LOCUS       NM_001076789            8837 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chromobox 5 (Cbx5), transcript variant 2, mRNA.
ACCESSION   NM_001076789 XM_001000807 XM_001000893 XM_001004073
VERSION     NM_001076789.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8837)
  AUTHORS   Xiong,F., Wang,D., Xiong,W., Wang,X., Huang,W.H., Wu,G.H.,
            Liu,W.Z., Wang,Q., Chen,J.S., Kuai,Y.Y., Wang,B. and Chen,Y.J.
  TITLE     Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic
            target for HP1alpha-positive intrahepatic cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 152 (2024)
   PUBMED   38812060
  REMARK    GeneRIF: Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a
            therapeutic target for HP1alpha-positive intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Jul 5;43(1):186. doi:
            10.1186/s13046-024-03112-w.. PMID: 38965576]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8837)
  AUTHORS   Leon,N.Y., Le,T.N.U., Garvie,A., Wong,L.H., Bagheri-Fam,S. and
            Harley,V.R.
  TITLE     Y chromosome damage underlies testicular abnormalities in ATR-X
            syndrome
  JOURNAL   iScience 27 (5), 109629 (2024)
   PUBMED   38616920
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8837)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8837)
  AUTHORS   Maeda,R. and Tachibana,M.
  TITLE     HP1 maintains protein stability of H3K9 methyltransferases and
            demethylases
  JOURNAL   EMBO Rep 23 (4), e53581 (2022)
   PUBMED   35166421
  REMARK    GeneRIF: HP1 maintains protein stability of H3K9 methyltransferases
            and demethylases.
REFERENCE   5  (bases 1 to 8837)
  AUTHORS   Zou,M., Gong,L., Ke,Q., Qi,R., Zhu,X., Liu,W., Sun,Q., Tang,X.,
            Luo,Z., Gong,X., Liu,Y. and Li,D.W.
  TITLE     Heterochromatin inhibits cGAS and STING during oxidative
            stress-induced retinal pigment epithelium and retina degeneration
  JOURNAL   Free Radic Biol Med 178, 147-160 (2022)
   PUBMED   34875339
REFERENCE   6  (bases 1 to 8837)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8837)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8837)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
REFERENCE   9  (bases 1 to 8837)
  AUTHORS   Wreggett,K.A., Hill,F., James,P.S., Hutchings,A., Butcher,G.W. and
            Singh,P.B.
  TITLE     A mammalian homologue of Drosophila heterochromatin protein 1 (HP1)
            is a component of constitutive heterochromatin
  JOURNAL   Cytogenet Cell Genet 66 (2), 99-103 (1994)
   PUBMED   8287692
REFERENCE   10 (bases 1 to 8837)
  AUTHORS   Friedrich,G. and Soriano,P.
  TITLE     Promoter traps in embryonic stem cells: a genetic screen to
            identify and mutate developmental genes in mice
  JOURNAL   Genes Dev 5 (9), 1513-1523 (1991)
   PUBMED   1653172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9 and AC162693.5.
