LOCUS       NM_001362560            2203 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chromobox 1 (Cbx1), transcript variant 2, mRNA.
ACCESSION   NM_001362560 XM_006532099
VERSION     NM_001362560.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Kuroda,Y., Iwata-Otsubo,A., Dias,K.R., Temple,S.E.L., Nagao,K., De
            Hayr,L., Zhu,Y., Isobe,S.Y., Nishibuchi,G., Fiordaliso,S.K.,
            Fujita,Y., Rippert,A.L., Baker,S.W., Leung,M.L., Koboldt,D.C.,
            Harman,A., Keena,B.A., Kazama,I., Subramanian,G.M., Manickam,K.,
            Schmalz,B., Latsko,M., Zackai,E.H., Edwards,M., Evans,C.A.,
            Dulik,M.C., Buckley,M.F., Yamashita,T., O'Brien,W.T., Harvey,R.J.,
            Obuse,C., Roscioli,T. and Izumi,K.
  TITLE     Dominant-negative variants in CBX1 cause a neurodevelopmental
            disorder
  JOURNAL   Genet Med 25 (7), 100861 (2023)
   PUBMED   37087635
  REMARK    GeneRIF: Dominant-negative variants in CBX1 cause a
            neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Hayashi,S., Oe,S., Koike,T., Seki-Omura,R., Nakano,Y., Hirahara,Y.,
            Tanaka,S., Ito,T., Yasukochi,Y., Higasa,K. and Kitada,M.
  TITLE     OLIG2 is an in vivo bookmarking transcription factor in the
            developing neural tube in mouse
  JOURNAL   J Neurochem 165 (3), 303-317 (2023)
   PUBMED   36547371
  REMARK    Erratum:[J Neurochem. 2024 Jan;168(1):66. doi: 10.1111/jnc.16019..
            PMID: 38073276]
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Qin,W., Ugur,E., Mulholland,C.B., Bultmann,S., Solovei,I.,
            Modic,M., Smets,M., Wierer,M., Forne,I., Imhof,A., Cardoso,M.C. and
            Leonhardt,H.
  TITLE     Phosphorylation of the HP1beta hinge region sequesters KAP1 in
            heterochromatin and promotes the exit from naive pluripotency
  JOURNAL   Nucleic Acids Res 49 (13), 7406-7423 (2021)
   PUBMED   34214177
  REMARK    GeneRIF: Phosphorylation of the HP1beta hinge region sequesters
            KAP1 in heterochromatin and promotes the exit from naive
            pluripotency.
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Mohlke,K.L., Nichols,W.C., Westrick,R.J., Novak,E.K., Cooney,K.A.,
            Swank,R.T. and Ginsburg,D.
  TITLE     A novel modifier gene for plasma von Willebrand factor level maps
            to distal mouse chromosome 11
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15352-15357 (1996)
   PUBMED   8986815
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Feil,R., Baldacci,P.A., Tarttelin,E., Rhodes,M., Singh,P.B. and
            Reik,W.
  TITLE     Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin
            protein 1 gene, maps to distal chromosome 11 and is nonallelic to
            Om
  JOURNAL   Mamm Genome 6 (7), 469-471 (1995)
   PUBMED   7579889
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Hamvas,R.M., Reik,W., Gaunt,S.J., Brown,S.D. and Singh,P.B.
  TITLE     Mapping of a mouse homolog of a heterochromatin protein gene the X
            chromosome
  JOURNAL   Mamm Genome 2 (1), 72-75 (1992)
   PUBMED   1543904
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Singh,P.B., Miller,J.R., Pearce,J., Kothary,R., Burton,R.D.,
            Paro,R., James,T.C. and Gaunt,S.J.
  TITLE     A sequence motif found in a Drosophila heterochromatin protein is
            conserved in animals and plants
  JOURNAL   Nucleic Acids Res 19 (4), 789-794 (1991)
   PUBMED   1708124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596384.17.
