LOCUS       NM_145970               3452 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus coiled-coil and C2 domain containing 1A (Cc2d1a),
            transcript variant 1, mRNA.
ACCESSION   NM_145970
VERSION     NM_145970.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3452)
  AUTHORS   Vahid-Ansari,F., Newman-Tancredi,A., Fuentes-Alvarenga,A.F.,
            Daigle,M. and Albert,P.R.
  TITLE     Rapid reorganization of serotonin projections and antidepressant
            response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant
            cF1ko mice
  JOURNAL   Neuropharmacology 261, 110132 (2024)
   PUBMED   39208980
REFERENCE   2  (bases 1 to 3452)
  AUTHORS   Chen,K.R., Yang,C.Y., Shu,S.G., Lo,Y.C., Lee,K.W., Wang,L.C.,
            Chen,J.B., Shih,M.C., Chang,H.C., Hsiao,Y.J., Wu,C.L., Tan,T.H. and
            Ling,P.
  TITLE     Endosomes serve as signaling platforms for RIG-I ubiquitination and
            activation
  JOURNAL   Sci Adv 10 (45), eadq0660 (2024)
   PUBMED   39504361
REFERENCE   3  (bases 1 to 3452)
  AUTHORS   Sener,E.F., Dana,H., Tahtasakal,R., Taheri,S. and Rassoulzadegan,M.
  TITLE     Autism-Related Cc2d1a Heterozygous Mice: Increased Levels of miRNAs
            Retained in DNA/RNA Hybrid Profiles (R-Loop)
  JOURNAL   Biomolecules 14 (9), 1183 (2024)
   PUBMED   39334949
  REMARK    GeneRIF: Autism-Related Cc2d1a Heterozygous Mice: Increased Levels
            of miRNAs Retained in DNA/RNA Hybrid Profiles (R-Loop).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3452)
  AUTHORS   Vahid-Ansari,F., Zahrai,A., Daigle,M. and Albert,P.R.
  TITLE     Chronic Desipramine Reverses Deficits in Cell Activity,
            Norepinephrine Innervation, and Anxiety-Depression Phenotypes in
            Fluoxetine-Resistant cF1ko Mice
  JOURNAL   J Neurosci 44 (3), e1147232023 (2024)
   PUBMED   38050173
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3452)
  AUTHORS   Sener,E.F., Dana,H., Tahtasakal,R., Hamurcu,Z., Taheri,S.,
            Delibasi,N., Mehmetbeyoglu,E., Sukranli,Z.Y., Dal,F., Tufan,E.,
            Oflamaz,A.O., Doganyigit,Z., Ozkul,Y. and Rassoulzadegan,M.
  TITLE     Heterozygous Cc2d1a mice show sex-dependent changes in the
            Beclin-1/p62 ratio with impaired prefrontal cortex and hippocampal
            autophagy
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 125, 110764 (2023)
   PUBMED   37059290
  REMARK    GeneRIF: Heterozygous Cc2d1a mice show sex-dependent changes in the
            Beclin-1/p62 ratio with impaired prefrontal cortex and hippocampal
            autophagy.
REFERENCE   6  (bases 1 to 3452)
  AUTHORS   Rogaeva,A., Ou,X.M., Jafar-Nejad,H., Lemonde,S. and Albert,P.R.
  TITLE     Differential repression by freud-1/CC2D1A at a polymorphic site in
            the dopamine-D2 receptor gene
  JOURNAL   J Biol Chem 282 (29), 20897-20905 (2007)
   PUBMED   17535813
  REMARK    GeneRIF: Freud-1 has a key role in regulating DRD2 expression
REFERENCE   7  (bases 1 to 3452)
  AUTHORS   Jaekel,R. and Klein,T.
  TITLE     The Drosophila Notch inhibitor and tumor suppressor gene lethal (2)
            giant discs encodes a conserved regulator of endosomal trafficking
  JOURNAL   Dev Cell 11 (5), 655-669 (2006)
   PUBMED   17084358
  REMARK    GeneRIF: Paper describes a function of Cc2d1a/Cc2d1b and its
            Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.
REFERENCE   8  (bases 1 to 3452)
  AUTHORS   Basel-Vanagaite,L., Attia,R., Yahav,M., Ferland,R.J., Anteki,L.,
            Walsh,C.A., Olender,T., Straussberg,R., Magal,N., Taub,E.,
            Drasinover,V., Alkelai,A., Bercovich,D., Rechavi,G., Simon,A.J. and
            Shohat,M.
