LOCUS       NM_007625               5213 bp    mRNA    linear   ROD 17-DEC-2023
DEFINITION  Mus musculus chromobox 4 (Cbx4), mRNA.
ACCESSION   NM_007625
VERSION     NM_007625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5213)
  AUTHORS   Ren L, Li Z, Zhou Y, Zhang J, Zhao Z, Wu Z, Zhao Y, Ju Y, Pang X,
            Sun X, Wang W and Zhang Y.
  TITLE     CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in
            T cells
  JOURNAL   Mol Oncol 17 (12), 2694-2708 (2023)
   PUBMED   37691307
  REMARK    GeneRIF: CBX4 promotes antitumor immunity by suppressing Pdcd1
            expression in T cells.
REFERENCE   2  (bases 1 to 5213)
  AUTHORS   Huang W, Yu C, Wu H, Liang S, Kang J, Zhou Z, Liu A and Liu L.
  TITLE     Cbx4 governs HIF-1alpha to involve in Th9 cell differentiation
            promoting asthma by its SUMO E3 ligase activity
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119524 (2023)
   PUBMED   37348765
  REMARK    GeneRIF: Cbx4 governs HIF-1alpha to involve in Th9 cell
            differentiation promoting asthma by its SUMO E3 ligase activity.
REFERENCE   3  (bases 1 to 5213)
  AUTHORS   Chen F, Hou W, Yu X, Wu J, Li Z, Xu J, Deng Z, Chen G, Liu B, Yin
            X, Yu W, Zhang L, Xu G, Ji H, Liang C and Wang Z.
  TITLE     CBX4 deletion promotes tumorigenesis under KrasG12D background by
            inducing genomic instability
  JOURNAL   Signal Transduct Target Ther 8 (1), 343 (2023)
   PUBMED   37696812
  REMARK    GeneRIF: CBX4 deletion promotes tumorigenesis under Kras[G12D]
            background by inducing genomic instability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5213)
  AUTHORS   Melo GA, Xu T, Caloba C, Schutte A, Passos TO, Neto MAN, Brum G,
            Oliveira-Vieira B, Higa L, Monteiro FLL, Berbert L, Goncalves ANA,
            Tanuri A, Viola JPB, Werneck MBF, Nakaya HI, Pipkin ME, Martinez GJ
            and Pereira RM.
  TITLE     Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively
            Regulates Effector Responses in CD8 T Cells
  JOURNAL   J Immunol 211 (5), 721-726 (2023)
   PUBMED   37486206
  REMARK    GeneRIF: Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4
            Positively Regulates Effector Responses in CD8 T Cells.
REFERENCE   5  (bases 1 to 5213)
  AUTHORS   Cho KW, Andrade M, Bae S, Kim S, Eyun Kim J, Jang EY, Lee S, Husain
            A, Sutliff RL, Calvert JW, Park C and Yoon YS.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   6  (bases 1 to 5213)
  AUTHORS   Vogel T, Stoykova A and Gruss P.
  TITLE     Differential expression of polycomb repression complex 1 (PRC1)
            members in the developing mouse brain reveals multiple complexes
  JOURNAL   Dev Dyn 235 (9), 2574-2585 (2006)
   PUBMED   16786585
REFERENCE   7  (bases 1 to 5213)
  AUTHORS   Bernstein E, Duncan EM, Masui O, Gil J, Heard E and Allis CD.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
REFERENCE   8  (bases 1 to 5213)
  AUTHORS   Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S,
            Deschamps J and van Lohuizen M.
  TITLE     Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle
            inhibition
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2468-2473 (2003)
   PUBMED   12589020
REFERENCE   9  (bases 1 to 5213)
  AUTHORS   Hemenway CS, Halligan BW, Gould GC and Levy LS.
  TITLE     Identification and analysis of a third mouse Polycomb gene, MPc3
  JOURNAL   Gene 242 (1-2), 31-40 (2000)
   PUBMED   10721694
REFERENCE   10 (bases 1 to 5213)
  AUTHORS   Alkema MJ, Jacobs J, Voncken JW, Jenkins NA, Copeland NG, Satijn
            DP, Otte AP, Berns A and van Lohuizen M.
