LOCUS       NM_144855               2437 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cystathionine beta-synthase (Cbs), transcript variant
            1, mRNA.
ACCESSION   NM_144855
VERSION     NM_144855.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Oberholtzer,N., Chakraborty,P., Kassir,M.F., Dressman,J., Das,S.,
            Mills,S., Comte-Walters,S., Gooz,M., Choi,S., Parikh,R.Y.,
            Hedley,Z., Vaena,S., DeMass,R., Scurti,G., Romeo,M.,
            Gangaraju,V.K., Berto,S., Hill,E., Ball,L.E., Mehta,A.S.,
            Maldonado,E.N., Nishimura,M.I., Ogretmen,B. and Mehrotra,S.
  TITLE     H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T
            cell immunotherapeutic response
  JOURNAL   Sci Adv 10 (46), eadp1152 (2024)
   PUBMED   39546607
REFERENCE   2  (bases 1 to 2437)
  AUTHORS   Majtan,T., Olsen,T., Sokolova,J., Krijt,J., Krizkova,M., Ida,T.,
            Ditroi,T., Hansikova,H., Vit,O., Petrak,J., Kuchar,L., Kruger,W.D.,
            Nagy,P., Akaike,T. and Kozich,V.
  TITLE     Deciphering pathophysiological mechanisms underlying cystathionine
            beta-synthase-deficient homocystinuria using targeted metabolomics,
            liver proteomics, sphingolipidomics and analysis of mitochondrial
            function
  JOURNAL   Redox Biol 73, 103222 (2024)
   PUBMED   38843767
  REMARK    GeneRIF: Deciphering pathophysiological mechanisms underlying
            cystathionine beta-synthase-deficient homocystinuria using targeted
            metabolomics, liver proteomics, sphingolipidomics and analysis of
            mitochondrial function.
REFERENCE   3  (bases 1 to 2437)
  AUTHORS   Liu,J., Lu,X., Zeng,S., Fu,R., Wang,X., Luo,L., Huang,T., Deng,X.,
            Zheng,H., Ma,S., Ning,D., Zong,L., Lin,S.H. and Zhang,Y.
  TITLE     ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis
            in colorectal cancer
  JOURNAL   Redox Biol 71, 103118 (2024)
   PUBMED   38490069
REFERENCE   4  (bases 1 to 2437)
  AUTHORS   Xin,L., Liu,Z.Y., Liu,C.X., Sheng,J., Zhou,Q., Yuan,Y.W., Yue,Z.Q.,
            Lu,H. and Gan,J.H.
  TITLE     KLF10/CBS increases the sensitivity of gastric carcinoma cells to
            methionine restriction by promoting sulfur transfer pathway
  JOURNAL   Exp Cell Res 437 (1), 114007 (2024)
   PUBMED   38499142
  REMARK    GeneRIF: KLF10/CBS increases the sensitivity of gastric carcinoma
            cells to methionine restriction by promoting sulfur transfer
            pathway.
REFERENCE   5  (bases 1 to 2437)
  AUTHORS   Dong,B., Sun,Y., Cheng,B., Xue,Y., Li,W. and Sun,X.
  TITLE     Activating transcription factor (ATF) 6 upregulates cystathionine
            beta synthetase (CBS) expression and hydrogen sulfide (H2S)
            synthesis to ameliorate liver metabolic damage
  JOURNAL   Eur J Med Res 28 (1), 540 (2023)
   PUBMED   38007457
  REMARK    GeneRIF: Activating transcription factor (ATF) 6 upregulates
            cystathionine beta synthetase (CBS) expression and hydrogen sulfide
            (H2S) synthesis to ameliorate liver metabolic damage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2437)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   7  (bases 1 to 2437)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 2437)
  AUTHORS   Stubbs,L., Kraus,J. and Lehrach,H.
  TITLE     The alpha-A-crystallin and cystathionine beta-synthase genes are
            physically very closely linked in proximal mouse chromosome 17
  JOURNAL   Genomics 7 (2), 284-288 (1990)
   PUBMED   2347594
REFERENCE   9  (bases 1 to 2437)
  AUTHORS   Locker,J., Gill,T.J. 3rd, Kraus,J.P., Ohura,T., Swarop,M.,
            Riviere,M., Islam,M.Q., Levan,G., Szpirer,J. and Szpirer,C.