            
            On Dec 14, 2017 this sequence version replaced NM_001076789.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008792.1, SRR10662774.122937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC164069.9         103646-103765
            121-303             AC164069.9         130244-130426
            304-490             AC164069.9         137820-138006
            491-591             AC164069.9         142597-142697
            592-6566            AC164069.9         143707-149681
            6567-8837           AC162693.5         1-2271
FEATURES             Location/Qualifiers
     source          1..8837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.34 cM"
     gene            1..8837
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /note="chromobox 5"
                     /db_xref="GeneID:12419"
                     /db_xref="MGI:MGI:109372"
     exon            1..120
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            121..303
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..742
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /note="HP1 alpha; chromobox homolog 5; heterochromatin
                     protein 1 homolog alpha; mHP1(alpha); heterochromatin
                     protein 1 alpha"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001070257.1"
                     /db_xref="CCDS:CCDS37231.1"
                     /db_xref="GeneID:12419"
                     /db_xref="MGI:MGI:109372"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     exon            304..490
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            491..591
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            592..8837
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8813..8818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /note="hexamer: AATAAA"
     polyA_site      8837
                     /gene="Cbx5"
                     /gene_synonym="2610029O15Rik; HP1; Hp1a; Hp1alpha"
                     /note="major polyA site"
ORIGIN      
        1 gatccgtttt ggcgggcggt tggcattgcg cagaaggcgg cggtagcggt ggcttgtggt
       61 gccgctttac cacagaggaa ccgtgcaggc cttagcgtga gtgatcactt tagatcttgg
      121 gaacctggtg gccatactcc ttcaggtgga tcaacaggca cacgacatgg gaaagaagac
      181 caagaggaca gccgacagct cttcttcaga ggatgaggag gaatatgtgg tggaaaaggt
      241 gttggacagg cgcatggtta aggggcaagt ggaatatctg ttgaagtgga aaggcttttc
      301 tgaggagcac aatacttggg aacctgagaa gaacttggat tgtcctgaac taatttctga
      361 gtttatgaaa aagtataaga agatgaagga gggtgaaaac aataagccca gggagaaatc
      421 agaaggaaac aagaggaaat ccagtttctc caacagcgct gatgatatta aatctaaaaa
      481 aaagagagag caaagcaatg atatcgctcg gggctttgag agaggactgg aaccagaaaa
      541 gatcatcgga gcaacagatt cctgcggtga cttaatgttc ttaatgaaat ggaaagacac
      601 agatgaagct gacctggttc ttgcaaaaga agctaacgtg aagtgtccac agattgtgat
      661 agcattttat gaagagagac tgacgtggca cgcatatcca gaggatgcgg aaaacaaaga
      721 aaaagaaagc gcgaagagct aaaggaggag gcagtctctg tcgtttctct ttgtatataa
      781 tacctttact ttcctgcctc ctctctctcc tcccacccct ttccatccta aacgcatcca
      841 taaaccactg cgctcatcac tgtgctccac gggggagatg ctggtattgg ttctcctgta
      901 atataactga tgatctgatt cctaagtgta gctctgtgaa cgtcaggcat tacgtcattc
      961 acatgctgtg tggttcccat agtgttctct ttcaccctga tcttttcctt ctgttcccct
