LOCUS       NM_001253847            4007 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Casitas B-lineage lymphoma-like 1 (Cbll1), transcript
            variant 1, mRNA.
ACCESSION   NM_001253847
VERSION     NM_001253847.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Roca-Lema,D., Quiroga,M., Khare,V., Diaz-Diaz,A.,
            Barreiro-Alonso,A., Rodriguez-Alonso,A., Concha,A., Romay,G.,
            Cerdan,M.E., Gasche,C. and Figueroa,A.
  TITLE     Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation
            and cancer bowel disease
  JOURNAL   Sci Rep 12 (1), 17571 (2022)
   PUBMED   36266428
  REMARK    GeneRIF: Role of the E3 ubiquitin-ligase Hakai in intestinal
            inflammation and cancer bowel disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
            Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   3  (bases 1 to 4007)
  AUTHORS   Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
            Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
            and Liu,J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4007)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 4007)
  AUTHORS   Mukherjee,M., Chow,S.Y., Yusoff,P., Seetharaman,J., Ng,C.,
            Sinniah,S., Koh,X.W., Asgar,N.F., Li,D., Yim,D., Jackson,R.A.,
            Yew,J., Qian,J., Iyu,A., Lim,Y.P., Zhou,X., Sze,S.K., Guy,G.R. and
            Sivaraman,J.
  TITLE     Structure of a novel phosphotyrosine-binding domain in Hakai that
            targets E-cadherin
  JOURNAL   EMBO J 31 (5), 1308-1319 (2012)
   PUBMED   22252131
REFERENCE   6  (bases 1 to 4007)
  AUTHORS   Figueroa,A., Kotani,H., Toda,Y., Mazan-Mamczarz,K., Mueller,E.C.,
            Otto,A., Disch,L., Norman,M., Ramdasi,R.M., Keshtgar,M., Gorospe,M.
            and Fujita,Y.
  TITLE     Novel roles of hakai in cell proliferation and oncogenesis
  JOURNAL   Mol Biol Cell 20 (15), 3533-3542 (2009)
   PUBMED   19535458
  REMARK    GeneRIF: Results suggest that Hakai is an important regulator of
            cell proliferation and that Hakai may be an oncoprotein and a
            potential molecular target for cancer treatment.
REFERENCE   7  (bases 1 to 4007)
  AUTHORS   Kim,T.S., Nakagawa,T., Endo,T., Iguchi,F., Murai,N., Naito,Y. and
            Ito,J.
  TITLE     Alteration of E-cadherin and beta-catenin in mouse vestibular
            epithelia during induction of apoptosis
  JOURNAL   Neurosci Lett 329 (2), 173-176 (2002)
   PUBMED   12165405
  REMARK    GeneRIF: E-cadherin distribution and expression is altered in
            utricle epithelia with induction of apoptosis.
REFERENCE   8  (bases 1 to 4007)
  AUTHORS   Fujita,Y., Krause,G., Scheffner,M., Zechner,D., Leddy,H.E.,
            Behrens,J., Sommer,T. and Birchmeier,W.
