LOCUS       NM_007617               1172 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus caveolin 3 (Cav3), mRNA.
ACCESSION   NM_007617 XM_973503
VERSION     NM_007617.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Guo,P., Hu,S., Liu,X., He,M., Li,J., Ma,T., Huang,M., Fang,Q. and
            Wang,Y.
  TITLE     CAV3 alleviates diabetic cardiomyopathy via inhibiting
            NDUFA10-mediated mitochondrial dysfunction
  JOURNAL   J Transl Med 22 (1), 390 (2024)
   PUBMED   38671439
  REMARK    GeneRIF: CAV3 alleviates diabetic cardiomyopathy via inhibiting
            NDUFA10-mediated mitochondrial dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Ahn,J.W., Kim,S.E., Kim,D.Y., Jeong,I., Kim,S., Chung,S. and
            Lee,S.E.
  TITLE     Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes
            to Chronic Itch and Inflammation in Experimental Atopic Dermatitis
  JOURNAL   J Invest Dermatol 144 (3), 612-620 (2024)
   PUBMED   37863387
  REMARK    GeneRIF: Cav3.2 T-Type Calcium Channel Mediates Acute Itch and
            Contributes to Chronic Itch and Inflammation in Experimental Atopic
            Dermatitis.
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Zhang,Y., Zhou,L., Fu,Q. and Liu,Z.
  TITLE     ANKRD1 activates the Wnt signaling pathway by modulating CAV3
            expression and thus promotes BMSC osteogenic differentiation and
            bone formation in ovariectomized mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166693 (2023)
   PUBMED   36958710
  REMARK    GeneRIF: ANKRD1 activates the Wnt signaling pathway by modulating
            CAV3 expression and thus promotes BMSC osteogenic differentiation
            and bone formation in ovariectomized mice.
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Hagiwara,Y., Sasaoka,T., Araishi,K., Imamura,M., Yorifuji,H.,
            Nonaka,I., Ozawa,E. and Kikuchi,T.
  TITLE     Caveolin-3 deficiency causes muscle degeneration in mice
  JOURNAL   Hum Mol Genet 9 (20), 3047-3054 (2000)
   PUBMED   11115849
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Engelman,J.A., Zhang,X.L., Galbiati,F. and Lisanti,M.P.
  TITLE     Chromosomal localization, genomic organization, and developmental
            expression of the murine caveolin gene family (Cav-1, -2, and -3).
            Cav-1 and Cav-2 genes map to a known tumor suppressor locus
            (6-A2/7q31)
  JOURNAL   FEBS Lett 429 (3), 330-336 (1998)
   PUBMED   9662443
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Song,K.S., Scherer,P.E., Tang,Z., Okamoto,T., Li,S., Chafel,M.,
            Chu,C., Kohtz,D.S. and Lisanti,M.P.
  TITLE     Expression of caveolin-3 in skeletal, cardiac, and smooth muscle
            cells. Caveolin-3 is a component of the sarcolemma and
            co-fractionates with dystrophin and dystrophin-associated
            glycoproteins
  JOURNAL   J Biol Chem 271 (25), 15160-15165 (1996)
   PUBMED   8663016
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   Way,M. and Parton,R.G.
  TITLE     M-caveolin, a muscle-specific caveolin-related protein
  JOURNAL   FEBS Lett 378 (1), 108-112 (1996)
   PUBMED   8549793
REFERENCE   9  (bases 1 to 1172)
  AUTHORS   Way,M. and Parton,R.G.
  TITLE     M-caveolin, a muscle-specific caveolin-related protein
  JOURNAL   FEBS Lett 376 (1-2), 108-112 (1995)
   PUBMED   8521953
REFERENCE   10 (bases 1 to 1172)
  AUTHORS   Tang,Z.L., Scherer,P.E. and Lisanti,M.P.