  TITLE     MPc2, a new murine homolog of the Drosophila polycomb protein is a
            member of the mouse polycomb transcriptional repressor complex
  JOURNAL   J Mol Biol 273 (5), 993-1003 (1997)
   PUBMED   9367786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662835.11, BC117801.1, U63387.1 and AW045299.1.
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NM_007625.3.
            
            On Nov 30, 2007 this sequence version replaced NM_007625.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63387.1, BC117801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AL662835.11        86465-86590         c
            127-900             BC117801.1         1-774
            901-1845            U63387.1           813-1757
            1846-4901           AL662835.11        78220-81275         c
            4902-5213           AW045299.1         1-312               c
FEATURES             Location/Qualifiers
     source          1..5213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.34 cM"
     gene            1..5213
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /note="chromobox 4"
                     /db_xref="GeneID:12418"
                     /db_xref="MGI:MGI:1195985"
     exon            1..289
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1876
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /note="polycomb 2 homolog; chromobox protein homolog 4;
                     chromobox homolog 4; E3 SUMO-protein transferase CBX4"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase CBX4"
                     /protein_id="NP_031651.2"
                     /db_xref="CCDS:CCDS25710.1"
                     /db_xref="GeneID:12418"
                     /db_xref="MGI:MGI:1195985"
                     /translation="MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEP
                     EENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSAD
                     NRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERSGKPPPPGKSGKYYYQLNSKKHH
                     PYQPDPKMYDLQYQGGHKEAPSPTCPDLGTKSHPPDKWAHGAAAKGYLGAVKPLGGGA
                     GAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQA
                     VKIKSGEAAEGEARSPSHKKRAAEERHPQGDRTFKKAAGASEEKKAEVPCKRREEEAL
                     VSGDAQPQDLGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARSSHPPAHHHHHHHHHH
                     HHHTVGLNLSHARKRCLSETHGEREPCKKRLTARSISTPTCLGGSPVSEHPANVSPTA
                     ASLPQPEVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAPAVAAVVAPAPASEK
                     PPAEAQEEPVEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV"
     exon            290..333
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..399
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..466
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..5197
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2588..2593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
     polyA_site      2613
                     /gene="Cbx4"
                     /gene_synonym="MPc2; PC2"
ORIGIN      
        1 gtctgagcga gcgagcgagc gagcgagcgc gagctgagag ccggcgggtg caggcagcgg
       61 cggcggcggc ggcggccagg ctgttgaggg gcgagtggcg gcggcggggg ccgggcgcgt
