LOCUS       NM_001109873            7678 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CBFA2/RUNX1 translocation partner 3 (Cbfa2t3),
            transcript variant 2, mRNA.
ACCESSION   NM_001109873
VERSION     NM_001109873.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7678)
  AUTHORS   Lamacova,L., Jansova,D., Jiang,Z., Dvoran,M., Aleshkina,D.,
            Iyyappan,R., Jindrova,A., Fan,H.Y., Jiao,Y. and Susor,A.
  TITLE     CPEB3 Maintains Developmental Competence of the Oocyte
  JOURNAL   Cells 13 (10), 850 (2024)
   PUBMED   38786074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7678)
  AUTHORS   Kim,D., Ha,S.K. and Gonzalez,F.J.
  TITLE     CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid
            Accumulation in Mouse Liver
  JOURNAL   Cells 13 (10), 831 (2024)
   PUBMED   38786053
  REMARK    GeneRIF: CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced
            Lipid Accumulation in Mouse Liver.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7678)
  AUTHORS   Asgarian,Z., Oliveira,M.G., Stryjewska,A., Maragkos,I., Rubin,A.N.,
            Magno,L., Pachnis,V., Ghorbani,M., Hiebert,S.W., Denaxa,M. and
            Kessaris,N.
  TITLE     MTG8 interacts with LHX6 to specify cortical interneuron subtype
            identity
  JOURNAL   Nat Commun 13 (1), 5217 (2022)
   PUBMED   36064547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7678)
  AUTHORS   Hendrikse,L.D., Haldipur,P., Saulnier,O., Millman,J., Sjoboen,A.H.,
            Erickson,A.W., Ong,W., Gordon,V., Coudiere-Morrison,L.,
            Mercier,A.L., Shokouhian,M., Suarez,R.A., Ly,M., Borlase,S.,
            Scott,D.S., Vladoiu,M.C., Farooq,H., Sirbu,O., Nakashima,T.,
            Nambu,S., Funakoshi,Y., Bahcheli,A., Diaz-Mejia,J.J., Golser,J.,
            Bach,K., Phuong-Bao,T., Skowron,P., Wang,E.Y., Kumar,S.A.,
            Balin,P., Visvanathan,A., Lee,J.J.Y., Ayoub,R., Chen,X., Chen,X.,
            Mungall,K.L., Luu,B., Berube,P., Wang,Y.C., Pfister,S.M., Kim,S.K.,
            Delattre,O., Bourdeaut,F., Doz,F., Masliah-Planchon,J.,
            Grajkowska,W.A., Loukides,J., Dirks,P., Fevre-Montange,M.,
            Jouvet,A., French,P.J., Kros,J.M., Zitterbart,K., Bailey,S.D.,
            Eberhart,C.G., Rao,A.A.N., Giannini,C., Olson,J.M., Garami,M.,
            Hauser,P., Phillips,J.J., Ra,Y.S., de Torres,C., Mora,J.,
            Li,K.K.W., Ng,H.K., Poon,W.S., Pollack,I.F., Lopez-Aguilar,E.,
            Gillespie,G.Y., Van Meter,T.E., Shofuda,T., Vibhakar,R.,
            Thompson,R.C., Cooper,M.K., Rubin,J.B., Kumabe,T., Jung,S.,
            Lach,B., Iolascon,A., Ferrucci,V., de Antonellis,P., Zollo,M.,
            Cinalli,G., Robinson,S., Stearns,D.S., Van Meir,E.G., Porrati,P.,
            Finocchiaro,G., Massimino,M., Carlotti,C.G., Faria,C.C.,
            Roussel,M.F., Boop,F., Chan,J.A., Aldinger,K.A., Razavi,F.,
            Silvestri,E., McLendon,R.E., Thompson,E.M., Ansari,M., Garre,M.L.,
            Chico,F., Eguia,P., Perezpena,M., Morrissy,A.S., Cavalli,F.M.G.,
            Wu,X., Daniels,C., Rich,J.N., Jones,S.J.M., Moore,R.A., Marra,M.A.,
            Huang,X., Reimand,J., Sorensen,P.H., Wechsler-Reya,R.J.,
            Weiss,W.A., Pugh,T.J., Garzia,L., Kleinman,C.L., Stein,L.D.,
            Jabado,N., Malkin,D., Ayrault,O., Golden,J.A., Ellison,D.W.,
            Doble,B., Ramaswamy,V., Werbowetski-Ogilvie,T.E., Suzuki,H.,
            Millen,K.J. and Taylor,M.D.
