LOCUS       NM_001418673            1106 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus chibby family member 1, beta catenin antagonist
            (Cby1), transcript variant 3, mRNA.
ACCESSION   NM_001418673
VERSION     NM_001418673.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Guo,L., Beck,T., Fulmer,D., Ramos-Ortiz,S., Glover,J., Wang,C.,
            Moore,K., Gensemer,C., Morningstar,J., Moore,R., Schott,J.J., Le
            Tourneau,T., Koren,N. and Norris,R.A.
  TITLE     DZIP1 regulates mammalian cardiac valve development through a
            Cby1-beta-catenin mechanism
  JOURNAL   Dev Dyn 250 (10), 1432-1449 (2021)
   PUBMED   33811421
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Cyge,B., Voronina,V., Hoque,M., Kim,E.N., Hall,J.,
            Bailey-Lundberg,J.M., Pazour,G.J., Crawford,H.C., Moon,R.T.,
            Li,F.Q. and Takemaru,K.I.
  TITLE     Loss of the ciliary protein Chibby1 in mice leads to exocrine
            pancreatic degeneration and pancreatitis
  JOURNAL   Sci Rep 11 (1), 17220 (2021)
   PUBMED   34446743
  REMARK    GeneRIF: Loss of the ciliary protein Chibby1 in mice leads to
            exocrine pancreatic degeneration and pancreatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Li,F.Q., Chen,X., Fisher,C., Siller,S.S., Zelikman,K., Kuriyama,R.
            and Takemaru,K.I.
  TITLE     BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To
            Facilitate Ciliogenesis
  JOURNAL   Mol Cell Biol 36 (21), 2668-2680 (2016)
   PUBMED   27528616
  REMARK    GeneRIF: FAM92 proteins interact with Cby1 to promote ciliogenesis
            via regulation of membrane-remodeling processes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Burke,M.C., Li,F.Q., Cyge,B., Arashiro,T., Brechbuhl,H.M., Chen,X.,
            Siller,S.S., Weiss,M.A., O'Connell,C.B., Love,D., Westlake,C.J.,
            Reynolds,S.D., Kuriyama,R. and Takemaru,K.
  TITLE     Chibby promotes ciliary vesicle formation and basal body docking
            during airway cell differentiation
  JOURNAL   J Cell Biol 207 (1), 123-137 (2014)
   PUBMED   25313408
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Enjolras,C., Thomas,J., Chhin,B., Cortier,E., Duteyrat,J.L.,
            Soulavie,F., Kernan,M.J., Laurencon,A. and Durand,B.
  TITLE     Drosophila chibby is required for basal body formation and
            ciliogenesis but not for Wg signaling
  JOURNAL   J Cell Biol 197 (2), 313-325 (2012)
   PUBMED   22508513
REFERENCE   7  (bases 1 to 1106)
  AUTHORS   Love,D., Li,F.Q., Burke,M.C., Cyge,B., Ohmitsu,M., Cabello,J.,
            Larson,J.E., Brody,S.L., Cohen,J.C. and Takemaru,K.
  TITLE     Altered lung morphogenesis, epithelial cell differentiation and
            mechanics in mice deficient in the Wnt/beta-catenin antagonist
            Chibby
  JOURNAL   PLoS One 5 (10), e13600 (2010)
   PUBMED   21049041
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1106)
  AUTHORS   Voronina,V.A., Takemaru,K., Treuting,P., Love,D., Grubb,B.R.,
            Hajjar,A.M., Adams,A., Li,F.Q. and Moon,R.T.
  TITLE     Inactivation of Chibby affects function of motile airway cilia
  JOURNAL   J Cell Biol 185 (2), 225-233 (2009)
   PUBMED   19364920
REFERENCE   9  (bases 1 to 1106)
  AUTHORS   Li,F.Q., Singh,A.M., Mofunanya,A., Love,D., Terada,N., Moon,R.T.
            and Takemaru,K.
