LOCUS       NM_007621               1021 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carbonyl reductase 2 (Cbr2), mRNA.
ACCESSION   NM_007621
VERSION     NM_007621.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Li,S., Wang,Y., Zhang,Y., Lu,M.M., DeMayo,F.J., Dekker,J.D.,
            Tucker,P.W. and Morrisey,E.E.
  TITLE     Foxp1/4 control epithelial cell fate during lung development and
            regeneration through regulation of anterior gradient 2
  JOURNAL   Development 139 (14), 2500-2509 (2012)
   PUBMED   22675208
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Yang,X.Y., Yang,T.T., Schubert,W., Factor,S.M. and Chow,C.W.
  TITLE     Dosage-dependent transcriptional regulation by the calcineurin/NFAT
            signaling in developing myocardium transition
  JOURNAL   Dev Biol 303 (2), 825-837 (2007)
   PUBMED   17198697
REFERENCE   5  (bases 1 to 1021)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1021)
  AUTHORS   Wei,J., Dlouhy,S.R., Hara,A., Ghetti,B. and Hodes,M.E.
  TITLE     Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum:
            murine genes that express cbr map to chromosomes 16 and 11
  JOURNAL   Genomics 34 (1), 147-148 (1996)
   PUBMED   8661038
REFERENCE   7  (bases 1 to 1021)
  AUTHORS   Tanaka,N., Nonaka,T., Nakanishi,M., Deyashiki,Y., Hara,A. and
            Mitsui,Y.
  TITLE     Crystal structure of the ternary complex of mouse lung carbonyl
            reductase at 1.8 A resolution: the structural origin of coenzyme
            specificity in the short-chain dehydrogenase/reductase family
  JOURNAL   Structure 4 (1), 33-45 (1996)
   PUBMED   8805511
REFERENCE   8  (bases 1 to 1021)
  AUTHORS   Nakanishi,M., Deyashiki,Y., Ohshima,K. and Hara,A.
  TITLE     Cloning, expression and tissue distribution of mouse tetrameric
            carbonyl reductase. Identity with an adipocyte 27-kDa protein
  JOURNAL   Eur J Biochem 228 (2), 381-387 (1995)
   PUBMED   7705352
REFERENCE   9  (bases 1 to 1021)
  AUTHORS   Matsuura,K., Bunai,Y., Ohya,I., Hara,A., Nakanishi,M. and Sawada,H.
  TITLE     Ultrastructural localization of carbonyl reductase in mouse lung
  JOURNAL   Histochem J 26 (4), 311-316 (1994)
   PUBMED   8040004
REFERENCE   10 (bases 1 to 1021)
  AUTHORS   Navre,M. and Ringold,G.M.
  TITLE     A growth factor-repressible gene associated with protein kinase
            C-mediated inhibition of adipocyte differentiation
  JOURNAL   J Cell Biol 107 (1), 279-286 (1988)
   PUBMED   2455724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY118518.1, AK081816.1 and BF730701.1.
            
            [WARNING] On May 8, 2024 this sequence was replaced by NM_007621.3.
            
            On Apr 25, 2009 this sequence version replaced NM_007621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081816.1, BC010758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY118518.1         2-31
            31-1015             AK081816.1         2-986
            1016-1021           BF730701.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.47 cM"
     gene            1..1021
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /note="carbonyl reductase 2"
                     /db_xref="GeneID:12409"
                     /db_xref="MGI:MGI:107200"
     exon            1..101
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..784
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /EC_number="1.1.1.184"
                     /note="LCR; AP27; adipocyte protein P27; NADPH-dependent
                     carbonyl reductase 2; lung carbonyl reductase"
                     /codon_start=1
                     /product="carbonyl reductase [NADPH] 2"
                     /protein_id="NP_031647.1"
                     /db_xref="CCDS:CCDS25756.1"
                     /db_xref="GeneID:12409"
                     /db_xref="MGI:MGI:107200"
                     /translation="MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDL
                     VSLAKECPGIEPVCVDLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDR
                     SFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLT
                     KAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNS
                     ILFLLSDRSASTSGGGILVDAGYLAS"
     exon            102..199
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            200..354
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            355..397
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            398..497
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            498..562
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            563..680
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1021
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      990..995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /note="hexamer: AATAAA"
     polyA_site      1017
                     /gene="Cbr2"
                     /gene_synonym="MLCR"
                     /note="major polyA site"
ORIGIN      
        1 ataaaagctg agcccatctc ttgcttcgga agaagctggt gtcagcagca tgaagctgaa
       61 tttcagtggc ctgagggccc tggtgacagg ggcagggaaa gggattggac gggacactgt
      121 gaaggccctg cacgcctcag gagccaaagt ggtggcggtg actcggacca actcagacct
      181 ggtcagcctt gccaaagagt gtcccggaat agagcccgtg tgtgtggacc tgggtgactg
      241 ggatgccaca gagaaggcgc tgggcggtat cggccctgtg gacttactgg tgaacaatgc
      301 agcgctggtt ataatgcagc ccttcctgga agttaccaag gaagcctttg acaggtcctt
      361 cagtgtaaat cttcgctctg tgtttcaggt atcccagatg gtagccaggg acatgattaa
      421 ccgtggcgtg ccagggtcca ttgtcaatgt ctccagcatg gtggcccatg tcacctttcc
      481 taacttgatc acctacagct ccaccaaggg agcgatgact atgctgacca aagccatggc
      541 catggaacta gggccacaca agatccgggt aaactccgta aaccccactg tggtgctgac
      601 tgacatgggc aagaaagtct ctgcagaccc tgagtttgcc aggaagctca aggagcgcca
      661 cccactgagg aagttcgcag aggttgaaga cgtcgtcaac agcatcctct tcctgctcag
      721 cgacagaagt gcctctacca gtggcggtgg catcctggtg gatgctggct acctggcctc
      781 ctagtctgct cagttgccgc ggacatctga gtggccttct tagccccacc ctcagccaaa
      841 gcatttactg atctcgtgac tccgccctca tgctacagcc acgcccacca cgcagctcac
      901 agttccaccc ccatgttact gtcgatccca caaccactcc aggcgcagac cttgttctct
      961 ttgtccactt tgttgggctc atttgcctaa ataaacgggc caccgcgtta cctttaacta
     1021 t
//
