LOCUS       NM_008986               3218 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus caveolae associated 1 (Cavin1), transcript variant 1,
            mRNA.
ACCESSION   NM_008986
VERSION     NM_008986.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Tomita,S., Nakanishi,N., Ogata,T., Higuchi,Y., Sakamoto,A.,
            Tsuji,Y., Suga,T. and Matoba,S.
  TITLE     The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in
            pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding
  JOURNAL   Commun Biol 7 (1), 40 (2024)
   PUBMED   38182755
  REMARK    GeneRIF: The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad
            signaling in pulmonary hypertension by interfering with
            BMPR2/Caveolin-1 binding.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Du,J., Liu,Y., Lan,G., Zhou,Y., Ni,Y., Liao,K., Zheng,F., Cheng,Q.,
            Shi,G. and Su,X.
  TITLE     PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis
            contributes to HDM-induced airway inflammation
  JOURNAL   Cell Death Dis 14 (7), 432 (2023)
   PUBMED   37454215
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Li,X., Zhong,Z., Zhang,R., Zhang,J., Zhang,Y., Zeng,S., Du,Q.,
            Wang,H., Zhang,S., Lu,L., Li,M. and Long,K.
  TITLE     Decoding the transcriptome of muscular dystrophy due to Ptrf
            deficiency using single-nucleus RNA sequencing
  JOURNAL   FASEB J 37 (6), e22993 (2023)
   PUBMED   37235502
  REMARK    GeneRIF: Decoding the transcriptome of muscular dystrophy due to
            Ptrf deficiency using single-nucleus RNA sequencing.
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Tillu,V.A., Rae,J., Gao,Y., Ariotti,N., Floetenmeyer,M., Kovtun,O.,
            McMahon,K.A., Chaudhary,N., Parton,R.G. and Collins,B.M.
  TITLE     Cavin1 intrinsically disordered domains are essential for fuzzy
            electrostatic interactions and caveola formation
  JOURNAL   Nat Commun 12 (1), 931 (2021)
   PUBMED   33568658
  REMARK    GeneRIF: Cavin1 intrinsically disordered domains are essential for
            fuzzy electrostatic interactions and caveola formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Bai,L., Lyu,Y., Shi,G., Li,K., Huang,Y., Ma,Y., Cong,Y.S., Zhang,L.
            and Qin,C.
  TITLE     Polymerase I and transcript release factor transgenic mice show
            impaired function of hematopoietic stem cells
  JOURNAL   Aging (Albany NY) 12 (20), 20152-20162 (2020)
   PUBMED   33087586
  REMARK    GeneRIF: Polymerase I and transcript release factor transgenic mice
            show impaired function of hematopoietic stem cells.
REFERENCE   6  (bases 1 to 3218)
  AUTHORS   Miyoshi,K., Cui,Y., Riedlinger,G., Robinson,P., Lehoczky,J.,
            Zon,L., Oka,T., Dewar,K. and Hennighausen,L.
  TITLE     Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
            zebrafish to mouse
  JOURNAL   Genomics 71 (2), 150-155 (2001)
   PUBMED   11161808
REFERENCE   7  (bases 1 to 3218)
  AUTHORS   Jansa,P., Burek,C., Sander,E.E. and Grummt,I.
  TITLE     The transcript release factor PTRF augments ribosomal gene
            transcription by facilitating reinitiation of RNA polymerase I
  JOURNAL   Nucleic Acids Res 29 (2), 423-429 (2001)
   PUBMED   11139612
REFERENCE   8  (bases 1 to 3218)
  AUTHORS   Hasegawa,T., Takeuchi,A., Miyaishi,O., Xiao,H., Mao,J. and Isobe,K.
  TITLE     PTRF (polymerase I and transcript-release factor) is
            tissue-specific and interacts with the BFCOL1 (binding factor of a
            type-I collagen promoter) zinc-finger transcription factor which
            binds to the two mouse type-I collagen gene promoters
  JOURNAL   Biochem J 347 Pt 1 (Pt 1), 55-59 (2000)
   PUBMED   10727401
REFERENCE   9  (bases 1 to 3218)
  AUTHORS   Jansa,P. and Grummt,I.