  TITLE     Failure of human rhombic lip differentiation underlies
            medulloblastoma formation
  JOURNAL   Nature 609 (7929), 1021-1028 (2022)
   PUBMED   36131014
  REMARK    Erratum:[Nature. 2022 Dec;612(7940):E12. doi:
            10.1038/s41586-022-05578-0.. PMID: 36446943]
REFERENCE   5  (bases 1 to 7678)
  AUTHORS   Brown,R.E., Jacobse,J., Anant,S.A., Blunt,K.M., Chen,B., Vega,P.N.,
            Jones,C.T., Pilat,J.M., Revetta,F., Gorby,A.H., Stengel,K.R.,
            Choksi,Y.A., Palin,K., Piazuelo,M.B., Washington,M.K., Lau,K.S.,
            Goettel,J.A., Hiebert,S.W., Short,S.P. and Williams,C.S.
  TITLE     MTG16 regulates colonic epithelial differentiation, colitis, and
            tumorigenesis by repressing E protein transcription factors
  JOURNAL   JCI Insight 7 (10), e153045 (2022)
   PUBMED   35503250
  REMARK    GeneRIF: MTG16 regulates colonic epithelial differentiation,
            colitis, and tumorigenesis by repressing E protein transcription
            factors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7678)
  AUTHORS   Goardon,N., Lambert,J.A., Rodriguez,P., Nissaire,P., Herblot,S.,
            Thibault,P., Dumenil,D., Strouboulis,J., Romeo,P.H. and Hoang,T.
  TITLE     ETO2 coordinates cellular proliferation and differentiation during
            erythropoiesis
  JOURNAL   EMBO J 25 (2), 357-366 (2006)
   PUBMED   16407974
  REMARK    GeneRIF: The dynamics of ETO2 recruitment within nuclear complexes
            couple cell proliferation to cell differentiation and determine the
            onset of terminal erythroid maturation.
REFERENCE   7  (bases 1 to 7678)
  AUTHORS   Schuh,A.H., Tipping,A.J., Clark,A.J., Hamlett,I., Guyot,B.,
            Iborra,F.J., Rodriguez,P., Strouboulis,J., Enver,T., Vyas,P. and
            Porcher,C.
  TITLE     ETO-2 associates with SCL in erythroid cells and megakaryocytes and
            provides repressor functions in erythropoiesis
  JOURNAL   Mol Cell Biol 25 (23), 10235-10250 (2005)
   PUBMED   16287841
  REMARK    GeneRIF: association with T-cell acute lymphocytic leukemia 1,
            ETO-2 represses gene expression in the early stages of erythroid
            differentiation
REFERENCE   8  (bases 1 to 7678)
  AUTHORS   Ibanez,V., Sharma,A., Buonamici,S., Verma,A., Kalakonda,S.,
            Wang,J., Kadkol,S. and Saunthararajah,Y.
  TITLE     AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor
            corepressor, an effect that impairs granulocyte differentiation
  JOURNAL   Cancer Res 64 (13), 4547-4554 (2004)
   PUBMED   15231665
REFERENCE   9  (bases 1 to 7678)
  AUTHORS   Davis,J.N., Williams,B.J., Herron,J.T., Galiano,F.J. and Meyers,S.
  TITLE     ETO-2, a new member of the ETO-family of nuclear proteins
  JOURNAL   Oncogene 18 (6), 1375-1383 (1999)
   PUBMED   10022820
REFERENCE   10 (bases 1 to 7678)
  AUTHORS   Calabi,F. and Cilli,V.
