LOCUS       NM_007616               2469 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus caveolin 1, caveolae protein (Cav1), transcript
            variant 1, mRNA.
ACCESSION   NM_007616
VERSION     NM_007616.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2469)
  AUTHORS   Aboy-Pardal,M.C.M., Guadamillas,M.C., Guerrero,C.R.,
            Catala-Montoro,M., Toledano-Donado,M., Terres-Dominguez,S.,
            Pavon,D.M., Jimenez-Jimenez,V., Jimenez-Carretero,D., Zamai,M.,
            Folgueira,C., Cerezo,A., Lolo,F.N., Nogueiras,R., Sabio,G.,
            Sanchez-Alvarez,M., Echarri,A., Garcia,R. and Del Pozo,M.A.
  TITLE     Plasma membrane remodeling determines adipocyte expansion and
            mechanical adaptability
  JOURNAL   Nat Commun 15 (1), 10102 (2024)
   PUBMED   39609408
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2469)
  AUTHORS   Zhang,L., Chu,W., Feng,X., Li,J., Ren,Y., Yang,Y., Zheng,Z. and
            Li,H.
  TITLE     Caveolin-1 protects retinal ganglion cells in glaucoma by reducing
            TLR4 and activating the Akt/PTEN signaling pathway
  JOURNAL   Pathol Res Pract 262, 155552 (2024)
   PUBMED   39180803
  REMARK    GeneRIF: Caveolin-1 protects retinal ganglion cells in glaucoma by
            reducing TLR4 and activating the Akt/PTEN signaling pathway.
REFERENCE   3  (bases 1 to 2469)
  AUTHORS   Liu,S., Zhao,L., Peng,Y., Liu,X., Yan,W., Zhang,L. and Zhang,J.
  TITLE     Obesity induced caveolin-1 impairs osteogenesis via activating
            mitophagy and inhibiting Sirt1 signaling
  JOURNAL   Bone 186, 117146 (2024)
   PUBMED   38844017
  REMARK    GeneRIF: Obesity induced caveolin-1 impairs osteogenesis via
            activating mitophagy and inhibiting Sirt1 signaling.
REFERENCE   4  (bases 1 to 2469)
  AUTHORS   Huang,M., Wang,X., Chen,Y., Pessoa,M.T., Terrell,K.C., Zhang,J.,
            Tian,J., Xie,Z., Pierre,S.V. and Cai,L.
  TITLE     Role of Na/K-ATPase alpha1 caveolin-binding motif in adipogenesis
  JOURNAL   Am J Physiol Cell Physiol 327 (1), C48-C64 (2024)
   PUBMED   38708522
  REMARK    GeneRIF: Role of Na/K-ATPase alpha1 caveolin-binding motif in
            adipogenesis.
REFERENCE   5  (bases 1 to 2469)
  AUTHORS   Islam,M. and Behura,S.K.
  TITLE     Molecular Regulation of Fetal Brain Development in Inbred and
            Congenic Mouse Strains Differing in Longevity
  JOURNAL   Genes (Basel) 15 (5), 604 (2024)
   PUBMED   38790233
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2469)
  AUTHORS   Tang,Z., Scherer,P.E., Okamoto,T., Song,K., Chu,C., Kohtz,D.S.,
            Nishimoto,I., Lodish,H.F. and Lisanti,M.P.
  TITLE     Molecular cloning of caveolin-3, a novel member of the caveolin
            gene family expressed predominantly in muscle
  JOURNAL   J Biol Chem 271 (4), 2255-2261 (1996)
   PUBMED   8567687
REFERENCE   7  (bases 1 to 2469)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
REFERENCE   8  (bases 1 to 2469)
  AUTHORS   Way,M. and Parton,R.G.
  TITLE     M-caveolin, a muscle-specific caveolin-related protein
  JOURNAL   FEBS Lett 376 (1-2), 108-112 (1995)
   PUBMED   8521953
REFERENCE   9  (bases 1 to 2469)
  AUTHORS   Scherer,P.E., Tang,Z., Chun,M., Sargiacomo,M., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Caveolin isoforms differ in their N-terminal protein sequence and
            subcellular distribution. Identification and epitope mapping of an
            isoform-specific monoclonal antibody probe
  JOURNAL   J Biol Chem 270 (27), 16395-16401 (1995)
   PUBMED   7608210
REFERENCE   10 (bases 1 to 2469)
  AUTHORS   Tang,Z.L., Scherer,P.E. and Lisanti,M.P.
  TITLE     The primary sequence of murine caveolin reveals a conserved
            consensus site for phosphorylation by protein kinase C
  JOURNAL   Gene 147 (2), 299-300 (1994)
   PUBMED   7926819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023173.3.
