LOCUS       NM_015733               3899 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus caspase 9 (Casp9), transcript variant 1, mRNA.
ACCESSION   NM_015733
VERSION     NM_015733.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   Schwermann,N., Haller,R., Koch,S., Grassl,G.A. and Winstel,V.
  TITLE     Pathogen-driven nucleotide overload triggers mitochondria-centered
            cell death in phagocytes
  JOURNAL   PLoS Pathog 19 (12), e1011892 (2023)
   PUBMED   38157331
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3899)
  AUTHORS   Li,J., Han,X., Sun,M., Li,W., Yang,G., Chen,H., Guo,B., Li,J.,
            Li,X. and Wang,H.
  TITLE     Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated
            tumor intrinsic innate sensing and enhances antitumor immunity
  JOURNAL   J Immunother Cancer 11 (12), e007625 (2023)
   PUBMED   38056894
  REMARK    GeneRIF: Caspase-9 inhibition triggers Hsp90-based
            chemotherapy-mediated tumor intrinsic innate sensing and enhances
            antitumor immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3899)
  AUTHORS   Matsui,Y., Djekidel,M.N., Lindsay,K., Samir,P., Connolly,N., Wu,G.,
            Yang,X., Fan,Y., Xu,B. and Peng,J.C.
  TITLE     SNIP1 and PRC2 coordinate cell fates of neural progenitors during
            brain development
  JOURNAL   Nat Commun 14 (1), 4754 (2023)
   PUBMED   37553330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3899)
  AUTHORS   Kuzelova,A., Dupacova,N., Antosova,B., Sunny,S.S., Kozmik,Z. Jr.,
            Paces,J., Skoultchi,A.I., Stopka,T. and Kozmik,Z.
  TITLE     Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell
            Proliferation and Photoreceptor Maintenance
  JOURNAL   Cells 12 (7), 1035 (2023)
   PUBMED   37048108
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3899)
  AUTHORS   Batoon,L., Koh,A.J., Kannan,R., McCauley,L.K. and Roca,H.
  TITLE     Caspase-9 driven murine model of selective cell apoptosis and
            efferocytosis
  JOURNAL   Cell Death Dis 14 (1), 58 (2023)
   PUBMED   36693838
  REMARK    GeneRIF: Caspase-9 driven murine model of selective cell apoptosis
            and efferocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3899)
  AUTHORS   Los,M., Wesselborg,S. and Schulze-Osthoff,K.
  TITLE     The role of caspases in development, immunity, and apoptotic signal
            transduction: lessons from knockout mice
  JOURNAL   Immunity 10 (6), 629-639 (1999)
   PUBMED   10403638
  REMARK    Review article
REFERENCE   7  (bases 1 to 3899)
  AUTHORS   Zou,H., Li,Y., Liu,X. and Wang,X.
  TITLE     An APAF-1.cytochrome c multimeric complex is a functional
            apoptosome that activates procaspase-9
  JOURNAL   J Biol Chem 274 (17), 11549-11556 (1999)
   PUBMED   10206961
REFERENCE   8  (bases 1 to 3899)
  AUTHORS   Kumar,S. and Colussi,P.A.
  TITLE     Prodomains--adaptors--oligomerization: the pursuit of caspase
            activation in apoptosis
  JOURNAL   Trends Biochem Sci 24 (1), 1-4 (1999)
   PUBMED   10087912
  REMARK    Review article
REFERENCE   9  (bases 1 to 3899)
  AUTHORS   Hakem,R., Hakem,A., Duncan,G.S., Henderson,J.T., Woo,M.,
            Soengas,M.S., Elia,A., de la Pompa,J.L., Kagi,D., Khoo,W.,
            Potter,J., Yoshida,R., Kaufman,S.A., Lowe,S.W., Penninger,J.M. and
            Mak,T.W.
  TITLE     Differential requirement for caspase 9 in apoptotic pathways in
            vivo
  JOURNAL   Cell 94 (3), 339-352 (1998)
   PUBMED   9708736
REFERENCE   10 (bases 1 to 3899)
  AUTHORS   Kuida,K., Haydar,T.F., Kuan,C.Y., Gu,Y., Taya,C., Karasuyama,H.,
            Su,M.S., Rakic,P. and Flavell,R.A.
  TITLE     Reduced apoptosis and cytochrome c-mediated caspase activation in
            mice lacking caspase 9
  JOURNAL   Cell 94 (3), 325-337 (1998)
   PUBMED   9708735
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC056447.1, BC056372.1 and
            BY549141.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_015733.6.
            
            On May 1, 2013 this sequence version replaced NM_015733.4.
