LOCUS       NM_028022               1574 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus cytosolic arginine sensor for mTORC1 subunit 1
            (Castor1), mRNA.
ACCESSION   NM_028022 XM_125970
VERSION     NM_028022.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Iskarpatyoti,J.A., Shi,J., Abraham,M.A., Rathore,A.P.S., Miao,Y.
            and Abraham,S.N.
  TITLE     Mast cell regranulation requires a metabolic switch involving
            mTORC1 and a glucose-6-phosphate transporter
  JOURNAL   Cell Rep 40 (13), 111346 (2022)
   PUBMED   36170813
  REMARK    GeneRIF: Mast cell regranulation requires a metabolic switch
            involving mTORC1 and a glucose-6-phosphate transporter.
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN719833.1, AK010455.1 and BC039988.1.
            
            On Jan 19, 2019 this sequence version replaced NM_028022.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039988.1, AK010455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CN719833.1         6-50
            46-1172             AK010455.1         3-1129
            1173-1574           BC039988.1         1147-1548
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..1574
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /note="cytosolic arginine sensor for mTORC1 subunit 1"
                     /db_xref="GeneID:71962"
                     /db_xref="MGI:MGI:1919212"
     exon            1..202
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1085
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /note="GATS-like protein 3; GATS protein-like 3"
                     /codon_start=1
                     /product="cytosolic arginine sensor for mTORC1 subunit 1"
                     /protein_id="NP_082298.1"
                     /db_xref="CCDS:CCDS24381.1"
                     /db_xref="GeneID:71962"
                     /db_xref="MGI:MGI:1919212"
                     /translation="MELHILEHRVRVLSIARPGLWLYTHPLIKLLFLPCRSRCKFFSL
                     TETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVMNVSHSGSVVQAAGVTKIARSVIA
                     PLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFQIYREVGGEPVPVTGDDSSN
                     GFPQIQHGPSPTVHPIQSPQNRFCVLTLDPETLPAVATTLIDVLFYSHSVPKEAASGG
                     PESTSIPFFAFSLIEGYISIVMDAEIQRKFPSDLLLTSSSGELWRMVRIGGQPLGFDE
                     CGIVAQIAGPLAAVDISAYYISTFNFDHALVPEDEIGCVIDILQRRQESQASKDP"
     exon            203..273
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..458
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            459..591
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..715
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            716..829
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..912
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1007
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1574
                     /gene="Castor1"
                     /gene_synonym="2410008K03Rik; Gatsl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgggcggt gcttctttaa gcccggcgcc accgcatcgc ctcctgccta ggtctcgctg
       61 gcggccaggc cggggctgcc gtatctgcga tggaacttca catcctagag caccgggtgc
      121 gagtactgag cattgcccgt ccgggcctct ggctctacac ccacccgctc atcaagctgc
      181 tcttcctgcc ctgtcgcagt cggtgcaagt tcttcagcct gactgagact ccggaagatt
      241 acactctcat ggtggatgag gagggcttta aagagctacc cccatccgag ttcctgcaag
      301 tggctgaggc cacatggctg gtgatgaacg tatctcacag tggctccgtg gtgcaggctg
      361 ctggagtaac caagattgcc cggtctgtca ttgccccgct ggctgaacac catgtgtctg
      421 ttctgatgtt gtccacatac cagacagact tcatcctggt acgggagcag gacctgtctg
      481 tggtgatcca cacactggcc caggagttcc aaatctaccg tgaagtaggc ggggagcctg
      541 tgcccgttac tggagacgat tccagcaatg gctttcccca gatccagcac gggcccagtc
      601 ccacggtgca tcccattcag agccctcaga accgcttttg tgtcctcaca ctggaccctg
      661 agacactgcc ggctgtcgcc accaccctca tcgatgtcct cttctactcc cacagtgtcc
      721 ccaaggaagc ggcctcgggc ggtcctgaat caacgtccat tccgttcttc gctttctccc
      781 tcatcgaggg gtacatctcc attgtcatgg atgcagagat ccagagaaag ttccccagtg
      841 acctcctgct gaccagttct tctggggagc tgtggaggat ggtgcgcatc gggggacagc
      901 ccctgggctt cgatgaatgt gggattgtgg cccagattgc gggtcccctg gcggctgttg
      961 acatctctgc ttactacatc agcacattca actttgacca tgcgctggtt cctgaagacg
     1021 agatcggctg tgtcattgat attctccagc gaaggcagga aagccaggct tccaaggacc
     1081 catagggaag caccagaccc ccagcattcc cgtaaagccc cccggggctc cagaaacttt
     1141 tctgagcttc agaacaagtc cctggtcctg ccaagggatc ctggttctgc tgtctgtctg
     1201 tcagctgtat ggagctggga ctcgtggcca tgcctggttc tgctgtctgt ctgtcagctg
     1261 tatggagctg ggactcgtgg ccatgcctgc ccacaaaaga taccttggtg cttggggctt
     1321 agatccccga cccaacattt tctatgtgac ctcagcaatg cacagagcct gcttgcctgc
     1381 agctggagcc gcctctcccc tggctaaggc tcacatcccc gggccgggct ctgacctcca
     1441 gcctgcactg ctttcctagc cagatgagtt cagcagtgca ctcccttcgc gggactccga
     1501 aggaagaatt aaatctcact tttattttca tgactgttta tataaataaa agacttgcgg
     1561 atttgtgccc tctg
//
