LOCUS       NM_001122978            6566 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus caspase 8 associated protein 2 (Casp8ap2), transcript
            variant 2, mRNA.
ACCESSION   NM_001122978
VERSION     NM_001122978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6566)
  AUTHORS   Hemker,S.L., Cerqueira,D.M., Bodnar,A.J., Cargill,K.R.,
            Clugston,A., Anslow,M.J., Sims-Lucas,S., Kostka,D. and Ho,J.
  TITLE     Deletion of hypoxia-responsive microRNA-210 results in a
            sex-specific decrease in nephron number
  JOURNAL   FASEB J 34 (4), 5782-5799 (2020)
   PUBMED   32141129
REFERENCE   2  (bases 1 to 6566)
  AUTHORS   Jiang,X., Yin,S., Fan,S., Bao,J., Jiao,Y., Ali,A., Iqbal,F., Xu,J.,
            Zhang,Y. and Shi,Q.
  TITLE     Npat-dependent programmed Sertoli cell proliferation is
            indispensable for testis cord development and germ cell mitotic
            arrest
  JOURNAL   FASEB J 33 (8), 9075-9086 (2019)
   PUBMED   31084574
REFERENCE   3  (bases 1 to 6566)
  AUTHORS   Ghule,P.N., Xie,R.L., Colby,J.L., Rivera-Perez,J.A., Jones,S.N.,
            Lian,J.B., Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     Maternal expression and early induction of histone gene
            transcription factor Hinfp sustains development in pre-implantation
            embryos
  JOURNAL   Dev Biol 419 (2), 311-320 (2016)
   PUBMED   27609454
REFERENCE   4  (bases 1 to 6566)
  AUTHORS   Hirano,T., Murakami,T., Ono,H., Sakurai,A., Tominaga,T.,
            Takahashi,T., Nagai,K., Doi,T. and Abe,H.
  TITLE     A Novel Interaction between FLICE-Associated Huge Protein (FLASH)
            and E2A Regulates Cell Proliferation and Cellular Senescence via
            Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis
  JOURNAL   PLoS One 10 (7), e0133205 (2015)
   PUBMED   26208142
  REMARK    GeneRIF: the functional interaction of E2A and FLASH play an
            important role in cell proliferation and cellular senescence via
            regulation of p21 expression in experimental glomerulonephritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6566)
  AUTHORS   Minamida,Y., Someda,M. and Yonehara,S.
  TITLE     FLASH/casp8ap2 is indispensable for early embryogenesis but
            dispensable for proliferation and differentiation of ES cells
  JOURNAL   PLoS One 9 (9), e108032 (2014)
   PUBMED   25238250
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6566)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   7  (bases 1 to 6566)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 6566)
  AUTHORS   Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
            Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
  TITLE     FLASH coordinates NF-kappa B activity via TRAF2
  JOURNAL   J Biol Chem 276 (27), 25073-25077 (2001)
   PUBMED   11340079
REFERENCE   9  (bases 1 to 6566)
  AUTHORS   Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
  TITLE     Apoptosis. Searching for FLASH domains
  JOURNAL   Nature 401 (6754), 662 (1999)
   PUBMED   10537104
REFERENCE   10 (bases 1 to 6566)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA526466.1, AK142148.1 and AL805973.6.