  TITLE     Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis
            of the E-cadherin complex
  JOURNAL   Nat Cell Biol 4 (3), 222-231 (2002)
   PUBMED   11836526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974423.21 and AK051737.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167441.1, AK051737.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                CR974423.21        23036-23097
            63-500              AK051737.1         2-439
            501-501             CR974423.21        32164-32164
            502-1308            AK051737.1         441-1247
            1309-4007           CR974423.21        35125-37823
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.49 cM"
     gene            1..4007
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="Casitas B-lineage lymphoma-like 1"
                     /db_xref="GeneID:104836"
                     /db_xref="MGI:MGI:2144842"
     exon            1..94
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1557
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     E-cadherin binding protein E7; E3 ubiquitin-protein ligase
                     Hakai; c-Cbl-like protein 1; casitas B-lineage
                     lymphoma-transforming sequence-like protein 1; RING-type
                     E3 ubiquitin transferase Hakai"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Hakai isoform 1"
                     /protein_id="NP_001240776.1"
                     /db_xref="CCDS:CCDS56834.1"
                     /db_xref="GeneID:104836"
                     /db_xref="MGI:MGI:2144842"
                     /translation="MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRT
                     QRTVSRMPAKAPQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKD
                     DTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTR
                     GSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPD
                     RFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRS
                     VSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHI
                     MPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHII
                     AQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMS
                     PGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ"
     exon            95..262
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            263..363
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            364..447
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            448..521
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            522..4007
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="hexamer: ATTAAA"
     polyA_site      1940
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="major polyA site"
     regulatory      3877..3882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="hexamer: AATAAA"
     polyA_site      3900
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="major polyA site"
ORIGIN      
        1 ctccggaagg tagggcgcag gcgcttactg cgactccgga gcgactgact tccgttccca
       61 ctgtgccccg cgagccgaat catggatcac actgacaatg agttacaagg cactaatagt
      121 tctggatcct tgggtggtct tgatgttcgc agaagaatcc ctataaagct catctccaaa
      181 caagccagca aagttaagcc ggcacctcgg actcaaagga ctgtcagcag gatgcccgca
      241 aaggccccgc aaggtgatga agaaggattt gattataacg aagaacagcg atatgactgt
      301 aaaggaggcg aactctttgg gaatcagcga agatttccag gacacctttt ttgggatttc
      361 aagataaaca tcttaggtga aaaggacgat acaccagtac atttctgtga caaatgtgga
      421 ctgcctatta aagtctatgg gagaatgatt ccatgcaagc atgtcttttg ctatgactgt
      481 gctattttac atgaaaaaaa aggagataag atgtgcccag gatgtagtga tcctgtgcag
      541 cggattgagc agtgcacacg aggttctctc tttatgtgta gcattgttca aggatgcaag
      601 agaacatatc tgtctcagag agacttacaa gctcatatca accatcgcca tatgagagct
      661 ggaaagcccg ttacccgtgc ttcacttgag aatgttcatc ctcctattgc ccccccacca
      721 actgacatcc ccgatcggtt cataatgcca ccagacaagc atcatatgag ccatattcct
