LOCUS       NM_013926               1413 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chromobox 8 (Cbx8), mRNA.
ACCESSION   NM_013926
VERSION     NM_013926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Oza,J., Ganguly,B., Kulkarni,A., Ginjala,V., Yao,M. and Ganesan,S.
  TITLE     A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response
  JOURNAL   J Biol Chem 291 (44), 22881-22893 (2016)
   PUBMED   27555324
  REMARK    GeneRIF: CBX8 plates roles in epigenetic regulation in DNA damage
            response.
            Erratum:[J Biol Chem. 2017 Jan 13;292(2):761. doi:
            10.1074/jbc.A116.725879.. PMID: 28087730]
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Beguelin,W., Teater,M., Gearhart,M.D., Calvo Fernandez,M.T.,
            Goldstein,R.L., Cardenas,M.G., Hatzi,K., Rosen,M., Shen,H.,
            Corcoran,C.M., Hamline,M.Y., Gascoyne,R.D., Levine,R.L.,
            Abdel-Wahab,O., Licht,J.D., Shaknovich,R., Elemento,O.,
            Bardwell,V.J. and Melnick,A.M.
  TITLE     EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress
            Bivalent Promoters, Mediate Germinal Center Formation and
            Lymphomagenesis
  JOURNAL   Cancer Cell 30 (2), 197-213 (2016)
   PUBMED   27505670
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Chung,C.Y., Sun,Z., Mullokandov,G., Bosch,A., Qadeer,Z.A.,
            Cihan,E., Rapp,Z., Parsons,R., Aguirre-Ghiso,J.A., Farias,E.F.,
            Brown,B.D., Gaspar-Maia,A. and Bernstein,E.
  TITLE     Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary
            Tumorigenesis
  JOURNAL   Cell Rep 16 (2), 472-486 (2016)
   PUBMED   27346354
  REMARK    GeneRIF: Cbx8 associates with non-PRC1 complexes containing the
            H3K4 methyltransferase complex component WDR5, which together
            regulate Notch gene expression.
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Creppe,C., Palau,A., Malinverni,R., Valero,V. and Buschbeck,M.
  TITLE     A Cbx8-containing polycomb complex facilitates the transition to
            gene activation during ES cell differentiation
  JOURNAL   PLoS Genet 10 (12), e1004851 (2014)
   PUBMED   25500566
  REMARK    GeneRIF: Cbx8 is upregulated and recruited to activated genes
            during embryonic stem cell differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Vogel,T., Stoykova,A. and Gruss,P.
  TITLE     Differential expression of polycomb repression complex 1 (PRC1)
            members in the developing mouse brain reveals multiple complexes
  JOURNAL   Dev Dyn 235 (9), 2574-2585 (2006)
   PUBMED   16786585
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Bernstein,E., Duncan,E.M., Masui,O., Gil,J., Heard,E. and
            Allis,C.D.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Cao,R., Tsukada,Y. and Zhang,Y.
  TITLE     Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene
            silencing
  JOURNAL   Mol Cell 20 (6), 845-854 (2005)
   PUBMED   16359901
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Hemenway,C.S., de Erkenez,A.C. and Gould,G.C.
  TITLE     The polycomb protein MPc3 interacts with AF9, an MLL fusion partner
            in t(9;11)(p22;q23) acute leukemias
  JOURNAL   Oncogene 20 (29), 3798-3805 (2001)
   PUBMED   11439343
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Hemenway,C.S., Halligan,B.W., Gould,G.C. and Levy,L.S.