     1021 gtaacttttt aatcacctta gagtcatgat ctttggggtt ggttgctttg ggagatttta
     1081 ttatgacgat gacttcagtt tcttgattgt tattagatta tattgatgac cagctggcct
     1141 ttgttttgac atactggcat agaaaggata ttgtccatct atttagaaaa ctattaaggg
     1201 caacctacct gttgtgtctt ttccgatctc atttagctct gccaggagaa tacagggtcc
     1261 ctggtgtggt cttgggccgc tcctgactat cctcacatac cctcccataa caattcagtt
     1321 ctcttagggc ttgaaacttc acatttaaat ctgtcaaggc gctctgttta gccctcacac
     1381 tttcttggcc ttgttacttt caatccctga ttctgcttct gtaaagtggt atcaatttgt
     1441 tattaaatga caagattaac tgtggagtct gtaagctgta gtgcaggaag ataataggat
     1501 ggggctggat acagttatca cgtggtgtgt gtgtattctt tcctttatcc ctcatattta
     1561 gactgtattt atgtaggtgt gagtgattgc ctggtgcttg cttgtgccaa ggtgctgggc
     1621 accctctaac cctgccaatt tttatggcct cccaaagcat tcctgtacca aagaggcatc
     1681 agcagatcca tgccattccc ttccgtgcca ttattttaag ttgggaattt ttggagagga
     1741 gccactagcc acagtgtcac tggcttttac gtccttgcag cagtgatgct ctttaattta
     1801 ctgcctcatg gcttgtggat ttgccaccaa gtcctcagag gattaatgtt cctgtcctct
     1861 ccacttgagt ctgaggattt ttagttgtag cttattttaa aaacatagaa gattatggcc
     1921 tcagaaaccg acaggtcttg atattaactt tttgacacaa ccttctctca caacaaacta
     1981 cttccttttt ggtttactct tgctttgcta ttatttctgc tcctattcta ctttttgtcc
     2041 cctgaaaaat gcccatcttc tcttcatttc tttcttcttg tatagttgag gaagctggag
     2101 aatcaggact aaaagtaagg aaataacaga gtttggagct gagcagtctt gtcccagctc
     2161 caacgctgag gaaaaagaat aaacgctgaa gtagccttaa ttccagactt cgtcagctac
     2221 tgagctgctt ttgttgttgc gtttgatttt tttaaagcaa agctgtctgg gccagagcat
     2281 ctagccaccg ggttgttgat agtaatgaga ggaatggatg gagtgcttca gtccacagat
     2341 gagccagata atatgcaaac cctagaccca ttcacagcat ttgttaacac tgctttcctg
     2401 ctcagctgct acttgagttc tgtgttcttg aataaattat gccaacaatt atactgcacc
     2461 gttgagaagg cagcttgtac tgcagtgaca tggtagacag acagtgaagc tttgccttac
     2521 ttaagtcagc caggaacaac ttgtgaatgg taatgtggtg ggagaatagc acctaaccca
     2581 tacctcacat gggtgagctt tttctctctg tagtccgtag ttgtctgaag atgttagagg
     2641 caatatcaaa tgctggataa gtgaccgatg tctgtactta acttgatgaa atgaaggatg
     2701 gttagagagc agatctgtcc ttcaggcaac caaggctagt agtaattagg gcagatgaaa
     2761 atagcacaga agtagccaga gctcctgagg atcttgactg gcaactagag gaaaggacca
     2821 cccactgagt agtcaggagt agtgggcatg tacattgcag tgaccatatt ttttaaagca
     2881 aaatcttagc ctttgggcaa ccataacaat gatatttagt cctatataat ataaaccata
     2941 ataatgagat tagtcctaag aagtctggcc tggtgacaaa aaagtacaca gtcccagact
     3001 gatacagggg tactgtatgt tcaaggcctg tttgggaact tagtgagacc ctgactcaag
     3061 ataaaaaata aaaggaccga ggatacagtc tgagagttaa tgccttgtaa tgcaaaaaat
     3121 gaagggaaaa agtgtcctgc tggttttaat gctctttgta atttttttct cttaaaagtt
     3181 catggagtat tggttttctg ttaactatta ccaaaacatc cttgttttct tcttagtact
     3241 tttcctggtt atatatagaa atagggaacc gggattctag tattatcttc aacactcagt
     3301 gtaaagaagc cagacaccca tctgtgcctc cagcatgtgt tgtgccaagt agcttgtttc
     3361 tgctggagaa ttgcagcctt ggacagaagt gtttcctaga gctatcttcc ctctaaagag
     3421 ttcacaacca aaggtgaaat actcctaaac acttgactat attctcctgt gttaatcctc
     3481 tttcaaaact aattttgtgg tactgggact tgagcttaga catgccaggc aagtgctgtg
     3541 ccactgaact gatgtctttt tctgcccctt ccccgccata caccatttta ttgttgttct
