LOCUS       NM_001418672            1194 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus chibby family member 1, beta catenin antagonist
            (Cby1), transcript variant 2, mRNA.
ACCESSION   NM_001418672
VERSION     NM_001418672.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Guo,L., Beck,T., Fulmer,D., Ramos-Ortiz,S., Glover,J., Wang,C.,
            Moore,K., Gensemer,C., Morningstar,J., Moore,R., Schott,J.J., Le
            Tourneau,T., Koren,N. and Norris,R.A.
  TITLE     DZIP1 regulates mammalian cardiac valve development through a
            Cby1-beta-catenin mechanism
  JOURNAL   Dev Dyn 250 (10), 1432-1449 (2021)
   PUBMED   33811421
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Cyge,B., Voronina,V., Hoque,M., Kim,E.N., Hall,J.,
            Bailey-Lundberg,J.M., Pazour,G.J., Crawford,H.C., Moon,R.T.,
            Li,F.Q. and Takemaru,K.I.
  TITLE     Loss of the ciliary protein Chibby1 in mice leads to exocrine
            pancreatic degeneration and pancreatitis
  JOURNAL   Sci Rep 11 (1), 17220 (2021)
   PUBMED   34446743
  REMARK    GeneRIF: Loss of the ciliary protein Chibby1 in mice leads to
            exocrine pancreatic degeneration and pancreatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Li,F.Q., Chen,X., Fisher,C., Siller,S.S., Zelikman,K., Kuriyama,R.
            and Takemaru,K.I.
  TITLE     BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To
            Facilitate Ciliogenesis
  JOURNAL   Mol Cell Biol 36 (21), 2668-2680 (2016)
   PUBMED   27528616
  REMARK    GeneRIF: FAM92 proteins interact with Cby1 to promote ciliogenesis
            via regulation of membrane-remodeling processes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Burke,M.C., Li,F.Q., Cyge,B., Arashiro,T., Brechbuhl,H.M., Chen,X.,
            Siller,S.S., Weiss,M.A., O'Connell,C.B., Love,D., Westlake,C.J.,
            Reynolds,S.D., Kuriyama,R. and Takemaru,K.
  TITLE     Chibby promotes ciliary vesicle formation and basal body docking
            during airway cell differentiation
  JOURNAL   J Cell Biol 207 (1), 123-137 (2014)
   PUBMED   25313408
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Enjolras,C., Thomas,J., Chhin,B., Cortier,E., Duteyrat,J.L.,
            Soulavie,F., Kernan,M.J., Laurencon,A. and Durand,B.
  TITLE     Drosophila chibby is required for basal body formation and
            ciliogenesis but not for Wg signaling
  JOURNAL   J Cell Biol 197 (2), 313-325 (2012)
   PUBMED   22508513
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Love,D., Li,F.Q., Burke,M.C., Cyge,B., Ohmitsu,M., Cabello,J.,
            Larson,J.E., Brody,S.L., Cohen,J.C. and Takemaru,K.
  TITLE     Altered lung morphogenesis, epithelial cell differentiation and
            mechanics in mice deficient in the Wnt/beta-catenin antagonist
            Chibby
  JOURNAL   PLoS One 5 (10), e13600 (2010)
   PUBMED   21049041
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Voronina,V.A., Takemaru,K., Treuting,P., Love,D., Grubb,B.R.,
            Hajjar,A.M., Adams,A., Li,F.Q. and Moon,R.T.
  TITLE     Inactivation of Chibby affects function of motile airway cilia
  JOURNAL   J Cell Biol 185 (2), 225-233 (2009)
   PUBMED   19364920
REFERENCE   9  (bases 1 to 1194)
  AUTHORS   Li,F.Q., Singh,A.M., Mofunanya,A., Love,D., Terada,N., Moon,R.T.
            and Takemaru,K.
  TITLE     Chibby promotes adipocyte differentiation through inhibition of
            beta-catenin signaling
  JOURNAL   Mol Cell Biol 27 (12), 4347-4354 (2007)
   PUBMED   17403895
REFERENCE   10 (bases 1 to 1194)
  AUTHORS   Singh,A.M., Li,F.Q., Hamazaki,T., Kasahara,H., Takemaru,K. and
            Terada,N.
