LOCUS       NM_007624               1822 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chromobox 3 (Cbx3), transcript variant 1, mRNA.
ACCESSION   NM_007624
VERSION     NM_007624.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Higashiyama,M., Haniuda,K., Nihei,Y., Kazuno,S., Kikkawa,M.,
            Miura,Y., Suzuki,Y. and Kitamura,D.
  TITLE     Oral bacteria induce IgA autoantibodies against a mesangial protein
            in IgA nephropathy model mice
  JOURNAL   Life Sci Alliance 7 (4), e202402588 (2024)
   PUBMED   38331476
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Stylianakis,E., Chan,J.P.K., Law,P.P., Jiang,Y., Khadayate,S.,
            Karimi,M.M., Festenstein,R. and Vannier,J.B.
  TITLE     Mouse HP1gamma regulates TRF1 expression and telomere stability
  JOURNAL   Life Sci 331, 122030 (2023)
   PUBMED   37598977
  REMARK    GeneRIF: Mouse HP1gamma regulates TRF1 expression and telomere
            stability.
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Hayashi,S., Oe,S., Koike,T., Seki-Omura,R., Nakano,Y., Hirahara,Y.,
            Tanaka,S., Ito,T., Yasukochi,Y., Higasa,K. and Kitada,M.
  TITLE     OLIG2 is an in vivo bookmarking transcription factor in the
            developing neural tube in mouse
  JOURNAL   J Neurochem 165 (3), 303-317 (2023)
   PUBMED   36547371
  REMARK    Erratum:[J Neurochem. 2024 Jan;168(1):66. doi: 10.1111/jnc.16019..
            PMID: 38073276]
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Le,P.T., Ha,N., Tran,N.K., Newman,A.G., Esselen,K.M.,
            Dalrymple,J.L., Schmelz,E.M., Bhandoola,A., Xue,H.H., Singh,P.B.
            and Thai,T.H.
  TITLE     Targeting Cbx3/HP1gamma Induces LEF-1 and IL-21R to Promote
            Tumor-Infiltrating CD8 T-Cell Persistence
  JOURNAL   Front Immunol 12, 738958 (2021)
   PUBMED   34721405
  REMARK    GeneRIF: Targeting Cbx3/HP1gamma Induces LEF-1 and IL-21R to
            Promote Tumor-Infiltrating CD8 T-Cell Persistence.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Ryan,R.F., Schultz,D.C., Ayyanathan,K., Singh,P.B., Friedman,J.R.,
            Fredericks,W.J. and Rauscher,F.J. 3rd.
  TITLE     KAP-1 corepressor protein interacts and colocalizes with
            heterochromatic and euchromatic HP1 proteins: a potential role for
            Kruppel-associated box-zinc finger proteins in
            heterochromatin-mediated gene silencing
  JOURNAL   Mol Cell Biol 19 (6), 4366-4378 (1999)
   PUBMED   10330177
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Horsley,D., Hutchings,A., Butcher,G.W. and Singh,P.B.
  TITLE     M32, a murine homologue of Drosophila heterochromatin protein 1
            (HP1), localises to euchromatin within interphase nuclei and is
            largely excluded from constitutive heterochromatin
  JOURNAL   Cytogenet Cell Genet 73 (4), 308-311 (1996)
   PUBMED   8751383
REFERENCE   9  (bases 1 to 1822)
  AUTHORS   Rothstein,J.L., Johnson,D., DeLoia,J.A., Skowronski,J., Solter,D.
            and Knowles,B.
  TITLE     Gene expression during preimplantation mouse development
  JOURNAL   Genes Dev 6 (7), 1190-1201 (1992)
   PUBMED   1628826
REFERENCE   10 (bases 1 to 1822)
  AUTHORS   Singh,P.B., Miller,J.R., Pearce,J., Kothary,R., Burton,R.D.,
            Paro,R., James,T.C. and Gaunt,S.J.
  TITLE     A sequence motif found in a Drosophila heterochromatin protein is
            conserved in animals and plants
  JOURNAL   Nucleic Acids Res 19 (4), 789-794 (1991)
   PUBMED   1708124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093936.1, AK083957.1, AK002910.1 and BC059831.1.