     3601 aaagacttag tctctgatac caggctagcc tcaacttgct gtatagacaa gttgaaaaga
     3661 attttttttt tcatctgtag cagtcttcag acataccaga agagggcatt gaatctcatt
     3721 acagatggtt gtgagccacc atgtggtttc tgggaattga actgggggcc tttagaagag
     3781 cagtcaatgc tcttaactgc tgtgccatct ctccagccct gccaagctga attcttgatc
     3841 tcttgcctct atctcccagt ctctaggatt gtaagtgttt gtcaccatat ctggctcctt
     3901 cttttgtaga gactggacct tcaaaattac ctatgttagc caggtatagt gtaatacacc
     3961 tttaattaca gcatctagga ggcagaagta gaccaatctt aattagaggc cagtctggtc
     4021 tatatagtga gttctaggcc agccagacca gtatagattc tgttgcgaaa ggaaaaaaag
     4081 aaaagattgg ccttgaactt aggatctgtt tgtatcagtt ttgtgccact atacctggct
     4141 caaaatcttt ttttttttaa ttaagttatt gtgtatatgg gatttctgcc tgcatgtata
     4201 tctgtgcacc atatgcatgc ctggttccct aggagaccag aagagggtct tatatcctct
     4261 gggataggag tgagctgcta tgtgagtatt gagaatcaaa tcctggtcct ctggaagagt
     4321 gggtgccacc tcccaccctt caaaacatct ttttaatgtt gaattttttt cttttttttc
     4381 tcccccgccc cgcccccctt ttctgtttaa tcctggctgt ttcttgccgg cttcaccctt
     4441 taatgctcaa gttttgctag ctttacacga aagcagaggt gaactgggtg atccatcaac
     4501 attatacact gtgctgttca catttctacc actttagcat acatcaatat tgttttcatt
     4561 caacaaacat tttggctcag gatacaaagt ttaaactcct ttgctagaga actttgatag
     4621 tggtatggga tgagttgatc attatagttt tgtataatga atattgcaca tgtatataaa
     4681 ttactggtct ggggcagcaa caggtataca gaagcatgag cctttagtgg gcagttagct
     4741 cagtggttga gtgctggtgg agaatacatg aagcaaagca ctgggttctc acgggaggag
     4801 ggggaggatc tgcaatagga gggtgccatt aactggttta tctgtgggaa agacctgttg
     4861 tcttggatga actgagttaa ctggccatgt ggaatattgc agaaaataaa gctagaaatg
     4921 tggtcattac caagagtgca gatacgtgag cataagaacc atcttgttta gactgccaaa
     4981 gtattcatga ctttgtattg tctgaagatc tcattgtatg tggtggtgtt atgggtctgt
     5041 ttgtatattt cttcttaatg ggcattttag caagttgctc acactgttca atttctcacc
     5101 cttttggaga aatcaacatt agtctggctt taaagcctaa aacataccat ctaatgacag
     5161 actttgttag agaaaagctt agaagtcagc taatatctga gtgtctgcct ttggggagca
     5221 agcagctcct gtgtctctta tatcaaaacc ttccacagga ataatgtgtt ctggctcctc
     5281 attgtgcatg acgcccctcc cagataagaa acagtctggt tttcaggttc tcattctgac
     5341 ttttgagagc acaagataaa gatcttagct ctacttggat aattgactat agaaatcaga
     5401 attctcagaa atcaactgct ttagaaggtt aaaatgtgaa gtttcttgtt tgttttttgc
     5461 ttgtactgaa tattttgaat tttaatctac ctcgtctcat tttttgtagt tacttctgtc
     5521 attgccactt gagcatgaag cttgactttg gtcgttgtct aaaatgggat ctctcctgtt
     5581 cagtgacagt ttattctctt gcctttcctc ttggccccca tttcacctaa catcatctct
     5641 tattgctcct gtcagaaata tgttttaaag tcttgtttta tgggaaaaag tggttcacca
     5701 atgctgtttg tctctgaggt cagtgagaga aggagttaaa acacagtggt gaaggaaggg
     5761 cagatcctgc tctggaggca aaagctgaca aggaaggagt cattaattac agacaatttc
     5821 aaagtcaact gattgtgatc attaatgtca caatagatca aaacctaatt atcacagcct
     5881 aggtaagagc catcagtatt aatcggaaaa tctaatagga aactattacc aagaaattag
     5941 gccaaattga atgcaatgaa ctttttatca tctttttttg gtaatgttct tggtgttggc
     6001 aactgtgacc ctaacagctg gtccaagccc agattgctaa tttcactttt aaagagccta
     6061 ggctggccct agtgcttgta gtactcctgc ctcagcctta aatactggga ttatgagggg
     6121 atgtgtgcat tcctgtttgt gtgggtgggt aggagagaat tgaactcagg gccttgtaca
     6181 ttttagacaa gtgctcaacc actgagctgt attcctagtt cagagtgttt tgtttgttag