  TITLE     CBFA2T1, a gene rearranged in human leukemia, is a member of a
            multigene family
  JOURNAL   Genomics 52 (3), 332-341 (1998)
   PUBMED   9790752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041887.1, BB658300.1, AK033680.1, AC151999.5 and AA221901.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an in-frame portion of the 5' coding region compared to
            variant 1. The resulting protein (isoform 2) is shorter and has a
            distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041887.1, SRR7974084.20429.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               AK041887.1         2-417
            417-865             BB658300.1         160-608
            866-1293            AK033680.1         685-1112
            1294-2863           AK041887.1         1297-2866
            2864-7621           AC151999.5         153335-158092       c
            7622-7678           AA221901.1         343-399
FEATURES             Location/Qualifiers
     source          1..7678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.93 cM"
     gene            1..7678
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="CBFA2/RUNX1 translocation partner 3"
                     /db_xref="GeneID:12398"
                     /db_xref="MGI:MGI:1338013"
     exon            1..314
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..461
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..2098
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein CBFA2T3; ETO/MTG8-related protein ETO-2; myeloid
                     translocation gene-related protein 2; MTG8-related protein
                     2; eight twenty one protein 2"
                     /codon_start=1
                     /product="protein CBFA2T3 isoform 2"
                     /protein_id="NP_001103343.1"
                     /db_xref="CCDS:CCDS52697.1"
                     /db_xref="GeneID:12398"
                     /db_xref="MGI:MGI:1338013"
                     /translation="MPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGED
                     GPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLST
                     QHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKL
                     QEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPV
                     DSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHP
                     TPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREW
                     AEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTP
                     ISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKA
                     VSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASET
                     CSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDATASPSEAGSAG
                     PSRPCSPGPPGPLDAAVPR"
     exon            462..539
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..781
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..871
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1053
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1283
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1369
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1568
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1637
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1828
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..7669
