LOCUS       NM_009813               1874 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus calsequestrin 1 (Casq1), mRNA.
ACCESSION   NM_009813
VERSION     NM_009813.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Tan,R.L., Sciandra,F., Hubner,W., Bozzi,M., Reimann,J., Schoch,S.,
            Brancaccio,A. and Blaess,S.
  TITLE     The missense mutation C667F in murine beta-dystroglycan causes
            embryonic lethality, myopathy and blood-brain barrier
            destabilization
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38616731
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Michelucci,A., Pietrangelo,L., Rastelli,G., Protasi,F.,
            Dirksen,R.T. and Boncompagni,S.
  TITLE     Constitutive assembly of Ca2+ entry units in soleus muscle from
            calsequestrin knockout mice
  JOURNAL   J Gen Physiol 154 (12) (2022)
   PUBMED   36222861
  REMARK    GeneRIF: Constitutive assembly of Ca2+ entry units in soleus muscle
            from calsequestrin knockout mice.
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Serano,M., Pietrangelo,L., Paolini,C., Guarnier,F.A. and Protasi,F.
  TITLE     Oxygen Consumption and Basal Metabolic Rate as Markers of
            Susceptibility to Malignant Hyperthermia and Heat Stroke
  JOURNAL   Cells 11 (16), 2468 (2022)
   PUBMED   36010545
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Shi,Y., Fan,W., Xu,M., Lin,X., Zhao,W. and Yang,Z.
  TITLE     Critical role of Znhit1 for postnatal heart function and vacuolar
            cardiomyopathy
  JOURNAL   JCI Insight 7 (6), e148752 (2022)
   PUBMED   35167494
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Cho,J.H., Oh,Y.S., Park,K.W., Yu,J., Choi,K.Y., Shin,J.Y.,
            Kim,D.H., Park,W.J., Hamada,T., Kagawa,H., Maryon,E.B.,
            Bandyopadhyay,J. and Ahnn,J.
  TITLE     Calsequestrin, a calcium sequestering protein localized at the
            sarcoplasmic reticulum, is not essential for body-wall muscle
            function in Caenorhabditis elegans
  JOURNAL   J Cell Sci 113 (Pt 22), 3947-3958 (2000)
   PUBMED   11058082
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Suzuki,Y.J., Ikeda,T., Shi,S.S., Kitta,K., Kobayashi,Y.M.,
            Morad,M., Jones,L.R. and Blumberg,J.B.
  TITLE     Regulation of GATA-4 and AP-1 in transgenic mice overexpressing
            cardiac calsequestrin
  JOURNAL   Cell Calcium 25 (6), 401-407 (1999)
   PUBMED   10579051
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Park,K.W., Goo,J.H., Chung,H.S., Kim,H., Kim,D.H. and Park,W.J.
  TITLE     Cloning of the genes encoding mouse cardiac and skeletal
            calsequestrins: expression pattern during embryogenesis
  JOURNAL   Gene 217 (1-2), 25-30 (1998)
   PUBMED   9795116
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Bataille,N., Schmitt,N., Aumercier-Maes,P., Ollivier,B.,
            Lucas-Heron,B. and Lestienne,P.
  TITLE     Molecular cloning of human calmitine, a mitochondrial calcium
            binding protein, reveals identity with calsequestrine
  JOURNAL   Biochem Biophys Res Commun 203 (3), 1477-1482 (1994)
   PUBMED   7945294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY772893.1, BC064057.1, CR756967.1, AK049865.1 and AW108209.1.
