LOCUS       NM_019820               4723 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus cerebellin 3 precursor protein (Cbln3), mRNA.
ACCESSION   NM_019820
VERSION     NM_019820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4723)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4723)
  AUTHORS   Song,J.H.T., Ruven,C., Patel,P., Ding,F., Macklis,J.D. and Sahni,V.
  TITLE     Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically
            toward Thoraco-Lumbar Spinal Cord
  JOURNAL   J Neurosci 43 (11), 1871-1887 (2023)
   PUBMED   36823038
REFERENCE   3  (bases 1 to 4723)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4723)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 4723)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4723)
  AUTHORS   Miura,E., Matsuda,K., Morgan,J.I., Yuzaki,M. and Watanabe,M.
  TITLE     Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at
            parallel fiber-Purkinje cell synapses in the mouse cerebellum
  JOURNAL   Eur J Neurosci 29 (4), 693-706 (2009)
   PUBMED   19250438
  REMARK    GeneRIF: immunohistochemical localization suggests the basis for
            anatomical convergence of the Cbln-GluRdelta2 signaling pathway in
            parallel fiber-Purkinje cell synapses
REFERENCE   7  (bases 1 to 4723)
  AUTHORS   Iijima,T., Miura,E., Matsuda,K., Kamekawa,Y., Watanabe,M. and
            Yuzaki,M.
  TITLE     Characterization of a transneuronal cytokine family
            Cbln--regulation of secretion by heteromeric assembly
  JOURNAL   Eur J Neurosci 25 (4), 1049-1057 (2007)
   PUBMED   17331201
REFERENCE   8  (bases 1 to 4723)
  AUTHORS   Bao,D., Pang,Z., Morgan,M.A., Parris,J., Rong,Y., Li,L. and
            Morgan,J.I.
  TITLE     Cbln1 is essential for interaction-dependent secretion of Cbln3
  JOURNAL   Mol Cell Biol 26 (24), 9327-9337 (2006)
   PUBMED   17030622
  REMARK    GeneRIF: Cbln3 is a secreted glycoprotein that participates in
            heteromeric complexes with Cbln1.
REFERENCE   9  (bases 1 to 4723)
  AUTHORS   Miura,E., Iijima,T., Yuzaki,M. and Watanabe,M.
  TITLE     Distinct expression of Cbln family mRNAs in developing and adult
            mouse brains
  JOURNAL   Eur J Neurosci 24 (3), 750-760 (2006)
   PUBMED   16930405
REFERENCE   10 (bases 1 to 4723)
  AUTHORS   Pang,Z., Zuo,J. and Morgan,J.I.
  TITLE     Cbln3, a novel member of the precerebellin family that binds
            specifically to Cbln1
  JOURNAL   J Neurosci 20 (17), 6333-6339 (2000)
   PUBMED   10964938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC098877.3.
            
            On Nov 17, 2006 this sequence version replaced NM_019820.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065108.1, SRR1660811.74297.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AC098877.3         199726-200070       c
            346-465             AC098877.3         199281-199400       c
            466-4723            AC098877.3         194734-198991       c
FEATURES             Location/Qualifiers
     source          1..4723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..4723
                     /gene="Cbln3"
                     /note="cerebellin 3 precursor protein"
                     /db_xref="GeneID:56410"
                     /db_xref="MGI:MGI:1889286"
     exon            1..345
                     /gene="Cbln3"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..663
                     /gene="Cbln3"
                     /note="precerebellin 3; cerebellin-3"
                     /codon_start=1
