LOCUS       NM_028763               5449 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus chromobox 6 (Cbx6), mRNA.
ACCESSION   NM_028763
VERSION     NM_028763.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5449)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5449)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   3  (bases 1 to 5449)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5449)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5449)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5449)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   7  (bases 1 to 5449)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5449)
  AUTHORS   Vincenz,C. and Kerppola,T.K.
  TITLE     Different polycomb group CBX family proteins associate with
            distinct regions of chromatin using nonhomologous protein sequences
  JOURNAL   Proc Natl Acad Sci U S A 105 (43), 16572-16577 (2008)
   PUBMED   18927235
  REMARK    GeneRIF: different CBX proteins are recruited to distinct chromatin
            regions through nonconserved interactions. Metaphase spreads
            revealed reciprocal patterns of chromosome association by CBX2 and
            CBX6
REFERENCE   9  (bases 1 to 5449)
  AUTHORS   Bernstein,E., Duncan,E.M., Masui,O., Gil,J., Heard,E. and
            Allis,C.D.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
REFERENCE   10 (bases 1 to 5449)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     Neuronal pentraxin with chromo domain (NPCD) is a novel class of
            protein expressed in multiple neuronal domains
  JOURNAL   J Comp Neurol 481 (4), 391-402 (2005)
   PUBMED   15593341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237361.1, AK035250.1, AK004679.2 and AC113595.11.
            
            On Mar 21, 2005 this sequence version replaced NM_028763.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004679.2, BC011199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                BY237361.1         2-95
            95-1844             AK035250.1         2-1751
            1845-3216           AK004679.2         1750-3121
            3217-5449           AC113595.11        38799-41031         c
FEATURES             Location/Qualifiers
     source          1..5449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..5449
                     /gene="Cbx6"
                     /note="chromobox 6"
                     /db_xref="GeneID:494448"
                     /db_xref="MGI:MGI:3512628"
     exon            1..191
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            192..235
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            236..301
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            302..368
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            369..5449
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5425..5430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx6"
                     /note="hexamer: AATAAA"
     polyA_site      5449
                     /gene="Cbx6"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgcgc cccgccgagc gcccgcccgc cgggggcctg agcgctgggg cgcgtgcgcg
       61 agcggtgcag caccggccgc gggagcaggg agtattatgg gctgtgggtg ccgctgagca
      121 agatggagct gtctgcagta ggcgagcggg tcttcgcggc cgaatccatc attaaacgcc