            
            On Nov 18, 2015 this sequence version replaced NM_001122978.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.4585.1,
                                           SRR10223970.6106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CA526466.1         1-5
            6-128               AK142148.1         2-124
            129-129             AL805973.6         14325-14325
            130-1946            AK142148.1         126-1942
            1947-2662           AL805973.6         24968-25683
            2663-5783           AL805973.6         27665-30785
            5784-5883           AL805973.6         32152-32251
            5884-5968           AL805973.6         33298-33382
            5969-6566           AL805973.6         36799-37396
FEATURES             Location/Qualifiers
     source          1..6566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 14.27 cM"
     gene            1..6566
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:26885"
                     /db_xref="MGI:MGI:1349399"
     exon            1..23
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            24..106
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5940
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /note="FLICE-associated huge protein"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001116450.1"
                     /db_xref="CCDS:CCDS18016.1"
                     /db_xref="GeneID:26885"
                     /db_xref="MGI:MGI:1349399"
                     /translation="MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSAVSDST
                     ARSCVSFRNCLDLYEEILTEEGTAKEATYNDLQIEYGKCQQQMKDLMKRFKEIQTQNL
                     NLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSQS
                     TSPHLDDCSKTDHGVKSDVQKDVHPNTAQPNLEKEGKSHSEAQNPLHLSTGVEKHCAN
                     NVWSRSPYQVGEGNSNEDNRRGRSGTRHSQCSRGTDRTQKDLHSSCNDSEPRDKEANS
                     RLQGHPEKHGNSEARTESKISESKSSTGMGYKSERSASSWEKETSRERPHTRVESQHD
                     KNLEKQNERLQNMHRKELPSQDKTERKVDVKFKPAGEEQGHRGRVDRALPPHPKNDVK
                     HYGFNKYHPEERRGREDCKRDRGMNSHGFQDRRCSSFLSSNRNSKYPHSKEVSVAHQW
                     ENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTADGKRQT
                     EPKHGKGAVSNSELSKGTDSKEGATKVESGPNEAKGKDLKLSFMEKLNLTLSPAKKQP
                     ACQDNPHQITGVPEPSGTCDSRSLETTGTVACLPSGSEHNREETKSELPEPKEALLAT
                     SQLRISIPENKMKEEKRLLFKSVENTVPCELLACGTEISLPAPVEIEQARCLLGSVEV
                     EETCGGARTAASVVMHVLPEHASEDASQELDTKRHDGINACAISEGVKTKVILSPKAA
                     AASESHLAPLVEEPSISLVNCSGDNNPKLEPSLEERPIVETKSCPLESCLPKETFVPS
                     PQKTELIDHKIETGESNSVYQDDDNSVLSIDFNNLRPIPDPISPLNSPVRPVCKVVSM
                     ESSCAIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKFDKCSEADSCKHLSLD
                     ELEEGEIRSDDEESVAQKRLEKSARPRVSAEVQPGKSSPGSRRSTVHVHKDNGRTAVK
                     LPRDRLTWSKRSSESRPSNTERKSKTMSISSLEKILPLILVPSSLWEVMHMLRLLGKH
                     VRKNYMKFKIKFSLTQFHRIIESAILSFTSLVKCLDLSKICKSVSTLQKSLCEVIESN
                     LKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVNFENENS
                     EGKLGKKYKERTQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKSEEKHQDQN
                     KTNASIVKHDVKRTFSTCSDNTKNAECKEQFLEKSCPSTPRPGKDEGHTEEEAQAAQH
                     ASAKSERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTSGTEKAEWELKT
