LOCUS       NM_001359906            5415 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil and C2 domain containing 2A (Cc2d2a),
            transcript variant 5, mRNA.
ACCESSION   NM_001359906 XM_006503935
VERSION     NM_001359906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5415)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5415)
  AUTHORS   Jayarajan,R.O., Chakraborty,S., Raghu,K.G., Purushothaman,J. and
            Veleri,S.
  TITLE     Joubert syndrome causing mutation in C2 domain of CC2D2A affects
            structural integrity of cilia and cellular signaling molecules
  JOURNAL   Exp Brain Res 242 (3), 619-637 (2024)
   PUBMED   38231387
  REMARK    GeneRIF: Joubert syndrome causing mutation in C2 domain of CC2D2A
            affects structural integrity of cilia and cellular signaling
            molecules.
REFERENCE   3  (bases 1 to 5415)
  AUTHORS   Reissig,L.F., Geyer,S.H., Winkler,V., Preineder,E., Prin,F.,
            Wilson,R., Galli,A., Tudor,C., White,J.K., Mohun,T.J. and
            Weninger,W.J.
  TITLE     Detailed characterizations of cranial nerve anatomy in E14.5 mouse
            embryos/fetuses and their use as reference for diagnosing subtle,
            but potentially lethal malformations in mutants
  JOURNAL   Front Cell Dev Biol 10, 1006620 (2022)
   PUBMED   36438572
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5415)
  AUTHORS   Abrams,S.R. and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling regulates cell survival to build the
            facial midline
  JOURNAL   Elife 10, e68558 (2021)
   PUBMED   34672258
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5415)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5415)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   7  (bases 1 to 5415)
  AUTHORS   Veleri,S., Manjunath,S.H., Fariss,R.N., May-Simera,H., Brooks,M.,
            Foskett,T.A., Gao,C., Longo,T.A., Liu,P., Nagashima,K.,
            Rachel,R.A., Li,T., Dong,L. and Swaroop,A.
  TITLE     Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal
            appendages on the mother centriole during cilia biogenesis
  JOURNAL   Nat Commun 5, 4207 (2014)
   PUBMED   24947469
  REMARK    GeneRIF: CC2D2A is essential for the assembly of subdistal
            appendages, which anchor cytoplasmic microtubules and prime the
            mother centriole for axoneme biogenesis
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5415)
  AUTHORS   Chih,B., Liu,P., Chinn,Y., Chalouni,C., Komuves,L.G., Hass,P.E.,
            Sandoval,W. and Peterson,A.S.
  TITLE     A ciliopathy complex at the transition zone protects the cilia as a
            privileged membrane domain
  JOURNAL   Nat Cell Biol 14 (1), 61-72 (2011)
   PUBMED   22179047
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5415)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5415)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161536.7 and AC140277.3.
            
            On Jan 18, 2018 this sequence version replaced XM_006503935.3.
