LOCUS       NM_001033238            6323 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Casitas B-lineage lymphoma b (Cblb), mRNA.
ACCESSION   NM_001033238 XM_001003161 XM_001003441 XM_001003447 XM_001003456
            XM_001003462 XM_001003472 XM_001003476 XM_001003639 XM_001003649
            XM_156257 XM_902056 XM_902058 XM_917535 XM_924994 XM_924996
VERSION     NM_001033238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6323)
  AUTHORS   You,H., Chang,F., Chen,H., Wang,Y. and Han,W.
  TITLE     Exploring the role of CBLB in acute myocardial infarction:
            transcriptomic, microbiomic, and metabolomic analyses
  JOURNAL   J Transl Med 22 (1), 654 (2024)
   PUBMED   39004726
  REMARK    GeneRIF: Exploring the role of CBLB in acute myocardial infarction:
            transcriptomic, microbiomic, and metabolomic analyses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6323)
  AUTHORS   Li,X., Sun,W., Huang,M., Gong,L., Zhang,X., Zhong,L., Calderon,V.,
            Bian,Z., He,Y., Suh,W.K., Li,Y., Song,T., Zou,Y., Lian,Z.X. and
            Gu,H.
  TITLE     Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T
            follicular helper cell responses and lupus by reducing BCL6
            degradation
  JOURNAL   Immunity 57 (7), 1603-1617 (2024)
   PUBMED   38761804
  REMARK    GeneRIF: Deficiency of CBL and CBLB ubiquitin ligases leads to
            hyper T follicular helper cell responses and lupus by reducing BCL6
            degradation.
REFERENCE   3  (bases 1 to 6323)
  AUTHORS   Sharma,J., Mudalagiriyappa,S., Abdelaal,H.F.M., Kelly,T.C.,
            Choi,W., Ponnuraj,N., Vieson,M.D., Talaat,A.M. and Nanjappa,S.G.
  TITLE     E3 ubiquitin ligase CBLB regulates innate immune responses and
            bacterial dissemination during nontuberculous mycobacteria
            infection
  JOURNAL   J Leukoc Biol 115 (6), 1118-1130 (2024)
   PUBMED   38271280
  REMARK    GeneRIF: E3 ubiquitin ligase CBLB regulates innate immune responses
            and bacterial dissemination during nontuberculous mycobacteria
            infection.
REFERENCE   4  (bases 1 to 6323)
  AUTHORS   Vos,W.G., van Os,B.W., den Toom,M., Beckers,L., van
            Roomen,C.P.A.A., van Tiel,C.M., Mohapatra,B.C., Band,H., Nitz,K.,
            Weber,C., Atzler,D., de Winther,M.P.J., Bosmans,L.A., Lutgens,E.
            and Seijkens,T.T.P.
  TITLE     T cell specific deletion of Casitas B lineage lymphoma-b reduces
            atherosclerosis, but increases plaque T cell infiltration and
            systemic T cell activation
  JOURNAL   Front Immunol 15, 1297893 (2024)
   PUBMED   38504977
  REMARK    GeneRIF: T cell specific deletion of Casitas B lineage lymphoma-b
            reduces atherosclerosis, but increases plaque T cell infiltration
            and systemic T cell activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6323)
  AUTHORS   Eggert,J., Zinzow-Kramer,W.M., Hu,Y., Kolawole,E.M., Tsai,Y.L.,
            Weiss,A., Evavold,B.D., Salaita,K., Scharer,C.D. and Au-Yeung,B.B.
  TITLE     Cbl-b mitigates the responsiveness of naive CD8+ T cells that
            experience extensive tonic T cell receptor signaling
  JOURNAL   Sci Signal 17 (822), eadh0439 (2024)
   PUBMED   38319998
REFERENCE   6  (bases 1 to 6323)
  AUTHORS   Fang,N., Fang,D., Wang,H.Y., Altman,A. and Liu,Y.C.
  TITLE     Regulation of immune responses by E3 ubiquitin-protein ligases
  JOURNAL   Curr Dir Autoimmun 5, 161-175 (2002)
   PUBMED   11826757
  REMARK    GeneRIF: novel E3 ubiquitin-protein ligase; role in regulation of
            immune response - review
            Review article
REFERENCE   7  (bases 1 to 6323)
  AUTHORS   Fang,D. and Liu,Y.C.
  TITLE     Proteolysis-independent regulation of PI3K by Cbl-b-mediated
            ubiquitination in T cells
  JOURNAL   Nat Immunol 2 (9), 870-875 (2001)
   PUBMED   11526404
REFERENCE   8  (bases 1 to 6323)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
REFERENCE   9  (bases 1 to 6323)
  AUTHORS   Chiang,Y.J., Kole,H.K., Brown,K., Naramura,M., Fukuhara,S.,
            Hu,R.J., Jang,I.K., Gutkind,J.S., Shevach,E. and Gu,H.