                     /product="cerebellin-3 precursor"
                     /protein_id="NP_062794.1"
                     /db_xref="CCDS:CCDS27133.1"
                     /db_xref="GeneID:56410"
                     /db_xref="MGI:MGI:1889286"
                     /translation="MGTEWHKPKLSLALVLLTLEAGWAQEGSEPVLLEGECLVVCEPG
                     RPTAGGPGGAALGEAPPGRVAFAAVRSHHHEPAGETGNGTSGAIYFDQVLVNEGEGFD
                     RTSGCFVAPVRGVYSFRFHVVKVYNRQTVQVSLMLNTWPVISAFANDPDVTREAATSS
                     VLLPLDPGDRVSLRLRRGNLLGGWKYSSFSGFLIFPL"
     exon            346..465
                     /gene="Cbln3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..4723
                     /gene="Cbln3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbln3"
                     /note="hexamer: TATAAA"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbln3"
                     /note="hexamer: AATAAA"
     polyA_site      1907
                     /gene="Cbln3"
                     /note="major polyA site"
     polyA_site      1921
                     /gene="Cbln3"
ORIGIN      
        1 agcagagggg ggagagccaa ggggacagaa gacaggaaaa tctgtgagtt acagaggcac
       61 ctagcaagga tggggacgga atggcacaaa cccaagctgt ccttggccct ggtgcttctg
      121 accctggagg ctgggtgggc tcaagaaggg tcagagcctg tcctactgga gggggagtgc
      181 ctggtggtct gtgagccagg ccgacctact gcaggaggac ctgggggtgc agccctggga
      241 gaggcacccc caggacgagt ggcgtttgct gcagtccgaa gccatcacca tgaaccagca
      301 ggagaaaccg gcaacggtac cagtggtgcc atctacttcg accaggtact ggtcaatgag
      361 ggcgagggct ttgatcggac ctcgggctgc ttcgtggccc ctgtccgtgg agtctacagc
      421 ttccgattcc acgtggtcaa ggtgtacaac cgccaaactg tccaggtgag tctgatgctg
      481 aacacatggc cggtcatctc agcctttgca aatgaccctg atgtgacccg agaggcagcc
      541 acaagctctg tgctgcttcc cctggacccg ggggaccgtg tgtccctgcg cctgcgtcgg
      601 gggaatcttc tgggtggctg gaagtattcg agcttctcag gcttcctcat cttcccactc
      661 tgaggaccca agcctttaaa cggagatgtc tagcatcttt ctgcccttcc ctgccccaga
      721 aacaaagtat ctttggagca agagaaaggc cccctccagg ctgcctacgg cccacctcct
      781 tgcatgagat catagttaaa cacccaaggc taggagcaga gcagagctac ggaacctcta
      841 gacaaaacgc ctcactcagg tcgccctccc agtctcctgc tgcccctcct gcccctccgc
      901 agctccagtt taaggcaggg tttgctaaga gggaagcttg cacttcttca cagactccac
      961 tcctcctgtt ctccacccca gcttcctgct cagcgctatt tggtgacagg tggcgcaggt
     1021 aagcttgaca ggctcccaca ggggcccaga tggaccagcc tcatagtacc tgcgggctcc
     1081 atcctgtgag gaatgccagc aatgagagct ctcggccagc accctgtgaa cagggctgac
     1141 agctcaacca caaaaaagca gtgtggggaa ggccacagag catccgtagc tggagagaca
     1201 ggatggggcc atgtgcctac cctgaacatg taaacattct gcaggtaaac tgggacagtc
     1261 agaaggcagg aatcctgccg tccatctgtg ccaggtccca atggactctg gccctcattg
     1321 cctgaccaga ggcttgggtg tgtgtgtgtg tgtgtttgct ctggctaata ggggaaacta
     1381 gagcaggtat acagacctgg aggcagagtc aaaggtcacg aatgagtcat cagtaaccac
     1441 atgtcctctc cctcagccac ctcctagaac tgccccacct tggaaatctg aatttcagtc
     1501 actccctact cttgatcgac atgtagttcc tccagctgtc tcccagctaa tttccctgta
     1561 gtctgctccc ccccccaaac gcatcgttct tcctctactt ctactactgt cttactcttc
     1621 ttttaaggtc tcctgttacc tgggagtcca tgactcatct cccccaacta gtatcccacc
     1681 aacatcagaa actcttttta cccagttgtc ccaatggtcc agcatgaacg gacctaccta
     1741 gaacaactgg ggagctgcgg ctgttaaaac agtgacttgt cctgttcgtg agggtgtgaa
     1801 acagggactg caggactaca gcatgctgaa gagaaataaa ttcaaagctg ggcatagcag
     1861 tcaacgtttt taaagtgcta taatataaag tactcgtgct aaataaatac cagggcaagt