      181 ggatccgcaa gggacgcatc gagtacctgg tgaaatggaa agggtgggcg atcaagtaca
      241 gcacttggga gccagaggag aacattctgg attcgaggct catcgcagcc ttcgagcaga
      301 aggaaaggga acgtgagctg tatgggccca agaagagggg acctaaaccc aaaactttcc
      361 tcctaaaggc ccgggcccag gcggaggccc tccgcatcag tgatgtgcat ttctctgtca
      421 agccgagcgc cagcgcctcc tcgcccaagc tgcactccag cgctgcggtg caccggctca
      481 agaaagacat ccgccgctgc caccgtatgt ctcgccgtcc cctgccacga ccagacccac
      541 aagggggtag ccctggccta cgcccaccca tctcgccctt ttctgagacc gtgcgcatca
      601 tcaaccgtaa ggtgaagccc cgggagccca agcggaaccg catcatcctg aacctgaagg
      661 tgattgacaa gggtccggga ggtggcagca ctgcgcaggg caccggggca ctggcccgcc
      721 cgaaagtccc ctcgcggaac cgggtcattg ggaagagcaa gaagttcagc gagagcatgc
      781 tccgtaccca gatccgccac atgaagtttg gcacatttgc gctctacaag ccccctcctg
      841 cccctctggc gccctctact gcgggcaaag ccgatgtggc ctcctcgggg cctgggctgc
      901 tcctggccac cccagctgct gccccctttg acgcacacag ctccagctct tccggctgcc
      961 cctcacccac actgcagtcc tctgacccag acgatgcacc acccaagcta ctcccggaga
     1021 ccctgagccg atctgtgccc aactggcgag agtcagaggt gctcgatctg tccatccctc
     1081 ctgaggcggc tgccaccggc cagcgggtgc ctcctgatgt cactggtgct gcggaccagg
     1141 cgctacatac agctctggag cccacaggtg ctggctcctc cgagcctgag gctggggact
     1201 ggcgccccga gatgtcgcca tgctccaatg tagttgtcac agatgtcacc agcaacctcc
     1261 tgaccgtgac catcaaggaa ttctgcagcc cggaggattt tgagaaggtg gccgctgggg
     1321 tggcaggtgc tacagggggc gggggtggca ctgggccaag taagtgaggg gcttcctcaa
     1381 ggaggggggc tttggggggc ctccttcctg gagtcatact tgtgctccca ccccgtccct
     1441 gccctcagac ccgtatgcct gtgcttagct tgcctcagat ggctcagtgt tgacccaggg
     1501 atagggctgg tagccctgga cttggttagg gccttggtag ggcttagaaa ggaagatctg
     1561 ctccctagtg tacctggcac tgtccctgac tgtgcaggtg gggcccacta gatggtttct
     1621 gggggatccc cagaacatgg ggttcaccta tcctatctac atccccccac cctgcctctc
     1681 ctagcttgct tcttgctctg tgtgcagtgt ttggtctcgg tgctatctcg ccatctgcag
     1741 ggcccccagg agatcccgcc tagggtgggc acaggctctc accaccctgg cactgagtga
     1801 aggatgaggc caaaatgggt ccctccctcg acaccattga gggtggcagc agctgggcca
     1861 gaggtccgct tccctgcttg cctacgtgtg gaccaggcct atgcagatct cttgccccac
     1921 acactgtcta tcccaaaccc cctttttgaa ggtggagggg ctggcagaca tggcaccctg
     1981 ccacagcctc tgggtatctg aaaacccctt ccgttttcta ccaaaggtgc tgcaagaacc
     2041 tgctgtagga acttctggct gtgcatgtgt gtttgcccct tggctccttc ttgtgtagat
     2101 ccgtgtgtgt gtgttgggtg cagggcctta gttttccctg caacaccctt tacggttcct
     2161 cagaacaggg tcgctgaagg cgtggcctcc cttgccttag ccaggcctgg cacagtccag
     2221 tctgtgcggt ttgtcgtgga agccacaggc cactctgatc ccaggttgct gggggacgtg
     2281 gagccacctc aggcccttct tgggatggtc atcttgaagg tcagatcttc actgcagatg
     2341 tggtactgtg gggactggta gaggaagagc ccagctacag cctcctcttg cagatgtttg
     2401 tggaggaaag aggaggccta gagacctccc cggggtcttc agtttccccc acccttccag
     2461 tttgctttta actgctgagg tttcctaaca gcctagcctg ttggaagact tcgggtgcct
     2521 tgggcagcgt ctgttgccct ctgctgctag ggaactgagg catccatgcc aatggcagag
     2581 accaaagccc cagattcagg ccaggcactg ggagactagc agggagggag ggaggtgccg
     2641 gtccccaggc ggcactggcc tgcccttggc cactgcctgg gattcacctg ggcgttgacc
     2701 agagtgttcc tgtatgtggc ctgagctggc ttctggtgta cacagccctt ggtagcttgc
     2761 tcagaagcat gggaagaggc agaagcagtg accttaggac aagtattctg gtcttagagg