  TITLE     Cbl-b regulates the CD28 dependence of T-cell activation
  JOURNAL   Nature 403 (6766), 216-220 (2000)
   PUBMED   10646609
REFERENCE   10 (bases 1 to 6323)
  AUTHORS   Bachmaier,K., Krawczyk,C., Kozieradzki,I., Kong,Y.Y., Sasaki,T.,
            Oliveira-dos-Santos,A., Mariathasan,S., Bouchard,D., Wakeham,A.,
            Itie,A., Le,J., Ohashi,P.S., Sarosi,I., Nishina,H., Lipkowitz,S.
            and Penninger,J.M.
  TITLE     Negative regulation of lymphocyte activation and autoimmunity by
            the molecular adaptor Cbl-b
  JOURNAL   Nature 403 (6766), 211-216 (2000)
   PUBMED   10646608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ102432.1, AK147367.1, CJ110973.1, AK161486.1, AK164519.1 and
            CJ244362.1.
            
            On or before Nov 24, 2006 this sequence version replaced
            XM_001003639.1, XM_156257.6, XM_001003649.1, XM_902056.2,
            XM_924996.2, XM_902058.2, XM_917535.2, XM_001003161.1, XM_924994.2,
            XM_001003441.1, XM_001003472.1, XM_001003456.1, XM_001003462.1,
            XM_001003476.1, XM_001003447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147367.1, SRR1660811.218050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CJ102432.1         326-341
            17-19               AK147367.1         2-4
            20-487              CJ110973.1         5-472
            488-963             AK147367.1         473-948
            964-2447            AK161486.1         550-2033
            2448-4825           AK147367.1         2434-4811
            4826-5817           AK164519.1         1819-2810
            5818-6317           AK147367.1         5803-6302
            6318-6323           CJ244362.1         464-469
FEATURES             Location/Qualifiers
     source          1..6323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 32.88 cM"
     gene            1..6323
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /note="Casitas B-lineage lymphoma b"
                     /db_xref="GeneID:208650"
                     /db_xref="MGI:MGI:2146430"
     exon            1..137
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            138..319
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            320..570
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            571..717
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            718..874
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            875..996
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1134
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1222
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1354
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1558
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1744
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..2107
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2202
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2349
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2447
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2588
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2708
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..6323
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /note="hexamer: AATAAA"
     polyA_site      3662
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
     regulatory      6303..6308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /note="hexamer: TATAAA"
     polyA_site      6323
                     /gene="Cblb"
                     /gene_synonym="Cbl-b"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcccca cgccttggtc tccggggatg gctcaggggt ggggtggcca gtgagtggtc
       61 tcctcctccg gcgggcgctg cggcggcctc ccgagtgtgg cgcgggactg ccgggcgggc
      121 gtggagcttt ttgcacggac taagattcca gatggcaaat tctatgaatg gcagaaatcc
      181 tggtggtcga ggaggaaacc cccgcaaagg tcgcattttg gggattattg atgctattca
