LOCUS       NM_016900               2748 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus caveolin 2 (Cav2), transcript variant 1, mRNA.
ACCESSION   NM_016900
VERSION     NM_016900.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2748)
  AUTHORS   Choi,M., Jeong,K. and Pak,Y.
  TITLE     Caveolin-2 controls preadipocyte survival in the mitotic clonal
            expansion for adipogenesis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119793 (2024)
   PUBMED   39038612
  REMARK    GeneRIF: Caveolin-2 controls preadipocyte survival in the mitotic
            clonal expansion for adipogenesis.
REFERENCE   2  (bases 1 to 2748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2748)
  AUTHORS   Park,H., Shin,J.A., Lim,J., Lee,S., Ahn,J.H., Kang,J.L. and
            Choi,Y.H.
  TITLE     Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes
            Age-Related Neuroinflammation
  JOURNAL   Mol Cells 45 (12), 950-962 (2022)
   PUBMED   36572563
  REMARK    GeneRIF: Increased Caveolin-2 Expression in Brain Endothelial Cells
            Promotes Age-Related Neuroinflammation.
REFERENCE   4  (bases 1 to 2748)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2748)
  AUTHORS   Kogo,H., Ishiguro,K., Kuwaki,S. and Fujimoto,T.
  TITLE     Identification of a splice variant of mouse caveolin-2 mRNA
            encoding an isoform lacking the C-terminal domain
  JOURNAL   Arch Biochem Biophys 401 (1), 108-114 (2002)
   PUBMED   12054493
  REMARK    GeneRIF: Splice variant of mouse caveolin-2 mRNA, encoding an
            isoform lacking the C-terminal domain, localized to the endoplasmic
            reticulum, while the authentic caveolin-2 was distributed to the
            Golgi and the plasma membrane along with caveolin-1.
REFERENCE   6  (bases 1 to 2748)
  AUTHORS   Engelman,J.A., Lee,R.J., Karnezis,A., Bearss,D.J., Webster,M.,
            Siegel,P., Muller,W.J., Windle,J.J., Pestell,R.G. and Lisanti,M.P.
  TITLE     Reciprocal regulation of neu tyrosine kinase activity and
            caveolin-1 protein expression in vitro and in vivo. Implications
            for human breast cancer
  JOURNAL   J Biol Chem 273 (32), 20448-20455 (1998)
   PUBMED   9685399
REFERENCE   7  (bases 1 to 2748)
  AUTHORS   Engelman,J.A., Zhang,X.L., Galbiati,F. and Lisanti,M.P.
  TITLE     Chromosomal localization, genomic organization, and developmental
            expression of the murine caveolin gene family (Cav-1, -2, and -3).
            Cav-1 and Cav-2 genes map to a known tumor suppressor locus
            (6-A2/7q31)
  JOURNAL   FEBS Lett 429 (3), 330-336 (1998)
   PUBMED   9662443
REFERENCE   8  (bases 1 to 2748)
  AUTHORS   Okamoto,T., Schlegel,A., Scherer,P.E. and Lisanti,M.P.
  TITLE     Caveolins, a family of scaffolding proteins for organizing
            'preassembled signaling complexes' at the plasma membrane
  JOURNAL   J Biol Chem 273 (10), 5419-5422 (1998)
   PUBMED   9488658
  REMARK    Review article
REFERENCE   9  (bases 1 to 2748)
  AUTHORS   Scherer,P.E., Lewis,R.Y., Volonte,D., Engelman,J.A., Galbiati,F.,
            Couet,J., Kohtz,D.S., van Donselaar,E., Peters,P. and Lisanti,M.P.
  TITLE     Cell-type and tissue-specific expression of caveolin-2. Caveolins 1
            and 2 co-localize and form a stable hetero-oligomeric complex in
            vivo
  JOURNAL   J Biol Chem 272 (46), 29337-29346 (1997)
   PUBMED   9361015
REFERENCE   10 (bases 1 to 2748)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ157462.1, AK151397.1,
            AK009913.1, AK158419.1 and AC023173.3.
            
            On Apr 18, 2013 this sequence version replaced NM_016900.3.
            
            Summary: This gene belongs to the caveolin family whose members
            encode the major protein components of caveolae, which are
            invaginations of plasma membrane. This gene is located adjacent to
            caveolin-1 and the proteins coexpressed by the two genes localize
            together in caveolae, where they form hetero-oligomers. The encoded
            protein may be involved in diverse cellular functions including
            proliferation, differentiation, endocytosis and trafficking.
