LOCUS       NM_173047               1178 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carbonyl reductase 3 (Cbr3), mRNA.
ACCESSION   NM_173047
VERSION     NM_173047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Billingsley,C.N., Allen,J.R., Baumann,D.D., Deitz,S.L.,
            Blazek,J.D., Newbauer,A., Darrah,A., Long,B.C., Young,B.,
            Clement,M., Doerge,R.W. and Roper,R.J.
  TITLE     Non-trisomic homeobox gene expression during craniofacial
            development in the Ts65Dn mouse model of Down syndrome
  JOURNAL   Am J Med Genet A 161A (8), 1866-1874 (2013)
   PUBMED   23843306
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Galdzicki,Z., Siarey,R., Pearce,R., Stoll,J. and Rapoport,S.I.
  TITLE     On the cause of mental retardation in Down syndrome: extrapolation
            from full and segmental trisomy 16 mouse models
  JOURNAL   Brain Res Brain Res Rev 35 (2), 115-145 (2001)
   PUBMED   11336779
  REMARK    Review article
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003232.1, AK028150.1 and CF545530.1.
            
            On Apr 15, 2009 this sequence version replaced NM_173047.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028763.1, AK003232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK003232.1         6-30
            26-1166             AK028150.1         2-1142
            1167-1178           CF545530.1         162-173
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.58 cM"
     gene            1..1178
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /note="carbonyl reductase 3"
                     /db_xref="GeneID:109857"
                     /db_xref="MGI:MGI:1309992"
     exon            1..395
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..940
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /EC_number="1.1.1.184"
                     /EC_number="1.6.5.10"
                     /note="NADPH-dependent carbonyl reductase 3; quinone
                     reductase CBR3"
                     /codon_start=1
                     /product="carbonyl reductase [NADPH] 3"
                     /protein_id="NP_766635.1"
                     /db_xref="CCDS:CCDS28342.1"
                     /db_xref="GeneID:109857"
                     /db_xref="MGI:MGI:1309992"
                     /translation="MSSCSRVALVTGANKGIGFAITRDLCRKFSGDVVLTARDEARGR
                     AAVQQLQAEGLSPRFHQLDIDDPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTP
                     FDIQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNISSLQGLKALENCREDLQEKFRC
                     DTLTEVDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKA
                     DRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQT
                     W"
     exon            396..503
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1167
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1167
                     /gene="Cbr3"
                     /gene_synonym="1110001J05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcagcgc cgggtcccag aatctagtcc tacgccacgg ttttgaccac gcgtgacccg
       61 ctgcccagcc ggcccggcca tcaggtggtc cgtgtgtccc tctgacatgt cgtcctgcag
      121 ccgcgtggcc ctggtaactg gggctaacaa aggcatcggc tttgcgatca cgcgtgacct
      181 gtgtcggaaa ttctccgggg acgtggtgct cacggcgcgg gacgaggcgc ggggccgcgc
      241 ggcggtgcag cagctgcagg cggagggcct gagcccacgc ttccaccagc tggacatcga
      301 cgacccgcag agcatccgtg cgctgcgcga ctttctgcgc aaggagtacg ggggacttaa
      361 cgtgctggtc aacaacgcgg gcatcgcctt tagaatggat gacccaacac ccttcgacat
      421 tcaagctgag gtgacactga agacgaactt ttttgccact agaaatgtct gcactgagtt
      481 actgcctata atgaaaccac atggtagagt ggtgaacatc agcagtctgc aggggttaaa
      541 agcccttgag aactgcaggg aagatcttca ggaaaagttc cgatgtgaca cacttaccga
      601 ggtggacctg gtcgacctca tgaaaaagtt tgtggaggat acaaaaaatg aagtccatga
      661 gagggaaggt tggccagact cggcttacgg ggtgtcgaag ctgggggtga cagtccttac
      721 gaggatcctg gcccggcagc tggatgaaaa gaggaaagcg gacaggattc tgctcaatgc
      781 ctgctgcccg ggatgggtga agaccgacat ggcgagggac cagggctccc ggaccgtgga
      841 agagggggcc gaaacccccg tttacttggc tctcctgcct ccagatgcca ctgaacctca
      901 cggccagcta gtccgtgaca aagttgtgca aacttggtga acgtctgctc tggggcttgt
      961 ttgataaacg ttagcgggag agatgaatgc agcctggtgt ggtctgattc tttcccacat
     1021 caagggggaa ggtccgttcc tatctgcggc tctgcaaact cagtctgaac aattcgctgt
     1081 gtccacactc tcagctcatc gtgttttcaa ccagttaatg tgcctgcttt gattttcaaa
     1141 ttaaaaagat ttgttttatt ttatgtaaaa aaaaaaaa
//