            
            On Apr 20, 2018 this sequence version replaced XM_006532099.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.99252.1,
                                           SRR11927936.1561901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL596384.17        7892-8110
            220-396             AL596384.17        19528-19704
            397-574             AL596384.17        20186-20363
            575-669             AL596384.17        21485-21579
            670-2203            AL596384.17        25373-26906
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.11 cM"
     gene            1..2203
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /note="chromobox 1"
                     /db_xref="GeneID:12412"
                     /db_xref="MGI:MGI:105369"
     exon            1..219
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..396
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..814
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     chromobox protein homolog 1; modifier 1 protein;
                     heterochromatin protein p25; heterochromatin protein 1
                     homolog beta; chromobox homolog 1"
                     /codon_start=1
                     /product="chromobox protein homolog 1 isoform 1"
                     /protein_id="NP_001349489.1"
                     /db_xref="CCDS:CCDS25303.1"
                     /db_xref="GeneID:12412"
                     /db_xref="MGI:MGI:105369"
                     /translation="MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKG
                     FSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKK
                     KKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVV
                     ISFYEERLTWHSYPSEDDDKKDDKN"
     exon            397..574
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..669
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..2203
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="Cbx1"
                     /gene_synonym="Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta;
                     M31; MOD1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcagg cggcgggccg cgcagagtga gaggctcttt tgttcggctg aggggagggc
       61 cgttagcggg gcctgcggta cgccgcttca gcgggacggt cgacttgtgg ccacacggct
      121 ctttgctcct ctgggcgcgc tactcccctc ggaccgcccg acgcaacgcg cgagtagcgc
      181 ggcaccgatt cctctcggac tctcgggcgc tgctacgagc agtgtcaccc ttcacaccag
      241 aaagctggcg ggtactatgg ggaaaaagca aaacaagaag aaagtggagg aggtactaga
      301 agaagaggaa gaggaatatg tggtggaaaa agttcttgat cggcgagttg tcaagggcaa
      361 ggtggaatat cttctaaagt ggaagggttt ctcagatgag gacaacactt gggagccaga
      421 agagaatctg gattgccctg accttattgc tgagtttcta cagtcacaga aaacagctca
      481 tgagacagat aagtcagagg gaggcaagcg caaagctgat tctgattctg aagataaagg
      541 agaggaaagc aaaccaaaga agaagaaaga agagtcagaa aagccacgag gctttgcccg
      601 gggtttggag ccagagcgga ttattggagc tactgactcc agtggagagc tcatgttcct
      661 gatgaaatgg aaaaactctg atgaggctga cctggtccct gccaaggaag ccaatgtcaa
      721 gtgcccacag gttgtcatat ccttctatga ggaaaggcta acgtggcatt cctacccctc
      781 agaggatgat gacaaaaaag acgacaagaa ttagccctgt tgagtaccag cccctgtcac
      841 ctctgactgt gggtttcaag ggggagggaa ggagttatac ttgtcttgac accatagagg
      901 tggcttgaga agatgtcctt tgaagagcca gcatagtttg tgtgtcctgc agctgcccaa
      961 gtgctttaaa ttgttcaagc tgtgtagttt gcacacccat cccagtggag gggaaagggt
     1021 aagtgtttca aggcaacctg ttctgcgctt tgctaaggaa gcagttggcc ttccatgaag
     1081 gacaaaacct gcagaactgg ggtgtgggaa agcaaagata ctgtcgatct tcaaagagca
     1141 tctccacaac ccacagcctt cttcccgata gtgttaactg catttttaca gcctagcatg
     1201 tgtgtagttt ttggctatta ctggtatatt aattgggggt gggagggttg gggcagggag
     1261 gaagggagat gggtagaatc attttggtta aaatttgggg cctgattggg gaaatgatga
     1321 aatagtagaa cagctaacta ataaattggt tctgtgtcca gaatattttg ccttttcaaa
     1381 aaaaatgtca ttggcaccat aagtaaggac tatgagagac tgttaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa gtctgttaat cctaaaacct acagccaagg tgctcccagc ctgagctcaa
     1501 agtggcccac aaaggacaaa gccagttctg agttaccaaa gctgccattt gatgatggaa
     1561 actgactgga gagggaaagg ttacaggaga gtatatagag gcagactact ctgccataga
     1621 ggtgctaatt cttgaaattg gagaaaaaaa aaactttttc caattacaaa gttatatcag
     1681 tttgtccatc taagccattg gctcaagtat tgcaggatgg cctatgggag atggaagaga
     1741 agggcctttg ctcttagggt agaaactctt agagcccctc tctctctttc tttttttttt
     1801 ttctttcttt cttttctatt tttgtttttt ttttaatttt ttttttttat tttcagcttt
     1861 gaaccctgaa actgcttgtg gcaggttcag ttactgacag cacaaattcc attgagtcaa
     1921 ttcaaggatt gaatgacttc acaagccctg gtctcaggag attaactttc atattggggt
     1981 agtggttcac ttgagaatac aaaatcttca gattaactga tgtccaaaat actgtcttga
     2041 atcatgagat ccatcaattt ttagtattgt ctagacctac aaatagaact acattgtaaa
     2101 atctttttca gcatgtgtta agatgtatgt gaaaatttct gtttaagttt aaagttcata
     2161 ccatactgtc agtttttgtc ttaataaaat tatagatttc taa
//
