LOCUS       NM_008118               1532 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cobalamin binding intrinsic factor (Cblif), mRNA.
ACCESSION   NM_008118
VERSION     NM_008118.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   Won,Y., Jang,B., Lee,S.H., Reyzer,M.L., Presentation,K.S., Kim,H.,
            Caldwell,B., Zhang,C., Lee,H.S., Lee,C., Trinh,V.Q., Tan,M.C.B.,
            Kim,K., Caprioli,R.M. and Choi,E.
  TITLE     Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in
            Gastric Carcinogenesis
  JOURNAL   Gastroenterology 166 (5), 772-786 (2024)
   PUBMED   38272100
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Caldwell,B., Meyer,A.R., Weis,J.A., Engevik,A.C. and Choi,E.
  TITLE     Chief cell plasticity is the origin of metaplasia following acute
            injury in the stomach mucosa
  JOURNAL   Gut 71 (6), 1068-1077 (2022)
   PUBMED   34497145
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Lee,J.H., Kim,S., Han,S., Min,J., Caldwell,B., Bamford,A.D.,
            Rocha,A.S.B., Park,J., Lee,S., Wu,S.S., Lee,H., Fink,J.,
            Pilat-Carotta,S., Kim,J., Josserand,M., Szep-Bakonyi,R., An,Y.,
            Ju,Y.S., Philpott,A., Simons,B.D., Stange,D.E., Choi,E., Koo,B.K.
            and Kim,J.K.
  TITLE     p57Kip2 imposes the reserve stem cell state of gastric chief cells
  JOURNAL   Cell Stem Cell 29 (5), 826-839 (2022)
   PUBMED   35523142
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   6  (bases 1 to 1532)
  AUTHORS   Johnson,C.L., Kowalik,A.S., Rajakumar,N. and Pin,C.L.
  TITLE     Mist1 is necessary for the establishment of granule organization in
            serous exocrine cells of the gastrointestinal tract
  JOURNAL   Mech Dev 121 (3), 261-272 (2004)
   PUBMED   15003629
REFERENCE   7  (bases 1 to 1532)
  AUTHORS   Aubin,J., Dery,U., Lemieux,M., Chailler,P. and Jeannotte,L.
  TITLE     Stomach regional specification requires Hoxa5-driven
            mesenchymal-epithelial signaling
  JOURNAL   Development 129 (17), 4075-4087 (2002)
   PUBMED   12163410
REFERENCE   8  (bases 1 to 1532)
  AUTHORS   Fernandes,M., Poirier,C., Lespinasse,F. and Carle,G.F.
  TITLE     The mouse homologs of human GIF, DDB1, and CFL1 genes are located
            on chromosome 19
  JOURNAL   Mamm Genome 9 (4), 339 (1998)
   PUBMED   9530637
REFERENCE   9  (bases 1 to 1532)
  AUTHORS   Lorenz,R.G. and Gordon,J.I.
  TITLE     Use of transgenic mice to study regulation of gene expression in
            the parietal cell lineage of gastric units
  JOURNAL   J Biol Chem 268 (35), 26559-26570 (1993)
   PUBMED   8253786
REFERENCE   10 (bases 1 to 1532)
  AUTHORS   COFFEY,J.W., HANSEN,H.J. and MILLER,O.N.