  TITLE     The CC2D1A, a member of a new gene family with C2 domains, is
            involved in autosomal recessive non-syndromic mental retardation
  JOURNAL   J Med Genet 43 (3), 203-210 (2006)
   PUBMED   16033914
REFERENCE   9  (bases 1 to 3452)
  AUTHORS   Lemonde,S., Rogaeva,A. and Albert,P.R.
  TITLE     Cell type-dependent recruitment of trichostatin A-sensitive
            repression of the human 5-HT1A receptor gene
  JOURNAL   J Neurochem 88 (4), 857-868 (2004)
   PUBMED   14756806
REFERENCE   10 (bases 1 to 3452)
  AUTHORS   Ou,X.M., Lemonde,S., Jafar-Nejad,H., Bown,C.D., Goto,A., Rogaeva,A.
            and Albert,P.R.
  TITLE     Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A
            receptor gene
  JOURNAL   J Neurosci 23 (19), 7415-7425 (2003)
   PUBMED   12917378
  REMARK    GeneRIF: Novel calcium-regulated repressor that negatively
            regulates basal 5-HT1A receptor expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159266.3.
            
            On Jun 16, 2018 this sequence version replaced NM_145970.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016188.1, SRR7974084.7810.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC159266.3         139896-140166       c
            272-407             AC159266.3         138563-138698       c
            408-520             AC159266.3         136358-136470       c
            521-586             AC159266.3         136207-136272       c
            587-721             AC159266.3         135857-135991       c
            722-944             AC159266.3         135536-135758       c
            945-1063            AC159266.3         133330-133448       c
            1064-1136           AC159266.3         133012-133084       c
            1137-1208           AC159266.3         132855-132926       c
            1209-1339           AC159266.3         132633-132763       c
            1340-1412           AC159266.3         132490-132562       c
            1413-1546           AC159266.3         131539-131672       c
            1547-1658           AC159266.3         130967-131078       c
            1659-1831           AC159266.3         130710-130882       c
            1832-1954           AC159266.3         129319-129441       c
            1955-2013           AC159266.3         129179-129237       c
            2014-2130           AC159266.3         128988-129104       c
            2131-2204           AC159266.3         128136-128209       c
            2205-2263           AC159266.3         128007-128065       c
            2264-2315           AC159266.3         127854-127905       c
            2316-2415           AC159266.3         127311-127410       c
            2416-2506           AC159266.3         127146-127236       c
            2507-2644           AC159266.3         126871-127008       c
            2645-2706           AC159266.3         126725-126786       c
            2707-2770           AC159266.3         126226-126289       c
            2771-2897           AC159266.3         126013-126139       c
            2898-2974           AC159266.3         125713-125789       c
            2975-3022           AC159266.3         125581-125628       c
            3023-3452           AC159266.3         125077-125506       c
FEATURES             Location/Qualifiers
     source          1..3452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.32 cM"
     gene            1..3452
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /note="coiled-coil and C2 domain containing 1A"
                     /db_xref="GeneID:212139"
                     /db_xref="MGI:MGI:2384831"
     exon            1..271
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3043
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil and C2 domain-containing protein 1A; five'
                     repressor element under dual repression binding protein 1;
                     5-HT1A receptor; putative NFkB activating protein; FRE
                     under dual repression-binding protein 1; five prime
