LOCUS       NM_009804               2551 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus catalase (Cat), mRNA.
ACCESSION   NM_009804
VERSION     NM_009804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   da Cunha Menezes,E., de Abreu,F.F., Davis,J.B., Maurer,S.V.,
            Roshko,V.C., Richardson,A., Dowell,J., Cassella,S.N. and
            Stevens,H.E.
  TITLE     Effects of gestational hypothyroidism on mouse brain development:
            Gabaergic systems and oxidative stress
  JOURNAL   Dev Biol 515, 112-120 (2024)
   PUBMED   39048051
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Wen,C., Huang,C., Liao,X., Luo,Z. and Huang,C.
  TITLE     Mitochondria-targeted catalase induced cell malignant
            transformation by the downregulation of p53 protein stability via
            USP28/miR-200b/PP2A-Calpha axis
  JOURNAL   Arch Biochem Biophys 758, 110047 (2024)
   PUBMED   38844154
  REMARK    GeneRIF: Mitochondria-targeted catalase induced cell malignant
            transformation by the downregulation of p53 protein stability via
            USP28/miR-200b/PP2A-Calpha axis.
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Kim,K., Fazzone,B., Cort,T.A., Kunz,E.M., Alvarez,S., Moerschel,J.,
            Palzkill,V.R., Dong,G., Anderson,E.M., O'Malley,K.A., Berceli,S.A.,
            Ryan,T.E. and Scali,S.T.
  TITLE     Mitochondrial targeted catalase improves muscle strength following
            arteriovenous fistula creation in mice with chronic kidney disease
  JOURNAL   Sci Rep 14 (1), 8288 (2024)
   PUBMED   38594299
  REMARK    GeneRIF: Mitochondrial targeted catalase improves muscle strength
            following arteriovenous fistula creation in mice with chronic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Liu,Y., Chen,W., Li,C., Li,L., Yang,M., Jiang,N., Luo,S., Xi,Y.,
            Liu,C., Han,Y., Zhao,H., Zhu,X., Yuan,S., Xiao,L. and Sun,L.
  TITLE     DsbA-L interacting with catalase in peroxisome improves tubular
            oxidative damage in diabetic nephropathy
  JOURNAL   Redox Biol 66, 102855 (2023)
   PUBMED   37597421
  REMARK    GeneRIF: DsbA-L interacting with catalase in peroxisome improves
            tubular oxidative damage in diabetic nephropathy.
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   MacGregor,T.M., Copeland,N.G., Jenkins,N.A. and Giguere,V.
  TITLE     The murine gene for cellular retinoic acid-binding protein type II.
            Genomic organization, chromosomal localization, and
            post-transcriptional regulation by retinoic acid
  JOURNAL   J Biol Chem 267 (11), 7777-7783 (1992)
   PUBMED   1313808
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Feinstein,R.N., Fry,R.J. and Staffeldt,E.F.
  TITLE     Carcinogenic and antitumor effects of aminotriazole on acatalasemic
            and normal catalase mice
  JOURNAL   J Natl Cancer Inst 60 (5), 1113-1116 (1978)
   PUBMED   642030
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Holmes,R.S. and Masters,C.J.
  TITLE     Genetic control and ontogeny of microbody enzymes: a review
  JOURNAL   Biochem Genet 16 (3-4), 171-190 (1978)
   PUBMED   28117
  REMARK    Review article
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino
            acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid
            oxidase (Hao-1) loci on chromosome 2
  JOURNAL   Biochem Genet 14 (11-12), 981-987 (1976)
   PUBMED   13782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY093963.1, AK150893.1 and AL773505.5.
