LOCUS       NM_013803               7645 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus calcium-sensing receptor (Casr), mRNA.
ACCESSION   NM_013803
VERSION     NM_013803.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7645)
  AUTHORS   Adam,S., Maas,S.L., Huchzermeier,R., Rakateli,L., Abschlag,K.,
            Hohl,M., Liao,L., Bartneck,M., Teunissen,M., Wouters,K.,
            Santovito,D., Jankowski,J., Biessen,E.A.L. and van der Vorst,E.P.C.
  TITLE     The calcium-sensing-receptor (CaSR) in adipocytes contributes to
            sex-differences in the susceptibility to high fat diet induced
            obesity and atherosclerosis
  JOURNAL   EBioMedicine 107, 105293 (2024)
   PUBMED   39146692
  REMARK    GeneRIF: The calcium-sensing-receptor (CaSR) in adipocytes
            contributes to sex-differences in the susceptibility to high fat
            diet induced obesity and atherosclerosis.
REFERENCE   2  (bases 1 to 7645)
  AUTHORS   Daryadel,A., Kung,C.J., Haykir,B., Sabrautzki,S., de Angelis,M.H.,
            Hernando,N., Rubio-Aliaga,I. and Wagner,C.A.
  TITLE     The calcium-sensing receptor has only a parathyroid
            hormone-dependent role in the acute response of renal phosphate
            transporters to phosphate intake
  JOURNAL   Am J Physiol Renal Physiol 326 (5), F792-F801 (2024)
   PUBMED   38545651
REFERENCE   3  (bases 1 to 7645)
  AUTHORS   Kung,C.J., Daryadel,A., Fuente,R., Haykir,B., de Angelis,M.H.,
            Hernando,N., Rubio-Aliaga,I. and Wagner,C.A.
  TITLE     A novel mouse model for familial hypocalciuric hypercalcemia (FHH1)
            reveals PTH-dependent and independent CaSR defects
  JOURNAL   Pflugers Arch 476 (5), 833-845 (2024)
   PUBMED   38386045
  REMARK    GeneRIF: A novel mouse model for familial hypocalciuric
            hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR
            defects.
REFERENCE   4  (bases 1 to 7645)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 7645)
  AUTHORS   Tang,L.Q., Fraebel,J., Jin,S., Winesett,S.P., Harrell,J.,
            Chang,W.H. and Cheng,S.X.
  TITLE     Calcium/calcimimetic via calcium-sensing receptor ameliorates
            cholera toxin-induced secretory diarrhea in mice
  JOURNAL   World J Gastroenterol 30 (3), 268-279 (2024)
   PUBMED   38314127
  REMARK    GeneRIF: Calcium/calcimimetic via calcium-sensing receptor
            ameliorates cholera toxin-induced secretory diarrhea in mice.
REFERENCE   6  (bases 1 to 7645)
  AUTHORS   Vassilev,P.M., Ho-Pao,C.L., Kanazirska,M.P., Ye,C., Hong,K.,
            Seidman,C.E., Seidman,J.G. and Brown,E.M.
  TITLE     Cao-sensing receptor (CaR)-mediated activation of K+ channels is
            blunted in CaR gene-deficient mouse neurons
  JOURNAL   Neuroreport 8 (6), 1411-1416 (1997)
   PUBMED   9172145
REFERENCE   7  (bases 1 to 7645)
  AUTHORS   Quarles,L.D., Hartle,J.E. 2nd, Siddhanti,S.R., Guo,R. and
            Hinson,T.K.
  TITLE     A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts
            functionally related to the calcium receptor
  JOURNAL   J Bone Miner Res 12 (3), 393-402 (1997)
   PUBMED   9076582
REFERENCE   8  (bases 1 to 7645)
  AUTHORS   Ho,C., Conner,D.A., Pollak,M.R., Ladd,D.J., Kifor,O., Warren,H.B.,
            Brown,E.M., Seidman,J.G. and Seidman,C.E.
  TITLE     A mouse model of human familial hypocalciuric hypercalcemia and
            neonatal severe hyperparathyroidism
  JOURNAL   Nat Genet 11 (4), 389-394 (1995)
   PUBMED   7493018
REFERENCE   9  (bases 1 to 7645)
  AUTHORS   Janicic,N., Soliman,E., Pausova,Z., Seldin,M.F., Riviere,M.,
            Szpirer,J., Szpirer,C. and Hendy,G.N.