  TITLE     The rat MHC and cystathionine beta-synthase gene are syntenic on
            chromosome 20
  JOURNAL   Immunogenetics 31 (4), 271-274 (1990)
   PUBMED   2329008
REFERENCE   10 (bases 1 to 2437)
  AUTHORS   Munke,M., Kraus,J.P., Ohura,T. and Francke,U.
  TITLE     The gene for cystathionine beta-synthase (CBS) maps to the
            subtelomeric region on human chromosome 21q and to proximal mouse
            chromosome 17
  JOURNAL   Am J Hum Genet 42 (4), 550-559 (1988)
   PUBMED   2894761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090881.9 and AC166575.1.
            
            On Jul 26, 2022 this sequence version replaced NM_144855.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013480.1, SRR7652917.1106665.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC090881.9         66983-67058         c
            77-403              AC090881.9         62728-63054         c
            404-510             AC090881.9         57376-57482         c
            511-645             AC166575.1         1013-1147
            646-725             AC166575.1         1460-1539
            726-860             AC166575.1         1897-2031
            861-930             AC166575.1         2732-2801
            931-1022            AC166575.1         4512-4603
            1023-1148           AC166575.1         5467-5592
            1149-1233           AC166575.1         6017-6101
            1234-1339           AC166575.1         7787-7892
            1340-1414           AC166575.1         9568-9642
            1415-1549           AC166575.1         9769-9903
            1550-1658           AC166575.1         10876-10984
            1659-1743           AC166575.1         11472-11556
            1744-1785           AC166575.1         12460-12501
            1786-2437           AC166575.1         13737-14388
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 16.93 cM"
     gene            1..2437
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /note="cystathionine beta-synthase"
                     /db_xref="GeneID:12411"
                     /db_xref="MGI:MGI:88285"
     exon            1..76
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..403
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1889
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /EC_number="4.2.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-thionase; serine sulfhydrase"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform 1"
                     /protein_id="NP_659104.1"
                     /db_xref="CCDS:CCDS28609.1"
                     /db_xref="GeneID:12411"
                     /db_xref="MGI:MGI:88285"
                     /translation="MPSGTSQCEDGSAGGFQHLDMHSEKRQLEKGPSGDKDRVWIRPD
                     TPSRCTWQLGRAMADSPHYHTVLTKSPKILPDILRKIGNTPMVRINKISKNAGLKCEL
                     LAKCEFFNAGGSVKDRISLRMIEDAERAGNLKPGDTIIEPTSGNTGIGLALAAAVKGY
                     RCIIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILD
                     QYRNASNPLAHYDDTAEEILQQCDGKLDMLVASAGTGGTITGIARKLKEKCPGCKIIG
                     VDPEGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDKWFKSNDEDSFAFARM
                     LIAQEGLLCGGSSGSAMAVAVKAARELQEGQRCVVILPDSVRNYMSKFLSDKWMLQKG
                     FMKEELSVKRPWWWRLRVQELSLSAPLTVLPTVTCEDTIAILREKGFDQAPVVNESGA
                     ILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPIHLTDTLGTLSHILEMDHFALVV
                     HEQIQSRDQAWSGVVGGPTDCSNGMSSKQQMVFGVVTAIDLLNFVAAREQTQT"
     exon            404..510
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..645
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..725
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..860
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            861..930
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1022
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1148