                     repressor element under dual repression-binding protein 1"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1A
                     isoform 1"
                     /protein_id="NP_666082.2"
                     /db_xref="CCDS:CCDS40407.1"
                     /db_xref="GeneID:212139"
                     /db_xref="MGI:MGI:2384831"
                     /translation="MHKRNGPQAPPGRGAVTARQLGLLVDFSPDGLMIPEDGINEEEL
                     EAEFLALVGGQPQALEKLKGQGPLPMEAIEKMARLCMRDLDEDEEGTDEDDVEADEDL
                     LAELNEVLGEEQKAVEPLMPVAQPKPSGPNPGVEATLQERLTLYQSALESARQAGDSA
                     KMRRYDRGLKTLENLLVSAKKGNIINEADIPPPVASGKGAAAGHSHTQATSQLASVSP
                     PAPESSGTLEAPSTTTPTSAKPQLPPDPCSPLARLQSLQHEYKLAALRAKHQDDTATA
                     TRHLRIAKSFDPVLEALSRGELVDLSRLPPPPDQLSPEPPLPAAQPLTSASTLTRPEV
                     PQPPRNLLEALEQRMERYHVAAAQAKAKGDQRKARMHERIVKQYQDAIRAHKAGRAVD
                     VAELPVPPGFPPMQGLESAEPSQQSLVGVLETAMRLANHDEGSDDEEEETPKKQNTPA
                     ASTTQLKSSPSKAPPSGPAPAGKAAPKGTSNRAQQQLAFLEGRKKQLLQAALRAKQKN
                     DVEGAKMHLRQAKGLEPMLEASRNGLPVDIAKVPPAPVNKDDFVLVQRPGPGLSQEAV
                     RRYGELTKLLRQQHEMCLNHSTQFTHLGNIAETIKFEKLAEDCKRSMDTLKQAFARSL
                     PTPAARFEQRTFSVIKVFPDLSNSDMLLFIVKGINLPTPTGLSPSDLDAFVRFDFPYP
                     NVEEAQKDKTSVIKNTDSPEFKEQFKLCINRGHRGFRRAIQTKGIKFEVVHKGGLFKT
                     DRVLGTAQLKLGTLETACEVHEILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTER
                     WLVIDHIPAAMPTVTGPKAKAPLIPASSREAGNRSARPLHSLSVLAFDQERLERKILA
                     LRQARRPVPPEVAQQYQDVVQRSQWQRAQLEQGGAALRREYASHLERQLHFYTEAARR
                     LGYDGSREAAKEALYRRNLVESELQRLRR"
     exon            272..407
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            408..520
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            521..586
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            587..721
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            722..944
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1063
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1136
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1208
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1339
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1412
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1546
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1658
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1831
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1954
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2013
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2130
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2204
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2263
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2315
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2415
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2506
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2644
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2706
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2770
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2897
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2974
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3022
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3452
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /note="hexamer: AATGAA"
     polyA_site      3441
                     /gene="Cc2d1a"
                     /gene_synonym="Freud-1; Tape"
                     /note="major polyA site"
ORIGIN      
        1 agtttaacta gagagcccac gaatccagcc gccgcgctcc tgaaggccaa ggcggaagct
       61 gggcggccca aactcgagaa tcccgggggg ccgggcgcgg aggagggact cagggctcag
      121 gaacagcgcg agctctgaga ctcgacttcg gtgaagaggc aaggcaaggc aaaggtgcag
      181 gggctggtag tccgggcttc gagcctggaa gatgcacaag aggaatggac cccaggcacc
      241 cccgggccga ggtgctgtca ctgcccgcca gcttggtctg ctggttgact tctccccaga