  TITLE     Mapping of the calcium-sensing receptor gene (CASR) to human
            chromosome 3q13.3-21 by fluorescence in situ hybridization, and
            localization to rat chromosome 11 and mouse chromosome 16
  JOURNAL   Mamm Genome 6 (11), 798-801 (1995)
   PUBMED   8597637
REFERENCE   10 (bases 1 to 7645)
  AUTHORS   Pollak,M.R., Brown,E.M., Chou,Y.H., Hebert,S.C., Marx,S.J.,
            Steinmann,B., Levi,T., Seidman,C.E. and Seidman,J.G.
  TITLE     Mutations in the human Ca(2+)-sensing receptor gene cause familial
            hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
  JOURNAL   Cell 75 (7), 1297-1303 (1993)
   PUBMED   7916660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF110178.1 and AC074229.53.
            
            On Jun 4, 2016 this sequence version replaced NM_013803.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AF110178.1         1-8
            9-244               AF110178.1         10-245
            245-245             AC074229.53        153886-153886       c
            246-1751            AF110178.1         247-1752
            1752-1752           AC074229.53        101738-101738       c
            1753-2305           AF110178.1         1754-2306
            2306-2306           AC074229.53        87920-87920         c
            2307-3246           AF110178.1         2308-3247
            3247-3247           AC074229.53        86979-86979         c
            3248-3248           AF110178.1         3249-3249
            3249-3249           AC074229.53        86977-86977         c
            3250-3691           AF110178.1         3251-3692
            3692-3692           AC074229.53        86534-86534         c
            3693-4442           AF110178.1         3694-4443
            4443-4443           AC074229.53        85783-85783         c
            4444-4534           AF110178.1         4445-4535
            4535-7645           AC074229.53        82581-85691         c
FEATURES             Location/Qualifiers
     source          1..7645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.57 cM"
     gene            1..7645
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /note="calcium-sensing receptor"
                     /db_xref="GeneID:12374"
                     /db_xref="MGI:MGI:1351351"
     exon            1..281
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            282..708
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..3763
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /note="G protein-coupled receptor, family C, group 2,
                     member A; extracellular calcium-sensing receptor; PCaR1;
                     parathyroid cell calcium-sensing receptor; cation sensing
                     receptor"
                     /codon_start=1
                     /product="extracellular calcium-sensing receptor
                     precursor"
                     /protein_id="NP_038831.2"
                     /db_xref="CCDS:CCDS28154.1"
                     /db_xref="GeneID:12374"
                     /db_xref="MGI:MGI:1351351"
                     /translation="MAWFGYCLALLALTWHSSAYGPDQRAQKKGDIILGGLFPIHFGV
                     AAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNMTLGYRIFDTCN
                     TVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLF
                     YIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDY
                     GRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDL
                     EPLIKEIVRRNITGRIWLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFL
                     QKVHPRKSVHNGFAKEFWEETFNCHLQDGAKGPLPVDTFVRSHEEGGNRLLNSSTAFR
                     PLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCA
                     DIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEV
                     GYYNVYAKKGERLFINEGKILWSGFSREVPFSNCSRDCQAGTRKGIIEGEPTCCFECV
                     ECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLAWTEPFGIALTLFAVLGI
                     FLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQP
                     AFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICI
                     IWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLP
                     ENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNK
                     VYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSI
                     SSKSNSEDRFPQPERQKQQQPLALTQQEQQQQPLTLQPQQQQQPQQPRCKQKVIFGSG
                     TVTFSLSFDEPQKNAMAHRNSMRQNSLEAQKSNDTLNRHQALLPLQCAEADSEMTIQE
                     TGLQGPMVGDHQPEIESPDEMSPALVMSTSRSFVISGGGSSVTENILHS"
     exon            709..1015
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1900
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2131
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2255
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..7645
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4509..4514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
                     /note="hexamer: TATAAA"
     polyA_site      4541
                     /gene="Casr"
                     /gene_synonym="CaR; Gprc2a"
ORIGIN      
        1 tacagcccgc tgaagcaacg ctggagtcta gcagaacgcc taagagtgtt tattatactg
       61 tgagttctgg atctttacta ggaaaaaagt gccccatcct ctggcacagt tgccttgtga
      121 tcctctttcc atctccaggg aggagcggga agcgtgtgtg ctgcggggaa ggagggggtt
      181 gtatcttccc agaccaacag caggagcagg atcggaagcc tgggatggct agagcctcat
      241 cgcagacagg aggactccag cgctagacct cggtctctca gaaaacatct cgggcagtct
      301 ctacatgatg tcacttctca ggactcgagg accaaccacc ctacacctct gcatcggaga
      361 aggcagaaat ggacacagaa gggccatgac ttctcttctg tcattaacca ctctgtagac
      421 atgtatcccc atcagaaggc gtgaaccaca ccgagggctg tggagttctc gggcccccaa
      481 accactaaca cctttaactg tcccctggag agaaggcaga gccatggcat ggtttggcta
      541 ctgtttggcc ctcctggctc tcacctggca ctcctctgcc tatgggcctg accagcgagc
      601 ccaaaagaag ggggacatta tcctaggagg tctctttcct atccattttg gagtagcagc
      661 caaagatcaa gatctgaagt caagaccaga gtctgtggag tgcatcaggt ataacttccg
      721 tggattccga tggttacaag ccatgatctt tgccatagag gagataaaca gcagccccgc
      781 ccttcttccc aacatgactc tgggatatag gatattcgac acctgtaaca ccgtctccaa
      841 ggctctggag gccaccttga gttttgttgc ccagaacaaa atcgattctc tgaacctgga
      901 tgagttctgc aactgctccg agcacatccc ttcaaccatc gcagtggtgg gagcaaccgg
      961 ctccggtgtc tccacagcgg tagccaacct gctgggactt ttctatatcc cccaggtgag
     1021 ctacgcctcc tctagcaggc ttctcagcaa taagaaccag ttcaagtcct tcctccgcac
     1081 cattcccaac gacgaacacc aggccaccgc gatggctgac attatcgagt atttccgttg
     1141 gaactgggtg ggcacaattg cagccgacga cgactatggc aggcctggca ttgagaagtt
     1201 ccgagaggaa gccgaggaga gggacatctg cattgacttc agcgagctca tctcccagta
     1261 ctctgatgag gaagagatcc agcaggtggt ggaagtgatc cagaactcta cagccaaggt
     1321 cattgtcgtt ttctccagcg gcccagacct agaacctctc atcaaggaga ttgtgcgccg
     1381 taacatcaca ggcaggatct ggctggccag cgaggcctgg gccagttcct ccctgattgc
     1441 tatgcctgag tacttccatg tagtcggggg taccattggg ttcggtctga aggctgggca
     1501 gattccaggc ttccgagaat tcctacagaa agtccatccc aggaagtctg tccacaatgg
     1561 ttttgccaaa gagttttggg aagaaacatt taattgccac ctgcaagacg gcgcaaaagg
     1621 acctttaccc gtggacacct tcgtgagaag tcacgaggaa ggcggcaaca ggttactcaa
     1681 tagctccact gccttccgac ccctctgcac gggggatgaa aacatcaata gtgtcgagac
     1741 cccttacatg gactacgaac atttacggat atcctacaac gtgtacttag ccgtctactc