      781 ccaaagcagc acatcatgat gccaccgcct cctctgcagc atgtgccaca tgagcactat
      841 aatcagccac atgaggatat tcgtgctcct ccggcagaat tgtccatggc tccacctcca
      901 cctcgttcgg tcagtcagga aacctttcgt atttcaacaa gaaaacacag caatttaata
      961 acggtcccta ttcaggatga ctccagttca ggtgctagag aaccaccacc tcctgcccca
     1021 gcacctgctc atcaccatcc tgaatatcag ggtcagcccg tggtatctca ccctcatcat
     1081 attatgcctc cacagcaaca ttacgcacca cccccacctc ctccaccacc aataagccat
     1141 ccaatgccac accctcccca ggctgcaggt actcctcact tggtatatag ccaagctcca
     1201 cctccaccaa tgacctctgc tccaccccca ataacccctc cccctggaca tattattgcc
     1261 cagatgccac cttatatgaa tcatcctcct ccaggacccc ctccacctca gcatggtggt
     1321 ccacctgtaa ctgcaccccc tcctcaccat tacaatccta actctttacc ccagtttact
     1381 gaagaccaag gaactctgag ccctccattt acacaaccag gaggaatgag tcctggtata
     1441 tggcctgcac caagagggcc acctcctcct ccacgaatgc agggcccgcc ttctcaaacc
     1501 ccactacctg gaccgcatca tccagatcaa acaagataca gaccgtatta ccagtgatca
     1561 tagtgttttg aactgaagat atgacaagga aaaaaaagat tagtcaatct taattgacct
     1621 ttgactgtgg aaggaaaact acctcttttg aggtagctat taacacaagt cttgtctctc
     1681 aaaatggttt taatctgact aggattgctt tcaagtacta ttctgtagtg cagataagtg
     1741 gcttggttga gcacaattct atcttaactg ttactttgat gtgataaatt ttcccaaaac
     1801 gaccatttgt aaaaaattga aaaaaaattc actgttccac tttgagaaat actgacttta
     1861 ttaaacccaa tgtttagttt tcttgtgatg cattttgtta acctgtgtaa aagaattaaa
     1921 tttcaaaatg gttgtaaaaa tgctattttt atgtgaattt aagtgcagcc atatcatttt
     1981 ttaacccata ttttaccact aattttccaa ggttaaaatc ctaaaagtaa aaatctacta
     2041 aatcgttacc aggcagactg ttaaatgtag ggaattattc acactttagg cactgaaagt
     2101 tcaaagtgta gttctgtaat acggttcact cggatgcctt ttcacagcag ctgcagatca
     2161 tcagcgtttc tgtaactgtg cttggctggc atgtctccag gtagtgtgta attgggaaac
     2221 cgacctgctc tacaggctct aagctgccag tgagtgctgt tctcattgac gctttttctg
     2281 agtggctaca atcacataac ttgtcacact taaaggtctt aagttacatt attttatagg
     2341 actgtttaaa gttgttattg gatgaaatgt gctctctgtt cactgtctta acctacatgt
     2401 ttggggctga ctaggcttta tttaaatctc ctttttctca gtttgattct gtgttttagt
     2461 gcatagtgtg ttcttattta tggaattaca cactgcagtt tgaatgatgt ggaggaatct
     2521 gactaatgta ttagcagacg gtgttccttg tagtcacaag ctagcatgta ctcgggtttt
     2581 tgtggctgtg gtgagttttt cctctaagtt gaaattttaa aactatcatt tcttttattg
     2641 gtaaaacagt caaaaattgg aacaatttac tgtcgaatca atagtaagga caaccagata
     2701 attttgaatt ggacagaaga aaagtcatgg ttagattgtg aatttcagtg ccatgtaagg
     2761 tgcctttaga gtcagtgttt gcattatagg ggcttgttac agtccattgg agatgaccac
     2821 tcagtttata catatttcta agtcagcatc cttaggatat tatcgtatat cctttggatt
     2881 gactaaactc ttgtgaagct tttcttcccc tttaaaatgg tgcataatat aaacatggtg
     2941 tgtagtgtgc agataacatt tattagatag tttgtagtat ataaatttag aacattggtt
     3001 tttgacaagg ggtatactga ttgctaatta accattttat tctgtcaggt acaggaaaac
     3061 attctcatgg tggatgatca gatacaaaat catttctgaa ctttcagaag aaataatgta
     3121 catggccatt catccttggc tggccagaaa taactaatgc agttttttct tgagcaaata
     3181 attttatttt cacatgtagc attttgagaa tctggtttgc tcatgcacta tttctagtga
     3241 gaaattcttg ttattagaag catggacgtg aaatagtgtg acatgtggtg agtgtttctg
     3301 tcattactgt aggtacttgg actggtgcaa acttgattct ttttcatgcc cctgtttagg
     3361 agctattaaa tattactgtt aaaatccaaa taaccccttt gtttcatgta gttagaaaat
     3421 agccagattc atgtaagagc tttttaacta tttatgagaa gctcttatat tgagatttcc
     3481 tggggttaag tgtggtaaga aaccacttag cctgtatttt ggaccaaaaa aatcagtatc
     3541 atgaaaaaaa aaaaatccca cattatgaga attcttgtag gctttaaaaa acaatgtaaa
     3601 aaccattatg ctgggaggca ggccagatga atgttttgta atagaatttt aattgttaga
     3661 cttcagttca tcagttaatt gtttgaatga gggtgggtgg gtagacagat aacaagatta
     3721 ttattaagtg tttctgttct taaggaaaaa gatgtgaatc ccagcacatt tcagggaagc
     3781 cttcgaagct atctatgatg gacataagtc taaatgtatg tatgtttcat taattgctct
     3841 taagactact gaggtggcag tttaattctt taaaacaata aaatggaagc ataaatacta
     3901 ttttgcctag atgagtcttt aaacctaatg atgacatatt tgggagactg cagaactttc
     3961 catggttcta aagtaaaatt agattcacct tttaaacact tataagc
//
