LOCUS       NM_007619               5083 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus Casitas B-lineage lymphoma (Cbl), mRNA.
ACCESSION   NM_007619 XM_903344 XM_916663
VERSION     NM_007619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Yang,Y.H., Xie,K.F., Yang,S., Wang,H., Ma,H.H., Zhou,M., Wang,Z.W.,
            Gu,Y. and Jia,X.M.
  TITLE     BLNK negatively regulates innate antifungal immunity through
            inhibiting c-Cbl-mediated macrophage migration
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2400920121 (2024)
   PUBMED   39413134
  REMARK    GeneRIF: BLNK negatively regulates innate antifungal immunity
            through inhibiting c-Cbl-mediated macrophage migration.
REFERENCE   2  (bases 1 to 5083)
  AUTHORS   Li,X., Sun,W., Huang,M., Gong,L., Zhang,X., Zhong,L., Calderon,V.,
            Bian,Z., He,Y., Suh,W.K., Li,Y., Song,T., Zou,Y., Lian,Z.X. and
            Gu,H.
  TITLE     Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T
            follicular helper cell responses and lupus by reducing BCL6
            degradation
  JOURNAL   Immunity 57 (7), 1603-1617 (2024)
   PUBMED   38761804
  REMARK    GeneRIF: Deficiency of CBL and CBLB ubiquitin ligases leads to
            hyper T follicular helper cell responses and lupus by reducing BCL6
            degradation.
REFERENCE   3  (bases 1 to 5083)
  AUTHORS   Liang,L., He,M., Zhou,P., Pan,S., Chen,J., Lv,L., Hu,M., Zhou,S.,
            Liu,D. and Liu,Z.
  TITLE     c-Cbl induced podocin ubiquitination contributes to the podocytes
            injury in diabetic nephropathy
  JOURNAL   FASEB J 38 (10), e23662 (2024)
   PUBMED   38752545
  REMARK    GeneRIF: c-Cbl induced podocin ubiquitination contributes to the
            podocytes injury in diabetic nephropathy.
REFERENCE   4  (bases 1 to 5083)
  AUTHORS   Huang,L., Thiex,N.W., Lou,J., Ahmad,G., An,W., Low-Nam,S.T.,
            Kerkvliet,J.G., Band,H. and Hoppe,A.D.
  TITLE     The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by
            controlling CSF-1R import into macropinosomes
  JOURNAL   Mol Biol Cell 35 (3), ar38 (2024)
   PUBMED   38170572
  REMARK    GeneRIF: The ubiquitin ligases Cbl and Cbl-b regulate macrophage
            growth by controlling CSF-1R import into macropinosomes.
REFERENCE   5  (bases 1 to 5083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5083)
  AUTHORS   Blake,T.J. and Langdon,W.Y.
  TITLE     A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma
            cells results in a truncated protein
  JOURNAL   Oncogene 7 (4), 757-762 (1992)
   PUBMED   1565471
REFERENCE   7  (bases 1 to 5083)
  AUTHORS   Ballantyne,C.M., Kozak,C.A., O'Brien,W.E. and Beaudet,A.L.
  TITLE     Assignment of the gene for intercellular adhesion molecule-1
            (Icam-1) to proximal mouse chromosome 9
  JOURNAL   Genomics 9 (3), 547-550 (1991)
   PUBMED   1674500
REFERENCE   8  (bases 1 to 5083)
  AUTHORS   Eng,C.M., Kozak,C.A., Beaudet,A.L. and Zoghbi,H.Y.
  TITLE     Mapping of multiple subunits of the neuronal nicotinic
            acetylcholine receptor to chromosome 15 in man and chromosome 9 in
            mouse
  JOURNAL   Genomics 9 (2), 278-282 (1991)
   PUBMED   2004777
REFERENCE   9  (bases 1 to 5083)
  AUTHORS   Bergeron,D., Poliquin,L., Kozak,C.A. and Rassart,E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
REFERENCE   10 (bases 1 to 5083)
  AUTHORS   Morris,V.L., Rao,T.R., Kozak,C.A., Gray,D.A., Lee Chan,E.C.,
            Cornell,T.J., Taylor,C.B., Jones,R.F. and McGrath,C.M.