     1801 cattgcgcac gccctgcaag atatatacac ctgcttaccc ggaagagggc ttttcaccaa
     1861 cgggtcctgt gcagacatca agaaggttga ggcctggcag gtcctgaaac acctacggca
     1921 cctgaatttc accaacaaca tgggggagca ggtgaccttc gatgagtgcg gtgacctggt
     1981 ggggaactac tccatcatca actggcacct ctccccagag gacggctcca ttgtgttcaa
     2041 ggaagttggg tactacaatg tgtatgccaa gaagggagaa agactgttca tcaatgaggg
     2101 gaagatcttg tggagtgggt tctccagaga ggtgcccttc tccaactgca gccgggactg
     2161 tcaggcaggg accaggaagg gcatcattga gggagagccc acctgctgtt ttgagtgtgt
     2221 ggagtgtcct gacggcgagt acagtggtga gacagatgcg agtgcctgtg acaagtgccc
     2281 ggatgacttc tggtccaatg agaaccacac ttcctgcatt gccaaggaga ttgagttcct
     2341 ggcgtggact gagccctttg gaatcgctct cactctcttt gcggtgctgg gcattttcct
     2401 gaccgccttt gtgctgggcg tcttcatcaa gttccgaaac acgcccattg tcaaggccac
     2461 caaccgagag ctgtcctacc tcctgctctt ctcactcctc tgctgcttct ccagctccct
     2521 gttcttcatt ggggagcccc aggactggac ctgccgcctg cgacagcccg ccttcggcat
     2581 cagcttcgtg ctttgtatct cgtgcatctt ggtgaagacc aatcgagtcc tcctggtatt
     2641 tgaggccaaa atacccacca gcttccaccg gaagtggtgg ggactcaacc tgcagttcct
     2701 gctggttttc ctctgcacct tcatgcagat tgtcatctgc atcatctggc tctacacggc
     2761 acccccctcc agctaccgca accacgagct ggaagacgaa atcatcttca tcacgtgcca
     2821 tgagggctca ctcatggcgc tcggctccct gatcggctac acctgcctcc tggctgccat
     2881 ctgcttcttc tttgccttca agtctcggaa gctgccagag aacttcaacg aagccaagtt
     2941 cattaccttc agcatgctca tcttcttcat cgtctggatc tccttcattc cagcctatgc
     3001 cagcacctac ggcaagtttg tctctgccgt ggaggtgatc gccatcctgg cagccagctt
     3061 tggcttgcta gcctgcatct tcttcaacaa ggtctacatc atcctcttca agccttcacg
     3121 gaacaccatc gaggaggtgc gctccagcac tgcggctcat gctttcaaag tggcagcccg
     3181 cgccactcta cgccgcccca acatctcccg gaagcggtcc agcagcctcg gaggctccac
     3241 tgggtcgatt ccctcctcct ccatcagcag caaaagcaac agcgaagacc ggttcccaca
     3301 gccggagagg cagaagcaac agcaaccact ggccctgacc cagcaagaac agcagcagca
     3361 gcccctgact ctccagccgc agcaacagca acagccacag cagccgagat gcaaacagaa
     3421 ggtcatcttc ggcagtggca cagtcacctt ctctctgagc tttgatgagc ctcagaagaa
     3481 tgctatggcc cacaggaact ccatgcgcca gaactccctg gaggcccaga agagcaatga
     3541 cactttgaac agacaccagg ccctgcttcc cctacagtgt gcagaggcgg actcagaaat
     3601 gaccattcag gagacgggct tgcaagggcc aatggtgggg gaccaccagc cagaaataga
     3661 aagcccagat gaaatgtccc cagctctggt catgtccacc tctcggagct tcgtcatcag
     3721 cggtggaggt agctctgtga cggaaaacat actgcactcc taatggaggg agaggttacc
     3781 cggttgagag tttttcttag agtcccagga aaaaggatgg gtcttcccag gaagccaggg
     3841 atagtgggtg catcaaagcc tgtactcggc tgcactgctt tgaatgacag tgaactgact
     3901 ggtgggctct ttacaagtta gaagagccat gttttgggga tcgttttcca gagctcagtg
     3961 tcatacctgg atttgctgaa atcttttcct ctgctccatc caccaccagc tcggatgaaa
     4021 gcaaggctat aagctaccca cctgcttccc tctaaaaacg cttatatcca gaaatcccta
     4081 ccccgaggca cagtccagat acagatggat gggacatcag atctgccacc attaaagttg
     4141 agtctaaaag ccagatagtc accaggactg tctatcacat tgacagtgga cagaactgta
     4201 catttgcaag acatcaggca gacatgtcct ctcctattta taaagacctt aagaagtgtg
     4261 gcctttttat cctccctgtt gctgctactg tgtaacatct gttccatctg catccttcct
     4321 gtgacgtcat gcatggatgt atccagaacc tgaaggcaat gccacattta gatcttagga
     4381 tcataagtat cacctccaag caccgggaaa ggactgactc aacccaacga gctgtctctg
     4441 taactaatat caatgtacat agcgtaatcc ttaagaaact gcttctgttg taatagtcca
     4501 tgggcgatta taaactgaaa aatgtcgcag tctagattct ataaggcagt attattgagt
     4561 tctgttttcc ttttccatcc tgtaccctca tcctggtgag cagagcccat gcagtcccta
     4621 caaagacccc atggctctaa tcatgcccca agccctatcc ctgagctaaa ggctttatga
     4681 agccaaatcc tgacctggct ctatggagaa taagctccca gaagaaagtg tggttcccag