            
            On Feb 16, 2018 this sequence version replaced NM_007624.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108370.1, AK002910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CJ093936.1         1-87
            88-1088             AK083957.1         3-1003
            1089-1093           AK002910.1         1064-1068
            1094-1802           AK083957.1         1004-1712
            1803-1822           BC059831.1         1670-1689
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.89 cM"
     gene            1..1822
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /note="chromobox 3"
                     /db_xref="GeneID:12417"
                     /db_xref="MGI:MGI:108515"
     exon            1..124
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
     exon            125..177
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..705
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /note="HP1 gamma; modifier 2 protein; heterochromatin
                     protein 1 homolog gamma; heterochromatin protein 1 gamma"
                     /codon_start=1
                     /product="chromobox protein homolog 3"
                     /protein_id="NP_031650.3"
                     /db_xref="CCDS:CCDS20135.1"
                     /db_xref="GeneID:12417"
                     /db_xref="MGI:MGI:108515"
                     /translation="MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGK
                     VEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDS
                     KSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKC
                     PQIVIAFYEERLTWHSCPEDEAQ"
     exon            178..320
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
     exon            321..483
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
     exon            484..578
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
     exon            579..1803
                     /gene="Cbx3"
                     /gene_synonym="HP1g; M32"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggtgct ccccctcccc cccggcggag ctgcccgcgc cccctcccct cggatgtggc
       61 tgaaccgaag cgcgcaggcg ggagactctg caggatccgc ggccctgagc atcggagcgg
      121 tgaactcttc aagtctccga ttaaatttaa aaaatggcct ccaataaaac tacattgcaa
      181 aaaatgggaa agaaacaaaa tggaaagagt aaaaaagttg aagaggcaga gcctgaagaa
      241 tttgtggtag aaaaagtact ggaccgtcgt gtagtgaatg ggaaggtgga gtatttcctg
      301 aagtggaagg ggttcacaga tgctgataat acttgggaac cagaagaaaa tttagattgt
      361 ccagaattaa ttgaagcatt tcttaattct caaaaagctg gtaaagaaaa agatggtaca
      421 aaaaggaaat ctttatctga cagtgaatct gatgatagca aatcgaagaa gaagagagat
      481 gctgctgaca aaccaagggg ctttgccaga ggtctcgacc ctgaacgaat aatcggcgcc
      541 acagacagca gcggagagtt aatgtttctc atgaagtgga aggactcgga cgaggccgac
      601 ttggtgctgg caaaggaggc gaacatgaag tgtcctcaga ttgtcattgc cttctacgag
      661 gagcggctga cttggcattc ttgtcctgaa gatgaagcac aataattgtt tgcatttata
      721 tatatatatt tatatatata tataaaatct ggatcttggg ttttgaatta ctagtgtgga
      781 aaaaaatagc attctaatga aaatcaagtt tgatatgctg gttttgaaag tattgacagt
      841 agttgggata tttttggttt ttgttctgca tcaaaaggca ctgattcctt tgagcaagta
      901 agagctttct gtagttgctt cctttaacaa tagaatattt gataccatgt tgtatttcct
      961 cagctttgaa gaacagcttt tcttaaacgc tggggagatt ttacagttat tactcaagtc
     1021 agaacttatt tttaactggg acacagaagg accattctgg gttttttttt gttttttttt
     1081 tttttttttt tttgtttcta tgtggtgtat gcataaaaca cataacttgt ttgttttgtt
     1141 ttgtttttaa ctgaagatga aaatacaagt tgatgagatt ccctccttgt gaacattttc
     1201 ctgaaaccat aacctttcag attaagcaga ttctgtgatt tattggctag tttaaaggca
     1261 acaacatcag aattgatgta ttatcacata aatacagtgg tatatttaca gagtgttgta
     1321 catgtcccct ttggaaaatg gaattagact aagtaatagt gtgatttaat aacaagactt
     1381 gggctagagg cagatagagc tctgacctaa gaggccagct gagaggcaga ggcaggtcca
     1441 ggtcagccag tctatgtaaa ggttcctctg gtgaactttg tagaaagtta aagtctgtac
     1501 taaaaggtta tgatttatgg aatctgtttg atgtggaaat agaatcgtgg ctggagctga
     1561 cgttggcaat ttaagacctg ctaagtgagt gaacaaaatt tgctaatatc aattaatgac
     1621 ctgcatgctt tttctttacc ctgactcatt ccttactggt aggatcagtc ttttcagtat
     1681 ttgggttatg gttcaatgag ccagaaaagt aactttgtag tatcagaatg tcatccaact
     1741 gtatatttac tttattgtaa ataatggtga acagtggtca ataaatagtt ttatattcct
     1801 ttaaaaaaaa aaaaaaaaaa aa
//
