LOCUS       NM_001361142            2554 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus cerebellin 2 precursor protein (Cbln2), transcript
            variant 3, mRNA.
ACCESSION   NM_001361142
VERSION     NM_001361142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Song,J.H.T., Ruven,C., Patel,P., Ding,F., Macklis,J.D. and Sahni,V.
  TITLE     Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically
            toward Thoraco-Lumbar Spinal Cord
  JOURNAL   J Neurosci 43 (11), 1871-1887 (2023)
   PUBMED   36823038
REFERENCE   4  (bases 1 to 2554)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   5  (bases 1 to 2554)
  AUTHORS   Cagle,M.C. and Honig,M.G.
  TITLE     Parcellation of cerebellins 1, 2, and 4 among different
            subpopulations of dorsal horn neurons in mouse spinal cord
  JOURNAL   J Comp Neurol 522 (2), 479-497 (2014)
   PUBMED   23853053
  REMARK    GeneRIF: that neurons expressing Cblns 1, 2, and 4 tend to occupy
            different laminar positions within the dorsal spinal cord
REFERENCE   6  (bases 1 to 2554)
  AUTHORS   Rong,Y., Wei,P., Parris,J., Guo,H., Pattarini,R., Correia,K.,
            Li,L., Kusnoor,S.V., Deutch,A.Y. and Morgan,J.I.
  TITLE     Comparison of Cbln1 and Cbln2 functions using transgenic and
            knockout mice
  JOURNAL   J Neurochem 120 (4), 528-540 (2012)
   PUBMED   22117778
REFERENCE   7  (bases 1 to 2554)
  AUTHORS   Iijima,T., Miura,E., Matsuda,K., Kamekawa,Y., Watanabe,M. and
            Yuzaki,M.
  TITLE     Characterization of a transneuronal cytokine family
            Cbln--regulation of secretion by heteromeric assembly
  JOURNAL   Eur J Neurosci 25 (4), 1049-1057 (2007)
   PUBMED   17331201
REFERENCE   8  (bases 1 to 2554)
  AUTHORS   Bao,D., Pang,Z., Morgan,M.A., Parris,J., Rong,Y., Li,L. and
            Morgan,J.I.
  TITLE     Cbln1 is essential for interaction-dependent secretion of Cbln3
  JOURNAL   Mol Cell Biol 26 (24), 9327-9337 (2006)
   PUBMED   17030622
REFERENCE   9  (bases 1 to 2554)
  AUTHORS   Miura,E., Iijima,T., Yuzaki,M. and Watanabe,M.
  TITLE     Distinct expression of Cbln family mRNAs in developing and adult
            mouse brains
  JOURNAL   Eur J Neurosci 24 (3), 750-760 (2006)
   PUBMED   16930405
REFERENCE   10 (bases 1 to 2554)
  AUTHORS   Kavety,B., Jenkins,N.A., Fletcher,C.F., Copeland,N.G. and
            Morgan,J.I.
  TITLE     Genomic structure and mapping of precerebellin and a
            precerebellin-related gene
  JOURNAL   Brain Res Mol Brain Res 27 (1), 152-156 (1994)
   PUBMED   7877445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115783.11.
            
            Summary: The protein encoded by this gene belongs to a family of
            secreted neuronal glycoproteins. The transcript is broadly
            expressed in the embryonic and adult brain with higher levels in
            some regions including the olfactory bulb, thalamus, and cerebral
            cortex. The protein can bind to presynaptic neurexins and induce
            synaptogenesis in cultured neurons. Null mutant mice are viable,
            fertile and do not display obvious neuroanatomical defects.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (3) represents the longest
            transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2600336.1,
                                           SRR1660815.198515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC115783.11        60373-60537
            166-210             AC115783.11        61044-61088
            211-731             AC115783.11        62217-62737
            732-851             AC115783.11        65588-65707
            852-2554            AC115783.11        65893-67595
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 58.63 cM"
     gene            1..2554
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /note="cerebellin 2 precursor protein"
                     /db_xref="GeneID:12405"
                     /db_xref="MGI:MGI:88282"
     exon            1..165
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /inference="alignment:Splign:2.1.0"
     exon            166..210
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /inference="alignment:Splign:2.1.0"
     exon            211..731
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1049
