LOCUS       NM_177045               3286 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled-coil and C2 domain containing 1B (Cc2d1b),
            mRNA.
ACCESSION   NM_177045
VERSION     NM_177045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3286)
  AUTHORS   Acheta,J., Hong,J., Jeanette,H., Brar,S., Yalamanchili,A.,
            Feltri,M.L., Manzini,M.C., Belin,S. and Poitelon,Y.
  TITLE     Cc2d1b Contributes to the Regulation of Developmental Myelination
            in the Central Nervous System
  JOURNAL   Front Mol Neurosci 15, 881571 (2022)
   PUBMED   35592111
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3286)
  AUTHORS   Zamarbide,M., Mossa,A., Munoz-Llancao,P., Wilkinson,M.K.,
            Pond,H.L., Oaks,A.W. and Manzini,M.C.
  TITLE     Male-Specific cAMP Signaling in the Hippocampus Controls Spatial
            Memory Deficits in a Mouse Model of Autism and Intellectual
            Disability
  JOURNAL   Biol Psychiatry 85 (9), 760-768 (2019)
   PUBMED   30732858
REFERENCE   4  (bases 1 to 3286)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3286)
  AUTHORS   Zamarbide,M., Oaks,A.W., Pond,H.L., Adelman,J.S. and Manzini,M.C.
  TITLE     Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its
            Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and
            Hyperactivity
  JOURNAL   Front Genet 9, 65 (2018)
   PUBMED   29552027
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3286)
  AUTHORS   Hadjighassem,M.R., Galaraga,K. and Albert,P.R.
  TITLE     Freud-2/CC2D1B mediates dual repression of the serotonin-1A
            receptor gene
  JOURNAL   Eur J Neurosci 33 (2), 214-223 (2011)
   PUBMED   21155902
  REMARK    GeneRIF: data show that Freud-2 is the second component that, with
            Freud-1, mediates dual repression of the 5-HT1A receptor gene at
            the dual repressor element.
REFERENCE   7  (bases 1 to 3286)
  AUTHORS   Jaekel,R. and Klein,T.
  TITLE     The Drosophila Notch inhibitor and tumor suppressor gene lethal (2)
            giant discs encodes a conserved regulator of endosomal trafficking
  JOURNAL   Dev Cell 11 (5), 655-669 (2006)
   PUBMED   17084358
  REMARK    GeneRIF: Paper describes a function of Cc2d1b/Cc2d1a and its
            Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.
REFERENCE   8  (bases 1 to 3286)
  AUTHORS   Gallagher,C.M. and Knoblich,J.A.
  TITLE     The conserved c2 domain protein lethal (2) giant discs regulates
            protein trafficking in Drosophila
  JOURNAL   Dev Cell 11 (5), 641-653 (2006)
   PUBMED   17084357
REFERENCE   9  (bases 1 to 3286)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 3286)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK043839.1.