  TITLE     Identification and analysis of a third mouse Polycomb gene, MPc3
  JOURNAL   Gene 242 (1-2), 31-40 (2000)
   PUBMED   10721694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF180370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF180370.1, BC014815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.33 cM"
     gene            1..1413
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /note="chromobox 8"
                     /db_xref="GeneID:30951"
                     /db_xref="MGI:MGI:1353589"
     exon            1..132
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1152
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /note="mPc3; polycomb 3 homolog; chromobox homolog 8"
                     /codon_start=1
                     /product="chromobox protein homolog 8"
                     /protein_id="NP_038954.1"
                     /db_xref="CCDS:CCDS25709.1"
                     /db_xref="GeneID:30951"
                     /db_xref="MGI:MGI:1353589"
                     /translation="MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEP
                     EENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSTRGI
                     RIPYPGRSPQDLASTSRAREGLRNTGLPPPGSSTSTCRADPPRDRDRERDRGTSRVDD
                     KPSSPGDSSKKRGPKPRKEPLDPSQRPLGEPSAGLGEYLKGRKLDETSSGTGKFPAGH
                     SVIQLARRQDSDLVQYGVTSPSSAEASSKLAVDTFPARVIKHRAAFLEAKGQGALDPG
                     GARVRHSSGTPASVGSLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKV
                     VVTDVTSNFLTVTIKESNTDQGFFKEKR"
     exon            133..176
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            177..242
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..309
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /inference="alignment:Splign:2.1.0"
     exon            310..1393
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1370..1375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /note="hexamer: AATATA"
     polyA_site      1389
                     /gene="Cbx8"
                     /gene_synonym="Pc3"
                     /note="major polyA site"
ORIGIN      
        1 tcgagggctg gctgctgctt ttctgctcct ggaagcggct gaggggggaa gcggcgagtc
       61 aacatggagc tctcggcggt gggggagcgg gtgttcgcgg ccgaagccct cctgaagcgg
      121 cgcattcgca aaggacgcat ggaatatctc gtgaaatgga agggctggtc gcagaagtac
      181 agcacgtggg agcccgaaga aaatattctg gatgctcgcc tccttgcagc ctttgaggaa
      241 agggaacggg agatggagct ctatggcccc aaaaagcgag gacccaagcc taaaaccttc
      301 cttctcaagg cccaggccaa ggcaaaggcc aaaacctatg aattcagaag tgactctacc
      361 agaggcatcc ggatccctta cccaggccgc tcaccccagg atttggcgtc tacttccagg
      421 gcccgagagg gcctgcggaa cacggggcta cccccaccag ggagcagcac cagtacctgc
      481 agggcagacc cacctcggga ccgggaccga gagagggaca ggggtaccag ccgtgtagac
      541 gacaagccca gctcaccggg ggacagctcc aagaaacgag gaccgaaacc caggaaggag
      601 cccctggacc cttcacagag acctttggga gagcccagtg ccggccttgg agagtacctg
      661 aaaggcagga agctggatga gacctcttct gggacaggaa agttcccagc tggccacagt
      721 gtgatccagc ttgctcgaag gcaggactca gacctggtgc aatatggtgt gaccagtcct
      781 agctcagcag aggcctcgag caagttggct gtggacacct ttccagccag ggtaataaag
      841 cacagggctg ctttcctgga ggccaaaggc caaggtgccc tggaccctgg tggtgccagg
      901 gttcgacata gttcaggcac cccagcctca gtgggaagcc tgtatcggga catgggggcg
      961 caagggggaa ggccctccct catcgccagg atcccagtgg ccaggatcct gggggaccca
     1021 gaggaagagt cctggagccc ctctctgact aacctggaga aagtggtcgt tacagatgtg
     1081 acctcaaact ttttgaccgt caccattaag gagagcaaca cggaccaagg attctttaag
     1141 gaaaaaagat gaattgccgg ggtgggagcc caggaccagt gcaggggaga gtgagctcaa
     1201 atggcttagt gctttttatt tctgggtgac tgtggcctct ggctggtcct gtccttcttc
     1261 acacccctct tccctttcat tcctccgtcc tcagttctgg ctggaaaatt atctctagag
     1321 ttctattttc tattagatgt aaatatgtta tttaagagaa aaatatctaa atatatatat
     1381 ttcaactctt gaaaaaaaaa aaaaaaaaaa aaa
//