            
            Transcript Variant: This variant (5) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (d) has the same
            N- and C-termini but is shorter compared to isoform a. Variants 4
            and 5 both encode the same isoform (d).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.152078.1,
                                           SRR10223971.5776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC161536.7         12475-12655         c
            182-409             AC161536.7         8757-8984           c
            410-470             AC161536.7         6328-6388           c
            471-554             AC161536.7         3730-3813           c
            555-678             AC161536.7         1219-1342           c
            679-767             AC140277.3         9667-9755
            768-872             AC140277.3         10077-10181
            873-974             AC140277.3         11478-11579
            975-1148            AC140277.3         12418-12591
            1149-1311           AC140277.3         13636-13798
            1312-1448           AC140277.3         16502-16638
            1449-1580           AC140277.3         17296-17427
            1581-1790           AC140277.3         23463-23672
            1791-1897           AC140277.3         24904-25010
            1898-2038           AC140277.3         28317-28457
            2039-2195           AC140277.3         31569-31725
            2196-2437           AC140277.3         32239-32480
            2438-2615           AC140277.3         34435-34612
            2616-2772           AC140277.3         35121-35277
            2773-2920           AC140277.3         37422-37569
            2921-3059           AC140277.3         38883-39021
            3060-3263           AC140277.3         40618-40821
            3264-3356           AC140277.3         42887-42979
            3357-3448           AC140277.3         44132-44223
            3449-3616           AC140277.3         46931-47098
            3617-3722           AC140277.3         48719-48824
            3723-3832           AC140277.3         50767-50876
            3833-3929           AC140277.3         52079-52175
            3930-4028           AC140277.3         52652-52750
            4029-4205           AC140277.3         54574-54750
            4206-4409           AC140277.3         58235-58438
            4410-4499           AC140277.3         60756-60845
            4500-4613           AC140277.3         62206-62319
            4614-4748           AC140277.3         63694-63828
            4749-4871           AC140277.3         64412-64534
            4872-4930           AC140277.3         65874-65932
            4931-5108           AC140277.3         67676-67853
            5109-5415           AC140277.3         69044-69350
FEATURES             Location/Qualifiers
     source          1..5415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.78 cM"
     gene            1..5415
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /note="coiled-coil and C2 domain containing 2A"
                     /db_xref="GeneID:231214"
                     /db_xref="MGI:MGI:1924487"
     exon            1..181
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            182..409
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            410..470
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..5297
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /note="isoform d is encoded by transcript variant 5;
                     coiled-coil and C2 domain-containing protein 2A"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 2A
                     isoform d"
                     /protein_id="NP_001346835.1"
                     /db_xref="GeneID:231214"
                     /db_xref="MGI:MGI:1924487"
                     /translation="MNTNDEKMKIISEDFTGDGVDTEAGRRKKNSKVRRQQRKKKPPA
