LOCUS       NM_007623               3770 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus chromobox 2 (Cbx2), mRNA.
ACCESSION   NM_007623
VERSION     NM_007623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Han,M., Zhang,F., Wang,Y., Huang,Y., He,Y., Ren,J., Deng,Y.T.,
            Gao,Y., Li,X., Yu,L., Ma,L., Jiang,B.C. and Yan,M.
  TITLE     Spinal CBX2 contributes to neuropathic pain by activating ERK
            signaling pathway in male mice
  JOURNAL   Neurosci Lett 812, 137363 (2023)
   PUBMED   37422020
  REMARK    GeneRIF: Spinal CBX2 contributes to neuropathic pain by activating
            ERK signaling pathway in male mice.
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Kim,J.J., Steinson,E.R., Lau,M.S., de Rooij,D.G., Page,D.C. and
            Kingston,R.E.
  TITLE     Cell type-specific role of CBX2 and its disordered region in
            spermatogenesis
  JOURNAL   Genes Dev 37 (13-14), 640-660 (2023)
   PUBMED   37553262
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Wang,D., Tanaka-Yano,M., Meader,E., Kinney,M.A., Morris,V.,
            Lummertz da Rocha,E., Liu,N., Liu,T., Zhu,Q., Orkin,S.H.,
            North,T.E., Daley,G.Q. and Rowe,R.G.
  TITLE     Developmental maturation of the hematopoietic system controlled by
            a Lin28b-let-7-Cbx2 axis
  JOURNAL   Cell Rep 39 (1), 110587 (2022)
   PUBMED   35385744
  REMARK    GeneRIF: Developmental maturation of the hematopoietic system
            controlled by a Lin28b-let-7-Cbx2 axis.
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Core,N., Bel,S., Gaunt,S.J., Aurrand-Lions,M., Pearce,J., Fisher,A.
            and Djabali,M.
  TITLE     Altered cellular proliferation and mesoderm patterning in
            Polycomb-M33-deficient mice
  JOURNAL   Development 124 (3), 721-729 (1997)
   PUBMED   9043087
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Uchida,K., Koopman,P., Mita,A., Wakana,S., Wright,E., Kikkawa,Y.,
            Yonekawa,H., Moriwaki,K. and Shiroishi,T.
  TITLE     Exclusion of Sox9 as a candidate for the mouse mutant tail-short
  JOURNAL   Mamm Genome 7 (7), 481-485 (1996)
   PUBMED   8672134
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Muller,J., Gaunt,S. and Lawrence,P.A.
  TITLE     Function of the Polycomb protein is conserved in mice and flies
  JOURNAL   Development 121 (9), 2847-2852 (1995)
   PUBMED   7555711
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Gecz,J., Gaunt,S.J., Passage,E., Burton,R.D., Cudrey,C.,
            Pearce,J.J. and Fontes,M.
  TITLE     Assignment of a Polycomb-like chromobox gene (CBX2) to human
            chromosome 17q25
  JOURNAL   Genomics 26 (1), 130-133 (1995)
   PUBMED   7782071
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Pearce,J.J., Singh,P.B. and Gaunt,S.J.
  TITLE     The mouse has a Polycomb-like chromobox gene
  JOURNAL   Development 114 (4), 921-929 (1992)
   PUBMED   1352241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ176395.1, X62537.1,
            AK141647.1 and BE986063.1.
            
            On Sep 11, 2015 this sequence version replaced NM_007623.2.