      241 ggatgcagtc ggacccccaa agcaagctgc agctgaccgc aggactgtgg agaagacttg
      301 gaaactcatg gacaaagtgg taagactgtg ccaaaatccc aagcttcagt tgaaaaacag
      361 cccaccgtat atacttgata ttttacctga tacgtatcag cacttgagac ttatattgag
      421 taaatatgat gacaaccaga agctggctca actgagcgag aatgagtact ttaaaatcta
      481 catcgatagt ctcatgaaga agtcgaagcg agcgatccgg ctctttaaag aaggcaagga
      541 aaggatgtac gaagagcagt cgcaggacag acggaatctc acaaagctgt cccttatctt
      601 cagtcacatg ctggcagaaa tcaaggcgat ctttcccaat ggccagttcc agggagataa
      661 cttccggatc accaaagcag atgctgctga gttctggagg aagttttttg gagacaaaac
      721 tattgtacca tggaaagtct tcagacagtg cctgcatgag gtccatcaga tcagctctgg
      781 cctggaagca atggctctga agtcaaccat tgatttaact tgcaatgatt acatctcagt
      841 gtttgaattt gatattttta ccaggctatt tcagccctgg ggctctattt tacggaattg
      901 gaacttcttg gctgtgactc acccgggata catggcattt ctcacgtatg atgaagttaa
      961 agctcggcta cagaaataca gcaccaagcc tggaagttac attttccggt taagctgcac
     1021 tcggctggga caatgggcca ttggctatgt gactggggac ggcaatatcc tacagaccat
     1081 acctcataac aagcccctgt tccaagccct gattgatggt agcagggaag gcttttatct
     1141 ttatcctgat gggcggagct ataaccctga tttaaccgga ttatgtgaac ctacacctca
     1201 cgatcatata aaagttacac aggagcagta tgaactgtat tgtgaaatgg gctccacttt
     1261 tcagctctgc aagatctgtg cagagaatga caaagatgtc aagattgagc cttgcgggca
     1321 tctgatgtgc acttcgtgcc ttaccgcgtg gcaggagtct gatggccaag gctgcccctt
     1381 ctgtcgctgt gagataaaag gaacggagcc catcattgtg gaccccttcg accccagaga
     1441 tgaaggctcc aggtgctgca gcatcattga ccctttcagc atccccatgc ttgacttgga
     1501 cgatgacgat gatcgagagg agtctttgat gatgaacagg ctggcgagtg ttcgaaagtg
     1561 cacggacagg cagaactcac cagtcacatc gccaggctcc tcaccccttg cccagagaag
     1621 aaagcctcag ccagaccctc tccagatccc ccacctcagc ctgccaccag tgcctccccg
     1681 cctagatctc attcagaaag gcatcgtgcg ctctccgtgt ggcagcccca caggctcgcc
     1741 aaagtcttct ccatgcatgg ttagaaaaca agacaaacca ctcccggcac cccctcctcc
     1801 cttgagagat ccacctcctc caccagagag gcctcccccc atcccacctg acaatagact
     1861 gagcagacac ttccaccatg gagagagtgt gccttcccgg gaccagccca tgcccctcga
     1921 agcctggtgc cctcgggatg ccttcgggac taaccaggtg atgggatgtc gcatcctcgg
     1981 ggatggctct ccaaagcctg gcgtcaccgc aaactccagc ttaaatggga ggcacagtag
     2041 aatgggctcc gagcaggttc ttatgaggaa acacagacgc catgatttgc cttcagaagg
     2101 agccaaggtc ttttccaatg gccaccttgc cactgaagaa tacgatgtcc ctcctcggct
     2161 ttcccctccg cctccagtca ccacccttct cccaagcata aagtgtactg gtccattagc
     2221 aaattgtctc tcagagaaaa ctagagacac ggtagaagat gatgacgatg aatacaagat
     2281 tccttcatcc catcctgtgt ccctgaattc acaaccatct cattgccata atgtcaaagc
     2341 tcctgttcgg tcttgtgata atggtcattg tatattgaat ggaactcatg gtgcgccttc
     2401 agagatgaag aaatcgaaca tcccagattt aggcatctat ttgaagggtg aggacgcctt
     2461 tgatgctctc cctccatccc tccctcctcc cccacctcct gcaagacaca gtctcatcga
     2521 acattcaaaa cctccaggct ccagtagccg gccttcctca gggcaggacc ttttccttct
     2581 tccttcagat cccttttttg acccaacaag tggccaagtt ccattgcctc ctgccaggag
     2641 agcagcagga gacagcggca aagccaacag agcctcgcag gactatgacc agctcccttc
     2701 atcttccgat ggttcgcaag caccagctag accccccaaa ccacgacccc gaaggactgc
     2761 accagaaatt catcacagaa agccccatgg gcccgaagcg gcgttggaaa atgtcgatgc
     2821 aaaaattgca aaactcatgg gagaggggta tgcctttgaa gaggtgaaga gagccttaga
     2881 gattgcccag aataacgtgg aagtggccag gagcatactt cgagaatttg ccttcccccc
     2941 tcctgtctcc ccacgtctga atctatagca gccagaactg cagacaccaa agggcagtta
     3001 acaaatattc caggagtatg agacagaagg actgagaggg aatgcaggag ccacggtgtc
     3061 tttccgtgtg gcttccccag aaggcagcct ggagtccagc ttctctggtt ccacagctct
     3121 cttaggatgc ccacactgaa gcttctgtgt ttgtgctagc catactttga aatcagggtt
     3181 gaactgataa aataatttaa agacgtttac tcccccttga actttgaatc tgtgaaatgc
     3241 ttttccttgt ttacacgttg gcagaattgc agtttgtctc tgtttttgat ccctgtactg