  TITLE     Characterization of Int-5, a locus associated with early events in
            mammary carcinogenesis
  JOURNAL   Oncogene Res 6 (1), 53-63 (1991)
   PUBMED   1705320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029826.1, AK085140.1 and AC148328.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_916663.1, XM_903344.1, NM_007619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153915.1, AK029826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AK029826.1         5-351
            348-595             AK085140.1         292-539
            596-1584            AK029826.1         599-1587
            1585-2754           AK085140.1         1530-2699
            2755-5083           AC148328.3         140742-143070       c
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.72 cM"
     gene            1..5083
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /note="Casitas B-lineage lymphoma"
                     /db_xref="GeneID:12402"
                     /db_xref="MGI:MGI:88279"
     exon            1..347
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2900
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /EC_number="2.3.2.27"
                     /note="proto-oncogene c-CBL; signal transduction protein
                     CBL; casitas B-lineage lymphoma proto-oncogene; RING-type
                     E3 ubiquitin transferase CBL"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL"
                     /protein_id="NP_031645.2"
                     /db_xref="CCDS:CCDS40598.1"
                     /db_xref="GeneID:12402"
                     /db_xref="MGI:MGI:88279"
                     /translation="MAGNVKKSSGAGGGGSGGSGAGGLIGLMKDAFQPHHHHHHLSPH
                     PPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEG
                     KMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHML
                     AELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLE
                     AMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVK
                     ARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGF
                     YLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIE
                     PCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPS
                     PNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVP
                     ASTSVLGTASKAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCT
                     PGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPS
                     QMEPRADVPRLGSTFSLDTSMTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPMP
                     KLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEATQSSRACDCDQQIDSCTYEAM
                     YNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSD
                     ISNASSSFGWLSLDGDPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGATANPV
                     ATAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT"
     exon            348..595
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..742
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..899
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1021
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1159
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1247
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1379
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1583
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1715