            
            On Apr 6, 2007 this sequence version replaced NM_177045.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043839.1, AK146601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3286              AK043839.1         2-3287
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.64 cM"
     gene            1..3286
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /note="coiled-coil and C2 domain containing 1B"
                     /db_xref="GeneID:319965"
                     /db_xref="MGI:MGI:2443076"
     exon            1..118
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..201
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2682
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /note="freud-2; FRE under dual repression-binding protein
                     2; five prime repressor element under dual
                     repression-binding protein 2"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1B"
                     /protein_id="NP_796019.1"
                     /db_xref="CCDS:CCDS18454.1"
                     /db_xref="GeneID:319965"
                     /db_xref="MGI:MGI:2443076"
                     /translation="MPGPRPRKGPKTSGQGAETAKQLGLFVEFNPEDMLLGVDETEDD
                     GDLEAELLALTGETASRSRKPAPKGQAPLPMAHIEKLAADCMRDVEEDEEEEGLEDDA
                     DLLTELQEVLGEDEEAGLLDGSEAASPDLCEEKTWDNTELPVEQAACQQAVPAAAQAG
                     GPRGLQALLEERIRNYREAAASAKEAGEAAKARRCERGLKTLQSQLATVRKGGKICED
                     EIPPPVALGKRPPAPQERAIKNPEIDSPGPCAMEPGNLSQPESSLPAIAPLPDSDPDP
                     QALLLARQREYKAAALDAKRAGDLDRARELMRIGKRFGTVLEALEKGQPVDLSGMPPA
                     PADLKALPQASKASSATQGLSPAVEQMQPVMASDLPATPVAPAEPTTVLDALQQRLNK
                     YREAGIQARANGDERKARMHDRIAKQYQDAVRAHQAGQKVDFAELPVPPGFPPIPGLE
                     PRKGSEQDSVAATLATAQKLASEDAALVDDDEESDTPAQAPLAKKPAQTLVSPSHLLT
                     EPKASSSKESLSPSVREQVTLLEARKLQYQRAALQAKRRQDLEQAKSHLRVAKSLEAQ
                     IIQARAGQPIDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLQEQQAKC
                     LLFSKQYMHQGNVAETTRFERLAEDRKKQLEILQLAQAQGLDPPSHHFELKTFQTVRI
                     FSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTN
                     SPEFEQVFKLNINRNHRGFRRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLEKE
                     CEIREIMEVLDGRKPTGGKLEVKVRLREPLSSQDVQTVTENWLVLEPRGL"
     exon            202..346
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..450
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..609
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..735
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..895
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1068
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1144
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1255
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1386
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1459
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1584
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1702
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1875
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2001
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2060
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2177
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2251
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2310
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2362
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2462
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2553
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2686
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..3286
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3261
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
     regulatory      3268..3273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /note="hexamer: AAGAAA"
     polyA_site      3284
                     /gene="Cc2d1b"
                     /gene_synonym="A830039B04Rik; Freud2"
                     /note="major polyA site"
ORIGIN      
        1 accgcctcct gggcgggagc ttcctgtggc tgtctccgcc gcggccgccc gggggccgcg