            Alternative splicing of this gene results in transcript variants
            encoding different isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009913.1, BC023095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CJ157462.1         2-18
            18-173              AK151397.1         2-157
            174-2622            AK009913.1         1-2449
            2623-2733           AK158419.1         2585-2695
            2734-2748           AC023173.3         89120-89134
FEATURES             Location/Qualifiers
     source          1..2748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 7.72 cM"
     gene            1..2748
                     /gene="Cav2"
                     /note="caveolin 2"
                     /db_xref="GeneID:12390"
                     /db_xref="MGI:MGI:107571"
     exon            1..326
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..665
                     /gene="Cav2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="caveolin-2 isoform 1"
                     /protein_id="NP_058596.1"
                     /db_xref="CCDS:CCDS19923.1"
                     /db_xref="GeneID:12390"
                     /db_xref="MGI:MGI:107571"
                     /translation="MGLETEKADVQLFMADDAYSHHSGVDYADPEKYVDSSHDRDPHQ
                     LNSHLKLGFEDLIAEPETTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGI
                     LFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVVIGPLCTSVGRSFSSVSMQLS
                     HD"
     exon            327..514
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..2748
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cav2"
                     /note="hexamer: AATAAA"
     polyA_site      2629
                     /gene="Cav2"
                     /note="major polyA site"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cav2"
                     /note="hexamer: AATAAA"
     polyA_site      2738
                     /gene="Cav2"
ORIGIN      
        1 ggggttcggc cagccaaggc tgggagcggg aaccggcagc gggaagcggc cgccgcccgg
       61 gcagcccgag gctaggcagg gcgaagccag gcggggcggg gctgagcgcc acgggaaggg
      121 gaggcagggc tgcctaggga ccgaacgacc gagccactct tgcaacgcca gccacgatgg
      181 ggctggagac cgagaaggcc gatgtgcagc tcttcatggc cgatgacgcc tacagccacc
      241 acagtggcgt tgactacgca gatcctgaga agtatgttga ctcgagtcac gaccgggatc
      301 ctcaccagct caactctcat ctcaagctag gcttcgagga tctgattgca gagcctgaga
      361 ctacacactc ctttgacaaa gtgtggatct gcagccatgc tctctttgaa atcagcaaat
      421 atgtgatgta caagttcctg accgtatttc tggccatccc cttggccttc attgcgggta
      481 tcctgtttgc taccctcagc tgtctgcaca tctggatcct gatgcctttt gtgaagacct
      541 gcctaatggt cttgccttcc gtgcagacaa tatggaagag tgtgacagac gttgtcattg
      601 gcccattgtg tacaagtgtg ggccgcagct tctcatcggt cagcatgcaa ctgagccacg
      661 actgaccact cagaccctgg gcaggtccag acatttggat actgtacaac tttattgatg
      721 caacaaactc actactgttc tgttcacttc ccaactgtta aaattattct taaaatggaa
      781 cccagattta tcgaagttca ctgtcagatc tttaaaaata atgatttttc tcaccaaaag
      841 ccaagttata tctaattata taacaagaat tggcaacacc caatgtaaga acagatatct
      901 ttaggaaaaa acatacaatt gcagtgatga cttgataatg gtcaaagggc aacttcctca
      961 gacattagag taattttgtg cataactgct cataaagagt aaggaatttc ttattttctt
     1021 ttcctctagg agtaatgttc ttgaagctac ttttacagat atggtcataa ggctagctag
     1081 aggcaataca ttccaacatt ctaggaactt tgtacattaa caaaagtata tacttatgat
     1141 aataactatt gaatagtaag agagataaat gtgaaaatgt gttcctctgt gatattatta
     1201 gcctgcaagc ctatttaaca agatgttttg tttttctgta tattgtatac ctaatgcaag
     1261 tgttactcta atgaaatcgc tttggagtgt gtttctcttg tgtttgctat tgtactaatc
     1321 tcattatata aagtaagcag agctaccata gggtaacttt ctttgtaaga ctgtgatgtc
     1381 ctataggaga atgttgatag attctttgga atgcagtgta aaatgtgctg tctaggtgtt
     1441 ctctccaact tacccagcaa atgttttatg actgggcttc atctggctgt gaccataaga
     1501 catgtagaca tgtagttgtt ttgtttacta taagttttct tctgaatggt tagaaactta
     1561 ttctgtattc tacattccta tgaatgcttc acttactttc aagtaattct ggtgctagtt
     1621 aataatattt tttatgataa aggctgtgtc taacatctaa gcacattttt ttttttacta
     1681 cagtggttca tatagagaaa cttacaggag aattaacaat tgtgagggtt tataaaactg
     1741 aagtacatgt gtaaattaga aactaacatt acaaattttc aagatgttct ctagtatgaa
     1801 tcttaaaacc tataaaacat tatttcctta ctcagtatgg tcttttaaaa attggtatgt
     1861 taaaaaattt ctacattata attacataat atttcaaatt tcagaattat tatcaaaccc
     1921 tgaatgagca tttgctcgaa tatgctcatg ggtgtcaaat cttcactgaa agaagataaa
     1981 tttttttcaa tttttcaatt ctggtcatta ttataggtca ttgaactggg attctattgc
     2041 agaccaggtc aaaatatcat attaagagac taagtgataa aactcatatc aatttgatgg
     2101 taatcataaa agaaacattt caaaacagcc ttagggtatt gtaccatcct cagtaaacga
     2161 agtcatagct tggtaatagc cacaagcatc gccattaatg tgactgtcaa gattgtatca
     2221 cactagtttc caaggtcagt ctcatgcttt atattatttt tgtaatttaa gttttaaatg
     2281 cctgggtgta ttgattagtc aaaactttaa caataaaata tcagtttaat aaattataag
     2341 cttcaacctt ttaaaatagt tctgacagat tttaagacaa atatgtataa ttatatataa
     2401 aaatctttaa tttttaatat atatgatttc cttttcctaa atagtattga ttactttcaa
     2461 ctgaactttt actgaaactt ttcatgaatt attttgtctc aaaaactcaa attgtggata
     2521 aaaggaatca aagttaaata tgcaaatatg ttgattttgg gggcagggca attggaagtc
     2581 agaggcaaag aaattccctt attatccata ataaacatct ctaaaaacag tggatgattt
     2641 cattgattct attatagttt gtctttctgc tgcttatgtc gtacatctgg tactcaggaa
     2701 caagaacctt ttcaaataaa gtttcttaaa atctcaaata acaaggac
//