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2093
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2188
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2329
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2427
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2607
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..5083
                     /gene="Cbl"
                     /gene_synonym="4732447J05Rik; c-Cbl; Cbl-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctcgcg cccgcgcagg ggcgcgcctc agggcgggcg cctccctctc actccctggg
       61 ctgcgagcgc cggcggtggt tgccggagag gcccctcctt ctcgcccggc tccattccct
      121 cgctcgcggc cgagcgggct cccgaccctc cgctggccat ggccggcaac gtgaagaaga
      181 gctcgggcgc cggcggcggc ggctctgggg gctcgggagc gggcggcctg atcgggctca
      241 tgaaggacgc cttccagccg caccaccacc accaccacct cagcccgcac cctccctgca
      301 cggtggacaa gaagatggtg gagaagtgct ggaagctcat ggacaaggtg gtgcggttgt
      361 gtcaaaaccc aaagctggcg ctcaagaaca gcccgcctta tatcttagac ctgctgcctg
      421 acacctacca gcacctccgc actgtcttgt caagatatga ggggaagatg gagacgcttg
      481 gagaaaatga gtatttcagg gtgttcatgg aaaatttgat gaagaaaact aagcagacta
      541 tcagcctctt caaggaggga aaagaaagga tgtatgagga gaattcccag cctaggcgaa
      601 acctgaccaa attatccctg atcttcagcc acatgctggc agaactgaaa ggcatctttc
      661 cgagcggact cttccaagga gacactttcc ggattactaa agctgatgct gccgaatttt
      721 ggagaaaagc ttttggtgaa aagacgatag tcccgtggaa gagctttcga caggccctgc
      781 atgaagtgca tcccatcagt tctgggctgg aggccatggc tctgaagtcc actattgatc
      841 tgacctgcaa tgattatatt tctgtctttg aatttgatat ttttacacgg ctgtttcagc
      901 cctggtcctc tttgctcaga aattggaaca gccttgctgt aactcaccct ggttacatgg
      961 ctttcctgac atacgatgaa gtgaaagcgc gcctgcagaa gttcatccac aaacctggca
     1021 gttacatctt tcggctgagc tgtactcgtt tgggtcagtg ggctattggg tatgttactg
     1081 ccgatgggaa cattctgcag acaatcccac acaataaacc gctcttccaa gcactgattg
     1141 atggcttcag ggaaggcttc tatttgtttc ctgatggacg aaatcaaaat cctgacctga
     1201 caggtttatg tgaaccaact cctcaagatc atatcaaagt aacccaggaa caatatgaat
     1261 tatactgtga aatgggctcc acatttcaac tgtgtaagat atgtgctgag aatgataagg
     1321 atgtgaagat tgagccctgt ggacacctca tgtgcacatc ctgcctcacg tcgtggcagg
     1381 aatcagaagg tcagggctgt cctttttgcc gatgtgaaat caaaggtact gagcccatcg
     1441 tggtggatcc gtttgacccc agaggcagtg gcagcctatt aaggcaagga gcagaaggtg
     1501 ctccttcccc aaattacgac gatgatgatg atgaacgagc tgatgattct ctcttcatga
     1561 tgaaggagtt ggcaggtgcc aaggtggaaa ggccttcctc tccattctcc atggccccac
     1621 aagcttccct tcctccagtg ccaccaagac ttgaccttct acagcagcga gcacctgttc
     1681 ctgccagcac ttcagttctg gggactgctt ccaaggctgc ttctggctcc cttcataaag
     1741 acaaaccatt gccaatacct cccacacttc gagatcttcc accaccaccc cctccagacc
     1801 ggccttactc tgttggagca gaaacaaggc ctcagagacg ccctctgcct tgtacaccag
     1861 gcgattgtcc atctagagac aaactgcccc ctgtcccttc tagccgccca ggggactcgt
     1921 ggttgtctcg gccaatccct aaagtaccag tagctactcc aaaccctggt gatccttgga
     1981 atgggagaga attgaccaat cggcactcgc ttccattctc attgccctca caaatggaac
     2041 ccagagcaga tgtccctagg cttggaagca catttagtct ggatacctct atgactatga
     2101 atagcagccc agtagcaggt ccagagagtg agcacccaaa gatcaagcct tcctcgtctg
     2161 ccaacgccat ttactctctg gctgccaggc ctcttcctat gccaaaactg ccacctgggg
     2221 agcaagggga aagtgaagag gacacagaat atatgactcc cacatctagg cctgtagggg
     2281 ttcagaagcc agagcccaaa cggccgttag aggcaaccca gagttcacga gcatgtgact