  TITLE     Mechanism of transcription termination: PTRF interacts with the
            largest subunit of RNA polymerase I and dissociates paused
            transcription complexes from yeast and mouse
  JOURNAL   Mol Gen Genet 262 (3), 508-514 (1999)
   PUBMED   10589839
REFERENCE   10 (bases 1 to 3218)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY132697.1, AF036249.1 and AL591466.8.
            
            On Jul 21, 2005 this sequence version replaced NM_008986.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110698.1, AF036249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY132697.1         1-45
            46-1444             AF036249.1         1-1399
            1445-3218           AL591466.8         37405-39178
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.95 cM"
     gene            1..3218
                     /gene="Cavin1"
                     /gene_synonym="2310075E07Rik; Cav-p60; Cavin; Ptrf"
                     /note="caveolae associated 1"
                     /db_xref="GeneID:19285"
                     /db_xref="MGI:MGI:1277968"
     exon            1..628
                     /gene="Cavin1"
                     /gene_synonym="2310075E07Rik; Cav-p60; Cavin; Ptrf"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1330
                     /gene="Cavin1"
                     /gene_synonym="2310075E07Rik; Cav-p60; Cavin; Ptrf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cavin-1; polymerase I and transcript release factor;
                     caveolae-associated protein 1"
                     /codon_start=1
                     /product="caveolae-associated protein 1 isoform 1"
                     /protein_id="NP_033012.1"
                     /db_xref="CCDS:CCDS25442.1"
                     /db_xref="GeneID:19285"
                     /db_xref="MGI:MGI:1277968"
                     /translation="MEDVTLHIVERPYSGFPDASSEGPEPTQGEARATEEPSGTGSDE
                     LIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAH
                     ATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQD
                     EVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEES
                     RAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRM
                     NKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGE
                     VEVLKATEMVEVGPEDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
                     "
     exon            629..3218
                     /gene="Cavin1"
                     /gene_synonym="2310075E07Rik; Cav-p60; Cavin; Ptrf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttctgg ctagagtccc ggtgcgcacg gacgtggctc gagtttcctc cgctctgggc
       61 tcctgctcgc tgtccagtct ctcgctcctc cttctctccc ggtctcccgc tccagttcca
      121 cccggtcggc cccgcacggc tccgggaagc catggaggat gtcacgctcc atatcgttga
      181 gcggccgtat tccggatttc ccgatgcttc ctcagagggc ccggagccca cccaagggga
      241 ggcgcgggcc acggaggagc cgtcggggac cggctccgac gagctgatca agtcggacca
      301 ggtgaacggt gtgctggtgc tgagccttct ggataaaatc atcggcgccg ttgaccagat
      361 ccagctgacc caagcccagc tggaggagcg acaggcggag atggagggcg ctgtgcagag
      421 catccaggga gagctgagca agctgggcaa ggcgcacgcc accacgagca acaccgtgag
      481 caagttgctg gagaaggtgc gcaaggtcag cgtcaacgtg aagaccgtgc gcggcagcct
      541 ggagcgccag gccggccaga taaagaaact ggaggtcaac gaggcggagc tgctgaggcg