  TITLE     STUDIES ON THE INTERACTION OF VITAMIN B12: INTRINSIC FACTOR AND
            RECEPTORS. 3. CHEMICAL AND BIOLOGICAL PROPERTIES OF VITAMIN B12
            COMBINING SUBSTANCES FROM THE STOMACH, SERUM, AND ASCITES FLUID OF
            THE MOUSE
  JOURNAL   Arch Biochem Biophys 110, 117-123 (1965)
   PUBMED   14321840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078933.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008118.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078933.1, BC118519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1532              AK078933.1         2-1533
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.51 cM"
     gene            1..1532
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /note="cobalamin binding intrinsic factor"
                     /db_xref="GeneID:14603"
                     /db_xref="MGI:MGI:1202394"
     exon            1..167
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1342
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /note="intrinsic factor; gastric intrinsic factor"
                     /codon_start=1
                     /product="cobalamin binding intrinsic factor precursor"
                     /protein_id="NP_032144.2"
                     /db_xref="CCDS:CCDS29609.1"
                     /db_xref="GeneID:14603"
                     /db_xref="MGI:MGI:1202394"
                     /translation="MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALME
                     NSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSS
                     CRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKT
                     LMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADG
                     IIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLK
                     GKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIE
                     VSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGK
                     TPLDEGVAYYIPFNHEHITANFTQY"
     exon            168..344
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            345..458
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            459..599
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            600..781
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            782..959
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1161
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1280
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1532
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
                     /note="hexamer: AATAAA"
     polyA_site      1499
                     /gene="Cblif"
                     /gene_synonym="Gif; IF; INF"
ORIGIN      
        1 attacaaaaa taagtgcaca caggagaagg tagaggaaca cttcactagc aaacactagt
       61 gttcgtggaa agggagacgt ggacaggcat ggcttggctt accctctacc tcctaagtgt
      121 tctctgggct gtggcaggaa ccagcacccg tgcccagagc tcttgctctg tgcccccaga
      181 tcagcaaccc tgggtcgatg gcctacaagc gctcatggag aactcggtga ctgactcaga
      241 cttcccaaac cccagcatcc tgattgccat gaacctggcc ggcgcctaca acgtggaggc
      301 ccagaaactc ctgacttacc agctcatggc cagtgacagt gcagacctga caagtgggca
      361 gcttgccctc accgttatgg ctctcacgtc ctcctgcaga gaccctggaa gtaaagtgtc
      421 cactctactg aagaaaatgg agaactggtc accttcaagc ccgggtgctg aatcctcggc
      481 cttctatggg cctggtttgg cgatcctcgc actgtgccag aagagttcag aggcgacctt
      541 acccatcgca gtgcgcttcg ctaagaccct gatgatggaa ccctctccct tcaatgtgga
      601 cacaggagca gtggcaacct tggccctgac ctgtatgtac aacaagattc ctgtgggttc
      661 tcaagaaaac tacagagacc tgtttggtca ggcactgaag gctattgtgg agaagatcag
      721 cttaaggatc aaagctgatg gcatcatcgg agacatctac agcactggcc ttgccatgca
      781 ggctctctcc gtgacacctg agcaacctac caagaagtgg gactgtgaga agactatgca
      841 tacaatactc aacgagatta agcaagggaa attccaaaac cccatgtcca ttgcccaaat
      901 tctcccttcc ttgaaaggca agacttacct agatgtgccc caagtaacat gtggtcctga
      961 tcatgaagtg ccaccaactt taactgacta tcctaccccg gtccccactt cagtatctaa
     1021 cattaccgtc atatatacca taaacaacca gctgagaggg gttgatctgc ttttcaatgt
     1081 gaccatcgag gttagtgtga aaagtggatc tgtgctactt gctgtcctag aagaagcaca
     1141 gcgcaaaaac tccatgttca aatttgaaac caccatgaca tcctggggcc ttattgtctc
     1201 ttctatcaat aatatcgctg agaatgttaa tcacaagaca tactgggagt ttcttagtgg
     1261 caaaacgcct ttggatgaag gggttgctta ctatatcccc ttcaatcatg agcacatcac
     1321 agccaacttc acccaatact gagacggagt atcttctgtc ccatgtgaca aaaggatggt
     1381 ttgggttgtt ttgttttgtt tttcatatca tttcaaatct gtgccaagaa aagcagatat
     1441 taacaatgct actctcttcc tgagccactg tgtggaataa atgatgcagg tgctcaccat
     1501 tgtgactcat gcaataaaat ttttggcttc tc
//