      121 ggcgaggtcc acgcgcagga tcgtatcggg gcgccggcgg gagctagctg tgtctgcagc
      181 cgcgccggcc gcttgcgccc ctgagcgctc gggttcggcc atggagctgc cagctgttgg
      241 cgagcacgtc ttcgcggtgg agagcatcga aaagaagcgg atacgcaagg gcagagtgga
      301 gtatctggtg aaatggagag gctggtcccc caaatataac acgtgggaac cagaggagaa
      361 catcttggat ccccggctgc tgatcgcctt ccagaacagg gaaaggcagg agcagctgat
      421 gggatatcgc aagagagggc ccaagcccaa accgctggtg gtgcaggtgc ccacctttgc
      481 ccgacgctcc aatgttctga ctgggcttca agactcctcc gctgacaacc gtgccaagct
      541 ggagttgggc acacagggca agggccaggg gcaccagtat gagctcaaca gcaagaagca
      601 ccatcagtac cagccacata gcaaggagag gtccggtaag ccgcccccgc cagggaagag
      661 cggcaagtat tattatcagc taaatagcaa aaagcaccac ccctaccagc cagaccccaa
      721 aatgtacgac ctgcagtacc agggcggcca caaggaggca cccagcccca cctgcccaga
      781 cctgggcacc aagagccacc ctcctgacaa gtgggcccac ggagctgcag ccaaaggcta
      841 cctcggggcc gtgaagccct tggggggagg ggcaggagct ccaggcaagg gctcggaaaa
      901 gggccccccc aatggcatga caccagcccc taaggaggca gtgaccggta atggtattgg
      961 gggcaagatg aaaatcgtca agaacaagaa caagaatggg cgcatcgtga tcgttatgag
     1021 caagtacatg gagaacggca tgcaggcagt gaaaatcaag tcgggcgagg ccgccgaggg
     1081 cgaggcgcgc tcccccagcc acaagaaacg tgctgccgag gagcgccatc cccagggcga
     1141 caggactttt aaaaaggcag ccggtgcctc tgaggagaag aaagccgaag tgccctgcaa
     1201 acgcagggag gaggaggctc tggtgtcggg ggacgcgcag ccccaggacc tagggtctcg
     1261 aaagctctcc ccgaccaagg aggcctttgg tgagcaaccg ctacagctca ccaccaagcc
     1321 agacctgctg gcctgggacc cagccaggag ctcgcacccg cccgcccacc accaccatca
     1381 ccaccaccat caccaccacc accatacggt gggcctgaac ctctcccatg cgcgcaagcg
     1441 ctgcctctcc gagacccatg gggagcgtga gccctgtaag aagcggttga ccgcccgcag
     1501 catcagcacg ccgacctgcc tggggggcag cccggtctcc gagcaccctg ccaacgtatc
     1561 ccccaccgcg gcctctctgc cgcagcccga ggtcatcctt ttagactcag acctggatga
     1621 acccatagac ttgcgctgtg tcaagatgcg cagcgacgcc ggggaaccgc ccagcaccct
     1681 ccaggtgaag cccgaggctc cagctgtggc ggcagtggtg gcgccggccc ctgcctcaga
     1741 gaagcctccc gctgaggccc aggaggagcc agtggagccc ttgagtgagt tcaagccctt
     1801 ctttgggaat ataattatca ctgacgtcac ggcgaactgc cttaccgtca ctttcaagga
     1861 atacgtgacg gtgtagtggg aaggagtcgc gcccactagg actcagcacc tacagaggtt
     1921 cccaaggaga aaacgcccca gtcgcggtgg ccaggccctt gctcactccc tgggatcccg
     1981 attgagttgt ccacctctca ctgtctcctt ccacgtggtg cctgcggtct caccgccacg
     2041 tccccttccc tataggagac ctgagccttc cctgtggacc accagaactg acccgcagcc
     2101 ccgaggcagt ctcagagcta tagtattata ttttaaccgt gctaactgtc aagtgctgac
     2161 tctactccgg tttgtacgtg gtgttattct tgaaatgtat tgtttgagct cagaaggccc
     2221 gactatcccc cttagggctg atatatatac atatatatat atttatttgt aggtatttat
     2281 atattgaaat ataaaaacct agatttatgg agtttcctct agatcatgtt atattctata
     2341 tcagacagac tattttaagt tggccttttc tttccccttc attcagtatt ttgattttat
     2401 ttccccttct ccaggaactg cgacaccagt aaccttggta tatatttttt gatactgtac
     2461 acatgggtgt gttgtttcta tgtgcaaaaa aaaaagtttg ttaaaaggct aaagagctct
     2521 ctagaacctg ctgctataga aatgtctgaa ctataagctt ccaattatta cctgcttgaa
     2581 tgtaaatatt aaatggagat gttgaaggtg caattcagtg tccgagatta gctccagggg