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="hexamer: AATAAA"
     polyA_site      4066
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="major polyA site"
     regulatory      7645..7650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="hexamer: AATAAA"
     polyA_site      7667
                     /gene="Cbfa2t3"
                     /gene_synonym="A630044F12Rik; Cbfa2t3h; ETO-2; Eto2;
                     MTGR2"
                     /note="major polyA site"
ORIGIN      
        1 gactcggtga gacgcgcggg cgagcgcgcg gcagcagagc cgaaagcacg gcggctggac
       61 ccggcggccg ccgaggccga aaccacccgg gcagcgtgcg ggctttgttc ccgcgctggg
      121 ggccgaacgc actcggcatg gcccaggcgg tcgccccgcg cgccccgacc ccgccgcgcg
      181 cctgagcccc gcgcagcgcg agaagacagc gtacggatcg cccccaagtt atggaggtgg
      241 cgacccagtg agaaggaaaa gccacttcgg gagccgggtt gcgagagagc tacggtcccc
      301 tggagctcca gaccctcaca ggaaggagaa ggctgcagca atgccagact ccccggctga
      361 agtgaagacg cagccccggt ccacaccccc cagcatgccg cccccacctc ccacctcatc
      421 ccagggagcc acacgaccac cctccttcac acctcacaca catggcgagg atggacctgc
      481 gacgtctctt ccccatggcc gtttccacgg ctgcttaaag tggtccatgg tctgtctctt
      541 gatgaacggc agcagccact cacccacggc catccacggt gccccatcta cacccaatgg
      601 cttcagcaac ggcccagcca cctcatccac ggcctcgctc tccacacagc acctgccccc
      661 ggcgtgcggg gcacggcagc tcagcaagct taagcgtttc ctcaccaccc tacagcagtt
      721 tggcagtgac atctcacctg agatcgggga gcgcgtgcgc acactggtgc tgggcctggt
      781 gaactcaact ctgacgatcg aagagtttca tgccaagctc caggaagcca ccaactttcc
      841 actgaggccg tttgttatcc cttttctgaa ggctaatctt ccactgctgc agcgtgagct
      901 cctgcactgt gcccgcctgg ccaaacagac acctgcccag tacctggccc agcacgaaca
      961 gctgctgctg gacgccagcg ccacctcccc tgtcgactcg tctgagctcc tgctggaagt
     1021 caacgagaac ggcaaaagga gaacacctga caggaccaaa gagaatggat cagaccggga
     1081 ccctctgcac cccgaccacc tcagtaagcg gtcctgcacc ctgagccccg cccagcgctg
     1141 cagccccagc aatgggctgc cccacccgac gccaccccca cccccgcact atcgcctgga
     1201 ggacatggcc atggcccacc atttccggga ctcctaccgc catcctgatc cccgagagct
     1261 acgggaacgc caccggcccc tggccatacc tgggtctcga caagaagaag tgattgatca
     1321 caggctcaca gaacgcgagt gggcagaaga atggaagcac ctcaacagtc ttctgaactg
     1381 catcatggac atggtggaga agacccggcg atccctcacc gtcctgcgcc ggtgtcagga
     1441 ggccgaccgt gaggaactca accactggat ccggtgctac agtgactctg aggaggggaa
     1501 gaagggccct acccccatct ctgcccggtc cctcaacagc tgcagtggcc ctgaggggtc
     1561 tcagctagat gttcaccggg acttcacgcc caggaccctg tctggctaca tgcctgaaga
     1621 gatctggagg aaggctgaag aagctgtgaa tgaggtgaag cgccaggcca tgtcagaact
     1681 acagaaagct gtgtctgatg cggagcgcaa agcccatgaa ctcatcacca cagagcgtgc
     1741 caagatggaa cgagccctgg cggaggccaa gcgacaggcc tcggaggatg ccctgactgt
     1801 catcaaccag caagaggact ccagcgagag ctgctggaac tgcgggcgca aggccagcga
     1861 gacgtgcagt ggctgtaacg ccgcccgcta ctgcgggtcc ttctgtcagc acaaagactg
     1921 ggagaaacac catcacgtgt gcggccagag tctgcagggc cccgcggctg cagtggctga
     1981 cccactacct ggacagcctg acgccactgc cagccccagc gaagccggct cggcagggcc
     2041 ctctcgtccc tgctctccgg ggccgccagg cccgctggac gctgctgtgc cccgctgacc
     2101 tccagatctg acacccagcc catggacgcc atgccctgcc aacctcctgg ccccaccgtg
     2161 gcccaccagt tgcctggagc cattgctgct actgcttctc tccaaaagaa aacacagatc
     2221 caacagaact gcatccgtgc agccccagct acctgacaag gtctgccggg acctctacag
