LOCUS       NM_139301               2304 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cation channel, sperm associated 1 (Catsper1), mRNA.
ACCESSION   NM_139301
VERSION     NM_139301.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Li,X., Yuan,C., Shi,J., Kang,H., Chen,Y., Duan,Y., Jin,J.,
            Cheung,L.P., Li,T.C., Liu,Y., Cui,Y., Ruan,Y.C., Jiang,X., Cai,Z.,
            Chan,H.C., Ji,L., Zeng,X., Liu,J., Chen,H. and Fok,K.L.
  TITLE     beta-Defensin 19/119 mediates sperm chemotaxis and is associated
            with idiopathic infertility
  JOURNAL   Cell Rep Med 3 (12), 100825 (2022)
   PUBMED   36513070
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Zhao,Y., Wang,H., Wiesehoefer,C., Shah,N.B., Reetz,E., Hwang,J.Y.,
            Huang,X., Wang,T.E., Lishko,P.V., Davies,K.M., Wennemuth,G.,
            Nicastro,D. and Chung,J.J.
  TITLE     3D structure and in situ arrangements of CatSper channel in the
            sperm flagellum
  JOURNAL   Nat Commun 13 (1), 3439 (2022)
   PUBMED   35715406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Behvarz,M., Rahmani,S.A., Siasi Torbati,E., Danaei Mehrabad,S. and
            Bikhof Torbati,M.
  TITLE     Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with
            idiopathic azoospermia and oligospermia risk in Iranian population
  JOURNAL   BMC Med Genomics 15 (1), 47 (2022)
   PUBMED   35248021
  REMARK    GeneRIF: Association of CATSPER1, SPATA16 and TEX11 genes
            polymorphism with idiopathic azoospermia and oligospermia risk in
            Iranian population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Hwang,J.Y., Wang,H., Lu,Y., Ikawa,M. and Chung,J.J.
  TITLE     C2cd6-encoded CatSpertau targets sperm calcium channel to Ca2+
            signaling domains in the flagellar membrane
  JOURNAL   Cell Rep 38 (3), 110226 (2022)
   PUBMED   34998468
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Yang,F., Gracia Gervasi,M., Orta,G., Tourzani,D.A., De la
            Vega-Beltran,J.L., Ruthel,G., Darszon,A., Visconti,P.E. and
            Wang,P.J.
  TITLE     C2CD6 regulates targeting and organization of the CatSper calcium
            channel complex in sperm flagella
  JOURNAL   Development 149 (2) (2022)
   PUBMED   34919125
  REMARK    GeneRIF: C2CD6 regulates targeting and organization of the CatSper
            calcium channel complex in sperm flagella.
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Carlson,A.E., Quill,T.A., Westenbroek,R.E., Schuh,S.M., Hille,B.
            and Babcock,D.F.
  TITLE     Identical phenotypes of CatSper1 and CatSper2 null sperm
  JOURNAL   J Biol Chem 280 (37), 32238-32244 (2005)
   PUBMED   16036917
  REMARK    GeneRIF: CatSper1 and CatSper2 null sperm show identical phenotypes
            in mice
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Podlaha,O., Webb,D.M., Tucker,P.K. and Zhang,J.
  TITLE     Positive selection for indel substitutions in the rodent sperm
            protein catsper1
  JOURNAL   Mol Biol Evol 22 (9), 1845-1852 (2005)
   PUBMED   15930155
  REMARK    GeneRIF: Catsper1's function in sperm physiology and role in sperm
            competition using rodent models
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Nikpoor,P., Mowla,S.J., Movahedin,M., Ziaee,S.A. and Tiraihi,T.
  TITLE     CatSper gene expression in postnatal development of mouse testis
            and in subfertile men with deficient sperm motility
  JOURNAL   Hum Reprod 19 (1), 124-128 (2004)
   PUBMED   14688170
  REMARK    GeneRIF: Potential role for CatSper in sperm motility and fertility
            in mouse and human. CatSper is therefore implicated as a potential
            target to explore the molecular mechanisms of male infertility.
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Carlson,A.E., Westenbroek,R.E., Quill,T., Ren,D., Clapham,D.E.,
            Hille,B., Garbers,D.L. and Babcock,D.F.
  TITLE     CatSper1 required for evoked Ca2+ entry and control of flagellar
            function in sperm
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14864-14868 (2003)
   PUBMED   14657352
  REMARK    GeneRIF: CatSper1 functions as a voltage-gated Ca2+ channel that
            controls Ca2+ entry to mediate the hyperactivated motility needed
            late in the preparation of sperm for fertilization
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Ren,D., Navarro,B., Perez,G., Jackson,A.C., Hsu,S., Shi,Q.,
            Tilly,J.L. and Clapham,D.E.
  TITLE     A sperm ion channel required for sperm motility and male fertility
  JOURNAL   Nature 413 (6856), 603-609 (2001)
   PUBMED   11595941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122861.4.
