LOCUS       NM_007620               1043 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus carbonyl reductase 1 (Cbr1), mRNA.
ACCESSION   NM_007620
VERSION     NM_007620.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Bell,R.M.B., Villalobos,E., Nixon,M., Miguelez-Crespo,A.,
            Murphy,L., Fawkes,A., Coutts,A., Sharp,M.G.F., Koerner,M.V.,
            Allan,E., Meijer,O.C., Houtman,R., Odermatt,A., Beck,K.R.,
            Denham,S.G., Lee,P., Homer,N.Z.M., Walker,B.R. and Morgan,R.A.
  TITLE     Carbonyl reductase 1 amplifies glucocorticoid action in adipose
            tissue and impairs glucose tolerance in lean mice
  JOURNAL   Mol Metab 48, 101225 (2021)
   PUBMED   33785425
  REMARK    GeneRIF: Carbonyl reductase 1 amplifies glucocorticoid action in
            adipose tissue and impairs glucose tolerance in lean mice.
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Arima-Yoshida,F., Raveau,M., Shimohata,A., Amano,K., Fukushima,A.,
            Watanave,M., Kobayashi,S., Hattori,S., Usui,M., Sago,H., Mataga,N.,
            Miyakawa,T., Yamakawa,K. and Manabe,T.
  TITLE     Impairment of spatial memory accuracy improved by Cbr1 copy number
            resumption and GABAB receptor-dependent enhancement of synaptic
            inhibition in Down syndrome model mice
  JOURNAL   Sci Rep 10 (1), 14187 (2020)
   PUBMED   32843708
  REMARK    GeneRIF: Impairment of spatial memory accuracy improved by Cbr1
            copy number resumption and GABAB receptor-dependent enhancement of
            synaptic inhibition in Down syndrome model mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Breysse,D.H., Boone,R.M., Long,C.M., Merrill,M.E., Schaupp,C.M.,
            White,C.C., Kavanagh,T.J., Schmidt,E.E. and Merrill,G.F.
  TITLE     Carbonyl Reductase 1 Plays a Significant Role in Converting
            Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the
            Majority of the Doxorubicinol-Forming Activity Remains Unidentified
  JOURNAL   Drug Metab Dispos 48 (3), 187-197 (2020)
   PUBMED   31955137
  REMARK    GeneRIF: Carbonyl Reductase 1 Plays a Significant Role in
            Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver,
            but the Majority of the Doxorubicinol-Forming Activity Remains
            Unidentified.
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Morgan,R.A., Beck,K.R., Nixon,M., Homer,N.Z.M., Crawford,A.A.,
            Melchers,D., Houtman,R., Meijer,O.C., Stomby,A., Anderson,A.J.,
            Upreti,R., Stimson,R.H., Olsson,T., Michoel,T., Cohain,A.,
            Ruusalepp,A., Schadt,E.E., Bjorkegren,J.L.M., Andrew,R.,
            Kenyon,C.J., Hadoke,P.W.F., Odermatt,A., Keen,J.A. and Walker,B.R.
  TITLE     Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids,
            modulating receptor activation and metabolic complications of
            obesity
  JOURNAL   Sci Rep 7 (1), 10633 (2017)
   PUBMED   28878267
  REMARK    GeneRIF: These findings suggest that CBR1 generating
            20beta-dihydrocortisol is a novel pathway modulating GR activation
            and providing enzymatic protection against excessive GR activation
            in obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Lim,S., Shin,J.Y., Jo,A., Jyothi,K.R., Nguyen,M.N., Choi,T.G.,
            Kim,J., Park,J.H., Eun,Y.G., Yoon,K.S., Ha,J. and Kim,S.S.
  TITLE     Carbonyl reductase 1 is an essential regulator of skeletal muscle
            differentiation and regeneration
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1784-1793 (2013)
   PUBMED   23732109
  REMARK    GeneRIF: CBR1 plays a critical role in controlling redox balance
            and detoxifying lipid peroxidation during muscle differentiation
            and regeneration.
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Nakanishi,M., Kakumoto,M., Matsuura,K., Deyashiki,Y., Tanaka,N.,
            Nonaka,T., Mitsui,Y. and Hara,A.
  TITLE     Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung
            carbonyl reductase in NADP(H)-binding and fatty acid activation:
            site-directed mutagenesis and kinetic analyses
  JOURNAL   J Biochem 120 (2), 257-263 (1996)
   PUBMED   8889808
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Wei,J., Dlouhy,S.R., Hara,A., Ghetti,B. and Hodes,M.E.
  TITLE     Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum:
            murine genes that express cbr map to chromosomes 16 and 11
  JOURNAL   Genomics 34 (1), 147-148 (1996)
   PUBMED   8661038
REFERENCE   8  (bases 1 to 1043)
  AUTHORS   Mjaatvedt,A.E., Cabin,D.E., Cole,S.E., Long,L.J., Breitwieser,G.E.
            and Reeves,R.H.
