LOCUS       NM_001159344            7966 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus castor zinc finger 1 (Casz1), transcript variant 1,
            mRNA.
ACCESSION   NM_001159344 XM_001472991 XM_001476949
VERSION     NM_001159344.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7966)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 7966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7966)
  AUTHORS   Sun,Y., Wang,L., Zhu,T., Wu,B., Wang,G., Luo,Z., Li,C., Wei,W. and
            Liu,Z.
  TITLE     Single-cell transcriptomic landscapes of the otic neuronal lineage
            at multiple early embryonic ages
  JOURNAL   Cell Rep 38 (12), 110542 (2022)
   PUBMED   35320729
REFERENCE   4  (bases 1 to 7966)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7966)
  AUTHORS   Mattar,P., Jolicoeur,C., Dang,T., Shah,S., Clark,B.S. and
            Cayouette,M.
  TITLE     A Casz1-NuRD complex regulates temporal identity transitions in
            neural progenitors
  JOURNAL   Sci Rep 11 (1), 3858 (2021)
   PUBMED   33594190
  REMARK    GeneRIF: A Casz1-NuRD complex regulates temporal identity
            transitions in neural progenitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7966)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 7966)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 7966)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 7966)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7966)
  AUTHORS   Vacalla,C.M. and Theil,T.
  TITLE     Cst, a novel mouse gene related to Drosophila Castor, exhibits
            dynamic expression patterns during neurogenesis and heart
            development
  JOURNAL   Mech Dev 118 (1-2), 265-268 (2002)
   PUBMED   12351199
  REMARK    GeneRIF: report the expression pattern of a murine Castor related
            gene (Cst) during embryogenesis [cst]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607145.28 and AL611967.21.
            
            On or before Apr 16, 2009 this sequence version replaced
            XM_001472991.1, XM_001476949.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL607145.28        2030-2152
            124-278             AL607145.28        35904-36058
            279-333             AL607145.28        87960-88014
            334-372             AL607145.28        99343-99381
            373-858             AL607145.28        126635-127120
            859-1693            AL607145.28        130396-131230
            1694-1762           AL607145.28        132219-132287
            1763-1853           AL607145.28        133804-133894
            1854-2018           AL607145.28        134597-134761
            2019-2191           AL607145.28        135779-135951
            2192-3039           AL607145.28        136113-136960
            3040-3172           AL607145.28        138920-139052
            3173-3236           AL607145.28        139305-139368
            3237-3391           AL607145.28        140541-140695
            3392-3514           AL607145.28        140841-140963
            3515-3853           AL607145.28        141896-142234
            3854-4052           AL607145.28        143661-143859
            4053-4224           AL607145.28        144628-144799
            4225-4376           AL607145.28        146162-146313
            4377-4518           AL607145.28        146431-146572
            4519-7966           AL611967.21        3187-6634
FEATURES             Location/Qualifiers
     source          1..7966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.87 cM"
     gene            1..7966
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /note="castor zinc finger 1"
                     /db_xref="GeneID:69743"