     1921 ttgtggtttt ttgttttggt ttggtttttg gttttttgag acagggtttc tctgtatagc
     1981 cctggctgtc ctggaactca ctttgtagac caagctggcc tcgaactcag aaatccgcct
     2041 gcctctgcct cctgagtgct gggattaaag gcgtgtgcca ccacacccgg caagtttatg
     2101 gttttaaaat aaaaatctag gtgttcattc aggagacaga ggcaggtgga tctctgtgag
     2161 tttcaggcaa gccatagtaa aacctgtcca aaagaaagac agagagacag agacagaaca
     2221 aagaaagaaa taaggatgga ggtgtcactc agaggcagac gctaatacgc atgaagcact
     2281 gggtttgaac cccagcactg gggtaggcgg gtagggagta gacaagaggg ggaggggcag
     2341 cactttcctt cagcatttgt ccttactttg tggccaggaa gaatagttta aacaagataa
     2401 gataatattt ctgtctcaca tggaagagtc tgcagctggg gagttcagga taaacagctg
     2461 cttagaacca cagagcccag tcttcccttt tgggatgcct ctctggcatg ccgcctcatg
     2521 gcccaagatg gcttcgtgca ggtcagcatt acatcccagc agcgctggaa aaagggagag
     2581 aagaaagaac acagctcctt ccttgaaagg ttttccgacc gctgacagct gcctacacac
     2641 atttctgatt gcatctcatc gccagaatgg agtcacactt ggccacacca agccaggaca
     2701 ggcaaggaaa caatctcaca atcttacctt tttgtcatat tttccatgtg catgcacctg
     2761 ggacgtgtgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga gaggggggac
     2821 aactttgggt gttggacccc acctcccact atgtttgaga cagggactct aatttttcat
     2881 tgcgtacacc aggctagctg gaaccttctg gaattctgcc ttctccttaa agtacaggat
     2941 tacaaatgca tggactatgg ctggctggaa tatgaactca ggccaacagg tgtgcacagc
     3001 aagtgttcta accactggac cacctccaaa gcccgtagac tttattccag gccatcacat
     3061 ccaaaatcag gatcttatag taaggaagaa gagtaattgg acattggaag tttttcagaa
     3121 tacaataaac tagatcagcc cgttaacacc gggaggtaca cgatgctctt tatttattta
     3181 ttgcaccttc tatatgtcaa cagtctggaa aagcgtgact attctctgat aaagtttcac
     3241 aacgctgaaa ataaggtggc aggtggtacc cttccttccc agaaggaaag agagaagaag
     3301 acacttccaa attcatttag tgctcaatcc cttagagctg tagtgctgat atcctcagga
     3361 gcttctgttt tccagctaaa acacacacag cacagccccg ccctctgact ggctccagcc
     3421 taaacctgcc acatctttct gatgtccata ggaaaagttc ctgtaggttg aaaattcgat
     3481 gcttagactg gacccaccga gaatatacag agcaatcttt ctattttaag gtccccacca
     3541 gcagtgtatt tgcaaagtcc ccatgccatg taaacgcata ttgagatatc ttggtgatta
     3601 gagtatagac tctgagatat ctgcatagca cagacttaaa atctcaagat gatgttttga
     3661 gaaaacactt ggcacaattc acccactgag atactcaaga caaagaagat caacataggc
     3721 tttggttttg gtttgtttta ctttttagtt tatttttatt ttatagtgtt ttgcctgtgc
     3781 accacataca tgcagttccc ttggaggcca gagggggtgc ctcagatccc ttgagactga
     3841 actgcagtgg cagtgagcca ccttatggat gctgagagtg taagctggat cctctacaag
     3901 agcagccaga gctcttatcc attactccat ctctccagct cgctcctcca ctcacacaca
     3961 ctctggtttt aatcatttta gaaggtaaat cagttcctac ccaaacaaga attcattggt
     4021 tgatagtcca agacttcctt gccatgaaga aaatgcccct cttttctttt gacccagaaa
     4081 cagatgtctt gtctttaggc cacatagccg tgtggccctc ttttttacat ttgaagacca
     4141 aatccaaact tggtctgagt gagatagtat ccacttcata actacaaatt catttgtatg
     4201 atagtgagag tggaggttta aaattggaca atggatgtcc cataccttta atcccagccc
     4261 tcgggagaca gaggcaggtg gttatctgtg agttcaaggc tagcctgctc tgtagagtga
     4321 gttccaggat agccagggct tgtcttgaca caaaataaaa ctgagcaatc cagcctagtg
     4381 tgatggtaca cacctgtaaa cttggcactt aaaagacaga agcaggaaga tctggagttg
     4441 aaggctagcc tgggctacat aaactctgtc acacatacac acacaaaact tgtataatgc
     4501 tgtagtgatg tgtttgcttt atcaaaatgc tcaaagcttt taaaagtgct gacctattag
     4561 acttgcaatt ccatttaaat gttcaggaga atttaattga atttgtaatc ggtgtttaag
     4621 tgatttgact tgtaaaattt gttgtaaaaa ttgttgattt gttggctatg tgcttttgtg
     4681 ttccattttg cttaagtagg tttctattaa atactgaaga aag
//