      601 ccgcaacttc aaagtcatga tctaccagga tgaagtcaag ctgccggcca aactgagcgt
      661 cagcaagtcg ctgaaagagt cggaggcact gcctgagaag gagggtgacg agctgggcga
      721 gggcgagcgg cccgaggatg acaccgcggc gatcgagctg tcgtccgacg aggcggtgga
      781 ggtggaggag gtgatcgagg agtcccgcgc cgagcgcatc aagcgcagcg gcctgcggcg
      841 cgtggacgac ttcaagaagg ccttctccaa ggagaagatg gagaagacca aggtgcgcac
      901 gcgtgagaac ctggagaaga cgcgcctgaa gaccaaggag aacctggaga agacacggca
      961 cacgctggag aagcgcatga acaagctggg cacgcgcctg gtgcccgtgg agcgacgaga
     1021 gaagctgaag acatcccggg acaagctgcg caagtccttc acgcccgacc atgtggtgta
     1081 tgcgcgctcc aagaccgctg tctacaaggt gccgcctttc accttccacg tcaagaagat
     1141 ccgcgagggc gaggtggagg tgctgaaggc caccgagatg gtggaggtgg gtcccgagga
     1201 cgacgaggtt ggcgcggagc gcggcgaggc cactgacctg ctgcgcggga gcagccccga
     1261 cgtgcacacg ctgctggaga tcaccgagga gtcggacgcc gtcctggtgg acaagagcga
     1321 cagcgactga gcaggactcg cagggctctg ccctggaggc cggcgcctga ccctgccgcc
     1381 ccctgatccc ccacccctgc ccacaccgcc tttccctttt caaactttct cttttgcatt
     1441 ctaagcccca gtctggttgg gctttttttt ttttttttaa acaaaccggg ggggggggaa
     1501 tacacccccc cccccgaaga gcagccctcc aaagcacagg ccttagaccg aggggaggtg
     1561 gtctctcacc agcgacagcc tcaatttgga cacagtctgg gtaggatatg ggaagaatga
     1621 cccatgccct ggttgtcttg atccaggatg cttttatttt agctccctag ttaggcccct
     1681 cggcccctcc ccaacacagc ttcatactca gctgcaccac cctacttcct gagctgtttc
     1741 tccttttcct caccctggga gactccaaag cccaaatttc tgcaagagga aagagcaaat
     1801 cctaaagaca acccttgtag gggcagcttt ctagtgccag cttgctctcc cagagaggct
     1861 gaggcaggag acttgtaagt tcaaggcctg cctgggctgc agagtgagct caaagccagc
     1921 atgagcaatt tagccagatg cagtttcaaa ataagaggtg gtgggggtgt atcactgata
     1981 gagcccttgc ttagaaggag ggggtgggca attcaaaatt ccacgaagat aaaatgtgtg
     2041 tagagagacc tttgcccaga ggtggcccac tggaagacct gagggtcttt gggggaacta
     2101 aggcaatagg gtgaggtaaa aggcagagtg tttggtggat aaaggcccca ccaaaataag
     2161 cagaaggcgg gtagagcctg ggaaagggtg gtaggtgtgt ggggagaggg gcttatttac
     2221 aaagctacaa aacctgcaca caggagcacg tgagtattct ttggaaagag agaggaagct
     2281 agaagagggt tgaaatggaa ttagaaagaa atgcccttgt taacaacaca aagaaattca
     2341 agagtcccac tttggtagga tctcaagaca gcagggcagc ttccgggtca ggagggaagt
     2401 cagttttaga aagtgtgttc caaagagacg tcagcctgat tggattctct cttccagaat
     2461 ctaggaactg ccttccggga agccttgttt tccatgcccg gaaaattagg gttccagcag
     2521 ggggcagcag cgagttgtgg agaactggca gctggggaaa gcaaggtgcc tctggagctg
     2581 agctccctag ctggaagctg gagcagcagg gccagctggc ttgcccaccc taactccctc
     2641 tcagctgctt ctaccatgga tctttctcta atgtgaaact ttagagcttg ccaagaccct
     2701 cctgtgttcc ttgcctttgg ggcccccttt acctgaaagt tggggagagt ggggtgctgc
     2761 ttcatgtcca aggcttgatt tcttatagtt actgaccagg ttttctccta aggacacatt
     2821 tgttccccct ttaatggctg atcaggagca ggcaacacct cccccaattg atagctacag
     2881 gctacttcct tctcctcacc tacatgtatt ccctgcttct tagaattgta gctcattgat
     2941 attttggggt ggggagggga tgaaaaccac aaacctttta taccatacaa agctttgctt
     3001 tttatttttt atttttaatt tttttttctt ggtccccttc cctcctctga atgcttggag
     3061 acggagaagc tgaggagggt gggtaagtgt tggatgaggt cctctgtgct gatgggctaa
     3121 tgttgtgggc agatgcagtt tcctgtgggc tctaggggag tcccttgagt tgctgtgttc
     3181 tggtgagcag ccggaccaat aaacctgctt ttctaaaa
//