                     /db_xref="MGI:MGI:1196251"
     exon            1..123
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            124..278
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            279..333
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            334..372
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..5645
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein castor homolog 1; castor-related protein;
                     castor homolog 1, zinc finger"
                     /codon_start=1
                     /product="zinc finger protein castor homolog 1 isoform 1"
                     /protein_id="NP_001152816.1"
                     /db_xref="CCDS:CCDS51379.1"
                     /db_xref="GeneID:69743"
                     /db_xref="MGI:MGI:1196251"
                     /translation="MDLGTAESTRCTDPPAGKPPMAAKRKGGLKLNAICAKLSRQVVV
                     EKGAEAGSQAEGSPLHPRDKERSGPESGVSRAPRSEEDKRRAVIEKWVNGEYCEDPAP
                     TPVLGRIARDQELPPEGVYMVQPQGCSDEEDHAEEPSKDNSVLEEKESDGTASKDDSG
                     PSTRQASGETSSLRDYAASTMTEFLGMFGYDDQNTRDELAKKISFEKPHAGSTPEVAA
                     SSMLPSSEDTLSKRARFSKYEEYIRKLKAGEQLPWPAHGSKAEDRAGKEVVGPLPSLR
                     LPSNTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIHKLKTGENLRPQNGSTYKK
                     PSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPTKIPPAP
                     SLVPTPLTNVPSAPSTPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLP
                     TDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVI
                     RHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSD
                     VMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKC
                     DIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCMYSKATNHFHCIRAGCGFTFTSTS
                     QMTSHKRKHERRHIRSSGALGLPASLLGAKDTEHEESSNDDLVDFSALSSKNSSLSAS
                     PTSQQSSASLAAAAAATTAEAIPSATKPPNSKMAGLLPQGLSGSIPLALALSNSGLPT
                     TTPYFPLLPNRGSASLPVGSPGLLGSMSSGATTSATPDMPALMASRAGDSAPTAATSL
                     SVPPASIIERISASKGLISPMMARLAAAALKPSATFDPGSGQQPTPTKFPQAQVKQEP
                     DSAGTPGPHEASQDRSLDLTVKDPSNESNGHAVSANSSLLSSLMNKMSQGNPSLESFL
                     SIKTEAEGSPAGEPSPFLGKAVKALVQEKLSEPWKVYLRRFGTKDFCDAQCDFLHKAH
                     FHCVVEECGALFSTLDGAIKHANFHFRTEGGTAKGTPEASFPTSAAETKPPLAPSSLP
                     APPGTMVAGSSLEGPAPSPVSVPSTPTLLAWKQLASTIPQMPQIPSSVPHLPTSPLAT
                     TSLESAKPQVKPGFLQFQDNDPCLATDCKYASKFHFHCLFGNCKYVCKTSGKAESHCL
                     DHINPSNSLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWH
                     IKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSH
                     ARKHMRRMLGKNFDRVPPSQGPPSLMDAETDEGMDYTGCSPGAASSESSTMDRSCSST
                     PVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRR
                     FDLYEDCKDTACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKR
                     FKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFS
                     SSADCAVPDCKYKLKCSHFHCTYPGCRHTVVGMSQMDSHKRKHEKQERGEPPAASPGA
                     PVNLDGSLTLAAEQGSLLFLQTAAAGLGLLGDTGDPGPPVTASGTRDGPAAPTPAAAA
                     TTTTTTTATATATAGESSQEDDEELELPEEEAEDDDEDDDEEDDDDEDDDDDDDDEDL
                     RTDSEESLPEAAGEAGARTPLAALGGPGPAPTAASP"
     exon            373..858
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1693
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1762
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1853
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2018
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2191
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..3039