            
            Summary: This gene is part of a family of caspases,
            aspartate-specific cysteine proteases well studied for their
            involvement in immune and apoptosis signaling. This protein, the
            initiator caspase, is activated after cytochrome c release from
            mitochondria and targets downstream effectors. In mouse, deficiency
            of this gene can cause perinatal lethality. This protein may have a
            role in normal brain development. Alternative splicing results in
            multiple transcript variants that encode different protein
            isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056447.1, SRR1660815.270057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               BC056447.1         1-218
            219-3895            BC056372.1         1-3677
            3896-3899           BY549141.1         423-426
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.75 cM"
     gene            1..3899
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /note="caspase 9"
                     /db_xref="GeneID:12371"
                     /db_xref="MGI:MGI:1277950"
     exon            1..375
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1608
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /EC_number="3.4.22.62"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; apoptotic protease Mch-6; ICE-like apoptotic
                     protease 6; apoptotic protease-activating factor 3"
                     /codon_start=1
                     /product="caspase-9 isoform 1 precursor"
                     /protein_id="NP_056548.2"
                     /db_xref="CCDS:CCDS18883.1"
                     /db_xref="GeneID:12371"
                     /db_xref="MGI:MGI:1277950"
                     /translation="MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQ
                     QAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEA
                     VKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLR
                     PETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTR
                     TGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHG
                     CQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGF
                     EVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSW
                     RDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLF
                     FKTS"
     exon            376..775
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            776..810
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..987
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1077
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1225
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1405
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1515
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..3899
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3872..3877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
     polyA_site      3896
                     /gene="Casp9"
                     /gene_synonym="APAF-3; CASP-9; Caspase-9; ICE-LAP6; Mch6"
ORIGIN      
        1 tgggggctgg tggtggggtg agcggccgtg ggagctgttt tgattgcgga ggtggagccc
       61 agtgagcgcg agtcacaggc cgcggggcgg ggcggggcgg ggcggagcgg agcccagtgg
      121 accgggtgac cgctggccgg agcgggatcc ctggaggcgc tatgtggggg cggggcgtgg
      181 gcgccggggc ggaacccgag ggccggaagc ggacagaacc cggggtcccg caatcggctc
      241 gccatggacg aggcggaccg gcagctcctg cggcgatgca gggtgcgcct agtgagcgag
      301 ctgcaagtcg cggagctctg ggacgctctg ctgagtcgag agctcttcac gcgcgacatg
      361 atcgaggata ttcagcaggc aggatctggg tctcggcggg atcaggccag gcagctggtc
      421 acagaccttg agacccgagg gaggcaggcc cttcctctct tcatctcctg cttagaggac
      481 acaggccaag gcaccctggc ttcactcttg caaagcggtc ggcaagcagc caagcaggat
      541 ccagaggctg ttaaacccct agaccacctg gtgcctgtgg tcctgggacc aatgggactc
      601 acagcaaagg agcagagagt agtgaagctg gacccgtcac agcctgccgt gggaaacctc
      661 accccagtgg tgctggggcc agaagagctc tggcctgctc ggctcaagcc agaggttctc