                     SPPEEMVSDKFQDGGQQEVVEEEPETNLLSLTARRGPRSLPPIPSASRTGFAEFSMRE
                     RMREKLQAARSKAESALLRDVPTPRPRRLRSPSREKETETEFGTEPSTEVQDTQKEDD
                     TKSYSRIKFRDSVRKIKSKPQLPPGFPSAEEAYNFFTFNFDPEPEESEEKSPVKGGER
                     AHHEDQEGEEGTQAQERAKKTEEEELLNGKDAEDFLLGLDPTAHDFVAVRAAEYKSAR
                     IQLQKEKEILFTPSRLTVPTYKKLPENIQPRFLEDEGLYIGARPEVARTNENIMENRL
                     LIQEPGSKWFGDDGRILALPSPIKPFPSRPSLTTREQSPKAGLETLYKKAEKYVHSRQ
                     HMIGSGDPPGNFQLDIDISGLIFTHHPCFSREHVLASKLAQLYDQYLARQQRNKTKFL
                     TDKLQALRKAVQTSLNPEKPHQSLDTTQKTINEYKSEIRQTRKLRDAEQEKDRTLLKT
                     IIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDPKLDEDAYEAEIQAEIHELLEEHMEE
                     YATKMEEYRTSHQQWKAWRKAQRAKKKKKKQTTEEHLEEEEAEESFPEEEVTKPIPPE
                     PTDPAVIEQQVRERAAHSRRRPGEPTLIPELSLAGNVTPNDQCPRVEVSRREDVRRRS
                     VYLKVVFNSKEVSRTVSRPLGADFRVHFGQIFNLQIFNWPESLMLQVYETIGHSGTTL
                     LAEVFLPIPETTLVTGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMT
                     SGKVSHSVAWAVGENGIPLIPPLSQQNIGFRSALRRADAISSIGTSGLTDMKKLAKWA
                     AESKLDPNDPNHAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSEEELNRSKRFRL
                     LHLRSQEVPEFRNYKQIPAYDREIMEKVFQDYEKRLRDRNVIETKDHLDMHRATVAKY
                     LQQVREAVVNRFLTAKHHFLLTDLVVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRK
                     KVTAQNLSDGDIKLLVNIIRAYDIPVRKPVVSKFQQPSRSSRTFSEKQTASPSTHSPL
                     HNADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQ
                     SVKDDVYINIFDEVLYDILEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTF
                     KIDIPPVLLGYSKERNIIMERAFDSARSLSEGSYITLFITIEPQLVPGEPMREKFDTQ
                     EDEKLLQATEKFQAECALKFPQRQCLTTVTDMTGKTVFITRYLKPLNPPQELLHVYPN
                     NPQATAELVARYVSLIPFLPDSVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFL
                     FLGKKAWLVMGSAIPEGPTAYVLTWEKNYYLIWNPCSGHCYGQFDAFCPLKSVGCLIG
                     PDNIWFNIQHHDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQHTDKAVA
                     AELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLERSQGEDIEDDHRAELL
                     KQLGDYRFSGFPLHMPYSEVKPLVEAVYSTGVHNIDLPNVEFALAVYIHPYPKNVLSV
                     WIYVASLVRNR"
     exon            471..554
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            555..678
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            679..767
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            768..872
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            873..974
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1148
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1311
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1448
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1580
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1790
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1897
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2038
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2195
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2437
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2615
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2772
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2920
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3059
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3263
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3356
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3448
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3616
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3722
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3832
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3929