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3172
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3236
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3391
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3514
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3853
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..4052
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4224
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4376
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4518
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..7966
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6290..6295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /note="hexamer: AATAAT"
     polyA_site      6316
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
     regulatory      7402..7407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /note="hexamer: AATAAA"
     polyA_site      7441
                     /gene="Casz1"
                     /gene_synonym="2410019P08Rik; Cst; D4Ertd432e"
                     /note="major polyA site"
ORIGIN      
        1 gggagcgaaa aatccgggat ccggcaactt cggtcgcgca tgcgcgcccg cggcgctcca
       61 tcccaaacac acacacattt ttccccggac ttggaaagtc acccaaagcc gccccaagtg
      121 caggcacaca gaccttgctg acggaaggca gaccctctcc atctcacctg ccctccaact
      181 gcctgagcta cccactcctc cttctccggg ggaccctgca gctccccggt ggtgtgcatt
      241 ggaatggact tcggaccttg gactcttggg atgcaaagga tgaagtgacc cccaccccca
      301 actgtgtttg aggaatctct aggaccccgt gagagtttgg gaccaaggag cggagaatgg
      361 atcttggaac agctgaaagc acccggtgca ccgacccacc tgcaggcaag cctccaatgg
      421 cagccaagcg caaaggcggc ctgaagctca acgccatctg tgccaagctc agccgacagg
      481 tggtcgtgga gaagggagca gaggccggct cccaagccga aggtagccca ctacatcccc
      541 gggacaaaga gcgcagtggc cctgagtctg gggtgagccg ggctccccga agtgaagaag
      601 acaagaggcg ggcagtgatc gagaaatggg tcaatggaga gtactgtgag gatcccgcac
      661 ccaccccagt gttggggcgt attgcccgtg atcaggagct gcccccagag ggtgtctaca
      721 tggtccagcc acagggctgc agtgacgaag aagaccatgc agaagagccc tcaaaagata
      781 acagtgtcct ggaggagaag gagtcagatg gtacggcttc taaagatgac agcggcccca
      841 gcaccaggca ggcttcagga gaaacctcct ctctgaggga ctacgctgct tccaccatga
      901 ccgagttcct cggcatgttt ggctacgatg accagaacac cagggatgag ctggccaaga
      961 agatcagctt tgagaagccg catgcaggct ccacccccga ggtggctgcc tcttccatgt
     1021 tgccctcctc tgaggatacc ctcagcaagc gggcgcgctt ctccaaatac gaggaataca
     1081 tccgtaagct caaggccggc gagcaacttc cctggccagc ccacgggagc aaagccgagg
     1141 accgggcagg caaggaggtg gtgggtccct tacccagcct acggctgccc agcaacacgg
     1201 cccacctgga aaccaaggcc accatcctgc cactgccatc acacagcagt gtccagatgc
     1261 agaatctggt agctcgtgct tccaagtatg acttcttcat ccacaaactg aagacaggcg
     1321 agaacctgag gccccagaat ggaagcactt acaagaagcc atccaagtat gacctggaga
     1381 atgtcaagta cttgcacctc ttcaaacccg gggaaggcag ccctgacatg ggcggggcca
     1441 tcgccttcaa gacaggcaag gtggggcgcc cctctaagta cgacgttcgg ggcatccaga
     1501 agccaggccc taccaagatt ccgcccgccc ccagcctggt tcctacaccc ctcaccaatg
     1561 tgcccagtgc tcccagcacc cccggaccag gaccggagcc acctgcctcc ttgtccttca
     1621 acactcccga gtacctgaag tcaacctttt ccaaaacaga ctccatcacc acaggaactg
     1681 tctccactgt caagaacgga ttgcccacag ataaaccagc tgtcaccgaa gatgtaaaca
     1741 tttaccagaa atatattgcc aggttctcag gaagtcagca ctgcggtcac atccactgcg
     1801 cctaccagta ccgtgagcac tatcactgcc tggacccgga gtgcaactac cagcggttca
     1861 caagcaagca ggatgtgatc cgacattaca acatgcacaa gaagcgcgac aactccctgc
     1921 agcacggctt catgcgcttc agcccgctgg acgactgcag tgtctactac cacggctgcc
     1981 acctcaatgg gaagagcacc cactaccact gcatgcaggt gggatgtaac aaggtataca
     2041 caagtacgtc ggatgtgatg actcacgaga acttccacaa gaagaacacc cagctcatca