       61 gaaagctagg cggttccggg ctcgagaagg cccggttttg gttcggatcc gccgcgaggt
      121 atctagcctg ccaagatgcc agggccaaga cctcggaagg gccctaagac cagtggccag
      181 ggtgctgaga ctgccaagca gctggggctt tttgtggagt tcaaccctga ggacatgctc
      241 ctgggggtgg atgagactga agatgatgga gacctggagg ctgagttact ggcactcaca
      301 ggggaaacag cgagcaggag caggaagcca gcacccaagg ggcaggctcc actgcccatg
      361 gcccacattg agaagctggc agcagactgt atgcgagatg tggaggagga tgaagaagag
      421 gaagggctgg aggacgatgc agaccttctg acagagctgc aggaggtcct gggtgaggat
      481 gaagaagcgg gtctgctgga cggcagtgag gcagcaagtc cagacctctg tgaggagaag
      541 acttgggaca acactgaact acctgtagag caggcagcct gccaacaggc agtacctgct
      601 gcagctcagg ctggagggcc tcgggggctg caggctttgc tggaggaacg gatccgtaac
      661 taccgggagg ccgcagccag tgccaaggag gctggtgaag ctgccaaagc ccggcgctgt
      721 gagcgaggcc taaagactct gcagtcccag cttgccactg tgaggaaagg cgggaagatc
      781 tgtgaggatg agatcccacc tccagtagcc ttgggcaaaa ggcccccagc cccccaggaa
      841 agagccatca agaaccctga gatagactct ccaggtccct gtgccatgga gccaggcaac
      901 ctttcccagc ccgagtccag cctccctgcc attgctccct tgcctgattc agacccagac
      961 ccacaagccc tgctgttagc ccgacagaga gagtacaagg cggctgctct cgatgccaag
     1021 cgggctggag atctagaccg tgctcgggag ctcatgagga tcgggaagag atttggtact
     1081 gtcctagagg ccctggaaaa gggtcagcct gtggacctga gtggcatgcc cccagcacct
     1141 gcggatctga aggccctccc ccaggcttct aaggcctcct cagcaaccca aggcctgtcc
     1201 ccagcagtag agcaaatgca gccagtgatg gcctctgacc tcccagccac cccagtggcc
     1261 cctgcggagc caacaacagt gctggatgct ttacagcaaa ggctgaacaa gtatcgtgag
     1321 gcaggcatcc aggcccgggc caatggggat gagcgcaagg ccaggatgca cgatcgcatt
     1381 gccaagcaat atcaggatgc tgttcgagct catcaggcag gacagaaagt tgactttgcc
     1441 gagttacctg ttcctccagg atttcctccc atccctggcc tggagcccag gaaaggtagt
     1501 gagcaggatt cagtggcagc aactttagca actgcccaaa aactggcctc agaagatgca
     1561 gccctggtag atgacgacga ggagagtgac actccagcac aggccccatt ggccaagaag
     1621 ccagcgcaga ctctggtctc tccatcccat cttctgactg agcccaaggc ttcaagttct
     1681 aaggagtcac tgagtccatc tgttcgggag caggtgacac tgctggaggc tcggaaactg
     1741 caataccagc gagcagctct gcaagccaag cgcaggcagg atcttgagca ggccaaatcc
     1801 cacttacgag tagctaaaag tcttgaggct cagatcatcc aggcccgagc tggtcaaccc
     1861 attgatctct ccaaggtgcc ttcaccgttg acagatgaag agggggactt catcctcatt
     1921 caccatgagg atctgcgact ctcccagaag gctgaggagg tgtatgccca gctacagaaa
     1981 atgctccagg agcagcaagc gaagtgcctg ctattctcca agcagtacat gcaccaggga
     2041 aatgtggctg agaccactcg gtttgagagg cttgcggagg accgaaagaa acagcttgag
     2101 atcctgcagc tagcccaagc ccagggcctt gaccctccta gtcatcactt tgagctgaag
     2161 acattccaga ctgtgaggat cttctcagaa ctcaacagca cagaaatgca tctgatcatc
     2221 gtgcggggaa tgaacctccc agccccgcca ggagtgactc cggatgactt ggatgctttt
     2281 gtacggtttg agtttcacta ccctaactcg gaccaggctc aaaaaagcaa aacagctgtg
     2341 gtaaaaaata ccaattctcc agaatttgaa caagttttca agctaaacat caatcgaaac
     2401 caccgaggct ttaggagagt gatccagagc aaaggaatca aatttgagat cttccacaaa
     2461 ggatcctttt ttagaagtga caagctggtt ggcacagcac acttgaaatt ggaaaggctg
     2521 gagaaggagt gtgagatcag agagatcatg gaggttttgg atggcagaaa gcccactggg
     2581 gggaagctgg aggtgaaggt gaggcttcgg gagcctctga gcagccagga cgtgcagacg
     2641 gtcactgaga actggctggt cctggagcct cggggcctgt gaagaggtgg acatccttgg
     2701 taacagctca ctgacccagc tgtgccggct caagagccgt tgtacatcag agatgctgct
     2761 acacacgcac caaagacctg ataactaaca gtggcctggg ctttcctcct gctgcctctc
     2821 ctggaccttc gtggaagcag gcctcccacc ctccctgtgg gcgaagacaa ggatacccca
     2881 ctgctctgtg ccacagagtc ccgtaaccgc tgcatagtaa ttgcgtaccg cttaacccag
     2941 cccccatttg caccatttct ggatgtgcct ttcaaagatg taactgtagg gatgggagaa
     3001 ctcgagggtg atcggaacat cccgtgtggg gagggacagg attccgtgac tccagctggc
     3061 cagcggcaga ctgtcccgct cagctgtttt ccctctgcct gtgcctttgt tcctgacagc
     3121 tgctgcacta gcctttctgc ttcccagagg actcgggaac aggaacgtta ctttggtact
     3181 attggtggga agtaagggaa ggttctcttt ggtttggtcc atgtacctaa ggtgaaagac
     3241 tgttaattgg ggagaaaaaa aggaaaaaag aaaaagaaaa actatc
//