            
            On Oct 6, 2007 this sequence version replaced NM_009804.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047126.1, AK075853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY093963.1         1-30
            31-2451             AK150893.1         2-2422
            2452-2551           AL773505.5         7155-7254           c
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..2551
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /note="catalase"
                     /db_xref="GeneID:12359"
                     /db_xref="MGI:MGI:88271"
     exon            1..181
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1699
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /EC_number="1.11.1.6"
                     /note="catalase 1"
                     /codon_start=1
                     /product="catalase"
                     /protein_id="NP_033934.2"
                     /db_xref="CCDS:CCDS16478.1"
                     /db_xref="GeneID:12359"
                     /db_xref="MGI:MGI:88271"
                     /translation="MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTA
                     GSRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEH
                     IGKRTPIAVRFSTVTGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAIL
                     FPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSH
                     TFKLVNADGEAVYCKFHYKTDQGIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPS
                     WTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAF
                     DPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPM
                     CMHDNQGGAPNYYPNSFSAPEQQRSALEHSVQCAVDVKRFNSANEDNVTQVRTFYTKV
                     LNEEERKRLCENIAGHLKDAQLFIQKKAVKNFTDVHPDYGARIQALLDKYNAEKPKNA
                     IHTYTQAGSHMAAKGKANL"
     exon            182..353
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..464
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..595
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..700
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..826
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1018
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1171
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1310
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1441
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1549
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1633
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..2551
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2433..2438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /note="hexamer: AATAAA"
     polyA_site      2453
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /note="major polyA site"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="Cat"
                     /gene_synonym="2210418N07; Cas-1; Cas1; Cs-1"
ORIGIN      
        1 gaagtcacca ctccagcggg cctggccaac aagattgcct tctccgggtg gagaccgctg
       61 cgtccgtccc tgctgtctca cgttccgcag ctctgcagct ccgcaatcct acaccatgtc
      121 ggacagtcgg gacccagcca gcgaccagat gaagcagtgg aaggagcagc gggcctcgca
      181 gagacctgat gtcctgacca ccggaggcgg gaacccaata ggagataaac ttaatatcat
      241 gaccgcgggg tcccgagggc ccctcctcgt tcaggatgtg gttttcactg acgagatggc
      301 acactttgac agagagcgga ttcctgagag agtggtacac gcaaaaggag caggtgcttt
      361 tggatacttt gaggtcaccc acgatatcac cagatactcc aaggcaaagg tgtttgagca
      421 tattggaaag aggaccccta ttgccgttcg attctccaca gtcactggag agtcaggctc
      481 agctgacaca gttcgtgacc ctcgggggtt tgcagtgaaa ttttacactg aagatggtaa
      541 ctgggatctt gtgggaaaca acacccctat tttcttcatc agggatgcca tattgtttcc
      601 atcctttatc catagccaga agagaaaccc acagactcac ctgaaggatc ctgacatggt
      661 ctgggacttc tggagtcttc gtcccgagtc tctccatcag gtttctttct tgttcagtga
      721 ccgagggatt cccgatggtc accggcacat gaatggctat ggatcacaca ccttcaagtt
      781 ggttaatgca gatggagagg cagtctattg caagttccat tacaagaccg accagggcat
      841 caaaaacttg cctgttggag aggcaggaag gcttgctcag gaagatccgg attatggcct
      901 ccgagatctt ttcaatgcca tcgccaatgg caattacccg tcctggacgt tttacatcca
      961 ggtcatgact tttaaggagg cagaaacttt cccatttaat ccatttgatc tgaccaaggt
     1021 ttggcctcac aaggactacc ctcttatacc agttggcaaa ctggttttaa acaaaaatcc
     1081 agttaattac tttgctgaag ttgaacagat ggcttttgac ccaagcaata tgccccctgg
     1141 catcgagccc agccctgaca aaatgcttca gggccgcctt tttgcctacc cggacactca
     1201 ccgccaccgc ctgggaccca actatctgca gatacctgtg aactgtccct accgcgctcg
     1261 agtggccaac taccagcgtg atggccccat gtgcatgcat gacaaccagg gtggtgcccc
     1321 caactattac cccaacagct tcagcgcacc agagcagcag cgctcagccc tggagcacag
     1381 cgtccagtgc gctgtagatg tgaaacgctt caacagtgct aatgaagaca atgtcactca
     1441 ggtgcggaca ttctacacaa aggtgttgaa cgaggaggag aggaaacgcc tgtgtgagaa
     1501 cattgccggc cacctgaagg acgctcagct tttcattcag aagaaagcgg tcaagaattt
     1561 cactgacgtc caccctgact atggggcccg catccaggct cttctggaca agtacaacgc
     1621 tgagaagcct aagaacgcaa ttcacaccta cacgcaggcc ggctctcaca tggctgcgaa
     1681 gggaaaagct aacctgtaac tccggtgctc agcctccgct gaggagacct ctcgtgaagc
     1741 cgagcctgag gatcacctgt aatcaacgct ggatggattc tcccactccg gagcgcagac
     1801 tcacgctgat gactttaaaa cgataatccg ggcttctaga gtgaatgata accatgcttt
     1861 tgatgccgtt tcctgaaggg aaatgaaagg ttagggctta gcaatcattt aacagaaaca
     1921 tggatctaat aggacttctg tttggattat tcatttaaat gactacattt aaaatgatta
     1981 caagaaaggt gttctagcca gaaacatgac ttgattagac aagataaaaa tcttggcgag
     2041 aatagtgtat tctcctatta cctcatggtc tggtatatat acaatacaac acacatacca
     2101 cacacacaca cacatgcaat acacacacta cacacacata cacacactca cacacactca
     2161 tacacacaca tgaagagatg ataaagatgg cccactcaga attttttttt ttatttttct
     2221 aaggtcctta taagcaaaac catacttgca tcatgtcttc caaaagtaac tttagcactg
     2281 ttgaaactta atgtttattc ctgtgctgtg cggtgctgtg ctgtgctgtg ctgtgcagct
     2341 aatcagattc ttgttttttc ccacttggat tatgttgatg ttaatacgca gtgatttcac
     2401 ataggatgat ttgtacttgc ttacattttt acaataaaat gatctacatg gaaggaccgt
     2461 gtttggttgc tttcagctct gtataatgtg gaatgtgaag tagagattac cagctctctc
     2521 tgcagtaaca ataaaagcgc cagcggccag a
//