            
            On Jul 25, 2018 this sequence version replaced NM_139301.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF407332.1, SRR5189685.128480.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1050              AC122861.4         70130-71179
            1051-1257           AC122861.4         72134-72340
            1258-1371           AC122861.4         73219-73332
            1372-1525           AC122861.4         73497-73650
            1526-1617           AC122861.4         73973-74064
            1618-1761           AC122861.4         74220-74363
            1762-1825           AC122861.4         74497-74560
            1826-1898           AC122861.4         74720-74792
            1899-1959           AC122861.4         74882-74942
            1960-2035           AC122861.4         75940-76015
            2036-2150           AC122861.4         78386-78500
            2151-2304           AC122861.4         78632-78785
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.3 cM"
     gene            1..2304
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /note="cation channel, sperm associated 1"
                     /db_xref="GeneID:225865"
                     /db_xref="MGI:MGI:2179947"
     exon            1..1050
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2177
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /note="sperm protein CATSPER1; sperm ion channel; sperm
                     calcium channel 1"
                     /codon_start=1
                     /product="cation channel sperm-associated protein 1"
                     /protein_id="NP_647462.1"
                     /db_xref="CCDS:CCDS29456.1"
                     /db_xref="GeneID:225865"
                     /db_xref="MGI:MGI:2179947"
                     /translation="MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVY
                     YDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNI
                     SHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQ
                     QYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSH
                     HGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARY
                     TFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKIS
                     HLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFL
                     SIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRI
                     LKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLR
                     ALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYF
                     IFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEA
                     LKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDD
                     DYGK"
     exon            1051..1257
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1371
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1525
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1617
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1761
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1825
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1898
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1959
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2035
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2150
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2304
                     /gene="Catsper1"
                     /gene_synonym="Catsper; KSper"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctccct ggaagccggg gctgtggttg gactgagctt ggcttgaggg gatcccgaga
       61 agggactttg ggttatacac ctgagctgtc tttgttccag gggctccaag acagtcatgg
      121 atcaatcttc aaggagggac gagtcttacc atgagacaca ccccggtagc ttagacccaa
      181 gccatcaatc ccacccccac ccccaccccc accccaccct gcataggcca aaccaaggtg
      241 gcgtctatta cgattctcct cagcatggga tgttccaaca accataccaa cagcatggtg
      301 ggttccatca acaaaatgaa ttgcagcatt tgcgtgagtt ctcagactcc catgacaatg
      361 ctttctccca tcattcctat cagcaggaca gggctggtgt ctctacctta cctaataaca
      421 tctctcacgc ttatggtgga tcgcaccccc ttgctgagtc ccagcactct ggtggacccc
      481 agagtggacc tcgtattgac ccgaatcatc atccccacca agatgacccc catagaccca
      541 gtgaaccttt gtcccacccc tcctctactg gcagccacca agggacaacc catcaacaat
      601 accatgagag gtctcaccat cttaaccccc agcagaacag agatcatgca gacaccattt
      661 cctatcgctc cagtacgcgg ttctatcgct cccatgcgcc gttcagtcgc caggaaagac
      721 ctcatctcca cgctgatcac catcatgagg gccatcatgc ccattctcac catggtgaac
      781 atccccacca caaggagcaa cggcactatc acggagatca tatgcatcac catatccatc
      841 atcgctcccc aagtgcctcc caactctcac acaagtctca cagcacactt gccacctctc
      901 catctcatgt gggatcgaaa agcacagcca gtggggctcg gtacaccttt ggagctcgct
      961 ctcaaatttt cggcaaagct cagtccaggg agagcttgag agaatcagcc tctttgagtg
     1021 aaggggagga tcacgttcag aaacgcaaaa aggcccagag ggcccacaag aaggcacaca
     1081 ccgggaatat cttccaattg ctatgggaaa aaataagcca tctccttttg ggtcttcagc
     1141 aaatgatatt gtcactgacc cagtccctgg gctttgagac ctttatcttc atcgtggtct
     1201 gcctcaacac agtcatcctt gtggcccaga ctttcactga gctagagatc cgaggtgaat
     1261 ggtacttcat ggtcttggac tccatcttcc tctccatcta tgtactagaa gcagtcctca
     1321 agctaattgc cctgggcctg gagtattttt atgacccatg gaacaacctg gacttcttca
     1381 tcatggtcat ggcagtgctg gactttgtgc tccttcagat aaactcgctc tcatattcat
     1441 tctacaacca cagcctgttc cggattctca aagtcttcaa aagtatgcgg gccctgaggg
     1501 ccatccgggt tcttcggagg ctcagcatcc tgaccagcct ccacgaagtg gccgggactc
     1561 tgagtggatc tttaccatcc atcacggcca tcctcaccct catgtttacc tgcctcttcc
     1621 tcttctctgt ggttctccga gcactgtttc aggactcaga ccccaagcgc ttccagaaca
     1681 tctttaccac actcttcacc ctgttcacca tgctcaccct ggacgactgg tccctcatct
     1741 acatagacaa cagggcccaa ggcgcctggt acatcatacc gatcctcatg atttacattg
     1801 tcatccagta cttcatcttc ctcaacctgg tgattgctgt cctggtagat aacttccaga
     1861 tggcgttgct caaaggccta gagaaagtga agctggagca agctgcccgg gtccatgaga
     1921 agttgttgga tgactctctg acagatctca acaaagcaga cgccaatgca caaatgaccg
     1981 aggaggcctt gaagatgcag cttattgagg gaatgtttgg caacatgaca gtgaagcagc
     2041 gggtgctcca cttccagttc ctgcagttgg tggcagcggt agaacagcat caacagaagt
     2101 ttcgttccca agcgtacgtc atcgatgagc ttgtggacat ggcatttgag gctggagacg
     2161 acgactacgg gaagtgaccc tgaagaatac taacctgagt ttctggcaag ctacctacct
     2221 cggtgggttg ggacatggcc ctaatgctgc tggtattatc cagaaccatg ttggactgag
     2281 gtcccaatag agtttttaaa accc
//
