttccagccc agaacaaggt ctaatgccaa taaatgggag gaatgggtgt agagttgatg
     3361 cagccaagaa tgtccgtcct ctgggcggca caagtcccgc aggctctgtg tctgttaggt
     3421 gatggagccc attcaaggag catttggtgt tgggtcaggg ttgccaatag aacactgtgt
     3481 cccagctgcc cccaacttgc cagaagaacc agcacttact tctttctcta gttcttatgt
     3541 tcagaatgtg gtattggccc tggcctagcc ccttccactt cccataattc ttgcctcttt
     3601 ccataattca tggtttcagt tcgactttgt atataaagtt gtttgttggt tttttttttt
     3661 ttttttggct ttttgttttt taaataaacc aaagtgaaaa acaaa
//
