LOCUS       NM_175350               2565 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cation channel sperm associated auxiliary subunit
            delta (Catsperd), transcript variant 1, mRNA.
ACCESSION   NM_175350 XM_001052081 XM_001052082 XM_884088 XM_914378
VERSION     NM_175350.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Zhao,Y., Wang,H., Wiesehoefer,C., Shah,N.B., Reetz,E., Hwang,J.Y.,
            Huang,X., Wang,T.E., Lishko,P.V., Davies,K.M., Wennemuth,G.,
            Nicastro,D. and Chung,J.J.
  TITLE     3D structure and in situ arrangements of CatSper channel in the
            sperm flagellum
  JOURNAL   Nat Commun 13 (1), 3439 (2022)
   PUBMED   35715406
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Hwang,J.Y., Wang,H., Lu,Y., Ikawa,M. and Chung,J.J.
  TITLE     C2cd6-encoded CatSpertau targets sperm calcium channel to Ca2+
            signaling domains in the flagellar membrane
  JOURNAL   Cell Rep 38 (3), 110226 (2022)
   PUBMED   34998468
REFERENCE   3  (bases 1 to 2565)
  AUTHORS   Lin,S., Ke,M., Zhang,Y., Yan,Z. and Wu,J.
  TITLE     Structure of a mammalian sperm cation channel complex
  JOURNAL   Nature 595 (7869), 746-750 (2021)
   PUBMED   34225353
REFERENCE   4  (bases 1 to 2565)
  AUTHORS   Hwang,J.Y., Mannowetz,N., Zhang,Y., Everley,R.A., Gygi,S.P.,
            Bewersdorf,J., Lishko,P.V. and Chung,J.J.
  TITLE     Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates
            Sperm Motility
  JOURNAL   Cell 177 (6), 1480-1494 (2019)
   PUBMED   31056283
REFERENCE   5  (bases 1 to 2565)
  AUTHORS   Chung,J.J., Miki,K., Kim,D., Shim,S.H., Shi,H.F., Hwang,J.Y.,
            Cai,X., Iseri,Y., Zhuang,X. and Clapham,D.E.
  TITLE     CatSperzeta regulates the structural continuity of sperm Ca2+
            signaling domains and is required for normal fertility
  JOURNAL   Elife 6, e23082 (2017)
   PUBMED   28226241
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2565)
  AUTHORS   Chung,J.J., Shim,S.H., Everley,R.A., Gygi,S.P., Zhuang,X. and
            Clapham,D.E.
  TITLE     Structurally distinct Ca(2+) signaling domains of sperm flagella
            orchestrate tyrosine phosphorylation and motility
  JOURNAL   Cell 157 (4), 808-822 (2014)
   PUBMED   24813608
REFERENCE   7  (bases 1 to 2565)
  AUTHORS   Chung,J.J., Navarro,B., Krapivinsky,G., Krapivinsky,L. and
            Clapham,D.E.
  TITLE     A novel gene required for male fertility and functional CATSPER
            channel formation in spermatozoa
  JOURNAL   Nat Commun 2, 153 (2011)
   PUBMED   21224844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485788.18 and CT010491.8.
            
            [WARNING] On Aug 6, 2024 this sequence was replaced by NM_175350.4.