     2341 gtgaccagca gatcgacagc tgtacctatg aagcgatgta taacatccag tcccaagcac
     2401 tgtctgtagc agaaaacagc gcctctgggg aagggaatct ggccacagct cacacgagta
     2461 ctggccctga ggaatccgaa aacgaggatg atggctatga tgtgcctaag ccacccgtgc
     2521 cagctgtact ggcccgccgg accctgtctg acatctccaa tgccagctcc tcctttggct
     2581 ggttgtcttt ggatggtgac cctacaaact tcaatgaggg ttcccaagtt cctgagcggc
     2641 cccccaaacc attccctcgg agaatcaact cagaacgaaa agccagtagc tatcaacaag
     2701 gcggaggtgc cactgctaac cctgtggcca cagcaccctc accgcagctc tcaagtgaga
     2761 ttgaacgcct catgagtcag ggctattcct accaggacat tcagaaagct ttggtcattg
     2821 cccacaacaa cattgagatg gctaaaaaca tcctccggga atttgtttct atttcttctc
     2881 ctgctcacgt agccacctag cacatctctc cctgccacgg cttcagagga cccatgagcc
     2941 aggctcttac tcaaggacca cctaggaaag cagtggcttc ttttgggacg tcacagtaag
     3001 gtcctgcctt tcctgtgggg atcgacacat atggttccaa gatttcaaag cagtggaatg
     3061 aaaatggagc agctgatgtg tttcattgtt gtattggtct taagagtgtt tttgtagtcc
     3121 tgcagtctcc agtaggagag agtgggtttt tattaaatgg taacctaccc cagaaacagc
     3181 acaggaagca gtagcagtgc tgtgctgtgg ccctaattaa ggacttaagg ctttcctgtt
     3241 aagggtgtgt gtctctgttg tctgtgtgtc ctgtcattat aagattatcc tgctgtgtgt
     3301 gaatccaggc agggagttag cacaagagct tcaggaagga atctctgaag actcccatct
     3361 actgtggaat tgcacctagc cctgctggat actgtaacct caatcctccc ctttggctta
     3421 gattatcatg tacttagcta tgttttatat tgttagaaca accaatgtcc tttcccttgg
     3481 aaactcctta cttcacctcc tcctcattgg tgttctgtag gcttgccgtg accagtctta
     3541 ctgaaaccaa gcagcttata ggatggtctt tctaatgcgt gatggtgttg gtttgtttgg
     3601 tagactaagt gggaaggaaa gtactgttct gtggctaatt gatgctagca cctaacactg
     3661 gtcactccaa agtgctgttt ctataggaat gttgaatttg tttttgtttt tgttttttaa
     3721 agaagtttta attctcctag ttacctaatg accgatttga gatagaggcc ttcatataca
     3781 ttccgtgtcc tccccaggac atagcctgtg ggagtcggtt gccttgatgc caggtgtatg
     3841 tttctgatgt aggtcatgag tgtttctgcc taacaggaac agaacatttg tttccagggt
     3901 ggctttccaa cccaaaacca tagagctttt aggaagcgtc agtcatatat agatttacaa
     3961 aataaacagc taggacttat ctgtttagtc tttcttgcca gtggctaact tcagcttagg
     4021 aatttctccc ttgaatggga gccaggtaag cctttcagaa atgatttctt cttttgccct
     4081 gtgaggaacg gagctaacac cagtgaggac agcatttgct gatggcttct ctagattggt
     4141 gcacccagtg acttggttgt ccatgtgcct agcttgtgct ttggaatggt ttctctttcc
     4201 ttttccttgc cttttttatt gggtcctaga tgtaaccgct gtgtcatcca tctacagtat
     4261 ttagttatca ttcattggaa ttctttagct agacggtttg gaacagtgta atagtttgtg
     4321 tatttacagg ttcatcaagg agatgtaatt tgttttggag agtccgtttc tacgtcatcg
     4381 tagtgacctc ttgggttcag tttgttctct gactggagtc ttgctggctt ctctgacagc
     4441 gttgcccttt ctcctgttga gtacgagctg gcttttacat gaatcctctc tgttctttag
     4501 gtccaggcag aaatgaccca ccaagaatct gctttctttc cagtcttttg caacaaaaat
     4561 cttttgaact cttcttttag tttcttgatg cttcaaggtc tggattttat cctcttacct
     4621 taaggctatt cgaaaggcag atacggtatc tatggctacc cagtgtcttc tctacatagc
     4681 aatgagtaga aaacaatagc ttgtcatcca caaaaagttt gtgatatcca attttgtgtt
     4741 catttgaata ctgaaagcct aagccaggct tggtggcatc tcagcacctg agagatggtg
     4801 gcaagatgat caggagttca gcaccagctc aaagctcctg aaaccctgtc tcaaaaataa
     4861 caggggttaa agagatgact tcagttcaga gcagctcttc ttgcagagga cctaggtttg
     4921 gttcctagca cccacatgaa aggtttctca gatgtataag caactcacaa ccatctataa
     4981 cttcagttca gagcaatctg atgccctctt ctggcttctg tgggcaccag gcacacatac
     5041 gatgtacata tatacaggca ggtagagcat taaataaata cat
//