            
            Summary: This gene encodes a component of the polycomb multiprotein
            complex, which is required to maintain the transcriptionally
            repressive state of many genes throughout development via chromatin
            remodeling and modification of histones. Disruption of this gene in
            results in male-to-female gonadal sex reversal. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035199.1, AK157869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               CJ176395.1         2-481
            481-1237            X62537.1           540-1296
            1238-3742           AK141647.1         1-2505
            3743-3770           BE986063.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.33 cM"
     gene            1..3770
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /note="chromobox 2"
                     /db_xref="GeneID:12416"
                     /db_xref="MGI:MGI:88289"
     exon            1..160
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1648
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /note="M33 polycomb-like protein; modifier 3 protein;
                     chromobox homolog 2"
                     /codon_start=1
                     /product="chromobox protein homolog 2"
                     /protein_id="NP_031649.2"
                     /db_xref="CCDS:CCDS25708.1"
                     /db_xref="GeneID:12416"
                     /db_xref="MGI:MGI:88289"
                     /translation="MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWE
                     PEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKHTVTSSCSRRSKLKEPDAPS
                     KSKSSSSSSSSTSSSSSSDEEEDDSDLDSKRGPRGRETHPVPQKKAQILVAKPELKDP
                     IRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLGTSAAKLPPPLSAPVAGLAALKAH
                     TKEACGGPSTMATPENLASLMKGMAGSPSRGGIWQSSIVHYMNRMSQSQVQAASRLAL
                     KAQATNKCGLGLDLKVRTQKGGELGGSPAGGKVPKAPGGGAAEQQRGNHSGSPGAQLA
                     PTQELSLQVLDLQSVKNGVPGVGLLARHAPAKAIPATNPATGKGPGSGPTGANMTNAP
                     TDNNKGEKLTCKATALPAPSVKRDTVKSVAASGGQEGHTAPGEGRKPPALSELSTGEE
                     NSSSDSDPDSTSLPSAAQNLSVAIQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESP
                     TSVGFFNLRHY"
     exon            161..204
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /inference="alignment:Splign:2.1.0"
     exon            205..270
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /inference="alignment:Splign:2.1.0"
     exon            271..376
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /inference="alignment:Splign:2.1.0"
     exon            377..3753
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /note="hexamer: AATAAA"
     polyA_site      3748
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcgggg cggggcgcgg cgggggcggc gctttgtgtg cagcagtgag ccggggtctg
       61 cggggcgcgg gccgcggcgg gcggcggcat ggaggagctg agcagcgtgg gcgagcaggt
      121 cttcgccgcc gagtgcatcc tgagcaagcg gctccgcaag ggcaagctgg agtacctggt
      181 caagtggcgc ggctggtcct ccaaacacaa cagctgggag ccagaagaga acattttgga
      241 cccgaggctg ctcctagcct tccagaagaa ggaacatgag aaggaggttc agaaccggaa
      301 gagaggcaag agacccaggg gcaggccgag gaaacacaca gtcacatcct cctgcagccg
      361 gcgctccaag ctcaaggaac cagatgcgcc atccaaatcc aaatccagca gttcgtcctc
      421 ttcctccaca tcttcctcct cttcctcgga cgaagaggaa gacgacagcg acctagactc
      481 caagagaggc ccccggggcc gtgaaaccca tccagtgcct cagaaaaaag cccagatcct
      541 ggtagccaag ccagagctga aggatcccat tagaaagaaa cggggacgca agcctctacc
      601 cccagaacag aaggcagctc ggagacccgt cagcctggcc aaggtgctaa agaccaccag
      661 gaaggatctg gggacctcag ccgccaagct gccccctcca ctcagcgctc cggtggcagg
      721 cctggctgcc ctgaaggccc acaccaaaga ggcctgtggt ggccccagca ctatggcgac