      301 cggcctgatg atccccgagg atgggattaa tgaggaggag ctggaggctg aattcctggc
      361 tttggtgggg ggtcagcccc aggccctaga gaaactgaaa ggccaaggtc ccctgccaat
      421 ggaagccatt gagaagatgg cccggctctg catgagagac ctggatgagg acgaggaggg
      481 gacagacgag gatgatgtgg aggctgatga ggacctgctg gcagagctaa atgaggtcct
      541 tggagaagaa cagaaggctg tggagcccct gatgcctgtg gcccagccga agccttcagg
      601 ccccaatcca ggagtagagg ccacgctgca ggagaggcta accctctacc agtctgcact
      661 ggagagtgcc aggcaagctg gggacagtgc caagatgcga cgctatgacc gggggctcaa
      721 gacgctggaa aacctgctgg tctctgcaaa gaagggcaac atcatcaatg aagcagacat
      781 tccaccacct gtggcatcgg ggaagggagc agcagctggg cacagccaca cccaagctac
      841 ttcccagttg gcttctgtaa gcccgccagc cccagagtcc agcggcacct tggaggcccc
      901 atctaccact acacccacct ctgctaagcc ccagctaccc ccagatccct gcagccccct
      961 agcccggttg cagagcctcc agcacgagta caaactggct gcccttcgtg ccaagcatca
     1021 ggatgacact gctacagcca ccagacactt gagaatagct aagagctttg accctgtctt
     1081 ggaggccctg agccgtgggg aactggtgga cctgtcccgc ctgccccctc cccctgacca
     1141 gctgtcccca gagcccccct tgccagctgc ccaacctttg acctctgcct caacactcac
     1201 caggccagag gttccccaac ccccgaggaa cctcctggag gctctggaac agcgaatgga
     1261 gcggtaccat gtggctgcag cccaggccaa ggccaagggt gaccagcgga aggcacgcat
     1321 gcatgaacga attgtcaagc aataccaaga cgccattcgt gcccacaagg caggccgagc
     1381 tgtggatgtg gcggagctgc cagtgccccc aggcttcccc ccaatgcagg gtttggagtc
     1441 tgcagagccc tctcaacaga gcctagtggg tgtcctggaa actgccatga ggcttgccaa
     1501 ccacgacgaa ggctcggatg acgaagagga ggagactcct aagaagcaga atacccctgc
     1561 tgcctccaca acccagctga agtcctcgcc ctccaaagca cctccatcag gaccagcccc
     1621 agccggcaaa gctgccccca agggcacatc caacagagcc cagcagcagc tggccttcct
     1681 ggagggccgt aagaagcagc tcctgcaggc cgcgctgcgt gccaagcaaa agaacgacgt
     1741 agaaggcgcc aagatgcacc tgcgccaggc caaagggcta gagcccatgc tagaggcctc
     1801 tcgcaatgga ctgcctgtgg acattgccaa ggtgccacct gctcctgtca acaaggacga
     1861 ctttgtgctg gtgcagcggc ctggcccagg cttgtctcag gaagctgtgc gtcgctatgg
     1921 ggaacttacc aagctcctga gacagcaaca tgaaatgtgt ctaaaccact ccacacagtt
     1981 cacccacctg ggcaacattg ctgaaaccat taagttcgag aagctggcag aagactgtaa
     2041 gcggagcatg gacaccttaa aacaagcctt cgcccgcagt ctgcccacac ccgcagcccg
     2101 ctttgagcag aggaccttca gtgtcatcaa ggtctttccg gacttgagca acagtgacat
     2161 gctcctgttt atcgtgaagg gcatcaactt gcccacaccc acagggctgt cccccagtga
     2221 cctggatgcc tttgtccgct ttgacttccc ttatcccaat gtggaagaag ctcagaaaga
     2281 caagaccagt gtgatcaaaa acacagactc ccctgaattt aaggagcagt tcaaactctg
     2341 catcaaccgt ggccaccgtg gcttccgaag ggccatccaa accaagggca tcaagttcga
     2401 agtggtccac aagggggggc tgttcaagac ggacagggtg ctaggtacag cccagctgaa
     2461 gctgggtacg ttggaaacag cttgtgaagt ccacgagatc ctggaggttt tggatggacg
     2521 ccgacccacg ggggggaggc ttgaagtgat ggttcgcatc cgggagccac tgacagccca
     2581 gcagttggaa actacaactg agaggtggct ggtcattgat cacatcccag cagctatgcc
     2641 cactgtcact gggcccaaag caaaggctcc tctcataccg gcgtcttcaa gggaagcagg
     2701 caacagatca gcacggcccc tgcatagcct tagcgtgttg gcctttgacc aagagcggct
     2761 agaaaggaag atcctggccc tgaggcaggc acgccggcct gtgcctccag aagtggccca
     2821 gcagtaccag gacgtagtac agcgtagcca atggcagagg gcacagctgg agcagggggg
     2881 tgctgccctc cgcagggagt atgcaagcca tctggagcgc cagctgcact tctatacaga
     2941 ggctgcccgg cgcctgggct acgatggaag cagggaggct gcaaaggagg cattgtatcg
     3001 gcggaacctg gtggagagcg agctgcagcg actccgcagg tgaggcccat cctggactac
     3061 aggccccaca gcccgatgct aggcagagct ccagggccac cgaacagaca agcagacaat
     3121 cagcggacag ttggttctgg actcgccctg tccaggccct cggccccagg ggcatcggga
     3181 cagcacagtc accccagcct ggctggttgg gccttggaga gtcctgtttg cacatccagg
     3241 agcatctgga gcaaggaggg tagctgggat gtgaacccag agggccctgc aagcacttta
     3301 cttcctgccc ctcccattgt gaaccccaca gccctctcca aagatacctc tgaggctgtc
     3361 cagctcagct ggcttcttag gaactgtact gacccagctg ccctcacccc agggccaaca
     3421 cagaatgaac agccaaggcc acacttgcct ca
//