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1233
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1339
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1414
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1549
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1658
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1743
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1785
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2437
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2418..2423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /note="hexamer: TATAAA"
     polyA_site      2437
                     /gene="Cbs"
                     /gene_synonym="HIP4"
                     /note="major polyA site"
ORIGIN      
        1 atctgagctg ggatcctgtc cgagcgtgct ctccatccta gcacaggccg agccgttttc
       61 ccgcgtccga gtctagcagc tggaacctgc tccttttctc ccatccttgc tgagtttgtt
      121 tgagtggagc caacactccc agaggggact caagagccaa cgacttaaca cgacaggtct
      181 tcgctccctc tgaaaatccc agcatgcctt cagggacatc ccagtgtgaa gatggctctg
      241 ctgggggctt ccagcacttg gacatgcact cagaaaagag acaactggag aagggcccct
      301 caggggacaa ggatcgagtc tggatccggc ctgatacccc aagcagatgt acctggcagc
      361 tgggcagggc catggcggac tccccacatt atcacacagt gctgaccaaa tcccccaaaa
      421 ttttaccaga tattctgagg aaaattggga acacccctat ggtcagaatc aacaagatct
      481 caaagaatgc cggtctcaag tgtgagctct tggccaagtg tgagttcttc aatgcgggtg
      541 ggagtgtgaa ggaccgcatc agccttcgga tgatcgaaga tgctgagcga gctggaaact
      601 tgaagcctgg agacactatc attgagccaa cttctggcaa cacagggatc gggctggctc
      661 tggctgctgc agtgaagggc tatcgctgca ttatcgtgat gccggagaag atgagtatgg
      721 agaaggtgga tgtgctgcgg gctctgggag ccgagattgt gaggacgccc accaatgcca
      781 gatttgattc ccccgagtcc cacgtgggag tggcatggcg actgaagaac gaaatcccta
      841 attctcacat tctggaccag taccgcaatg ccagcaaccc tttggcacac tacgatgaca
      901 ccgccgagga gatcctgcag cagtgtgacg ggaagctgga tatgctggtg gcttcagcag
      961 gcacgggtgg caccatcaca gggatcgcca gaaagctgaa ggagaagtgc cctggctgta
     1021 aaatcatcgg tgtcgatcct gaaggctcca tccttgcgga gcccgaggag ctgaaccaga
     1081 cggagcaaac agcctatgag gtggaaggga ttggctacga cttcatcccg acagtcctgg
     1141 acagggcggt ggtggataag tggttcaaga gcaacgatga agattccttc gcctttgccc
     1201 gcatgctcat cgcacaggaa ggactgctat gtggtggaag ctctggcagc gccatggctg
     1261 tggctgtgaa ggctgcccgg gagctgcagg aagggcagcg ctgtgtggtc atcctgcctg
     1321 actctgtgcg gaactacatg tccaagttcc tgagtgacaa atggatgctg cagaaaggtt
     1381 tcatgaaaga ggagctctca gtgaagaggc cctggtggtg gcgtctgcgt gttcaagagc
     1441 tgagcctgtc ggccccgctg accgtgttgc ccacggtcac ctgtgaggac accatcgcca
     1501 tcctccggga gaagggtttt gaccaggcac ctgtggtcaa cgagtctggg gccatcctag
     1561 ggatggtgac cctcgggaac atgctgtcat ccctgctggc tggaaaggtg cggccatcag
     1621 acgaagtctg caaagtcctc tacaagcagt tcaaaccgat ccacctgacc gacacgctgg
     1681 gcacactctc tcacatcctg gagatggacc acttcgccct ggtggtccac gagcagatcc
     1741 aatcacgaga ccaggcctgg tcaggagtgg tgggggggcc cacagactgc agcaatggca
     1801 tgtccagcaa gcagcagatg gtgtttgggg ttgtcactgc cattgacctg ctaaacttcg
     1861 tggcagcccg tgagcagacc cagacataga gccaggactg gcttccatcc tccttgctgg
     1921 ggcttcttgg ctttcagaga cacctaccag cttcctcacc caagtccagc aggtggctgc
     1981 tgaggccagc accctcccct cctaacaccc agctacctaa atgaatcctc tatgcccgag
     2041 tagcttacag ggcctttcct ctggtgtcac agaactgagg aatgttagcc aggaaggatg
     2101 ggcacagact acaatagcaa caagactcag ggtgcccaaa aaagcgtcct ccccacagag
     2161 ggctccatcg tgggaaaggg caaaccttgg actgattgtg tggacatcct cagggacctg
     2221 gttagcccta gcatgggagt gtgtgggttt taaatgaagg tgggcttctg tgacctgaga
     2281 cccacagctg tgaagtgcct gcacaaagtg tcaccacctg ggccatgacc ctgcttagcc
     2341 cactcctcac gtcccactcc ttccctgaca agcacccact ttctgtctca atggatctcc
     2401 ctgttctgga ctcttcctat aaatggaatc acatacc
//