  TITLE     Chibby promotes adipocyte differentiation through inhibition of
            beta-catenin signaling
  JOURNAL   Mol Cell Biol 27 (12), 4347-4354 (2007)
   PUBMED   17403895
REFERENCE   10 (bases 1 to 1106)
  AUTHORS   Singh,A.M., Li,F.Q., Hamazaki,T., Kasahara,H., Takemaru,K. and
            Terada,N.
  TITLE     Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates
            cardiomyocyte differentiation of murine embryonic stem cells
  JOURNAL   Circulation 115 (5), 617-626 (2007)
   PUBMED   17261658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117806.11 and AC118227.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.773445.1,
                                           SRR7652917.557518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC117806.11        191288-191345
            59-212              AC117806.11        193423-193576
            213-314             AC118227.12        53869-53970
            315-433             AC118227.12        54050-54168
            434-1106            AC118227.12        55207-55879
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.84 cM"
     gene            1..1106
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="chibby family member 1, beta catenin antagonist"
                     /db_xref="GeneID:73739"
                     /db_xref="MGI:MGI:1920989"
     exon            1..58
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            59..212
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            213..314
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..514
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="isoform 2 is encoded by transcript variant 3; PKD2
                     interactor, golgi and endoplasmic reticulum associated 1;
                     protein chibby homolog 1; cytosolic leucine-rich protein;
                     PKD2 interactor, Golgi and endoplasmic
                     reticulum-associated 1"
                     /codon_start=1
                     /product="protein chibby homolog 1 isoform 2"
                     /protein_id="NP_001405602.1"
                     /db_xref="GeneID:73739"
                     /db_xref="MGI:MGI:1920989"
                     /translation="MNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEEN
                     NLLRLKVDILLDMLSETTAESHLKDKELDELKVTNRRRK"
     exon            315..433
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1106
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1088..1093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="hexamer: ATTAAA"
     polyA_site      1106
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="major polyA site"
ORIGIN      
        1 ctgggcagat ccttgcagaa agctgcaggc tagctcggga ttccggcttc gcagacagga
       61 gacggaagtg ctggtgtttt ctcgctgggt caggaaggag aaggaagtgc tggcgtttcc
      121 tcactgagtt agggatgcct ctctttggca gcatattcag cccaaagaag acccctcctc
      181 ggaagtcggc ctctctctcc aacctacatt ctatcggtca acgcgggaac tggagctggg
      241 gctcgactat ggaactccta ccatgaacct ggcggggcag agcctgaagt ttgaaaacgg
      301 ccagtgggtg gcagactccg tgattagtgg gggtgtggac cggagggaaa ctcagcgcct
      361 gcgcaaacga aaccaacagt tagaagaaga aaacaatctc ctgcggctga aagtggacat
      421 tctgctggac atgctttcag aaaccactgc tgagtcccac ctaaaggaca aagagctgga
      481 tgaactgaag gttaccaacc gcaggaggaa gtgaagagag cctggcagca ctcgctaggg
      541 gactggaaag agcccagtga ccaggggagg aggatgcggc agagcccttt gatttcccgt
      601 cagattagca gactagggga gagcattaac aggccctggc tcccttgggc aggggatagg
      661 gaggagacac aggatggaag aacccaaggt gccaggccag ggccatagcc aagcaagcac
      721 cccaggtcca cccagggtgt caatctaaaa cataccccag gaaggcctag aaataatgag
      781 ccttggatgc tgtcggcaag tgacagcatg taactgcctg tgtctcagaa tcaccatatt
      841 cagacagctg gcagctcacc tcttgacact ggtgtctggg gtttggcact cctcccagag
      901 agcacctcgc gtgagggtgc ccagtaagtg gctctgggtt gtctgcaccc cagcccccgg
      961 aacccccagc cgtaatctct ctgcctttaa agagccctca tcctcaaatc cacagcctct
     1021 tctggcatca gcttcccagc agcaagctcc agccttccac agcacactgt aatttactct
     1081 tttttttatt aaacggtgtt caataa
//