     2101 acgatggctt ccagcgcttc cgagccacgg aggactgcgg cacagctgac tgtcagttct
     2161 atggacagaa gaccacacac ttccactgca ggcgccctgg ctgcacattc accttcaaga
     2221 acaagtgtga catcgagaag cacaagagct accacatcaa ggatgatgcc tacgccaagg
     2281 acggcttcaa gaagttctac aagtacgagg agtgcaaata cgagggctgc atgtacagca
     2341 aggccaccaa ccatttccac tgcatccgcg ccggctgcgg cttcaccttc acctccacca
     2401 gccagatgac ctcacacaag cgcaagcacg agcggcggca catccggtcc tcgggggccc
     2461 tggggctgcc ggcctccctg ctgggcgcca aggacacgga gcacgaggaa tccagcaacg
     2521 atgacctcgt ggacttctct gccctgagca gcaagaactc cagcctgagc gcctccccca
     2581 ccagccagca atcgtccgca tccctggccg ctgcggctgc cgccaccact gctgaggcca
     2641 tccccagtgc caccaagcct cccaatagca agatggcagg cctgctgccc cagggcctgt
     2701 ctggttccat ccccttagca ctggccctct ctaactcagg cctgcccacc accacaccct
     2761 atttccctct gcttcctaac cgtgggagcg cctcattgcc tgtgggatct ccagggctcc
     2821 tgggctccat gtcctctggg gccacaacct cagcaacccc tgacatgccg gccctgatgg
     2881 cttccagagc tggagactcg gcccccacgg ctgccacctc tctctcggtg ccccctgcct
     2941 ccatcattga gagaatctct gcaagcaaag gcctcatctc acccatgatg gctagactgg
     3001 ctgcggccgc cctcaagccc tctgccacct ttgacccagg aagtgggcag cagcccaccc
     3061 ccaccaagtt cccccaggcc caggtgaagc aggagcctga cagtgctggc accccaggtc
     3121 cccacgaggc ctcccaagac cgcagtctag acctgaccgt gaaggatccc agtaatgaat
     3181 caaatggcca cgcagtctcg gcaaattcat ctcttttatc ctcgcttatg aataagatgt
     3241 ctcagggcaa ccccagcctc gaaagcttcc tgagcatcaa gacagaagcg gaggggagcc
     3301 ccgccgggga gccctcgcct ttcttgggca aggccgtgaa ggcactagtt caagagaagc
     3361 tgtcagagcc ttggaaggtg tatctccgca ggtttggtac caaggacttc tgtgatgccc
     3421 agtgtgactt cctccacaag gcgcatttcc attgtgtagt ggaggagtgc ggtgcgcttt
     3481 tcagcacctt ggacggagcc atcaaacatg caaacttcca cttccggaca gagggaggaa
     3541 cagcaaaagg aaccccagag gcttccttcc cgacctctgc tgctgagacc aaacctccct
     3601 tggcaccctc gtccctgcca gcacctcctg gcaccatggt cgctggatct tctctggagg
     3661 ggcctgctcc cagcccggtc tctgtgccct ccacccccac cctgctcgcc tggaagcagc
     3721 tggcttccac cataccccag atgcctcaga ttccctcctc agtgcctcac ctgcccacct
     3781 cgcccctggc gacgacgtct ctagagagcg ccaagcctca ggtcaaaccc gggttcctcc
     3841 agttccagga caacgatcca tgcctggcga cggactgcaa atacgccagc aagttccact
     3901 tccactgtct cttcgggaac tgcaagtacg tctgcaagac ctcgggcaag gctgagtccc
     3961 actgcttgga ccacatcaac cccagcaaca gcctggtgaa cgtgcgagac cagtttgctt
     4021 actactctct acagtgcctg tgtcccaacc agcactgtga gttccggatg cgtggacact
     4081 accactgcct ccggacgggc tgctactttg tcaccaacat caccaccaaa cttccatggc
     4141 atataaagaa gcatgagaag gctgaacgac gggcagccaa cgggttcaaa tacttcacca
     4201 agcgcgagga gtgcggaaga ctaggctgca agtacaacca ggtgaacagc cacttccact
     4261 gcatccggga aggttgtcag ttctcctttc tcctcaagca ccagatgacc tcgcatgccc
     4321 ggaagcacat gcggaggatg ctggggaaga actttgaccg agtgccccca tcccagggtc
     4381 ccccgagcct aatggatgcc gagacagacg agggcatgga ctatacaggc tgtagccctg
     4441 gagcggcgtc ctcagagtct tccaccatgg accgtagctg ttccagcacc cctgtgggca
     4501 atgagagcac agctgcaggg aacaccatct ccatgccgac agcctcgggg gccaaaaagc
     4561 gcttttggat catcgaggac atgtctccct ttggcaagcg aaggaagaca gcctcgtctc
     4621 ggaagatgct ggacgagggc atgatgctgg agggtttccg gcgctttgac ctctatgagg
     4681 actgcaagga tacagcctgc cagttctcac tcaaggtcac ccactaccac tgcacgcggg
     4741 aaaactgcgg ctacaagttt tgcggacgca cgcacatgta caagcacgca cagcaccacg
     4801 accgcgtgga caacctggtg ctggacgact tcaagcgctt caaggcctcc ctcagctgcc
     4861 acttcgccga ctgcccgttc tcgggcacca gcacgcactt ccactgcctg cgctgccgct
     4921 tccgttgcac agacagcacc aaggtcactg cgcaccgcaa gcaccacggc aagcaggacg
     4981 tgatcagcgc cgctggcttc tgccagttca gctcgagcgc cgactgcgca gtgcccgact
