LOCUS       NM_145595               1115 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus carbonyl reductase 4 (Cbr4), mRNA.
ACCESSION   NM_145595 XM_908715 XM_920996 XM_921006
VERSION     NM_145595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1115)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150763.1 and AK043313.1.
            
            On Nov 21, 2009 this sequence version replaced NM_145595.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150763.1, BC009118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               AK150763.1         2-923
            923-1115            AK043313.1         748-940
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 31.18 cM"
     gene            1..1115
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /note="carbonyl reductase 4"
                     /db_xref="GeneID:234309"
                     /db_xref="MGI:MGI:2384567"
     exon            1..257
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..826
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /EC_number="1.1.1.100"
                     /EC_number="1.6.5.10"
                     /note="carbonyl reductase family member 4; quinone
                     reductase CBR4; KAR beta subunit;
                     3-ketoacyl-[acyl-carrier-protein] reductase beta subunit"
                     /codon_start=1
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="NP_663570.2"
                     /db_xref="CCDS:CCDS40349.1"
                     /db_xref="GeneID:234309"
                     /db_xref="MGI:MGI:2384567"
                     /translation="MDKVCAVFGGSRGIGRAVAQLMAQKGYRLAIVSRNLEVAKVTAG
                     ELGGNHLAFRCDVAKEQDVQSTFQEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDMIS
                     QLHTNLLGSMLTCKAAMKTMIQQGGSIVNVGSIIGLKGNVGQSAYSATKGGLVGFSRS
                     LAKEVARKKIRVNVVAPGFIRTDMTRHLKEEHFKKNIPLGRFGETLEVAHAVVFLLES
                     PYITGHVLIVDGGLQLTV"
     exon            258..378
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..512
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            513..647
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1115
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1099
                     /gene="Cbr4"
                     /gene_synonym="A730083J17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttttgtggc ctgggttgtc tgttgaaagg agagcatact ggttttgtca gtagctgtgt
       61 cttttattac aagttctgag tctcagggat ccatcttgct ggtccgcggt ccaagatgga
      121 caaagtctgt gcggtttttg gaggctcccg ggggatcggc agggcggtag cccagctaat
      181 ggcccagaag ggttaccgtc tggcgatcgt ctccagaaac ctggaagtgg ccaaagtcac
      241 cgccggcgag ctcggcggaa accacttggc atttaggtgt gatgttgcca aagaacaaga
      301 tgttcagagt acatttcaag agatggagaa acatttaggt ccagtaaatt tcttggtaaa
      361 tgcagccggt atcaacagag acagtcttct agtaagaaca aagactgaag acatgatctc
      421 tcagctgcac actaacctcc tgggctccat gctgacctgt aaagctgcca tgaagacaat
      481 gattcagcag ggagggtcta ttgttaatgt gggaagtatt attggtttga aaggcaacgt
      541 tggccagtct gcatacagtg ccaccaaagg aggactcgtt gggttttcac gctcgcttgc
      601 taaagaggtt gcacggaaga aaatcagagt gaatgtggtg gcaccaggat ttattcgcac
      661 ggatatgaca agacacttga aagaagaaca cttcaagaaa aacattcctc ttgggaggtt
      721 tggagaaact cttgaggtag cacatgccgt tgtgtttctt ttagagtcac catacatcac
      781 aggccatgtt cttatcgtgg atggaggatt gcagctcacc gtctaattag agatgatgtt
      841 actgtgatgg cgctttgggt caagtacaca tttccctatt aatttgacaa tctcatctat
      901 atgggtgaca tttgctaatg gaaacaaatc agctaacgga tgctacaaag gattccatct
      961 ttgtatgaac atgtctcaaa aaacaaagtg tgaccagttg taaagggtgt gaattctctg
     1021 tcttagaggc catggacatt tttaagggtt attgtaacac acctgtatca agctggatat
     1081 taaaggcatc aaccttctag actgttgcta agagt
//