            
            On Jul 19, 2022 this sequence version replaced NM_007616.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003489.1, BC038280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC023173.3         106392-106483
            93-257              AC023173.3         107885-108049
            258-2469            AC023173.3         139117-141328
FEATURES             Location/Qualifiers
     source          1..2469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 7.73 cM"
     gene            1..2469
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /note="caveolin 1, caveolae protein"
                     /db_xref="GeneID:12389"
                     /db_xref="MGI:MGI:102709"
     exon            1..92
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..599
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caveolin, caveolae protein 1; caveolin-1; caveolin,
                     caveolae protein, 22 kDa"
                     /codon_start=1
                     /product="caveolin-1 isoform 1"
                     /protein_id="NP_031642.1"
                     /db_xref="CCDS:CCDS19924.1"
                     /db_xref="GeneID:12389"
                     /db_xref="MGI:MGI:102709"
                     /translation="MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVTEKQVYDA
                     HTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRL
                     LSTIFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLF
                     EAIGKIFSNIRISTQKEI"
     exon            93..257
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..2469
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /note="hexamer: AATAAA"
     polyA_site      2469
                     /gene="Cav1"
                     /gene_synonym="Cav; Cav-1"
                     /note="major polyA site"
ORIGIN      
        1 agttctctta aatcacagcc cagggaaacc tcctcagagc ctgcagccag ccacgcgcca
       61 gcatgtctgg gggcaaatac gtagactccg agggacatct ctacactgtt cccatccggg
      121 aacagggcaa catctacaag cccaacaaca aggccatggc agacgaggtg actgagaagc
      181 aagtgtatga cgcgcacacc aaggagattg acctggtcaa ccgcgacccc aagcatctca
      241 acgacgacgt ggtcaagatt gactttgaag atgtgattgc agaaccagaa gggacacaca
      301 gtttcgacgg catctggaag gccagcttca ccaccttcac tgtgacaaaa tattggtttt
      361 accgcttgtt gtctacgatc ttcggcatcc caatggcact catctggggc atttactttg
      421 ccattctctc cttcctgcac atctgggcgg ttgtaccgtg catcaagagc ttcctgattg
      481 agattcagtg catcagccgc gtctactcca tctacgtcca taccttctgc gatccactct
      541 ttgaagctat tggcaagata ttcagcaaca tccgcatcag cacgcagaaa gagatatgag
      601 ggacatttca aggatgaaag gtttttttcc ccccttacta tttccttggt gccaattcca
      661 agttgctctc gcagcagcaa atttatgaat ggtttgtctt gatcaagaac aaagaattca
      721 ttcccaccat tctcatatat actacttgtc tcttctaagc tactgcatct atgtttgaca
      781 gtctggaatg tttaaaccca ttcctgctct ctcttttata tgtgaatcat tgtttcattg
      841 gctaaaatat aaacatattg ttgaaagatg atttgagaaa aataggaagg actgggaggc
      901 agggaagagt accaacaacc tcaactgcct actcaaaggt gatgatgtca tacaaaggga
      961 agagattcag gttacggcca tttgtttagg ggcatgaagg aacgttttta atatatgcca
     1021 gttatctaag gaattggttg ctgtcctcac tcttaacaat ccagttagat ttagggattt
     1081 agggatcacc atcaatttgg agactataat cttcatgata ccaacaatgt tttacttatc
     1141 ctggcatttt aacctgttat tttgtatgcc tgaatatttg ctatactgag aataagacct
     1201 acgtgccttc taatttttca tgtttttttt ttttccaaat aggatctaac tcatctactt
     1261 gcatgatgcc ggcagctttc ctaaaaacaa aacatacaaa ttgcacttgc tagttctctg
     1321 tacttgtttc tgactctgaa atacagaacc tgttgatgtt gatatctgtg ctcagctatg
     1381 tagcatcttt ctctctgtta agcctggtca acattaaccc aatgaaatga tttgaagcag
     1441 acaaatgggg gtgagacctc tctggactgg cagaagtaga agccagcttt ccctgccact
     1501 cagcaactga atgaggccag cgtgtctatt cagtttcact cattttcaag aataatcaca
     1561 ggttcctgac tctaagccag cccctcacca ggatcaaggt ttagtgactg actgggatga
     1621 tttaggagct caacattgta cttccttttc agctgatgag tgaacctcca gggaggggtg
     1681 tcaaaaagga ggctgctaaa ccgagactgc caagcctgtt gtaaacatga ccccttttat
     1741 gcaaagccct tgcaatagtc tgcaatgctg tgaagctcga cctttccccc tgcaaggaac
     1801 ctttgaccta atccaaccat cattttgttc agaaaggtgg gggaagggtg gtaacaaaag
     1861 cttgaggtaa tgttcttgct gtaataaatt caagtttttc tgaacccaaa ctgaggaatt
     1921 tcacctgtgt acctgagtct ccagaaagct gcctgcctgg gacacccaaa agccttttac
     1981 ttcccagctc acattacagc tctgcccttg gggatatttt taaaattcca gataggcttt
     2041 cattttcact ttcatacatg tattggaacc ctgcttgact tgttttctcc ttcagtcttg
     2101 ccgacacttt accaacctgc tacctacttt gattgtttgc atttaaaaca gacactggca
     2161 tggccacagt ttgaatttta aactgtgcac ataactgaaa gtgtactaga ctgtatacct
     2221 ttttacatgt agagatattc tttatcttta tataaggaga atcacttggg aaatgattct
     2281 acaattcagt ctgtaaactg tgtgttccaa gacatgtctg ttctccctag atactcagtt
     2341 ttatacaagt caattgctga tccaaaaggt tactgaaatt ttatatgctt actgatatat
     2401 tttacacttt tttatgctgc atgtcctata aagatttcaa atctgcacaa taaaattgtt
     2461 taacagtta
//