     2281 cctctcgtcc atcgcaagca ccctcagaaa gcatcgcaga gcgtcagaca gtggcaccag
     2341 caggagtgtg gccagctccg ccgctgtctg tcccctctgt gtccgtctct ctgtgtccgt
     2401 ctgtctttct gcgtctgcct ctctctgtgt gtctctccgt gtctttgtct cctgccgttt
     2461 ccctgactct ccggcgtctc tgtctttgta aagtccacat gatctctctg tcatcagaga
     2521 aacctagttg gtagcttttc ttttccatga agaacttttg gagattttgt tttgttttgt
     2581 tggcaaacaa gctacttaga aatggacaaa gaagactgtg gggttctccc cattcctcat
     2641 gagtaaggga agaaactgtg atttttctat ccagagttgc tgtatcgccc agccagcccc
     2701 aggggcatca gcgagcacac agcagagata atgagagcaa ctgcaatttc caacttaaga
     2761 agcagctttt gtttcaggtt ttactccttt aatgtcaaac tctttggctt taagtgaaaa
     2821 aaaaaaaaag gaaaaaaaaa tccaaaaagt tttttttttt tttaagcaaa agaaacacac
     2881 ctgtaaacta ccttgccagc tagccagcca aggatgccag acacacctcg ctccaaagga
     2941 agcccaaaaa agcaaactca agaaattgaa atccaaaatt tatttttatc actgccaaag
     3001 tattttcttc atggtctctc cgccctgggt tggtttgcat gtcagtcttt gatttgggtt
     3061 ttgattttgt tcagggggtg ttgggatgct gggatttggt gggtggggcc aagaagaaac
     3121 cttttgttcc tttttgacta gtaggcagca tccttgctgg gcagagccat cggcagcaag
     3181 gccacgtgac cctcagcacc gcatccagaa gccccagtca gcgtgagcct gagcgttgtg
     3241 tgccctaggg ctccgtccat gcgttcccta catgcaaggg aggcacctcc ttccatcggt
     3301 ccccacacct tcctgggact tctcataagt catttccact tgtgaaaaaa aaaaaagtgc
     3361 taaagtgctc ttcccagaga gagcacactt cctaaacgaa actgtgacaa tctttttggt
     3421 tgattcttga ctgcttttga gagcataagg agacagcaaa tcacgctttc tcagttttcc
     3481 ctcctctacc tctctgctct tccatcccac cctacctcca tctcggcccc atcaccctgc
     3541 ccccagtgtc ttgctgtggc taccctcatt tctttcaaac ttttacagaa aaaaaggaaa
     3601 aagaaaaaaa aaaaacacga aagccagcag ccacccgcac ctcacccgga agactccagc
     3661 ccggctgtac atatccctgt gttgtatccc caatgttggt ctccagtcct gggggtgacg
     3721 gtgatgcttg cccatctaca ctctagcccc tgcccaccct gcccttcgcc cgctcgactc
     3781 cctcaaggat tcaaggagga aatgaaggaa gaaggctcat gcctgtacca aacaaaaaga
     3841 gacagcagac tcagtccagg tctgcacctc tgttgtggct gcagcaagcc gcaggcctag
     3901 cgtgcaatat gggggattgc tcctgaaccc tgggcccggg ggggccctgc ccagagcaag
     3961 gtgtgcagcg tgtgttaatg tgaatgtaca tagtctccac agaggtccca aaccgtggca
     4021 tcagtaccga ggagatgttt gccaaataaa aagaaattaa gacaaaccac ggaagtctgt
     4081 gaggtttagg aaacgctttg gaaggagtct gagtcctata ggcttctttg gtggctggtg
     4141 tttcttcaca gctgtatgac cattgtttaa cagaacgttc tatggattct gttgggtagc
     4201 ccggaatgga gcctgacagc aacccttgct cggaaggctg gggtagatct cattccctgg
     4261 aaggttcccg cggccgcagc cctccaaggc cgcagagatg tattcttgtg ggtttcagag
     4321 aagccaggac acaaggcggc ctcctgcctg cccgcccttc tctagtggac cagtcctcct
     4381 gagcgtctgc ctgcaaacac tgagtctgtg tgctggtaga gcgagacctg cctcccgtcg
     4441 caaggagcat cactggattc cattcccaac tgtaccccat gcggtacttc ttgtctctgc
     4501 tactccactg catgcagcaa ccttggccct tccagaaggg caggccagtg accactggta
     4561 ggaaagagct ctgggtgatg gggtggtgag caccatgttg gggggggggg ggaacaaagc
     4621 taagcccctc aggttgtgct taagagctgt agtctctaga agtccgggcc aggagtcctg
     4681 aggtggcatt cctgatgacc tacgtccctg gtgtcaggac ttcggagcac ctgctcctat
     4741 gtggtccaga tattctgagg taggtcccaa agggtcacca gtttgcttta gttcaaatac
     4801 ctcctttctt acccttacca gccttaccca ccttttagga acagagggcc caccacagac
     4861 aacaaaatgc tgcccagcca aattcatctc catgagccag gttacatatt tagggtttag
     4921 cagagacacc acccccccat ctatactcta gccgttggga gcgacagccc ctcaaggcgg