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4028
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4205
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4409
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4410..4499
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4500..4613
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4748
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4871
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..4930
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5108
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            5109..5415
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5392..5397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /note="hexamer: AATAAA"
     polyA_site      5415
                     /gene="Cc2d2a"
                     /gene_synonym="5730509K17Rik; b2b1035Clo"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtttttt tttaaaccct gagatatggc tgcagcttcc cagggagtaa cctctcttac
       61 cccagcccac cctttcgctc atttctaaaa ggttctctgg cttgacacaa ctggtctctc
      121 atctcatccc ttcagcccag caagtggaat ctgcaaactt cgttttgtag agtggacgaa
      181 gcatcctagc gaggctttga aggactccag aatgtgccca tgaaaaatgg atccgaatag
      241 caattgagcc attcatttga caaacacaca tgaactgtcc gtctactgag tggcctgggc
      301 aaaggctctg gggataaaca atacacaaag tactgctcct gctctctgga agctctattc
      361 taatggtgat ggagagatgc tgacatataa ttacgaatgc tgattggtgt caggaagcca
      421 tcacggacaa gatgaatacc aacgacgaaa aaatgaaaat aatttcagag gacttcactg
      481 gagatggtgt ggacacagag gcgggaagac ggaagaagaa ttcaaaggtg cgaagacagc
      541 agagaaagaa aaagccaccc gcctctcccc ctgaggaaat ggtgtcagac aaattccaag
      601 atggtgggca gcaggaagtg gtggaggaag agcccgagac caacctcctg agcttgacag
      661 cccggcgggg gccccggagc ttacctccca tcccttcagc ttctagaacc ggctttgcag
      721 aattttccat gagggaacga atgagggaga aacttcaggc tgcaaggtcc aaggcagaaa
      781 gcgcattgtt gcgggatgtc cccaccccta gacccaggcg cctgcgcagt ccctccagag
      841 agaaggaaac agagactgaa tttggcacag agccaagtac agaggtgcaa gacactcaaa
      901 aagaagacga cacaaagagt tattcaagaa ttaagttccg tgattctgta cgaaaaatta
      961 agtcaaaacc ccagctccct cctggtttcc catctgcaga agaggcctat aatttcttta
     1021 cgttcaactt tgatcctgag ccagaggaat cagaggaaaa atcaccagta aaaggtggag
     1081 agagagctca tcatgaggac caagaaggag aagaaggaac acaagctcaa gagagagcga
     1141 agaaaacgga agaggaagag ctgcttaatg ggaaggatgc tgaagacttc ctgttgggct
     1201 tagatcccac ggcccatgac ttcgtggcag tcagagctgc agagtacaag agtgcccgca
     1261 ttcagctgca gaaggagaaa gaaatcctct tcacgcctag tcggctgaca gtgccgacct
     1321 ataaaaagct tcctgagaac atacagccaa gattcctgga agatgaaggt ctttacatcg
     1381 gggccagacc agaggtggca cgcaccaatg agaacatcat ggagaaccga ctgctgatac
     1441 aggagcctgg gagtaagtgg ttcggagatg atggcagaat cctggcactg cccagcccca
     1501 tcaagccgtt tccctcaagg ccatcactaa ccacacggga gcaaagcccc aaggctggac
     1561 tggagacttt gtacaagaag gcagagaagt atgtccacag tagacagcat atgattggat
     1621 ctggagaccc tccaggaaat ttccaactgg acatcgatat ttctggctta atcttcactc
     1681 atcacccctg ttttagccga gagcatgtct tggcatcaaa gctggcccag ttgtatgacc
     1741 agtaccttgc aagacagcaa agaaataaga cgaaattcct tacagataag cttcaagcac
     1801 taagaaaagc tgttcagacc agtcttaacc cagagaaacc tcatcagtct cttgacacaa
     1861 cccagaaaac catcaatgag tataaatctg aaattcggca gactcgaaaa ctgcgagatg
     1921 ctgaacaaga gaaagatcga acactgctga agaccatcat aaaggtctgg aaagagatga
     1981 agtcattacg ggagttccag aggtttacaa acacgccgtt gaagctcgtc ttgagaaagg
     2041 aaaaagttga cccgaaacta gatgaggatg catatgaagc cgagattcaa gctgagatcc
     2101 atgaactgct ggaggaacac atggaggaat atgcaacaaa gatggaagag tacagaacat
     2161 ctcatcagca atggaaagcc tggaggaaag cccagagggc caaaaagaag aaaaagaagc
     2221 aaacaacaga ggaacacctc gaggaggaag aggctgagga gtccttccct gaggaagagg
     2281 ttactaagcc cattccccca gagcccactg acccagctgt catagagcag caggtgcggg