  TITLE     Assessment of a mutation in the H5 domain of Girk2 as a candidate
            for the weaver mutation
  JOURNAL   Genome Res 5 (5), 453-463 (1995)
   PUBMED   8808466
REFERENCE   9  (bases 1 to 1043)
  AUTHORS   Mjaatvedt,A.E., Citron,M.P. and Reeves,R.H.
  TITLE     High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and
            Erg on distal mouse chromosome 16
  JOURNAL   Genomics 17 (2), 382-386 (1993)
   PUBMED   8406490
REFERENCE   10 (bases 1 to 1043)
  AUTHORS   Brookes,S., Maccarone,P., de Haan,J.B., Tymms,M., Forrest,G.L.,
            Graves,J.A. and Kola,I.
  TITLE     Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR,
            and CBR--to two different chromosomes in the marsupial species
            Macropus eugenii
  JOURNAL   Cytogenet Cell Genet 61 (1), 25-28 (1992)
   PUBMED   1380419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160993.5.
            
            On Feb 13, 2023 this sequence version replaced NM_007620.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158029.1, AK146805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AC160993.5         117049-117439
            392-499             AC160993.5         117974-118081
            500-1043            AC160993.5         118980-119523
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.53 cM"
     gene            1..1043
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /note="carbonyl reductase 1"
                     /db_xref="GeneID:12408"
                     /db_xref="MGI:MGI:88284"
     exon            1..391
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..936
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /EC_number="1.1.1.189"
                     /EC_number="1.1.1.197"
                     /EC_number="1.1.1.184"
                     /EC_number="1.1.1.196"
                     /EC_number="1.1.1.71"
                     /note="alcohol dehydrogenase [NAD(P)+] CBR1; prostaglandin
                     9-ketoreductase; prostaglandin-E(2) 9-reductase;
                     NADPH-dependent carbonyl reductase 1;
                     15-hydroxyprostaglandin dehydrogenase; Carbonyl reductase
                     [NADPH] 1 (NADPH-dependent carbonyl reductase 1);
                     20-beta-hydroxysteroid dehydrogenase"
                     /codon_start=1
                     /product="carbonyl reductase [NADPH] 1"
                     /protein_id="NP_031646.2"
                     /db_xref="CCDS:CCDS28341.1"
                     /db_xref="GeneID:12408"
                     /db_xref="MGI:MGI:88284"
                     /translation="MSSSRPVALVTGANKGIGFAITRDLCRKFSGDVVLAARDEERGQ
                     TAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTP
                     FHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRS
                     ETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRG
                     DKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEP
                     W"
     exon            392..499
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1043
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1018..1023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /note="hexamer: AATAAA"
     polyA_site      1043
                     /gene="Cbr1"
                     /gene_synonym="Cbr; CR; PG-9-KR"
                     /note="major polyA site"
ORIGIN      
        1 agtccgccag tgaaccggtc ttgaaccact ctccagcagc ctcgagaggc agagtttgcg
       61 ccaagttcct tggtctccga cggcctccct tctcacgcag ccatgtcttc cagcagaccc
      121 gtggcgctgg tgaccggtgc taacaaagga atcggattcg cgatcactcg tgacctgtgt
      181 cggaaattct ccggggacgt ggtgctcgcg gcgcgggacg aggagcgggg ccaaacggca
      241 gtgcaaaagc tgcaggcgga gggcctgagc ccacgcttcc accagctgga catcgacaac
      301 ccgcagagca ttcgcgcact gcgcgacttt ctgctcaagg aatacggagg cctggacgtg
      361 ctggtcaaca acgcaggcat cgccttcaag gtcaatgacg acaccccctt ccacattcaa
      421 gcagaggtga caatgaaaac gaactttttt ggtacccgag atgtctgcaa ggagctgctc
      481 cctctaataa aaccccaagg cagagtggtg aatgtgtcca gcatggtgag tctcagggcc
      541 ctgaaaaact gcaggctgga gctgcagcag aagtttcgaa gcgagaccat cacagaggag
      601 gagctggtgg ggctcatgaa caagtttgtg gaagatacaa agaaaggagt ccatgcggaa
      661 gaaggttggc ctaatagtgc atatggggtc accaagattg gggtgacagt cctgtccaga
      721 atccttgcca ggaaacttaa tgagcagagg agaggggaca agatccttct gaatgcctgc
      781 tgccctgggt gggtcagaac cgacatggca ggaccaaaag ccaccaaaag cccagaagaa
      841 ggagcagaga cccctgtgta cttggccctt ttgcctccag atgcagaggg gcctcatggg
      901 cagtttgttc aagataaaaa agttgaacca tggtgaaccc aactctcacc tcccaccccc
      961 ttgtatccag actttatgaa ggccaaggac atttataatg tagtaacact tctgaaaaat
     1021 aaacatagaa ttctttgaat gca
//