     3301 tgttcctgac aggccctttg cagagttgct caggtctgct gtaagtttct ccatgcctgc
     3361 cctggtgccc acatcagagg ctaaaccatc tctttgtttt gctctctatc cgggccccac
     3421 ctcatgtccc cagccaggtc caattccatt tctcccattc acacggcacg ctagtctgaa
     3481 ggtcctgatt tttcagtgtt tcaaactaat gcagaaagaa aaaggaaaat gtgtgtggtc
     3541 ttgtcttcac tactgagtct tttctttggg aaccatcact gttgagaggt gggggaaaac
     3601 ctgaatgtaa aaagcattta tttgtcaata aactgccttt tgtaaggggt ttttatatac
     3661 tataaaagag cttctcttgt tagtttaagt tctgtgacct ttaggttccc gaactctccc
     3721 tctcatccac ccaggagtgt cataatgctg taaaagtgac tgctgcagat gcagggaaaa
     3781 caggcttgca ggagactgct tgtactccag taccataatg agatgccctg atattaatgc
     3841 ctgcatcact ttcaggagag atggaaaagg ggaccaccgc ctggaaatat gttaatatgc
     3901 ctttagataa ggtcatggac atacatgcct ttcccaagtg gaatagagcc cattttctat
     3961 tttatgatgt caccctggct cctcacagtg tgggagcccc ctaaggcact gacgactgtt
     4021 atgtatcact gcaactgcag gccttgtaag ttgcaaaact cttagtaccc tttctccact
     4081 catggtagga gtcctgttta ctctgtgggt tttgttgttg actgctctgt gttgccccca
     4141 tccaggcaga tgaaactgtg gttacttcta atctatggat atcttttgac catctgtaat
     4201 gtgcgttgca ctcttgtggg ctttgaaagc acaaactctc acacatggac tccatcatat
     4261 tatttgtgta gatgcgtttg gtggtaaatg tctccagtct gatggatgaa gcttccaaga
     4321 ttggtgtaag gactttagac ctctgtggca atttcaggtt tttgggttgg gttgggttag
     4381 gttgggttgg ggtttttgtt tctttggttt tttgtttttg ttttgttttg tatccctaat
     4441 agtgggggga aaagaataaa aactatctct gtgcaagaat gcttgaacca cattttgata
     4501 gtttctaaac attgatttta ggcttgtgtg gatgtttctt accactcgtt actccacacc
     4561 tagtctcaca tacagagatg cctcggataa tcacttatcc tgacaaatga caagatagta
     4621 agtacatcag acagatccga tggagctgcc attgtacaag actcatggac aaagctgtgt
     4681 ttgtccagga agggaaccca gcacattctt ttacagtttg gcttttatgg aatgagacag
     4741 gatttgagga ctcttagtct gcatatttta ggtttgtttg gatggtctta tgttgcttct
     4801 gctaccagag gtgtattttt ttttttaatg ttttcatatc ctatacctgg gaggaggtat
     4861 gaatacaagt ttttttttat actttctaca attggctatt tgttgttttc ttatctgctc
     4921 ttactttctg tacttgtttt ataagttctg atgtcatact gatacagtgc tgtgtctgtt
     4981 gggcttcatg tagcttgcca gcaatcagca tagcctaata cctagagttg cccctttgtt
     5041 gtccttacac tgttaaaaca tccttaaagg aggagggggt aggtttacaa gaggaaccct
     5101 gggacccaca gcatattcac ctccactctc agaaagtaca agagattttc ctccagaatt
     5161 taaaagctaa ggatgtgctg acacagtttt ttggaacctg aagtttcggc agggtaggga
     5221 agtgtaaata attttctgga ttgtaccaag atccctactg cagccactca gtagccactg
     5281 ttggttttct catcaaggaa agtgaatctt aggagtcata tgtaagacaa agcaaagaga
     5341 aaatgggaaa actcacaaaa tttatttgaa aaaaaaatgt tgaaattatt tttcattttg
     5401 aaagggacta ctagttaata gttgctaact aacacaatgt tccacacttt gttccctctg
     5461 atccagaaat tgaggtgccc ccccatgctc aagatctgat aatagaatta ccctcaatcc
     5521 aatatcttat atagtctgca caattaaaac aaaccatggc taattgtaac ccctacctgg
     5581 gatccatctc caatgatatt ccagtcattg tttttctaga aatggggagt tatttttttc
     5641 cttttccttt tatcctcccc accccccacc ctgcacctga cttcttggta tctgatatat
     5701 atcacagcca aattttctgg acacaaatac tggcattttg atgcttaact tatcatggtc
     5761 ccacaattcc agtagatagc ccttttccac gttctccctc cctacagtac aacagagccc
     5821 tggctacaac cttcagaagt ctgtttgcta actcagtatt tcacacaccc aggacacatg
     5881 cagagctctt cataatgtga acttcctaat tgttcagttc cagaagcatt tcctgcagtt
     5941 tgaacgtgac tttgcctctc ggattttcaa cttgaagcct tagtttgcac tgaattgtct
     6001 catctggttt taaaatgtct caaatggact gatttggaat caaaatgtgg tatattttaa
     6061 atattgatgc aggtactttc tgtaagcctg aaatgttgag cttcgaagga gactttctgg
     6121 aaaaagacag caatagaaag ttttcttctc agttcctatt tttattgttt tgaaatgcag
     6181 tttttacgac ttgtctaatg tggcaaaata gctatgtgtt caattaattt atattttatt
     6241 cttttttcat ttctggatat gtaacaaacc tcaagtactt tatctgttct tttaaggtat
     6301 tttataaaat gaatgttaac aaa
//