     2341 agagagcagc ccacagcagg aggaggccag gggagcccac actcattcca gagttgagtc
     2401 tggcagggaa tgtgaccccc aatgaccagt gtcctagggt ggaggtctcc agaagggaag
     2461 atgtcaggag gcgctctgta tacttaaagg tggtcttcaa cagcaaagag gtgtcgagga
     2521 ctgttagccg gcctctaggg gcagatttcc gggttcactt tggacagatt ttcaacctgc
     2581 agatattcaa ctggccagag agcttaatgc ttcaggtcta tgaaactatt ggtcatagtg
     2641 gtaccacctt gctagctgag gtcttcctgc ctatccctga gacgaccctt gtcacgggaa
     2701 gggcccccat tgaagaggtg gagttcagca gtaaccagca tgtgacatta gaccatgagg
     2761 gagttggaag tggggtgccc ttctccttcg aagctgatgg cagcaatcaa ctgactctaa
     2821 tgacatcagg gaaagtgtcc cacagtgtgg catgggccgt tggggaaaat gggattcctt
     2881 taattcctcc actgtcacag cagaacattg gatttcgaag tgctttgagg agggcagatg
     2941 ccatctcatc cattggcaca tcagggctga cggacatgaa gaagttggcc aagtgggcag
     3001 cagagtccaa gcttgacccc aatgatccca accacgcccc attgatgcag ctgatctcgg
     3061 ttgctaccag tggtgaatcc tatgtccctg acttcttccg gctggagcag ctgcagcagg
     3121 aattcaactt cgtctcagag gaggaattaa atagatccaa acggttccga cttctccatc
     3181 ttaggagcca agaggtgcca gaattccgga actataaaca aattccagca tatgaccgag
     3241 aaattatgga aaaggtattc caggactatg agaaacgatt acgagacaga aatgtaattg
     3301 aaaccaagga ccacctggac atgcacagag ccacagtagc caagtacctt cagcaagtta
     3361 gagaagcagt ggtaaatcgc ttcctaactg ccaaacacca ttttcttctt actgatttgg
     3421 tagtagaaga agaagtcccc aatatcagca ttttgggcct aagccttttc aagctggcag
     3481 aacaaaagcg accactgagg ccacggagga aaggtcggaa gaaggtgaca gcccaaaacc
     3541 tgtctgatgg agacataaag ctgctggtga acattatccg ggcttacgac atccctgtaa
     3601 ggaaacctgt agtgagcaag tttcagcagc catcgagatc ttcaagaact ttcagtgaaa
     3661 agcaaactgc ttcccccagc acacacagcc cactacacaa cgctgactac cccctcggcc
     3721 aggtcttagt ccggcctttt gtggaggtct cttttcaaag aacaatttgc cacacaacca
     3781 cagctgaagg accaaatccc agctggaacg aagaacttga acttccgttc agggccccca
     3841 atggggacta cagcacagcc agcttacagt cagtgaagga tgacgtatac attaacattt
     3901 ttgatgaagt gctgtatgat atcctagagg atgaccgtga aagaggaagt gggatccata
     3961 cgcgtattga gagacactgg ttaggatgtg tgaaaatccc atttagcacc atctatttcc
     4021 aggcaaggat tgatggcaca tttaaaatag acattcctcc agttctcctg ggctatagta
     4081 aggagcgaaa cattattatg gaacgagcct ttgattctgc ccgaagcttg agtgaaggct
     4141 cctacatcac cctgtttatt accattgagc ctcagctggt tcctggggag cctatgagag
     4201 aaaagtttga tacccaggaa gatgagaaat tacttcaagc aacagagaaa tttcaagctg
     4261 aatgtgcctt aaaattcccc cagcgtcagt gcctcaccac agtgactgac atgaccggga
     4321 aaacggtttt tattacgcgt tatctcaagc ctttaaaccc tccgcaggag ctccttcacg
     4381 tctaccccaa caacccgcag gccactgcgg agctggtagc tcggtatgtg tccttgatcc
     4441 ctttcttgcc tgatagcgtg tcgtttgctg gagtctgtga cctgtggagc acttctgatc
     4501 aattccttga cctcctggcg ggtgatgaag aagagcatgc agtactgcta tgcaattact
     4561 ttctgttcct gggtaagaag gcatggctgg tgatgggcag tgcgattcct gagggtccaa
     4621 ctgcctatgt gctaacttgg gagaaaaatt attatttaat atggaatccc tgcagcggac
     4681 attgttacgg acaatttgat gcattttgcc ctttgaaaag tgtgggctgt ttaattggtc
     4741 ctgataatat ttggtttaat attcaacacc atgattctcc actaaggata aattttgatg
     4801 tcacaaagcc caaactatgg aaatcttttt tttcacgaag tcttccatat cctggcctat
     4861 ccagtgttca gccggaagag ctaatttatc aacacacaga caaagcagta gctgctgaac
     4921 tgcaagacag gattgaaaaa atactaaaag aaaaaatcat ggactggagg ccacgccacc
     4981 tgaccaggtg gaacaggtac tgtacctcca ccctgcgcca cttcttgcct ctactggaaa
     5041 gaagtcaagg agaagatata gaagacgacc acagggcaga gctgttgaag cagctggggg
     5101 actacaggtt ctctggattt cctcttcaca tgccttattc tgaagtgaag cctttggttg
     5161 aagcggtgta tagcactgga gtacataaca ttgaccttcc taatgttgag tttgctttag
     5221 ctgtatacat acacccttat cccaaaaacg ttttgtctgt ttggatctat gttgcttctc
     5281 ttgtacggaa caggtaattt ttcaatgtgt tttttatatc acctaaagag tattggtatg
     5341 tacatgttaa attataatgg aatcaaaaga aaatatattt tgaagttatg gaataaaatt
     5401 atcatctgta taaaa
//