     5041 gcaagtacaa gctcaagtgc tcgcacttcc actgcaccta tccgggctgt cgccacacag
     5101 tggtgggcat gtcgcagatg gactcgcaca agcgcaagca cgagaagcag gagcgagggg
     5161 agcctcccgc agcctctccg ggtgcgcctg tcaacctgga cggctccctc acgctggccg
     5221 ccgagcaggg ctcgctgctc ttcctgcaga cagcggctgc gggcctaggc ctgctcgggg
     5281 acacggggga ccccggccca cctgtcaccg cctccgggac tcgggacggc cccgctgcgc
     5341 ccacccccgc tgccgccgcc accaccacca ccaccaccac agccacagcc acagccaccg
     5401 ctggggagtc ctcccaagag gacgacgagg agctggagct gccggaggag gaggccgagg
     5461 acgacgacga ggatgacgat gaagaggacg acgacgacga ggatgatgat gatgatgacg
     5521 acgacgagga cctgcgcacc gactcggagg agtcgttgcc cgaggctgcg ggcgaggcgg
     5581 gcgcgcggac cccgctggca gccctgggtg gccccggccc tgcgcccacc gccgcatcac
     5641 cctagccgcc gcgccacccc agccccctct agaactgctc tgtatgtgaa cccctgtgta
     5701 cagaccccgc tgggccgccc cagggagtga ggcgccctgg ccccgccggt gcttccggac
     5761 cccgagtccg tctcagggcg aggcggggac ccctctggtg cttcgggccg cccgcgccct
     5821 ccccgcccgc ccgagcgggt gttcagggaa tagcaggtgc tgtgtcgggg tggcagcact
     5881 gacctgcact cctctcggta cccactcgcg aggtccttgt ttgctcaggg gctccccgcg
     5941 ggggtcaccg ggttgtgggg gcggcaggct cctgtagcat ctggttctct cccccccccc
     6001 cgccccaatg cagctaagac ctcctcctgg ctcaggggag ggccggccga agacggtcag
     6061 catcagcacg ggtgacacta cagggacatg gagggaatct catggaatca gcagcaagcc
     6121 ggcatccccg cccccaagct gtggtccagg tctggtgaca ctcaggcccc agcccaccct
     6181 ccagcgaatt tgaggctgtg gcccaaaggc aggcacagct ggtgggggcc tggaggtgag
     6241 ggtctcagcc actggtgcaa acaggaaggc tgcgactggt tttggcttta ataatcaaaa
     6301 tggaaaaaaa atccaagaaa gttgtacagt atttttcctg taaaggttat tattctacat
     6361 agaacaaaaa gagaaggggg aaaacggaaa aaaacaaaaa aaactaaaac aaaaaaaaca
     6421 aaaaaacaaa aaaaaaagca ggcgagtgcg gggggagcct cgcctcgcct tcagcccagc
     6481 cctgggattg gggacccgag tgcaattgct cctgtggaat tgttgtgcat ttactttcaa
     6541 ggcctcggtt tgaggcgttg tcctcacact agcactgatg ggggctgcgg gattccaact
     6601 tttaacttga attttgtaga gacaaggaaa aaaaaaaaga ctattctctt gatacaagtt
     6661 tgtagctaat ttaacatttg agggtttttc tgttggttat gcgtgtggct ttatagggct
     6721 tttttttctc tttctctctc tctctcgttc cagttttgtt ttattatttt atttgggatg
     6781 ctttcgtgca ggtgcagccc acccagatct ggttcctttt ccaaaatacc cctttcccgg
     6841 aggcaatgag gccacttaga ctctgcacag ggctcacctg caggcactta cttggccaga
     6901 ggctgctcca gattctggta ggggcaggct gtctgaggcc ggccttgtgg ggtaaacctg
     6961 tgcactccag gttctggcta gtgccaggct ggaagaaacc aggccaattc ggcaagtaat
     7021 ggaagggccg ggagttgcca gcaggaagcc ccgcccatag gtctttaaat ggggtctgcc
     7081 caaatggggc agtggttttc tttatctgta tcagagtgta tgtatgtgtg tgagagtgtg
     7141 tatctgtgta tgtgtgtgtg tgtgtcccct cttggctgcc cacagccaga aagccaggac
     7201 catctaaact ggagagggag cagggagggt acagctgaga gatgagggta cccaacaggc
     7261 aacgcgctga ttgctaaccg gccctgccag agcctccatg ctgctgagag ttcgttcgcc
     7321 cagattctaa cctaccacag gactctgcct ctgtggaagg agttttgtaa aggaaaagaa
     7381 aaacaaaaca caacaaaaca aaataaaaaa aaatttcaat gtagcaaaat caaataaaaa
     7441 attataaaag gaaaaaaaaa agccgcggag agtgcgcagt ctagcctttt gtaagcctca
     7501 tattgcacat taggactata agccattgct agctcatctt gaattttaat gtgtaatttt
     7561 tgttttattt tctttctgtg aggaaaacga tgcctgaccc accaatgctc tttttaatgt
     7621 tttataacta tgtatgtgta tatatataaa tataaaagta atatgtatgc acatatgtgt
     7681 gtatatatct atatgtatat acatatatag atatatagag atatatagag aggttttgag
     7741 acaaaaaaaa aaaaaaatgc agaccatgaa accgacctga acagcgcgcg ctctgattac
     7801 ttgaatctgg tctcctcggc acctggttat taagaactga atatttttcc acttgaattt
     7861 agtgctatta gaaatttaat atatgtgttt tatttatttg attttttttt gcatgactga
     7921 tgcaaggttt gacattttca ctcaataaaa actggaaaaa aaatcc
//