      781 cccagagaac ctggccagtc tgatgaaagg catggccggg agccccagca gaggcggcat
      841 ctggcagagc tccatcgtac actacatgaa ccgcatgagc cagagtcagg ttcaggctgc
      901 cagccgactg gcactcaagg cccaggccac caacaagtgc ggtctcgggc tagacctgaa
      961 agtgaggacg cagaaggggg gtgagctagg ggggagcccc gcaggaggca aggtcccgaa
     1021 ggcccccggt ggcggagctg cagagcagca gagagggaac cattcgggga gcccaggtgc
     1081 tcagctggca cccactcagg agttgagcct tcaggtcctt gacttgcaaa gcgtcaagaa
     1141 cggtgtgcct ggtgtgggcc tgcttgctcg ccatgcccca gccaaggcta ttcctgctac
     1201 caacccagcc acagggaaag gtcctgggag cggccccaca ggagcaaaca tgaccaacgc
     1261 tcccacagac aacaacaaag gggaaaagct gacttgcaag gcaacggctc tgcctgcccc
     1321 ttccgtcaag cgggacaccg ttaaaagcgt cgctgcctcc ggcgggcagg agggccacac
     1381 agccccggga gaaggccgaa agccacctgc gctgtctgag ctgagcacgg gagaggagaa
     1441 tagtagctct gactcggacc ctgactcgac ctcgcttccc agtgctgcgc agaacctatc
     1501 tgtagctatc cagaccagcc aggactggaa acctacccgc agtctcatcg aacacgtctt
     1561 tgtcacggat gtcacagcca acctcatcac tgtcaccgtg aaggagtcgc ccaccagcgt
     1621 gggcttcttc aacttgaggc attattgaga ccattgcccg agccagacct gccttccagt
     1681 ctctggtttt gctttgatgc ctgacctggg ggccaactct gccctgtcct gagactcagg
     1741 gctgggaaat ggcttcctgc tgattctacc tctctgggcc tccacttcag tctgtcctgt
     1801 catctcagga aagccgggtg gccactgact taaaagctac ctgcttggac atagcatcct
     1861 ttctacacat ccctccttaa cctagtgaga ccctcccctc cctggccaac tactgtgagg
     1921 tggattgggg aggggggggc actgatacag ctccctcccc aggccgttga ggagaggggt
     1981 ggggctggta gggccttctc ccacatccag ccacggcagg gtctttctgg tgagggagac
     2041 actctatgct ttgcaagtaa ggctataact tcagttttaa aaggctaatt agttgtgtgg
     2101 ttgggctcag ggaccctgcg gaaatcttca gtctctatcc gtggtgtggt gtcccctcta
     2161 gttgcaattg tagtcccaaa gcccagtcag ggtttggagt cctggcacta aggtgtacct
     2221 gggtgcttct ggacttggga atagagagag ccatgtcctt attgcctcct tcaagcaggc
     2281 tcaagcccca gtgagaagtg accctgttcc tctctgggtc tggacccata cccctgcttt
     2341 ggcccactaa attgcaccct agttctgagg tctgacactc ctgggcttgg ggaaggagca
     2401 ggctagacac ccagagcaag ctgatgtagg cacttggagt cctgggcaag caatcttcct
     2461 tcatgttgga cttttattac taggacccca taagtcacca tggtggcacc agtgtgggaa
     2521 tgcaggtgtt ttgtgggggc ctgtcaccct gctgcctgtc tagacatctc taaactactg
     2581 tggaagcatt ttctatagtc agtcttggtg cagagctccg cctggtgagt gggccactct
     2641 tgggtcccat attccctgac aatcctctcc cacatttggg agcttgtgtt tcctccctcg
     2701 ctgagaagca atagccctat gccatttgtg tggtggggtc gtttaggagc ccacctggca
     2761 gggggcccct aatttctttc ccatcctagg agataagtct agtgctgagc ccctttctaa
     2821 atgccttctc ccctgtcccc catcccgggt aactgtcttg aaactacctt gtcagattgc
     2881 tggccgatga caggattttc tgtcctggga tatcacggtg ggccgtgaca atctggtcag
     2941 tgagtctgtg atgccaaaaa gtaggggtgc tatgaaaccc tggttctgct tctgccattg
     3001 actgatcagc cagcaggtgt gggctcttca ctccagttgc cttgaaggga aatgtttccc
     3061 cttctaaaac cagtcagaca gtgggctgag gtgtctggga cctgccacac tttcaaagtg
     3121 caccccaccc ccaccccagt agctcaccct gcacaccaaa taagatggtc tttgtgtaac
     3181 caaaccaacc tcaatgctgt gccttttggg gcagacccat atccacagct cctgagagat
     3241 gcctgtgatg tgccagggga ccatgttact ggcagcagga gctacgtact gggaagaatt
     3301 cagggccagg aagtgggtaa caaaggggaa agggttgcct actgcattat caatgtccct
     3361 ccctgccctc agccagggtc tgcaaccttt gtaccagaca ctgcctttac aaacacctcc
     3421 ccgtctcttt ggggtcccat gagctgttgg agaagtgacc ctgtttgggg atctgggttg
     3481 actggccttt gtcccctgct gccagtctcc aaatcccaat ttggtgcctt ttattttact
     3541 ggttacgtca gtcccaaagt tgaaatctac aaatcctttc ctctcagcca ctttgccttc
     3601 ttgtgtgttt ttcctggtgc tgtgacccca gtggtctatg tcacaaagca catgtgtgta
     3661 gtgcgccagc gcgagcccca ctggagcagc gccattcgct ctgagtcaag ttctcgtgtt
     3721 taccgataaa taaagtagtt ggtttttatg tttaaaaaaa aaaaaaaaaa
//