     2641 gatgtcggaa ggtccgaagt tgagggaaag aggacggacc ctctctcacc ccaccaaggt
     2701 cacgtggaaa aagactctct aaagctaagt ctttgcacaa gccaagcctg tggggtctgg
     2761 tgtctctaga gcagctcctt cattggaagg tgactcagtg tgggaaaatc gagaggtgct
     2821 agcctggaag agtggagtgg ggggaatgta tcagagtcgc cctagtccct ggggctttct
     2881 ggctggcgat gctcacgtag ctggcaaacc agtaatttct gggttgtaga ggggcgagaa
     2941 atgggggcac tgcaccccca cttcctggat cctgactctt aggctggtgg cccttgcccc
     3001 gcccctcaag ccaagccctc agccctccct gctgtgggcc aggatacaag tggagtagac
     3061 cccaactctt tggggctgtc ccgggctcaa aggaagcaga ggaaaccctt tctctgccag
     3121 gctctctccc cggaaactac caggccaaag gccagggctg gagcaagtga actgctgtgt
     3181 tgggccttct actggatgat ttgggagggg gcgacagggc gctgagtctg gcctgccacc
     3241 ctctcttcct tagctgcgtg ggctggcact ggttgcccat ccccttggtg gctactagga
     3301 ggtgctaggt gtgtctggag aagggaagaa aggggttaat ggcccctagg ctaggggtgc
     3361 ggctcggcca ggccaggaag ccaccaccag cggccagctt tctgcagaca cagcgatctt
     3421 cctcctggtt cagtggctaa acaggccctg gggcctccgg cctggggaat ctggtgagct
     3481 tcaggattct ccctgctggc aaagcctcag ttcgggaccg agggtcgagc ctatagtgac
     3541 accagggcag aagatgacag cgtggtttgg agtgtgtgtt tgtgtgtgtg tggcaggggg
     3601 tgctgaggta gttcgagggg cagagttggg aaggctgggg aagagatgga gaggaaggcc
     3661 tagagggcgg gaggctcgat gcacggagtg gccagttttg gctgcaggcc atcagcggct
     3721 gtggctgggg gaggggcgcg gggcggggga ggggaggagg gaagggaacc gcttttttga
     3781 aaaagccttt gggagtttgt agccccggct tttgtgaatc gtccctccca ctaccccatc
     3841 cccgggagcc cccttcagag tgagttaaac acccctcccc ctctgtgtaa tgaacgccct
     3901 ttgccaccct gtgagtggag gaggctgatc ttgcttctgg caaccggcct gctcggcgct
     3961 agaattgggc ctgtccttca ctggctggtg cacaaaggcc cgtgccaggc aggaacctca
     4021 gcccctgctt ttccagttca tgagaactga aaactcccga atgctgctga tcagacctag
     4081 aggtggagcc ttggcagtag gtctggcccc tgaggtggcc ccttttctgc caagcttggg
     4141 gagagaaccg aagaggcgga agatggctct cctggatggc tactagttca ctagtcttcc
     4201 tggaaaagcc tggtctacag gtgccatgac tccttgaaag ctgggtatgg gtgcagggcc
     4261 tgtggagtga ggtgccccag tcagagggta aatagagggc cgagatctaa gggagcagat
     4321 aaggcgtcca gcctggttgt caagaccccc catctgtccc caaggggaca agggcttgtc
     4381 atttactgtg ttcctttgat gtcccatgag cattgtggct tatttagtcc ccaagtaggc
     4441 cagctctctg tgacacaggt ctgaggttct gatgggcatt ccctagttct tgtcttgatt
     4501 ctggaaccaa actggctggt cccaatcctg cagaggctcc ccaggactct gccctctcag
     4561 gcctcggtgc tggcctcaga ggacaagtag gacaaggata gaaacagact tcctccttca
     4621 aggggcactt gggcagaaag ggttcagaag gcccagctct cctggtgtgg gtggtctctg
     4681 accagcactt tataaacagc tggtcacgaa ctctctcttt gaagacgaga gttcagattc
     4741 aagagtgaaa aggaaggctt tgcattctac acatacccac accatccaaa tggcttttcc
     4801 ccccatcaga atgaacccaa accgttctta catgcttaag cctcaggcac agaggccaga
     4861 gctaggagtt caaaggccct gggggtattt gtgaagcctc ctgcccagag ctggcttgac
     4921 tacagctctg gtcgaccagt agtctgccct gactgtctca gcttagttcc agaagatcca
     4981 agtttatccc acagtcttta ctccatcctt ggacaccaca gttggtgtca tttgttggag
     5041 atgtcccaca gatgcagcat ggtgtgggtc tagagttgtc aggccaaaca aataagaatt
     5101 tagggttctt agctcaattt ggatagcgta tgcatataaa tcaatcacta gcatatgcat
     5161 gtaaatgctt ataaataaat aaatatttaa aggttgaaaa aaaaaaaaaa aaa
//