            
            On or before Oct 11, 2009 this sequence version replaced
            XM_001052081.2, XM_914378.2, XM_884088.2, XM_001052082.2,
            NM_175350.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ441159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               CT485788.18        122167-122274
            109-163             CT485788.18        125560-125614
            164-240             CT485788.18        126314-126390
            241-313             CT485788.18        127534-127606
            314-431             CT485788.18        129514-129631
            432-496             CT485788.18        130295-130359
            497-610             CT485788.18        135501-135614
            611-694             CT010491.8         2482-2565
            695-845             CT010491.8         5497-5647
            846-941             CT010491.8         6549-6644
            942-1024            CT010491.8         7211-7293
            1025-1201           CT010491.8         8334-8510
            1202-1315           CT010491.8         9189-9302
            1316-1405           CT010491.8         9851-9940
            1406-1464           CT010491.8         10743-10801
            1465-1543           CT010491.8         12827-12905
            1544-1596           CT010491.8         14283-14335
            1597-1671           CT010491.8         14925-14999
            1672-1800           CT010491.8         15996-16124
            1801-1984           CT010491.8         17416-17599
            1985-2142           CT010491.8         18022-18179
            2143-2565           CT010491.8         18788-19210
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.43 cM"
     gene            1..2565
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /note="cation channel sperm associated auxiliary subunit
                     delta"
                     /db_xref="GeneID:106757"
                     /db_xref="MGI:MGI:2147030"
     exon            1..108
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2464
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; catSperdelta; catSper-delta; cation channel
                     sperm-associated protein subunit delta; transmembrane
                     protein 146"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit delta isoform 1 precursor"
                     /protein_id="NP_780559.2"
                     /db_xref="CCDS:CCDS50153.1"
                     /db_xref="GeneID:106757"
                     /db_xref="MGI:MGI:2147030"
                     /translation="MLVLMLAAAVATMVRAHTLCRVHTVRTGKVFKSNIQLQGDPLFY
                     AFPNTFVLKNVCKADISVYLGQKVFLTIDNFESSLLPLTVPKSLAVGVPSITSAHFVS
                     GSLVLFVISGKGYSYDYYENTWRKLEGISEPVSHISGDVCCFKGSFCLELSNNLFAYL
                     RGGQIPGTNIYFSDNGGFSFQLMNTDKLSHLTGTLGGIFHLHSMSQVGVLMVENNLGT
                     FHYMEYPLNHSMGIAFSYKNLLEVIMKPYQRGFMVLWNQKSILVSSNSGQIVEHVRLI
                     DQKIFTDLDVEHANINIYSVASNAYELAFLVAEDHLYYGSQSYMGTYVIKLPHQPLWS
                     THTSIYFEDIGILQVLTPVADPHFAAYDFDKCTVNVQSSLMDEKLALQPCNVELLEST
                     MINTMFTIDMNSKLKLSALMIPRKGENPTPLVMVSNPHALGFKANLNEFGNTFDGNSK
                     YKLDIELKQQHHWGNSDFNFTASIKRHAISSVTVDIADKTLSCVDLKPLSTLISVGCD
                     MTKKIVVQNKISACTMGILNPVQLQKNYTYTIEKEAYDPINHNGEAQDDLIVFYEYKD
                     LGCPRLVYYDKPWKPVVELWKNGIVEEIMNAEYVISEINGLVTYSYSLTAATANCRSQ
                     PQNWSTFESDIENEEPFLWNRENYVSCHEDNKDNPLLWPNVEYQVLGGQTNNKIIFGQ
                     RNGIYTFHLSVVDPYYSYCNLNTIFSVYVHGALPVTKFQPLLTILLMVTTTLLTAWLA
                     YAIPKQLRSEKGQRLLGFCYQILQLCLGVCFCTWLRGKLRQWLRPRRVKDQNRGKVRV
                     AQKHPET"
     exon            109..163
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            164..240
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            241..313
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            314..431
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            432..496
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            497..610
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            611..694
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            695..845
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            846..941