  TITLE     The primary sequence of murine caveolin reveals a conserved
            consensus site for phosphorylation by protein kinase C
  JOURNAL   Gene 147 (2), 299-300 (1994)
   PUBMED   7926819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153594.15, CJ057698.1,
            AA434625.1 and AI385751.1.
            
            On Apr 18, 2013 this sequence version replaced NM_007617.2.
            
            Summary: This gene belongs to the caveolin family whose members
            encode the major protein components of caveolae, which are
            invaginations of plasma membrane. The encoded protein is
            muscle-specific and forms homooligomers in muscle cells. The
            protein binds and regulates phosphofructokinase M and neuronal
            nitric oxide synthase. It also associates with dystrophin in muscle
            cells. Mutations in this gene are associated with muscular
            dystrophy. [provided by RefSeq, Apr 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024383.1, U36579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC153594.15        134532-134754
            224-629             CJ057698.1         1-406
            630-1008            AA434625.1         81-459
            1009-1172           AI385751.1         1-164               c
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.26 cM"
     gene            1..1172
                     /gene="Cav3"
                     /gene_synonym="Cav-3; M-cav"
                     /note="caveolin 3"
                     /db_xref="GeneID:12391"
                     /db_xref="MGI:MGI:107570"
     exon            1..421
                     /gene="Cav3"
                     /gene_synonym="Cav-3; M-cav"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1157
                     /gene="Cav3"
                     /gene_synonym="Cav-3; M-cav"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cav3"
                     /gene_synonym="Cav-3; M-cav"
                     /note="hexamer: AATAAA"
     polyA_site      1157
                     /gene="Cav3"
                     /gene_synonym="Cav-3; M-cav"
                     /note="major polyA site"
ORIGIN      
        1 ggccctggtg gctggcaggg aatgccaggt ctcctctcgc gtgaggccaa tgtcctgcac
       61 agcccccttt aaggagcgtt ctgccatcca gtcttaattt tagcttggag gcgtgccacc
      121 agcagcttta actagaggcc ggctgaagtt atgcaggaca gctgtcagcc ggcatgctgg
      181 gtggggccta tttagccggc agcggcacca gtctggagac cctaagcttg gtctttctgc
      241 ccccaggact atcaacgata ccagccacaa ggctctgatc gcctcctgaa ggagccccag
      301 cctcacaatg atgaccgaag agcacacgga tctggaagct cggatcatca aggacattca
      361 ctgcaaggag atagacttgg tgaaccgcga ccccaagaac atcaatgagg acattgtgaa
      421 ggtagatttt gaagacgtga ttgcggagcc cgagggcacc tacagcttcg acggtgtatg
      481 gaaggtgagc ttcaccacgt tcaccgtctc caagtactgg tgctaccgcc tgttgtctac
      541 actgctgggt gttccactgg ccctgctctg gggattcctg ttcgcctgta tctccttctg
      601 ccacatctgg gccgtggtgc cctgcattaa gagctacctg atcgagatcc agtgcatcag
      661 ccacatctac tcactgtgta tccgcacctt ctgcaacccg ctcttcgctg cgttgggcca
      721 ggtctgcagc aacattaagg tggtgctgcg aagggaaggc taaagccagg ctgggctgtg
      781 gggaaggctg ggcaggggga tcaaaggtca ggtgagcata cctggctctg ctccacatgg
      841 gctgctggag agctcttcct tttgaggttc ctctcaattc cacctcaaga tgggaaaact
      901 tggtgcggga ggagccagaa ggaaaagaca gcccagtgtg gaaacacggg cacccctgct
      961 ccgctcagcc tcccatgaac cccggcggcc ctgactgagc ggagggttcc ttaagaggca
     1021 gctagcgcaa ggctttgcgt tcacatgtac tgtaatagcc agtcttctag aggtgtgact
     1081 cgtctcctca tgctaggggg agcaagcagt gactgccggc attgaggaag gtgctgcaat
     1141 aaagggtttt aactgcaaaa aaaaaaaaaa aa
//