                     PEKQLLESLKCESAPACATEELVSEGASLCPKVISDDNWSLLSSEKGPSLSSGLSLPV
                     HPDVLDENCMFEVSSNTALGKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHL
                     SFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSR
                     SVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGVVAEESLTSLPRTG
                     KEAGVATEKEPNLFQSTVLKPVKDLENTDKNIDKSKLTHEEQNSIVQTQVPDIYEFLK
                     DASNKVVHCDQVVDDCFKLHQVWEPKVSENLQELPSMEKIPHSLDNHLPDTHIDLTKD
                     SATETKSLGELMEVTVLNVDHLECSQTNLDQDAEITCSSLQPDTIDAFIDLTHDASSE
                     SKNEGSEPVLAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSC
                     EIKRHNLKSEPPSKLDCLELPETLGNGHKKRKNSPGVSHSSQKKQRKDIDLSSEKTQR
                     LSPNSDRNGDAHRKQASKKREPAVNETSLSSEASPEVKGSTAVLAASPASLSAKNVIK
                     KKGEIIVSWTRNDDREILLECQKRMPSLKTFTYLAVKLNKNPNQVSERFQQLKKLFEK
                     SKCR"
     exon            107..175
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            176..276
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            277..351
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            352..467
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            468..2662
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..5783
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            5784..5883
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..5968
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            5969..6566
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6536..6541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /note="hexamer: AATAAA"
     polyA_site      6560
                     /gene="Casp8ap2"
                     /gene_synonym="D4Ertd659e; FLASH"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgcggg gctggccggc cggatggcac ctatgagaag gatataggac catggcagca
       61 gatgatgaca atggtgatgg aacgggtttg tttgatgtct gtcctgcctc tccacttaaa
      121 aataatgatg aaggctcatt ggacatatat gctgggttgg acagtgctgt ttctgacagt
      181 actgctagat cctgtgtgtc attcagaaac tgtttagatt tgtatgaaga gatcctgact
      241 gaagaaggaa ctgcgaagga ggcaacgtac aatgacttgc agatagaata tgggaaatgt
      301 cagcagcaaa tgaaagacct gatgaaaagg tttaaggaaa tacagacaca gaacttgaac
      361 ttaaaaaatg aaaaccagtc tcttaagaag aatatctcag cacttatcaa aactgccaga
      421 gtggagataa accgtaagga tgaagagata aatcatcttc accaaagatt gtctgagttt
      481 ccacattttc gaaataacca taaaactgca agaacaaaag attcacagtc cacatctccc
      541 catttggatg attgttcaaa gactgatcac ggagttaaaa gtgatgttca gaaagatgta
      601 catcctaaca ctgcacagcc aaacttggaa aaggaaggaa aatcgcattc tgaagcacag
      661 aatcctttgc acttgtctac gggtgttgag aaacattgtg ccaataatgt ctggtcacgt
      721 tctccttacc aggttggaga aggtaactca aatgaggata ataggagagg aaggagtggc
      781 actagacata gccagtgtag cagaggaact gatagaacac agaaagactt acatagcagc
      841 tgtaatgaca gtgagccaag ggacaaggag gctaactcca gactacaagg acaccctgag
      901 aaacatggca acagtgaagc aaggacggag agcaaaattt cagagagtaa aagcagcact
      961 ggtatgggat ataaaagtga gcgcagtgcc tcttcttggg aaaaagagac ttccagagaa
     1021 aggccacaca ctcgagtgga atctcaacat gacaaaaatc tagagaaaca aaatgaaaga
     1081 ttacaaaata tgcacagaaa agagcttccg tctcaggaca aaacagaaag aaaagttgat
     1141 gtgaagttta aaccagcagg agaggagcag gggcatcggg gaagagtgga ccgggcgtta