  TITLE     Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates
            cardiomyocyte differentiation of murine embryonic stem cells
  JOURNAL   Circulation 115 (5), 617-626 (2007)
   PUBMED   17261658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117806.11 and AC118227.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1361696.1,
                                           SRR17253013.3361616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC117806.11        191288-191345
            59-142              AC117806.11        192784-192867
            143-296             AC117806.11        193423-193576
            297-402             AC118227.12        53865-53970
            403-521             AC118227.12        54050-54168
            522-1194            AC118227.12        55207-55879
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.84 cM"
     gene            1..1194
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="chibby family member 1, beta catenin antagonist"
                     /db_xref="GeneID:73739"
                     /db_xref="MGI:MGI:1920989"
     exon            1..58
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            59..142
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            143..296
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..602
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="isoform 1 is encoded by transcript variant 2; PKD2
                     interactor, golgi and endoplasmic reticulum associated 1;
                     protein chibby homolog 1; cytosolic leucine-rich protein;
                     PKD2 interactor, Golgi and endoplasmic
                     reticulum-associated 1"
                     /codon_start=1
                     /product="protein chibby homolog 1 isoform 1"
                     /protein_id="NP_001405601.1"
                     /db_xref="GeneID:73739"
                     /db_xref="MGI:MGI:1920989"
                     /translation="MPLFGSIFSPKKTPPRKSASLSNLHSLDRSTRELELGLDYGTPT
                     MNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEENNLLRLKVDILLDML
                     SETTAESHLKDKELDELKVTNRRRK"
     exon            297..402
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            403..521
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            522..1194
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1176..1181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="hexamer: ATTAAA"
     polyA_site      1194
                     /gene="Cby1"
                     /gene_synonym="1110014P06Rik; arb1; CBY; Pgea1; PGEA14"
                     /note="major polyA site"
ORIGIN      
        1 ctgggcagat ccttgcagaa agctgcaggc tagctcggga ttccggcttc gcagacagct
       61 gacctcttcc ccgagcctaa gtgatgttac tgattttatg agcattgcag gacgttgtgc
      121 tgtgactaaa gctagtgtgc cggagacgga agtgctggtg ttttctcgct gggtcaggaa
      181 ggagaaggaa gtgctggcgt ttcctcactg agttagggat gcctctcttt ggcagcatat
      241 tcagcccaaa gaagacccct cctcggaagt cggcctctct ctccaaccta cattctttag
      301 atcggtcaac gcgggaactg gagctggggc tcgactatgg aactcctacc atgaacctgg
      361 cggggcagag cctgaagttt gaaaacggcc agtgggtggc agactccgtg attagtgggg
      421 gtgtggaccg gagggaaact cagcgcctgc gcaaacgaaa ccaacagtta gaagaagaaa
      481 acaatctcct gcggctgaaa gtggacattc tgctggacat gctttcagaa accactgctg
      541 agtcccacct aaaggacaaa gagctggatg aactgaaggt taccaaccgc aggaggaagt
      601 gaagagagcc tggcagcact cgctagggga ctggaaagag cccagtgacc aggggaggag
      661 gatgcggcag agccctttga tttcccgtca gattagcaga ctaggggaga gcattaacag
      721 gccctggctc ccttgggcag gggataggga ggagacacag gatggaagaa cccaaggtgc
      781 caggccaggg ccatagccaa gcaagcaccc caggtccacc cagggtgtca atctaaaaca
      841 taccccagga aggcctagaa ataatgagcc ttggatgctg tcggcaagtg acagcatgta
      901 actgcctgtg tctcagaatc accatattca gacagctggc agctcacctc ttgacactgg
      961 tgtctggggt ttggcactcc tcccagagag cacctcgcgt gagggtgccc agtaagtggc
     1021 tctgggttgt ctgcacccca gcccccggaa cccccagccg taatctctct gcctttaaag
     1081 agccctcatc ctcaaatcca cagcctcttc tggcatcagc ttcccagcag caagctccag
     1141 ccttccacag cacactgtaa tttactcttt tttttattaa acggtgttca ataa
//
