LOCUS       NP_031649                519 aa            linear   ROD 08-APR-2025
DEFINITION  chromobox protein homolog 2 [Mus musculus].
ACCESSION   NP_031649
VERSION     NP_031649.2
DBSOURCE    REFSEQ: accession NM_007623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Han,M., Zhang,F., Wang,Y., Huang,Y., He,Y., Ren,J., Deng,Y.T.,
            Gao,Y., Li,X., Yu,L., Ma,L., Jiang,B.C. and Yan,M.
  TITLE     Spinal CBX2 contributes to neuropathic pain by activating ERK
            signaling pathway in male mice
  JOURNAL   Neurosci Lett 812, 137363 (2023)
   PUBMED   37422020
  REMARK    GeneRIF: Spinal CBX2 contributes to neuropathic pain by activating
            ERK signaling pathway in male mice.
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Kim,J.J., Steinson,E.R., Lau,M.S., de Rooij,D.G., Page,D.C. and
            Kingston,R.E.
  TITLE     Cell type-specific role of CBX2 and its disordered region in
            spermatogenesis
  JOURNAL   Genes Dev 37 (13-14), 640-660 (2023)
   PUBMED   37553262
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Wang,D., Tanaka-Yano,M., Meader,E., Kinney,M.A., Morris,V.,
            Lummertz da Rocha,E., Liu,N., Liu,T., Zhu,Q., Orkin,S.H.,
            North,T.E., Daley,G.Q. and Rowe,R.G.
  TITLE     Developmental maturation of the hematopoietic system controlled by
            a Lin28b-let-7-Cbx2 axis
  JOURNAL   Cell Rep 39 (1), 110587 (2022)
   PUBMED   35385744
  REMARK    GeneRIF: Developmental maturation of the hematopoietic system
            controlled by a Lin28b-let-7-Cbx2 axis.
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Core,N., Bel,S., Gaunt,S.J., Aurrand-Lions,M., Pearce,J., Fisher,A.
            and Djabali,M.
  TITLE     Altered cellular proliferation and mesoderm patterning in
            Polycomb-M33-deficient mice
  JOURNAL   Development 124 (3), 721-729 (1997)
   PUBMED   9043087
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Uchida,K., Koopman,P., Mita,A., Wakana,S., Wright,E., Kikkawa,Y.,
            Yonekawa,H., Moriwaki,K. and Shiroishi,T.
  TITLE     Exclusion of Sox9 as a candidate for the mouse mutant tail-short
  JOURNAL   Mamm Genome 7 (7), 481-485 (1996)
   PUBMED   8672134
REFERENCE   8  (residues 1 to 519)
  AUTHORS   Muller,J., Gaunt,S. and Lawrence,P.A.
  TITLE     Function of the Polycomb protein is conserved in mice and flies
  JOURNAL   Development 121 (9), 2847-2852 (1995)
   PUBMED   7555711
REFERENCE   9  (residues 1 to 519)
  AUTHORS   Gecz,J., Gaunt,S.J., Passage,E., Burton,R.D., Cudrey,C.,
            Pearce,J.J. and Fontes,M.
  TITLE     Assignment of a Polycomb-like chromobox gene (CBX2) to human
            chromosome 17q25
  JOURNAL   Genomics 26 (1), 130-133 (1995)
   PUBMED   7782071
REFERENCE   10 (residues 1 to 519)
  AUTHORS   Pearce,J.J., Singh,P.B. and Gaunt,S.J.
  TITLE     The mouse has a Polycomb-like chromobox gene
  JOURNAL   Development 114 (4), 921-929 (1992)
   PUBMED   1352241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ176395.1, X62537.1,
            AK141647.1 and BE986063.1.
            
            On Jun 9, 2003 this sequence version replaced NP_031649.1.
            
            Summary: This gene encodes a component of the polycomb multiprotein
            complex, which is required to maintain the transcriptionally
            repressive state of many genes throughout development via chromatin
            remodeling and modification of histones. Disruption of this gene in
            results in male-to-female gonadal sex reversal. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035199.1, AK157869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.33 cM"
     Protein         1..519
                     /product="chromobox protein homolog 2"
                     /note="M33 polycomb-like protein; modifier 3 protein;
                     chromobox homolog 2"
                     /calculated_mol_wt=54787
     Region          9..61
                     /region_name="CD_Cbx2"
                     /note="chromodomain of chromobox homolog 2; cd18647"
                     /db_xref="CDD:349294"
     Site            order(11..15,33..34,36,40,43..44,47..48,50..51,53..54)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349294"
     Region          60..180
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30658.2)"
     Region          164..169
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P30658.2)"
     Site            248
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q14781;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P30658.2)"
     Region          295..336
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30658.2)"
     Site            303
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14781; propagated from
                     UniProtKB/Swiss-Prot (P30658.2)"
     Region          367..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30658.2)"
     Region          478..510
                     /region_name="CBX7_C"
                     /note="CBX family C-terminal motif; pfam17218"
                     /db_xref="CDD:465385"
     CDS             1..519
                     /gene="Cbx2"
                     /gene_synonym="M33; MOD2; pc"
                     /coded_by="NM_007623.3:89..1648"
                     /db_xref="CCDS:CCDS25708.1"
                     /db_xref="GeneID:12416"
                     /db_xref="MGI:MGI:88289"
ORIGIN      
        1 meelssvgeq vfaaecilsk rlrkgkleyl vkwrgwsskh nswepeenil dprlllafqk
       61 kehekevqnr krgkrprgrp rkhtvtsscs rrsklkepda psksksssss ssstssssss
      121 deeeddsdld skrgprgret hpvpqkkaqi lvakpelkdp irkkrgrkpl ppeqkaarrp
      181 vslakvlktt rkdlgtsaak lppplsapva glaalkahtk eacggpstma tpenlaslmk
      241 gmagspsrgg iwqssivhym nrmsqsqvqa asrlalkaqa tnkcglgldl kvrtqkggel
      301 ggspaggkvp kapgggaaeq qrgnhsgspg aqlaptqels lqvldlqsvk ngvpgvglla
      361 rhapakaipa tnpatgkgpg sgptganmtn aptdnnkgek ltckatalpa psvkrdtvks
      421 vaasggqegh tapgegrkpp alselstgee nsssdsdpds tslpsaaqnl svaiqtsqdw
      481 kptrsliehv fvtdvtanli tvtvkespts vgffnlrhy
//