            
            On Apr 23, 2009 this sequence version replaced NM_009813.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064057.1, U93291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BY772893.1         4-138
            136-963             BC064057.1         74-901
            964-1024            CR756967.1         1-61                c
            1025-1086           BC064057.1         963-1024
            1087-1730           AK049865.1         205-848
            1731-1871           BC064057.1         1669-1809
            1872-1874           AW108209.1         3-5                 c
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..1874
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /note="calsequestrin 1"
                     /db_xref="GeneID:12372"
                     /db_xref="MGI:MGI:1309468"
     exon            1..484
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1423
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /note="calmitine"
                     /codon_start=1
                     /product="calsequestrin-1 precursor"
                     /protein_id="NP_033943.2"
                     /db_xref="CCDS:CCDS35781.2"
                     /db_xref="GeneID:12372"
                     /db_xref="MGI:MGI:1309468"
                     /translation="MRATDRMGARAVSELRLALLFVLVLGTPRLGVQGEDGLDFPEYD
                     GVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDK
                     GVGFGLVDSEKDAAVAKKLGLTEEDSVYVFKGDEVIEYDGEFSADTLVEFLLDVLEDP
                     VELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAYEDAAEEFHPYIPFFATFDSKV
                     AKKLTLKLNEIDFYEAFMEEPMTIPDKPNSEEEIVSFVEEHRRSTLRKLKPESMYETW
                     EDDLDGIHIVAFAEEADPDGYEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWE
                     KTFDIDLSAPQIGVVNVTDADSIWMEMDNEEDLPSADELEDWLEDVLEGEINTEDDDD
                     DDDDDDDDDDDDD"
     exon            485..569
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            570..670
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            671..782
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            783..856
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            857..987
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1033
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1088
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1189
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1264
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1874
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /note="hexamer: AAGAAA"
     polyA_site      1874
                     /gene="Casq1"
                     /gene_synonym="CSQ; CSQ-1; CSQ1; sCSQ"
                     /note="major polyA site"
ORIGIN      
        1 ttcctcctcc tgaccctttt tctcttggct ctgtcggcag tttctccagg acccagcagt
       61 gtcctctgtc cactgctctg gcccactctc taccccaccc ccacctggag cccctaactc
      121 aggattctgt atccgagggg cacctctccc tatttcagct aacctcctct ggaccaggag
      181 agcaggccca gattgtacta cctccatgag agctaccgac aggatggggg ccagagcagt
      241 gtccgagctg cggctggcac tgctgtttgt actggtgcta gggacgccca ggttaggggt
      301 ccagggggaa gatgggttgg acttccctga gtacgacggt gtggaccgtg tgatcaatgt
      361 gaacgccaag aactacaaga acgtgtttaa gaagtatgag gtgctggccc tcctctacca
      421 tgagcccccc gaggacgaca aggcctcgca gagacaattt gagatggagg agctaatcct
      481 ggagttagca gcccaagtct tagaagacaa gggtgttggc tttggcctgg tggactcaga
      541 gaaggatgca gctgtggcca agaaactagg actaactgaa gaagacagcg tttatgtgtt
      601 caaaggagat gaagtcattg aatatgacgg cgagttttct gcagacactc tggtggagtt
      661 tctgcttgat gtcctagaag accctgtaga gttgattgaa ggtgaacgag agctgcaggc
      721 atttgagaat attgaagatg aaatcaaact cattggctac ttcaagagca aagactcaga
      781 gcattacaaa gcctacgagg acgcagctga agagttccat ccctacatcc ctttcttcgc
      841 taccttcgac agcaaggtgg caaagaagct gactctgaag ttgaatgaga ttgatttcta
      901 cgaggccttc atggaagagc ctatgaccat cccagacaag cccaacagtg aagaggagat
      961 tgtcagcttc gtggaggagc acaggagatc aaccctgagg aaactgaagc ctgagagtat
     1021 gtacgagact tgggaggatg acctggatgg aatccacatt gtcgcctttg cagaggaagc
     1081 agatcccgat ggctatgagt tcttagagac tctcaaggct gtggcccaag acaacactga
     1141 gaaccccgac ctcagtatca tctggattga tcctgatgac ttcccgctgc tggtcccgta
     1201 ctgggagaag acctttgaca ttgacctgtc agctccacaa ataggagttg tcaatgttac
     1261 agacgccgac agcatatgga tggagatgga taacgaggag gacctgcctt ctgctgatga
     1321 gctggaggac tggctggagg acgtgctgga gggcgagatc aacacagagg atgacgacga
     1381 cgatgacgac gatgacgatg acgatgatga tgacgacgac tagatgacga gtggccgtgg
     1441 cagccgagta ccagccccac ttgctcctta cttgttgtac ctttctgcca tctgtgccct
     1501 tccctgggct ccttgggaca ctaggtcatt ctctactaca gggccaactg tggtctgcat
     1561 acagggtgct tgaggtcctg gtctccctct ccgaggagaa aaggagctgc tttttcttag
     1621 atcccagccc agttctctca tctgacttgc ttcttccccc ataccttatc tgtttctctt
     1681 cccgccactc cccatactta acggtttgca aactcttctc tatcccattt ctcaaatctt
     1741 aaacctctct cactgtcctg accctggcca ggaggaaggg aggtactgtg ttaggggcta
     1801 taatcttagc catctcctgt taatgtattt gggtcaaatg caaggcctta ataaagaaat
     1861 ctggggcaga atga
//