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /note="cerebellin-2"
                     /codon_start=1
                     /product="cerebellin-2 precursor"
                     /protein_id="NP_001348071.1"
                     /db_xref="CCDS:CCDS29388.1"
                     /db_xref="GeneID:12405"
                     /db_xref="MGI:MGI:88282"
                     /translation="MPAPGQGPRGPLLSMPGRRGALREPADFGSSLGAVLALLLLLLP
                     ACCPVRAQNDTEPIVLEGKCLVVCDSSPSGDGAVTSSLGISVRSGSAKVAFSATRSTN
                     HEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQV
                     SLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSG
                     FLVFPL"
     exon            732..851
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /inference="alignment:Splign:2.1.0"
     exon            852..2554
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="Cbln2"
                     /gene_synonym="6330593N19Rik; A730004O05"
                     /note="major polyA site"
ORIGIN      
        1 ggtaccctct cctctttaaa attatgaatg tggccactcc gttcaagatc aagacttgga
       61 gggaatttgg aaaagaaaaa gaatctggaa gaagaaactc ggctggtgct tcggagggcg
      121 cctagtttta agaaggtacc taagagaact gtcctagatg tctagaacaa cttctccgac
      181 atcggtactc gcccgtcatg gacattccag gtccgcaggt gccttccttc tgagaatcat
      241 ttggccttga ccatctgagg cgagcaccca gcccagagaa ggctactact ctagtcctgc
      301 gcgttcctgt gcgcacccag gcagccctcc ggcttctgcc ggccttgacg ttcacagggc
      361 gccccccagc ccagatgccc gcgcctggcc agggccccag agggccgctg ctgagcatgc
      421 ccgggcgccg gggggcgctg cgtgagccag ccgactttgg ctccagcctg ggggcggtgc
      481 tggccctgct gttgctgctg ctgcccgcct gctgccccgt aagggctcag aacgacacgg
      541 agcccatcgt gctagagggc aagtgcctgg tagtgtgcga ttccagccca tcgggggatg
      601 gcgccgtcac ttcttccctg ggcatttctg tgcgctcagg cagtgccaag gtggccttct
      661 ccgctactcg gagcaccaac cacgagccgt cagagatgag caaccgtacc atgaccatct
      721 acttcgacca ggtcttagta aacattggca accactttga ccttgcctcc agtatatttg
      781 tagcaccaag aaagggaatt tatagcttca gcttccacgt ggtcaaagtg tacaacagac
      841 aaactatcca ggtcagctta atgcagaatg gctacccggt gatctctgca tttgccggag
      901 accaggatgt taccagggaa gcagccagca atggtgttct gctgctcatg gaaagagaag
      961 acaaagttca tctcaaacta gagagaggca acctcatggg aggctggaaa tactccacat
     1021 tctcgggctt cttggttttt cctctataga ctcagagcca ccaggatgat gggaaggttt
     1081 tgatcaggac ccagggatct gccccctgta acaccttgaa cttgtctgga taggatggct
     1141 tgggcccacc tccatcagat tattgctgta gaagaatgac tttcttctaa agctccagta
     1201 ttttctttga ctattgacaa ttcctcggga acctggcctc taattagttt aagaagacaa
     1261 ggtcttaagg agaaatgaaa ttatcgattt gagcaatttg tacccgtgat tgtaaagtcg
     1321 atatcggatt ttattgttgg aaccattggc ttaacttctc atgtttgtac ggtgtatctt
     1381 gtcctgatga catagatgct gctgaccctc agatggattg cacgcttcag tcagggctta
     1441 aagcaagagc ccagcagagg accacctaac cagacagtct ttgacctgtg ttctgtgtgt
     1501 gtgtagcctt aagaaaaaga atggcttcat tttcattccg tagcttttcc ctagggtctt
     1561 gggggtcttg ggagggagct gggcattggt aacctgtcga aaagtgcttt atcctgagaa
     1621 gcaaattttg cacgattgga ctgcagtttc tgttttgtac cgtctgtgat tttctttttt
     1681 cctcgggaag ctttcctttt cttcctcagg tttcactcct caaacctact tagttttcat
     1741 gctgggggct cggagagaaa aacaaaacaa aacaaaacaa caaaacttat gttcagtcct
     1801 tgtatgagac caaacaaaac agaacaaaat ctgcatactt tgttttggat aaaggaaacc
     1861 aggaaaaaaa aaaaaagaaa gcctatattt caaagtaagg acagcaaata gaacatcctg
     1921 cataacctgc ataaccttcc ctggagttct ctctcagtgc agcttcaaac ttgcaacgtg
     1981 gatttcattt tttttttttt ttaatttatt ctctgggatc ccttagtaac ctggcattgc
     2041 tcattgctca tgaatccctt aacaatggcg gagctgacgc ggcctaatcc tctctttgct
     2101 tttcctctgg atatgtctca gtagtgagtt agatctgcct ctgagtggcc acacaattac
     2161 aagatgcttc aaagaaacag gaccagtgcc tcttcctcga gatcttcctt tgatctgtca
     2221 aggagagggt tgtgttgact gatgctctgt ggatgaacat ctggccagaa gccacctgga
     2281 ctggaaatct cagcagttaa aggtactggc tgctgtaccc catgggtggt tttttcaaac
     2341 cctgcttctt ttggcatctt gtgcaacagc actattaagt agcaactgag agacctggtg
     2401 cagtatttgt gtgccaagga aacgtcacta atcccaaagc aatcaaagat gtgacctcaa
     2461 actggatgtt aatttgtcct ttgtgtaaca atgtaaccaa aatattgatg ataaaactca
     2521 taatttaaga ttcagaataa atggatttga tgtc
//