      721 agaccagaaa cacccaggcc cgtggacatt ggttctggcg gagctcatga tgtctgtgtt
      781 ccagggaaga tcaggggaca tgcagatatg gcatacaccc tggattcgga tccctgtggc
      841 cactgcctca tcatcaacaa tgtgaacttc tgcccttcct cggggctcgg cacacgcacg
      901 ggctccaact tggaccgtga caaacttgag caccgattcc gctggctgcg cttcatggtg
      961 gaggtgaaga acgacctgac tgccaagaaa atggtcacgg ctttgatgga gatggcacac
     1021 cggaaccacc gtgccctgga ctgctttgtg gtggtcatcc tctctcatgg ctgccaggcc
     1081 agccacctcc agttcccggg tgctgtctat gggacagatg gatgctccgt gtccattgag
     1141 aaaattgtga atatcttcaa cgggagcggc tgccccagcc tgggagggaa gcccaagctc
     1201 ttcttcatcc aggcctgcgg tggtgagcag aaagaccatg gctttgaggt ggcctgcact
     1261 tcctctcaag gcaggacctt ggacagtgac tctgagccag atgctgtccc ctatcaggaa
     1321 ggcccaaggc ccttggacca gctggatgct gtgtcaagtt tgcctacccc cagtgacatc
     1381 cttgtgtcct actccacctt cccaggtttt gtctcctgga gggacaagaa aagtggctcc
     1441 tggtacatcg agaccttgga tggcattctg gagcagtggg ctcgctctga agacctgcag
     1501 tccctccttc tcagggttgc caatgctgtt tctgcgaaag ggacttacaa gcagattcct
     1561 ggctgtttta acttcctccg gaaaaagctg ttttttaaaa cttcatgagg ctcggggctg
     1621 ctctctgcct cattattctc tccgaagctc tcatggcttg gagctggcca aggccataac
     1681 tgtcctgcta agataggatt ttgaactggg gcaggctgct ctttcccttt ggcgatgcaa
     1741 acatgctcct agcagctttc aggttgtagg gcaatgtgga gcagtggtcg gaagaagacc
     1801 ggagtgcaat ggatgctgcc tggccccttc atctgtggtt agggattgtg ccctgggact
     1861 cccaggcctc tcaagaacag ggcttctctg ccactgtact actgacatgt gcggttgtat
     1921 aatcctgtca tgggactgcc tcgtgtattg tagagggttt taagctgtct ctgtcctcta
     1981 cctgccagct gccaggagca cccctcctga gatctgccaa ccaaaaatgt cttcagacat
     2041 tgtcacatgt gccctggggg acattatagc actcctctct gctcccccac ccgggggggg
     2101 gtcatcaacc acaggggtct atgcatctct cctttccaga ctcaaagtcc agctggccca
     2161 gtgtgcatac ctggatctgg gctgcatctc ttccaagtta ccagaagggc taattcttcc
     2221 ttgagaacat tatttattct tcaacaataa atcttcggca ataggactgt atttagcctg
     2281 tattgtccct accccaactc tgtccttctt acaaaggaga catgattttt cctgcgtttt
     2341 tctctgtgtc ttccaaggtc cctgcccgag cccagcaggt gaccgagata ggagtcagga
     2401 gtccccacag atcaagtctc ctgtctgaag gatcttggtt accctagtgg ggacaccagg
     2461 acagagctct gctgtttggg gtctcccaat ctcccattgt cttccttgct aagtgagcct
     2521 ggtccccagg tggcagtgac caggcagtac tgaagtgctg ggacttcctt gaaaatgtgc
     2581 cctcccctgt ctttaaagcg attctgcctt tcacttattt ttctttcttt ctggtttcct
     2641 ctactctttg ctttgtgaaa gtccacttga gtttagatgg tagatgtgcc aagccttgtt
     2701 tgtttatttt tgagctaggg tcttactttg tagcccaggc tgaccacaaa atctccatac
     2761 cactgcctcc tgggtaccag gattatagct tgtcccactg ccccaatctc ctcctgaaag
     2821 agcattgctt tcagggcccc gaggttaggg tatcggggta agaagacaga ctcattcaag
     2881 gatgtgattc ttaaattact ttattactat ttcttttcta tggcatttcc agggggacag
     2941 tggcagtaat gtcttcagtt agttccttgc catcacctgc aggacacaca ggagagagag
     3001 gaggttagct ggaacactgg gcattgagtt cagtgactct cagggccaag aggggtcaag
     3061 aagggtctta gcccggaatc ctgcttgggt atcaggccag gaaggcccgg aatcaccaat
     3121 cattacatgc caaatgcacc gatgggtatg ttttggtttt ttttttttca tgttgtctgt
     3181 ttctttgttg ttgttgttgt tgttgttttc cctgagactg ggtctctctg tgtagccctg
     3241 gctgtcccag aactcaccat gaagacaaga ctggccttga actcagagat ccgcctgccc
     3301 ttgcctctga gtagtggtct taaaagtgtg gaccagtgca caggcccctc acagttcaga
     3361 atggcaggtg ccagctgagt tcattaaaca aggaaaatgt gttgatggct tatggtgagc
     3421 agaccatcta cacatgcagt tgtgggcgtt tctttgttgt ttgttttgag gctgggactc
     3481 actatgtagc ctaggctggc cttattacca ccatacttgg cttcatttgg ttggttggtt
     3541 ttgtttgaga cactgtctca tgtagcccag gctgccctta aaacaatcct cctgcctctt
     3601 attcccaagt tctggccatt atgcatcttt accaccatct ctgccaatac aggatccttt
     3661 gttttgtttt gttttgtttt gttttgcagt tttggcgtct atgcacacaa ggcccaggtg
     3721 agcacagagc atacaattga cagcgattgc ctctgtggat tgggcgcaaa ggttaaagcc
     3781 aggggaatct tcatttctta cgtgatacac tcttgtgttc cttttataag caatatttta
     3841 aataaagcaa tgtattccct tctgaaccaa aaataaagct gtgattgttg aaggctccc
//