     6241 ggaagtttcc agagagactg aatctgagct aacattgctg aaacaccaac cttgaatttt
     6301 ctcatcatgg atttgtccag tctaatcaga tcagtgggat atacaggtat atattaaagt
     6361 catagagtgt ccctggtgaa cattgttgct gtatcatccg ttgagtgctt gtgtatagag
     6421 ctctgtactg gctgctgtga aggctgtggg aggaagacag tgtcctgctt tgaaattctt
     6481 tgagaactaa aaagatagtt tccttgtatg acaacaggaa gaagatgcaa gccagtgttt
     6541 tcctgtttgc agtaacgcta ggatttgatc ctgaacagcc tggcagtgtg cctgatccca
     6601 gtagttctaa gataggaaca aaatgatttc ccactggaat tctaagggat ggggaagata
     6661 tctttgtttt cctttctgtg ttacaagtta tatctctggt agtaggagaa gccatcagta
     6721 tgtccttaag atgtttgtaa agatgctacc acctttgggt gagatgagtc aggcagtgga
     6781 aaagttgctg tcctttgggt gtcacaggag gaatgccagg cagtagtaga gggaattgtg
     6841 cctaggagtc tacactgtgc cctgcagccc tgctgcactt caggtgctca gtgctaatct
     6901 tacttaggaa ggccatgctc ctttctggaa cttggattac ccactacaag actgagaatc
     6961 agtgtctttt gtttgtttgg tttttttttt ttttttttta agacagggtt tctatgtagc
     7021 catggatgtc ctggaacttg ctctgttgac caggctggcc tctaactcag agatctgcct
     7081 gcccctgcct cccaagtact gggatcaaac atgtgtatca ccactgcctg gctaaccctt
     7141 cacttcttaa gtgagtttta gtgtttaaaa tgcaacttaa ttttcaaaat ggcactaagg
     7201 tggtttgtcc agccttggtt tactccagat gagcagcagc cctcaacagt gtgttgattg
     7261 aactcatctg gctgcagtga aatggctgaa agtgagattt tctagtgcat acttctgtgc
     7321 tagcctccct acttggtctt aatggctgac cttgggcaag tctttccttt caatgcctca
     7381 gttccccatc tgtcaaatgg ggtgataata ctgacctacc tcatggggtg ttgtgaggca
     7441 ttacagatca gagctgatca actcctttag gattgcctgt ggaggatacc ttcagtcgaa
     7501 gtttttttag ccctcactga gctacttcca agtttggaag tacttagtga ccttggtgag
     7561 tttctgtccc caatccctta acccctcatc aatgctgcta gttcagatgt tgacagtgtt
     7621 ttgtgaatgt tggagtcttg atcatccagt ctaacttggg atgctgtgag ggaaggcact
     7681 tgtgggctct gtgtcttgca tcacaaagag acttagaaat tcaagagcct tgggttaggg
     7741 aatcttgagg caggagtgct acttcatgtc tttctctgca ggcaggagtt aaggtcctat
     7801 tctcatggat gacttgtgct gattgtcttg gtagtgtgga ttgatattgt tgcttccatt
     7861 ttccaggctg acctaggaca ggtcgtccac tgaactcttc atgctccgat gcctctgccc
     7921 tctcatagaa gccagacggc tcaagcaaca taacactccc ttcccctacc aaaaagagct
     7981 acattgtatt ttgttttttt ctagaaatag gtataccatt tcagaattga gcattggtcc
     8041 tcaaggcttc ttttcagttc actgtgtgtg gaatctgtca cctcttttca gtgtatacca
     8101 tctgacccac tgaggacatc ttggacactt gtttgcccac ctgagggttc aagagccttt
     8161 cttgctctgt ctcagtatag ggactaaggc atccccagat tcttcatgat aggtttcctt
     8221 ttcccctact tgaccttcta ttggtaccca tgaaaaagca caaggtccta gctccctgta
     8281 gatacacact ccagttctgt tgggtagact ctactcctaa caggggtcct agagggttct
     8341 ctggaggatg ggaaaggaac agtctcatgt cctgccaaat agtagccagc agttgcctta
     8401 cccctgcctg ctggccatga acccacattc tcacggaaag ggctttcaga gacccctggt
     8461 ttttctcagc actgtaccat tttgtgtagg aagcaggtca caccttgtag ccaggtctaa
     8521 atggaagtga gacagtgaat tctctgtgga cttttttggt ttgtgggggg gttttggttg
     8581 tgtttcttgg ttctgtttca gccaaacttg tctgcttttg atttctttaa aggataagtg
     8641 gtctatctat ctatctacac gtatgtttgc attttaagtg taagtgtttt gagaaaaaaa
     8701 aaaaacagac attatgtcat tctacaactg acatccaatt cagacatcat cctctccccc
     8761 ttccaccctc tttttcctct tttccctctt ttcatactct tgtattggtt ctaataaacg
     8821 attgcttttc aaatatg
//