     4981 ctgtcagatg gcattggacc acagtgagtc tcctgtgcat gggatttgac tagcaattgt
     5041 agacatcgag ggtgagatgc catgtctgct aggcagagct caggagtcaa ggcaagtgca
     5101 gaatcagggt ggcagggaga tggggctgga aagggttagg tgtcgcctga ggcaaggagg
     5161 ctggaggata aggtggggtt gctaagccgg gcaccgaggc cctggctaag ctgtgagttg
     5221 tgctttgacc ccagctaccc agagacctca cagcacaacc agacaacctc acagctttga
     5281 agggacaggg accatgggtg ttctttattg ggaggtatac cctgggtggc cataaccgca
     5341 gcctaccctt ggtttcaacc tacagtctgc ctggggctct ccacagagct gggggcgggg
     5401 catggtactc catccccatc cctgctacct ttctctggtt cacacaccat ggacccaggc
     5461 cctgcctcct gggaaccaca gccaagcatg aaccaaaccc cctaggcgat gtggctctca
     5521 cagagccttg ctcccccaga gcctccaact cagaatacca ctttacttcc tgttctgtgg
     5581 ccaaagctaa accaggaagg ctgagtaggg agggcaggta gcaggcagag ctctccaacc
     5641 cccaaggccc agcccagatc ccatctcatg accttatggc ttcttggcac aagtcctgtg
     5701 tgtcccagcc ctgcctcaga cccagactgg cctttccgtg aggactaccc aagagactac
     5761 tttccagctc agtcctaagc tctgctcagg agcggaggcc agtgtttctc ctcccaggtg
     5821 tggtcacagc tggataggaa ctggctgaat gacaccacag ctcaggtccc acccactgcc
     5881 tgacaagtga gaggagccag cccccagggg agcacccaga aggattcagt taacagggac
     5941 atctgtcaga agacctgaga gggttagctg gggatggaga aggccaagaa tgggaggcgg
     6001 ggcctctgtg ggcagtgtca ccttaaggcc acagtgggca gggatcagga tgggacccaa
     6061 agtttagttt ctccaaataa atcattaggc tgacaccaaa gtatcatccc ggcacccatc
     6121 tgtcctggca tccatctgtc cactcttgta ctcctcagcc taacggacag atcaacgctt
     6181 tcctgagctc ctccttctga cacgtgcagc catcttccca tgaacccgtt tgcctctgac
     6241 cattcatcat cctctgcctc ccttccagcc aactaccccc atctatctat cttgacccat
     6301 tggcaaatcc atctttccac ctgtccattg ctccatccaa actgtctctc caccccacca
     6361 tcccagcata ctatacctac gcccttacac cttccagccc catgcacaca accatgttcc
     6421 ctatcatctc tctattcact gtactcagag ttctgtcagc tccatcagtg taccaaagac
     6481 accaggtcct cctacgccct ctactctgct tggcctaaac tgtccagggc tgctctagga
     6541 atatctaccc atgaggcaac aggcgtctcc cacccctggc actctgcccc accatggtgt
     6601 tcagatacct ccagaaatat gagttcttac cgtaggcatc gtgggcaggt tggatacatt
     6661 cttgtggcag ctgtgacaca tctggagctg cttggggaga gaagggaaca agaattgtgc
     6721 tgtggggtgg gtctgtacgc ctgctcacga gctctggaag cctgggttag gcagccacgt
     6781 tccctgaaat tagggcaaag tccttgtttc caggagtctg tccagaagag agcaagccag
     6841 ggctggcctc ccttgacacc ggggtgctct tagtcccctg tgcccctgga cttttgtgca
     6901 ccattcccat cttctctgtt aggatcccga ggagctcaga gttggacctg tccggtctgc
     6961 ccctcctcaa tccacggatg gaaaggagta tttgctgggt gtttgggacc attcacaagt
     7021 ccccctggga actccttgct catcctgaag ctcctactat gtagggaagc ttctgaaatg
     7081 aggctgggca gagacccctg ggtacccatc atgctggcaa gaggaagaga agatagggag
     7141 agaagcctga ggcgagctgg gctcaggggg actgtctatt cctggagaca gctcacagat
     7201 aaagcccagg acagtcaacc aacaactcgc acaagtcccc aaatcctaga aacctctgtc
     7261 ttgtgttctg ttccttttcc ttccgttcag ctggccctta gggtaccaag ccagactggg
     7321 agacaggaat gcagcatctg agtcaaagca tggcctgctc agcacatcct cctgctccca
     7381 acccagacaa gaggcccagg agccctcagc tcacaccata cctggggtga gcatagcatc
     7441 acacagcctg cctggggagc cactgcttct ccccctacag gagctgggag gagagtactg
     7501 gatgttttgt tcatgaaaag ctgtgttcca tgccctacac atctatctgg gtgctgggtc
     7561 ccgccaccca cctctatcta ctgctgtcct atatgtttgc cctgtgggcc acggatgtgg
     7621 cgatcaggtt aattacatct gtgtaataaa gtaagcattt gctacgacga aaaaaaaa
//