     1201 cctcctcatc ccaagaatga cgtgaaacat tacggcttca ataagtatca tccagaagag
     1261 agaaggggaa gggaagattg taaaagagac agagggatga acagtcatgg ctttcaagat
     1321 agaagatgtt catcttttct ttcaagcaac agaaatagca aatacccgca ctccaaggaa
     1381 gttagtgttg cacaccagtg ggaaaatact cctttcaaag cagaaagaca tagaactgag
     1441 gacaggagga aaagagaacg agaaaacaaa gaagaaagta gacatgtgaa aagtgacaaa
     1501 aaatcacctc cagaacactt acaaaggact cataaagaca ctaagaaaag cactgctgat
     1561 ggaaagagac agactgagcc caaacatggt aaaggtgcag tctctaacag tgagctttct
     1621 aaagggacag acagtaaaga aggtgcaaca aaggtggaga gtgggccaaa tgaagcaaaa
     1681 ggcaaggact taaagttaag cttcatggaa aaactgaact taactctttc tcctgctaaa
     1741 aagcagcctg cttgtcaaga taacccacat caaataactg gtgttcccga gcccagtggc
     1801 acgtgtgact cacggtcctt ggagacgact ggaacggtgg catgccttcc ttctggcagt
     1861 gaacataata gagaggaaac caaatcagag ttaccagagc caaaggaggc tcttttggca
     1921 acatctcaac tcaggatcag cattccagaa aacaaaatga aggaagaaaa gaggttgtta
     1981 tttaaatctg ttgagaatac tgtgccttgt gaactgcttg cttgtggcac ggaaatttcc
     2041 ctcccagcac ctgtagaaat tgaacaagca agatgcttgc ttggatcagt ggaagtggaa
     2101 gagacctgtg gtggtgcaag gacagccgct tctgtggtga tgcatgtgtt accagaacat
     2161 gcttctgaag atgccagcca agaattggac accaaaagac acgatggtat aaatgcttgt
     2221 gctatttctg aaggtgtgaa aacaaaggtg attctttcac caaaagcagc tgcagccagt
     2281 gagagccatc ttgcaccttt ggttgaagaa cctagcattt cactagtaaa ctgttcggga
     2341 gacaataatc ctaaacttga accttctctt gaagagaggc ctatagttga gactaaatcc
     2401 tgtcctttgg agtcttgttt acctaaagag acttttgtac cttcaccaca gaagactgag
     2461 ttgattgacc acaaaataga aactggagaa tcaaactcag tatatcaaga tgatgataac
     2521 tcagttttga gtattgactt taataatctg agacctattc cagaccccat cagccctctg
     2581 aatagtccag tgagaccggt atgcaaagtt gttagcatgg agagctcatg tgcaattcca
     2641 ctgtatgata gcagtcataa agatgagttt ccatccaatt caactctttc taccttcaag
     2701 agtcagtctg atctaaataa ggaaaatgaa aaaccagttc ccaaatttga caaatgttca
     2761 gaagcagatt cttgtaagca tttgtcttta gatgaattag aagaaggcga aattagaagt
     2821 gatgatgaag aatctgtagc acaaaaacgc ttggaaaaga gtgcaagacc tagagtttct
     2881 gctgaagtgc agccagggaa aagcagccca ggaagcagga ggagcactgt gcatgtgcat
     2941 aaggacaacg ggaggactgc tgtaaaactc cctcgggaca gactcacatg gagcaaaaga
     3001 tcaagtgaat caagaccctc caacaccgaa aggaaaagta aaacaatgag catctccagc
     3061 ttggaaaaaa tacttccgct tatccttgta ccctcttccc tgtgggaggt tatgcatatg
     3121 ttacggttgc taggtaaaca tgtaagaaaa aattatatga aattcaagat aaaattttca
     3181 ttgacacaat ttcatagaat tattgaatct gcaattttga gtttcacatc actagttaaa
     3241 tgccttgatt tgtctaagat ctgtaagtca gtaagtactt tacaaaagag tctttgtgaa
     3301 gttatagaat ctaaccttaa acaagtgaag aagaatggca tagttgaccg tttatttgaa
     3361 cagcaacaaa cagatatgaa aaaaaaattg tggaagtttg tagatgaaca acttgattat
     3421 ttgtttgaaa agcttaaaaa aatcctacta aagttttgtg attctgtaaa ctttgaaaat
     3481 gagaatagtg aaggaaaact tggaaaaaaa tataaagaga gaacccaaca ttcaaattgt
     3541 cagaagaaaa aaatggacaa caaagaaata cggagagaaa aagtgctaaa atcagaaaat
     3601 actgtgaatt ttaaatcttc actgggatgt gaaaaatctg aagaaaaaca tcaggaccaa
     3661 aataaaacca atgctagtat agtaaagcat gatgtaaaaa gaacttttag cacttgcagt
     3721 gataatacaa agaacgctga atgtaaagag cagtttctgg aaaagagctg cccgagtacc
     3781 cctaggccag gaaaagatga aggacatact gaggaggagg cacaggcggc acagcatgca
     3841 agtgctaagt ccgaacggag ctttgagatc cttactgagc agcaggcatc cagccttact