     4741 tgaatgccac tgttccctca gcaatgaaat taacgtgccc actggccact gctaggacct
     4801 cagactccgg atgacagaga ccaaagttca ggctctggct tgatcactga caagatgggt
     4861 ggttataagg tagaaaccac agcctcttta agccccagat tctttgagtg tatagtaggg
     4921 aactacggtt cttttcccat ggggctctcg gatgagttaa gcatgtgtac acaccttagc
     4981 acagtgtcta acatatcata cacatttagg gttggtaaat acgattagcg atatagtaat
     5041 tactagtttc cacttgctca gactatgctg tagcttggac tgtgacacta aaggtcctca
     5101 tgttaacaga tctgtccctg ggattggcct ctttgaaggt catggtgcct tcagggggtg
     5161 ggacttagta ggacatcgtt cagtcacggg aggtgtgcct ttgaaggggg ttatgggact
     5221 ctggccgagt tctctttctc ttctctttcc tggccatatg atgaacagtt ttctctgaca
     5281 caggctgaca caccattgcc atccagcatc ccaccagaga gcatggacca gaacctgcat
     5341 aaacaaagca tcaagattac ccttttctct ctccaattat ctgaagtatt ttattacagt
     5401 gagagaaagc tgactagtac agaaggtaaa gcaaaaaggc ttactaagaa tccagatttt
     5461 aatgtctaat ccactgatca caataccttt cttcagaata agtccaaaac tcctgagtcc
     5521 caggtcaagg tgtcagcaga agccaaatgc tacccccagc aaacccagcg tttggcttct
     5581 gtggcagcag taccaactcc agcaccttca ctggttaata atttctcaga gcaggtttca
     5641 ccaagccaag ccacactgtg ccaagaccaa gccatagaat gtaaattcat cagtggtcta
     5701 agatttacag tccatggaga gtcttcctct ggccacttcc ttctgaggat ttttaaagta
     5761 atggttggca ttatgaccat aaagacaatg agtgtgctgt agagagcaca aagagtgtgc
     5821 agtagagggc acaatcctgt cccagaacac aaaactgtcc ccatgagcca ccaacacacc
     5881 aatcagaaag gtcgcagcct gtcagagcct gctgccttct gttgtcagcc tctgagcaag
     5941 gcagcatgct aagtaaagat ttactcctaa catttcactt ggcaaataaa taaataaata
     6001 aataacacaa ctgcagccaa aagtttaatg acttcaaaaa cctgtcacaa aactatgcaa
     6061 acaacttcag taaaatgtca cacattcatc cttactagtc tgatttcagt gcacaccacg
     6121 ccttctgcaa ataatcccca ttccatgatt ttttttcttg ttaaaaaaga aagaaagctg
     6181 agaatcagca ggaaaagcat tgctcaaagt gttcattttg ccaggggctt acgcatcaag
     6241 taatgtcttt gaacatcctc atcagaaagg tagataggaa ttctcattat gtctctatag
     6301 caacctaaca tttatctcaa attcctattt ggccagcaac caaagctata gtcaagtcaa
     6361 attaggggtt tccctggaaa tccagagttt tctgattcac attatatttt taggttcagt
     6421 tcagaagttg ttggtttttt tttttttctt ttccttcctc tttccaggtg agttgtagca
     6481 taaaggaggt gacggtcttt gaccaggggc atgttctctt agcgttcctg aagccctctt
     6541 gtctggctct cagtaattgt gtctccaagc tggcttcctg taatatatct gtggcagttc
     6601 actttttatt aatgtaacag aataatcaag caggctaact gtatagggat aagaggttta
     6661 tttaactcat acttatgccc actcaagggc caagactata caattaccca ctggtcacca
     6721 caatgacagg aaaacactgg tagggacgat tccacctcag gataggaagt gagagggtga
     6781 ttcaggagtc agctttaccc ttataacaac ttactcttaa gactccacag tccccataag
     6841 aacacttcaa ttcctcaaaa agcagatgac ctattgacca aaagtccttc cacaaggcta
     6901 caactctcag tgcgaccaca ctggggccaa gttcctaatg tgtggacccc ccctcagaaa
     6961 ttatatctaa actacagaaa caacatctct ccatccagtt cccacagcag catctatggt
     7021 ggtgttcatg gatggattac tgtctcagac aactgaccct tcctaggcct gcaagtgctt
     7081 tcagctccct ccaggcccat cccagggacc aggaaaccct ctgagctctc acagaggtta
     7141 ccccttattg ctgctgccca accctgccaa tgcagagact tcctgtactt tagcgggtat
     7201 acagcgcaca cgtgagtgag aagcggggta aaatgctgac aagcctgtgt ggacctgggc
     7261 gcctagacag aataacgttc agccaaagat gctgagagtt atggcaccca gagcctgtga
     7321 ttgtgtcaaa gtagcactgg tctaagatgc tcattcaatt aagattcttt ccgattagcc
     7381 gcaaggtaag aaaccgcgga accatcagtg tcaggaagat tccggagagc atccatcctc
     7441 catcgctttg tgtgtggaag tgcaggagag gcaaagggat acacactgtt tctagaagct
     7501 ggacaaacta aggacacgga tttttccctg ggagtctcca ggaaggaatg cagaactaga
     7561 gtaccttggt ttcagcccag tgagaccttt ggagggcttc tgacctctgg agctgtaaga
     7621 taataataaa tttgtgttgt tttaa
//