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1024
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1201
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1315
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1405
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1464
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1543
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1596
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1671
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1800
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1984
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2142
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2565
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /note="hexamer: AATAAA"
     polyA_site      2565
                     /gene="Catsperd"
                     /gene_synonym="4921529N20Rik; 4933402B14Rik; 619718;
                     Gm6095; Tmem146"
                     /note="major polyA site"
ORIGIN      
        1 agcttggcgg ttgaagagca gtgttagctg tggagaacca ggcaagatgc tggtgttgat
       61 gctagcagca gcagtggcca ccatggtcag ggctcacaca ctgtgccggg tgcacacagt
      121 gaggaccggg aaagtgttta agtccaatat acaacttcaa ggggacccac tgttctacgc
      181 cttccccaac acatttgtgc tcaagaacgt gtgcaaggct gacatttctg tgtatctagg
      241 gcagaaagtt ttcttgacga tagacaactt tgagtccagc ctcttgccgc tcaccgttcc
      301 caagtcattg gcggtggggg tgccatcaat cacaagcgcc cactttgtct ccggctcact
      361 agtactgttt gtgatcagtg gaaaaggcta cagttacgat tactatgaga acacctggcg
      421 taaattggaa ggtatatcag aacctgtctc tcacattagt ggtgacgttt gttgtttcaa
      481 aggctccttt tgcctggagt tatcaaataa cctgtttgca tatctccgtg gtggccagat
      541 ccctgggacc aacatatatt tctctgacaa tggaggattt tcattccagc tcatgaatac
      601 tgacaaactg agtcacctga caggaacact aggaggcatc ttccacttac attccatgtc
      661 tcaggtgggg gtactcatgg ttgaaaataa tttgggcaca tttcattaca tggagtaccc
      721 cctgaaccat agtatgggga tagccttttc atacaagaat ctccttgaag tcattatgaa
      781 accataccag agggggttta tggtcctctg gaatcagaaa agtatattgg tgtcctccaa
      841 ttcaggccag attgttgaac acgtgcggct gatagatcag aagatcttta cagacttaga
      901 tgtcgaacat gccaacatca acatctacag tgttgcctca aatgcttacg agctggcttt
      961 tttggtagca gaagatcatc tgtactatgg aagtcagagt tacatgggaa cctatgtaat
     1021 caaactgccc catcagcctc tctggtctac acacacaagc atctactttg aggacatcgg
     1081 catactgcag gtcctcaccc ctgttgctga cccacacttt gcagcctatg acttcgacaa
     1141 gtgtacagtg aatgtgcagt cctctctcat ggatgaaaag ctggcgcttc aaccatgtaa
     1201 tgtggaactt ctggaaagca ccatgataaa tacaatgttt acaatagaca tgaatagcaa
     1261 gctgaaactg tctgccctca tgataccccg gaagggcgag aaccctaccc ctctggtcat
     1321 ggtcagcaat ccccatgccc tggggtttaa ggcaaacctc aatgagtttg gcaatacgtt
     1381 tgatggcaac tctaagtaca aactggatat tgaactcaaa cagcagcatc actggggcaa
     1441 ctcagatttc aacttcactg ccagcatcaa gcgccatgcc atctcctctg taaccgtgga
     1501 catagctgac aagacacttt cgtgtgtgga cctaaagcct ctgtccacgc tcatctcagt
     1561 tggctgtgac atgacaaaga aaattgttgt gcaaaacaag atctccgcct gcaccatggg
     1621 aatcctgaac cccgtgcagc tgcagaagaa ctatacttac accattgaga aggaagcata
     1681 cgatcctatc aaccacaatg gtgaagccca ggatgacctg atagtatttt acgagtacaa
     1741 ggacctgggc tgcccgcgcc tagtctacta tgacaagccg tggaaacctg tggtggaact
     1801 gtggaagaat gggattgtag aagaaatcat gaacgcagag tatgtcatct cggagataaa
     1861 tggactagtc acctattcat actccttgac ggctgccact gcaaactgcc ggtcacagcc
     1921 ccagaactgg agcacctttg aatcggatat tgagaacgaa gaaccgttcc tctggaacag
     1981 agagaactat gtcagctgcc acgaagacaa caaggacaac cccctgctat ggccgaatgt
     2041 cgagtatcag gtcttaggtg gccagacaaa caacaagatt atttttggcc aaagaaatgg
     2101 gatctatacc ttccatctgt ctgtggtaga tccatactac agctactgca acctgaacac
     2161 catattcagc gtgtacgtgc acggggcctt accggtgacg aagttccaac cattgctcac
     2221 catcctcctg atggtcacca caacgctgct gactgcgtgg ctggcctatg ctatccccaa
     2281 acagctgagg agtgagaaag gccagcgact tctgggtttc tgctaccaga tactccagct
     2341 ctgcctaggg gtctgcttct gcacctggct gcgtggcaaa ctgagacagt ggctgcgccc
     2401 cagaagggtg aaagaccaga acagaggcaa ggtgcgagtt gcccagaaac atccagagac
     2461 ataggggccg ccctagactc agagtgcgct ccaatgagag gcctttccct tcccctccac
     2521 gtgtgtccac gttagctttt gtcccaataa attgttaacc gtgaa
//