     3901 tttaacttag tgagtgatgc acagatgggt gagatattta aaagcttgct acaaggttct
     3961 gatctgttgg acacaagtgg cactgaaaag gcagagtggg aattaaagac tccagagaaa
     4021 cagctgctgg aaagcctcaa gtgtgaatct gcaccagctt gtgcaacaga agagctggtt
     4081 tcagaggggg cttctctttg tccaaaagtg atcagtgatg ataattggtc tttattatca
     4141 tctgaaaagg gtccatcttt atcttcaggg ctttcactgc cagttcatcc tgatgtgtta
     4201 gatgaaaatt gtatgtttga agtatcttct aacactgctt taggtaaaga taatgtatac
     4261 agctcagaaa agagtaagcc ctgcatctct tccatactct tagaagatct tgcggtctct
     4321 ttaacagtac cgtcacctct gaaatcagat ggccatttga gtttcttaaa gccagaagtt
     4381 ttgtcaactt caactcctga agaagttatt agtgcacatt ttagtgagga tgctttgctt
     4441 gaggaagagg atgcatctga acaggacatt catctagctc tggagtctga taactcaagc
     4501 agtaagtcaa gctgttcatc atggacaagc cggtctgttg cttcaggctt tcagtaccac
     4561 cctaatcttc ccatgcatgc tgtcataatg gaaaagtcca atgatcattt cattgtgaaa
     4621 atacggcgtg caacaccatc tacctcccct ggccttaaac atggtgtggt agctgaggag
     4681 tcattgacat ctttgcctag aactggaaaa gaagctggtg tagcaacaga gaaagaacct
     4741 aacctgtttc agagtacagt tttaaaacct gtcaaggact tggaaaatac tgataaaaat
     4801 attgataaga gtaaactaac tcatgaagaa cagaactcta tagtacaaac acaggttcca
     4861 gatatatatg aatttcttaa agatgcctca aataaggtgg ttcattgtga tcaagtggtt
     4921 gatgattgct tcaagttgca tcaagtatgg gaaccaaaag tttctgagaa ccttcaagag
     4981 ttgccttcaa tggagaaaat cccacactct cttgataatc atcttcctga tacacacata
     5041 gatctaacga aagattcagc cactgagacc aaaagcttgg gggagctaat ggaagtaaca
     5101 gttttaaatg ttgatcactt ggaatgttct caaaccaact tagatcaaga tgcagagata
     5161 acatgtagtt ctttacagcc tgatactata gatgctttta ttgatttgac acatgatgct
     5221 tcaagtgaga gtaaaaatga aggtagtgaa cctgtgttag ctgttgaagg tatgggatgc
     5281 caggtaatat gtatagatga ggataccaac aaagaaggaa agatgggaag ggcaaacagt
     5341 cctttagaaa gtattgttga agaaacttgt attgatttga cctcagagtc tcctggctcc
     5401 tgtgaaatca agagacataa tttaaagtcg gagcctccat caaagttgga ttgtttagag
     5461 ttgcctgaaa ctctgggtaa tggtcacaag aagaggaaaa acagtcctgg tgttagtcac
     5521 tcttctcaga aaaaacaaag aaaggacata gacttaagta gtgaaaagac ccagagactt
     5581 agtcccaatt ctgatagaaa tggtgatgct cacagaaagc aagcgagcaa gaaaagagaa
     5641 cctgcagtaa atgaaacgtc cttgtcatca gaggccagcc cagaggtgaa gggttcaaca
     5701 gcagtacttg ctgcttcccc agcaagcctt tctgcaaaaa atgttatcaa aaagaaggga
     5761 gaaattatag tttcatggac aagaaatgat gaccgggaaa ttttactgga atgtcagaaa
     5821 agaatgccgt ccctgaaaac atttacttat ttagctgtca agctgaataa aaatccaaat
     5881 caggtttcag agaggttcca gcagctgaaa aagctctttg agaagtcaaa atgcaggtag
     5941 tagtggatcc atcaaggagg ctaatgctat gagttgctgg atttcatggt gcctcactga
     6001 taattcttct gcacagaagc ttcgattccc gtgttttaaa tggggaacta ggtggagggt
     6061 ttgtctccgt ttgacagcta gatgatcatc tacctttttt tttttacttt cctggtcatt
     6121 gtgcttggtg tattcagatc aacagtctga ttcacttacc tgttattggt cagaatgttt
     6181 ttaatcatta aaagttgtta tcaaatgaaa gactaaaagc aaccttgatg taatactgaa
     6241 accttagttt tgatattgga tgaaataaat tctttaaaaa acaattttgt agcattttaa
     6301 atgtaaaaac tagttcacct ttctattcat ttttgttttt ataattgcct cattttggaa
     6361 aattgtgaaa taatttaaat agtatatttg tatatatgta caattattgt gatgtaaaat
     6421 actgtaagtg tatgtgtcta cgtctatgta tgcacaccaa tggttttgct agccaaggtt
     6481 ttttttatct atattaaata ttttgtataa actttccttt cagttagtca tgtataataa
     6541 aaacatgaag tcctgtttta ttttta
//
