LOCUS       NM_001039494             781 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cation channel sperm associated auxiliary subunit zeta
            (Catsperz), mRNA.
ACCESSION   NM_001039494 XM_911967 XM_922228 XM_985760 XM_985793
VERSION     NM_001039494.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Zhao,Y., Wang,H., Wiesehoefer,C., Shah,N.B., Reetz,E., Hwang,J.Y.,
            Huang,X., Wang,T.E., Lishko,P.V., Davies,K.M., Wennemuth,G.,
            Nicastro,D. and Chung,J.J.
  TITLE     3D structure and in situ arrangements of CatSper channel in the
            sperm flagellum
  JOURNAL   Nat Commun 13 (1), 3439 (2022)
   PUBMED   35715406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Lin,S., Ke,M., Zhang,Y., Yan,Z. and Wu,J.
  TITLE     Structure of a mammalian sperm cation channel complex
  JOURNAL   Nature 595 (7869), 746-750 (2021)
   PUBMED   34225353
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Hwang,J.Y., Mannowetz,N., Zhang,Y., Everley,R.A., Gygi,S.P.,
            Bewersdorf,J., Lishko,P.V. and Chung,J.J.
  TITLE     Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates
            Sperm Motility
  JOURNAL   Cell 177 (6), 1480-1494 (2019)
   PUBMED   31056283
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Chung,J.J., Miki,K., Kim,D., Shim,S.H., Shi,H.F., Hwang,J.Y.,
            Cai,X., Iseri,Y., Zhuang,X. and Clapham,D.E.
  TITLE     CatSperzeta regulates the structural continuity of sperm Ca2+
            signaling domains and is required for normal fertility
  JOURNAL   Elife 6, e23082 (2017)
   PUBMED   28226241
  REMARK    GeneRIF: Targeted disruption of Tex40 (CatSperz) reduces CatSper
            current and sperm rheotactic efficiency in mice, resulting in
            severe male subfertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK006134.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001039494.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006134.1, BU938820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-781               AK006134.1         4-784
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..781
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /note="cation channel sperm associated auxiliary subunit
                     zeta"
                     /db_xref="GeneID:67077"
                     /db_xref="MGI:MGI:1914327"
     exon            1..89
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..656
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /note="protein expressed in male leptotene and zygotene
                     spermatocytes 622; testis-expressed sequence 40 protein;
                     testis-expressed protein 40; testis expressed 40;
                     catSperzeta; catSper-zeta; cation channel sperm-associated
                     protein subunit zeta"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit zeta"
                     /protein_id="NP_001034583.1"
                     /db_xref="CCDS:CCDS29510.1"
                     /db_xref="GeneID:67077"
                     /db_xref="MGI:MGI:1914327"
                     /translation="MEESVKPVPKHANHRRSSVRSSLYGDVRDLWSTATMSTANVSVS
                     DVCEDFDEEGKSVRNRIRKYSQTISIRDSLNLEPEEIQQQARRELELCHGRSLEHGED
                     HEESETSLASSTSESLIFSLWKPHRTYWTEQQNRLPLPLMELMETEVLDILKKALITY
                     RSTIGRNHFMTKELQGYIEGIRKRRNKRLYFLDQ"
     exon            90..402
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /inference="alignment:Splign:2.1.0"
     exon            403..479
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /inference="alignment:Splign:2.1.0"
     exon            480..546
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /inference="alignment:Splign:2.1.0"
     exon            547..781
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      758..763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /note="hexamer: ATTAAA"
     polyA_site      777
                     /gene="Catsperz"
                     /gene_synonym="1700019N12Rik; A430107B04Rik; MLZ-622;
                     Tex40"
                     /note="major polyA site"
ORIGIN      
        1 cccttcctgg agcgtgaccc ccctcccttc tcgattgagc cctgtggata ctggtccgtt
       61 ggtgcaggac gatggaggaa agcgtcaaac cggtgcccaa acacgcaaac catcgccgca
      121 gctcggtcag atccagcctg tacggagatg ttcgtgacct atggagcacg gccacgatgt
      181 ccacagcgaa tgtgtcggta tccgacgtct gcgaggactt cgacgaagag ggcaaatctg
      241 taagaaacag gattcgcaag tacagccaga ccatttctat tagggacagc ctcaacctcg
      301 agccagagga gatccagcag caagcacgtc gagagcttga actgtgccat ggcaggtcct
      361 tggagcatgg ggaggaccac gaagaatctg agacctcctt agcatcgtct acttcagaat
      421 cactaatatt cagcctatgg aagccacatc gaacctactg gacagagcag cagaacaggc
      481 tgcctctgcc tctgatggag ctcatggaga ctgaagttct ggatattctc aaaaaagccc
      541 tcatcacata taggtccacg attggcagga accacttcat gactaaagag ctgcagggat
      601 acatcgaagg gatcaggaag cgcaggaaca agaggctgta ctttttggat cagtgaacct
      661 ccagctcaag tggccgacga gacgtccgct ccgtgtcctt tccggtccct cgaacccaag
      721 ctcaacctca tctgcatgga atttgaatcc tagagaaatt aaagagtcta tgcatggtcc
      781 c
//
