LOCUS       NM_138741               3069 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus caveolae associated 2 (Cavin2), mRNA.
ACCESSION   NM_138741
VERSION     NM_138741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Higuchi,Y., Ogata,T., Nakanishi,N., Nishi,M., Tsuji,Y., Tomita,S.,
            Conway,S.J. and Matoba,S.
  TITLE     Cavin-2 promotes fibroblast-to-myofibroblast trans-differentiation
            and aggravates cardiac fibrosis
  JOURNAL   ESC Heart Fail 11 (1), 167-178 (2024)
   PUBMED   37872863
  REMARK    GeneRIF: Cavin-2 promotes fibroblast-to-myofibroblast
            trans-differentiation and aggravates cardiac fibrosis.
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Higuchi,Y., Ogata,T., Nakanishi,N., Nishi,M., Sakamoto,A.,
            Tsuji,Y., Tomita,S. and Matoba,S.
  TITLE     Requirement of Cavin-2 for the expression and stability of IRbeta
            in adequate adipocyte differentiation
  JOURNAL   Mol Metab 55, 101416 (2022)
   PUBMED   34896640
  REMARK    GeneRIF: Requirement of Cavin-2 for the expression and stability of
            IRbeta in adequate adipocyte differentiation.
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Boopathy,G.T.K., Kulkarni,M., Ho,S.Y., Boey,A., Chua,E.W.M.,
            Barathi,V.A., Carney,T.J., Wang,X. and Hong,W.
  TITLE     Cavin-2 regulates the activity and stability of endothelial
            nitric-oxide synthase (eNOS) in angiogenesis
  JOURNAL   J Biol Chem 292 (43), 17760-17776 (2017)
   PUBMED   28912276
  REMARK    GeneRIF: results indicate that in addition to its function in
            caveolae biogenesis, Cavin-2 plays a critical role in endothelial
            cell maintenance and function by regulating eNOS activity.
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Mohan,J., Moren,B., Larsson,E., Holst,M.R. and Lundmark,R.
  TITLE     Cavin3 interacts with cavin1 and caveolin1 to increase surface
            dynamics of caveolae
  JOURNAL   J Cell Sci 128 (5), 979-991 (2015)
   PUBMED   25588833
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Ludwig,A., Howard,G., Mendoza-Topaz,C., Deerinck,T., Mackey,M.,
            Sandin,S., Ellisman,M.H. and Nichols,B.J.
  TITLE     Molecular composition and ultrastructure of the caveolar coat
            complex
  JOURNAL   PLoS Biol 11 (8), e1001640 (2013)
   PUBMED   24013648
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   8  (bases 1 to 3069)
  AUTHORS   Ogata,T., Ueyama,T., Isodono,K., Tagawa,M., Takehara,N.,
            Kawashima,T., Harada,K., Takahashi,T., Shioi,T., Matsubara,H. and
            Oh,H.
  TITLE     MURC, a muscle-restricted coiled-coil protein that modulates the
            Rho/ROCK pathway, induces cardiac dysfunction and conduction
            disturbance
  JOURNAL   Mol Cell Biol 28 (10), 3424-3436 (2008)
   PUBMED   18332105
REFERENCE   9  (bases 1 to 3069)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (bases 1 to 3069)
  AUTHORS   Gustincich,S. and Schneider,C.
  TITLE     Serum deprivation response gene is induced by serum starvation but
            not by contact inhibition
  JOURNAL   Cell Growth Differ 4 (9), 753-760 (1993)
   PUBMED   8241023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027005.1, SRR1660813.219348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.13 cM"
     gene            1..3069
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /note="caveolae associated 2"
                     /db_xref="GeneID:20324"
                     /db_xref="MGI:MGI:99513"
     exon            1..743
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1517
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /note="serum deprivation-response protein;
                     phosphatidylserine-binding protein; serum deprivation
                     response; cavin-2"
                     /codon_start=1
                     /product="caveolae-associated protein 2"
                     /protein_id="NP_620080.1"
                     /db_xref="CCDS:CCDS14940.1"
                     /db_xref="GeneID:20324"
                     /db_xref="MGI:MGI:99513"
                     /translation="MGEDAAQAEKFQHPNTDMLQEKPSSPSPMPSSTPSPSLNLGSTE
                     EAIRDNSQVNAVTVHTLLDKLVNMLDAVRENQHNMEQRQINLEGSVKGIQNDLTKLSK
                     YQASTSNTVSKLLEKSRKVSAHTRAVRERLERQCVQVKRLENNHAQLLRRNHFKVLIF
                     QEESEIPASVFVKEPVPSAAEGKEELADENKSLEETLHNVDLSSDDELPRDEEALEDS
                     AEEKMEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLT
                     PNHQKASSGKSSPFKVSPLSFGRKKVREGESSVENETKLEDQMQEDREEGSFTEGLSE
                     ASLPSGLMEGSAEDAEKSARRGNNSAVGSNADLTIEEDEEEEPVALQQAQQVRYESGY
                     MLNSEEMEEPSEKQVQPAVLHVDQTA"
     exon            744..3055
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3021..3026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /note="hexamer: AATAAA"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /note="hexamer: AATAAA"
     polyA_site      3042
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
                     /note="major polyA site"
     polyA_site      3050
                     /gene="Cavin2"
                     /gene_synonym="Sdpr"
ORIGIN      
        1 ctcgggcttg tgcggagtgt ggctaggaag tgtgtgcttg tcactgaacc ctgagtgggt
       61 cctgtaacct ttgccttcca ctgggtggag caggtccttt aagagcaact ggaatgcagt
      121 tcccctgatc agcttagcca gttattcaaa acctctgcta gccctagaga gcagtgctca
      181 cttcagacca accagcctcc tgtgcttcta gcttgagcaa gaagtttcca gcggggaagt
      241 aagtttctag ctgcccagcc atgggagagg acgctgcaca ggcagaaaag ttccagcatc
      301 caaacacaga catgctccag gagaagccat ccagccccag cccaatgcct tcctccacac
      361 cgagccccag cctgaacctg gggtccacag aggaggccat ccgagacaac tcgcaggtga
      421 atgctgtcac cgtgcacaca ctcctggata aattggtcaa catgctggac gccgtgaggg
      481 agaaccagca caacatggaa cagcgtcaga tcaacctgga gggctcggtg aagggcatcc
      541 agaacgacct caccaagctc tccaagtacc aggcctccac cagcaacaca gtgagcaagc
      601 tgctagagaa gtctcgcaag gtcagcgctc acacgcgggc tgtccgggag cgcctcgaga
      661 ggcagtgtgt ccaggtgaag agactggaga acaaccacgc ccaactcctc cgacgcaacc
      721 acttcaaagt gctcatcttc caggaagaaa gtgagatccc tgccagtgtg tttgtgaagg
      781 agccagttcc cagcgctgca gaaggcaagg aggagcttgc tgatgagaac aagtccctgg
      841 aggaaactct gcacaacgtg gacctctcct ctgatgacga attgccccgt gatgaggaag
      901 ccctggaaga tagtgcagaa gagaagatgg aagaaagcag ggcagaaaaa ataaaaagat
      961 ccagcctcaa gaaagtcgat agcctcaaga aagcgttttc tcgtcagaac atcgagaaaa
     1021 agatgaacaa gctgggaacc aagatcgtat ctgttgagag gagagaaaag attaagaaat
     1081 cgctcacacc caaccaccag aaagcatctt ctgggaaaag ctcccccttc aaggtttctc
     1141 ccctctcctt tggtcgtaag aaagtccgag agggagaaag ctctgtagaa aatgagacca
     1201 agttggaaga ccagatgcag gaggaccgcg aggagggttc gttcacagag ggtctttctg
     1261 aagcatccct ccccagtggc ctgatggagg gcagcgcaga agatgctgag aaatcagcaa
     1321 ggagagggaa caactcagcc gtgggcagta atgcggatct gaccattgag gaagatgaag
     1381 aagaggagcc ggtagccctg cagcaggccc agcaggtgcg ctatgagagt ggctacatgc
     1441 tcaactccga ggagatggag gaacccagtg agaaacaggt ccagccagct gtgctgcatg
     1501 tggatcagac tgcctgagtg cacagccaga acactgggcc agtgcatcca cctcgtggaa
     1561 gccaccccgc acctcttcat ctctacctgc tccctactgt gactgtccag gccttaatca
     1621 ctgaccgtac agtagcctca atgggatcac agaaacaaac tgccaggaat cccatttcta
     1681 atttgctcat aggttctatt tctgtagagt ttctccaaga ttgcaaaaag aaagaaatgg
     1741 agcagttaaa aaaaaaatca actatctctt tggcttagtc agaaaaactg gaggatattt
     1801 aagttagtag ttataaaaag tgattttttt tttggtcatt ctatcagctt gctgaatagt
     1861 gtagcagtaa tgtagtgaat tcttactgta ttctgtgaat gattattctt caagtatgtg
     1921 atatggaata tacataagtc tgtaagctga gaatataact ctttatttta agaagaaaac
     1981 atttacaaaa gataaagctg aaggaccagc tggttattct cttatagaaa ccattgtttg
     2041 ttgtaagggg gctgaaagac ggtgctgatg gtaagctaat agcaccagga ctgctgagat
     2101 agaaaattaa gatgaaaagg ttggaaagtg ggagaaatgg agaacaaaga atgccaaaaa
     2161 taatgatgac aaagagaaaa aaaaaagatg tgcttaaaaa gtgaactact aacattttaa
     2221 aacttatttt gctctttaac aatactaaag aagttcatat gtcttgcaaa aatatatctt
     2281 atcttcccaa tatttttata gtctagtatt ataacctaac cagatgttct gatgtaaaaa
     2341 ctatggttct tttcactaaa taaatggcag tacacatctt tttgtgaaga agctcaaaat
     2401 aatattgtct ctttaacatt ggaacaagtg taagtctcaa ataagtagta tgtactgttt
     2461 tatggggatg tcaatcaaat gattattcaa tatttttcac tttgaagtga cctttccatt
     2521 ccaaatatga tataggttta ggaggtattc aaacttgcat gtttaagaac agtaaaagcc
     2581 tgggttttct ttaaacacat aatggtaatt tcaatccagg taatgtttta tttatacatt
     2641 aatttcacag gatattaatg gtttagatta taaaagcatg ctagtatttt atttcatgtg
     2701 tacatttgct ctaacatact acttaaaagt tgctttatct atttttcatt acaaaatgcc
     2761 aatgctttgt tatattgtag tctgaagatg agagacccag ggctcgaact ctctactctt
     2821 actgcgcagt agcacaagtg atcctacaca cagtggtgac taggcagcag tcctgggctg
     2881 cactctgact ttcagagaag gagtgaggtg aataatgggt gttgatggtg taacctcttc
     2941 agctgtgttc ctgtactgca attaatgtaa ccccaaatac tgaattgctg aactaaccat
     3001 gcctgtgtga aagaagatta aataaaccaa aaataaaaag tatataacaa tgtcaaaaaa
     3061 aaaaaaaaa
//