     2821 aagatactct tcctttcacc agcctgcctg ccagggtctg cagcacagcc ccagccctcc
     2881 ttgccccagg gtataaaaca ggggccctca cagggcttga gggggccaca gtctggcccc
     2941 accttgtccc gtgttagctc tcataccgtc caagtgccaa ttggcttttc ccccaaataa
     3001 gggctggtat ttcgcctctg tccccagagg tgatttcccc ctccccctcc cccaggtgaa
     3061 ccaccacctg ggtgccagtt acaggtgttt gcagagacca tagaaatgtg ttttcctgag
     3121 agtctgtgtc atttgtgacc tttttttgta aagaagttgt gttttcagag gtgattttat
     3181 gacaggaaag tgaaagttag ttttgcaaaa aaaaaaagaa aaaaaaagaa aaaaattttt
     3241 aaaaaggaaa aaaaaaagaa aagaaaaaat agaaaaaaaa aaaaaaagga ccattgtagg
     3301 actcctaaga gcatagggtg gggagggaga gagctattta agaacgtatt aacgcagcga
     3361 ttgcacaggt gagtggcaat gttggggtga gggtggaggc cttagctagc tggtggattc
     3421 cctgggatag aaggcgccac agaggtggcc acagctgtcc tccttccttg acagggtgag
     3481 tctgttgtga cataggaaca tgcttccagt tgcttgaaag gaaggacaac cagccctaag
     3541 gtgactagcg gggaagtgca ggggacaagt ggacagcggt agtgggaccc aacttactgt
     3601 tgttgccttt cccccaggaa ggcacccatc ccatcacggg tctttacgct tcagctctct
     3661 gggtcacgtg gttcccagtg gttcccagta gctccccaga caccctaacg ccctgggcac
     3721 ctttgagcat ccctgattgg gaaagggatg caggctttag aaagcggctg acgggtaaaa
     3781 tcgctgcata ctctgcacaa gcctcaaggt gcacgggcac agggaagatg cgagcctgcc
     3841 aatgagcagc cctcttctct ctcctgaatg gtctggagca ggaggcccag aggctgcaca
     3901 gactccttac atagccctgc atcatcagcc tactgaaggc ccctccccta cccctgctgc
     3961 ttttcatttg cctaattacc aagtcaaagt tgcagtccaa tttgctttat ttttgtaagt
     4021 gaaatgaccc ccctacgccc cctgtaggtc gtgtcctgta agcgcaccct tccctcctac
     4081 ttgtcaggaa ctaggagtgg gtgagtcctg ggtcttgggt tttgagatgg agggttggca
     4141 tccatccctg ctgtggttct tgccctgatc taagtcagtc cctctgtgaa aggctggaca
     4201 gggtggcaag gcagcatgaa gcactacagg tgcccagcct gagggggcaa aatgagcctc
     4261 cctccccaac ttcagaggga gctggtggat cagagggcgt tgcctcgttt caaaggaggc
     4321 tgagatactt cactggagta tggaggcttc agagcccagg ctggcctggc atttaaaggg
     4381 aaatgtggga ctcttgactg gccatggcag aaacaaggtc agtcaaggat ggactggcct
     4441 ctggggacct aagagggcac ccccaccttt tctccttact tttctggttg gttcgggttt
     4501 tcggggtttt tttgtttgtt tgttttattc ttgttttttg cacttaatgg atggtggaac
     4561 ccagcctggt cagttctacc cttgggttcc ggtgcactag accaaggtgg cctgcctggg
     4621 gctcctgtgg ttcaaggaat cactttttaa aagataggag aaaacttaag ggttttagtt
     4681 ttgctctgtc tgcttctctt cttggttcag gaagcccaga gagacacttg agaagcaaaa
     4741 ataggcacct ggtcaggtgg gggctcagga ccccacttcc caacctacag ttcccactgt
     4801 ccttaaaaga gtcggggctc tgttccagcc atgtgcagtg caccggctgt gtgatggacc
     4861 agagggtctg aaggggccga gtggcggggt cagacgttgg gcatacctgg ctgagggggg
     4921 aagcaggcat ctttttgttg gttttaactt aaaaacacaa aggcctaaag aaatatgtat
     4981 cttataattt ttttaatttt taagaagctc gtttgatgaa ctgcacgaat gaattctata
     5041 tatatatata tataatatac gtacatagct ctatatttgg ggacgggcac tgtctctttt
     5101 ctctcacatt ttaaagatga agtgtctttg cctttgcctg tggttcaacc atccagcccc
     5161 cagctggcta aactttgcct ccagtggtta atggcaggaa cctaatagag ccggccagcg
     5221 gacaaagggg cgggccccca gtctgccccg cccctcgggg aggacttcca gtggggaaga
     5281 tagcttattt tggacgtgga ttcggtagat ctgggccagg ggagggcggg ctcgtgctga
     5341 tcactctgtc ttgtacgttt tgttctgctg ctcttcaata ttgtatcgat gccaggaaag
     5401 ggggtgaaac ctccttcacc cccaaataaa ttgtcacatt ccgaagcta
//
