LOCUS       NM_001277926            2528 bp    mRNA    linear   ROD 05-MAR-2023
DEFINITION  Mus musculus caspase 8 (Casp8), transcript variant 3, mRNA.
ACCESSION   NM_001277926
VERSION     NM_001277926.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Kumar S, Budhathoki S, Oliveira CB, Kahle AD, Calhan OY, Lukens JR
            and Deppmann CD.
  TITLE     Role of the caspase-8/RIPK3 axis in Alzheimer's disease
            pathogenesis and Abeta-induced NLRP3 inflammasome activation
  JOURNAL   JCI Insight 8 (3), e157433 (2023)
   PUBMED   36602874
  REMARK    GeneRIF: Role of the caspase-8/RIPK3 axis in Alzheimer's disease
            pathogenesis and Abeta-induced NLRP3 inflammasome activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Hu J, Huang Z, Yu M, Zhang P, Xia Z and Gao C.
  TITLE     Caspase-8 activation in neutrophils facilitates autoimmune kidney
            vasculitis through regulating CD4+ effector memory T cells
  JOURNAL   Front Immunol 13, 1038134 (2022)
   PUBMED   36505410
  REMARK    GeneRIF: Caspase-8 activation in neutrophils facilitates autoimmune
            kidney vasculitis through regulating CD4[+] effector memory T
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Wang Y, Karki R, Mall R, Sharma BR, Kalathur RC, Lee S, Kancharana
            B, So M, Combs KL and Kanneganti TD.
  TITLE     Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I
            interferon production and regulation
  JOURNAL   Cell Rep 41 (1), 111434 (2022)
   PUBMED   36198273
  REMARK    GeneRIF: Molecular mechanism of RIPK1 and caspase-8 in homeostatic
            type I interferon production and regulation.
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Leena Hussein Bajrai, Sayed Sartaj Sohrab, Mohammad Khalid,
            Mohammad A Kamal and Esam Ibraheem Azhar.
  TITLE     Molecular interaction of cryptophycin 52 with Caspase 8 for the
            management of lung cancer during coronavirus outbreak : A
            computational study
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (6), 31-35 (2022)
   PUBMED   36227681
  REMARK    GeneRIF: Molecular interaction of cryptophycin 52 with Caspase 8
            for the management of lung cancer during coronavirus outbreak : A
            computational study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Vaux DL and Korsmeyer SJ.
  TITLE     Cell death in development
  JOURNAL   Cell 96 (2), 245-254 (1999)
   PUBMED   9988219
  REMARK    Review article
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Kumar S and Colussi PA.
  TITLE     Prodomains--adaptors--oligomerization: the pursuit of caspase
            activation in apoptosis
  JOURNAL   Trends Biochem Sci 24 (1), 1-4 (1999)
   PUBMED   10087912
  REMARK    Review article
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Van de Craen M, Van Loo G, Declercq W, Schotte P, Van den brande I,
            Mandruzzato S, van der Bruggen P, Fiers W and Vandenabeele P.
  TITLE     Molecular cloning and identification of murine caspase-8
  JOURNAL   J Mol Biol 284 (4), 1017-1026 (1998)
   PUBMED   9837723
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann
            JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O,
            Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H,
            Lonai P and Wallach D.
  TITLE     Targeted disruption of the mouse Caspase 8 gene ablates cell death
            induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal
            prenatally
  JOURNAL   Immunity 9 (2), 267-276 (1998)
   PUBMED   9729047
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Sakamaki K, Tsukumo S and Yonehara S.
  TITLE     Molecular cloning and characterization of mouse caspase-8
  JOURNAL   Eur J Biochem 253 (2), 399-405 (1998)
   PUBMED   9654089
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Kischkel FC, Kioschis P, Weitz S, Poustka A, Lichter P and Krammer
            PH.
  TITLE     Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8
            to the murine syntenic region on chromosome 1B-proximal C by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 95-96 (1998)
   PUBMED   9763668
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112968.11, BY203369.1,
            AK153340.1 and AK146758.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_001277926.2.
            
            Summary: This gene is part of a family of caspases,
            aspartate-specific cysteine proteases well studied for their
            involvement in immune and apoptosis signaling. This protein, an
            initiator of apoptotic cell death, is activated by death-inducing
            tumor necrosis family receptors and targets downstream effectors.
            In mouse deficiency of this gene can cause embryonic lethality.
            This protein may have a role in embryogenesis. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region and uses an alternate start codon, compared to
            variant 1. The encoded isoform (2) has a distinct and longer
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC112968.11        175673-175825
            154-313             BY203369.1         1-160
            314-1492            AK153340.1         80-1258
            1493-2528           AK146758.1         1550-2585
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.19 cM"
     gene            1..2528
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /note="caspase 8"
                     /db_xref="GeneID:12370"
                     /db_xref="MGI:MGI:1261423"
     exon            1..192
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            193..308
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1779
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /EC_number="3.4.22.61"
                     /note="isoform 2 is encoded by transcript variant 3;
                     Fas-linked ICE-like protease"
                     /codon_start=1
                     /product="caspase-8 isoform 2"
                     /protein_id="NP_001264855.1"
                     /db_xref="CCDS:CCDS78590.1"
                     /db_xref="GeneID:12370"
                     /db_xref="MGI:MGI:1261423"
                     /translation="MCVLLELLSDWLQLFYLLIRMDFQSCLYAIAEELGSEDLAALKF
                     LCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCN
                     REEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLL
                     EIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPS
                     VLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQL
                     RKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFIC
                     CILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVP
                     DEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQS
                     LRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP"
     exon            309..641
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            642..747
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            748..886
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            887..940
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1002
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1144
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1646
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..2528
                     /gene="Casp8"
                     /gene_synonym="CASP-8; FLICE; MACH; Mch5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtcattc tactactcag gccagcctgc ttgaggctgc ctcctcctat gtcctgtctc
       61 aggaaagcag gaagtgtgag aggctctacc ctccagctct ctgttgcccc ctgcctgcca
      121 cagaccccag acagagaagg ggcttgggag caaggtgcct cctgaggatc ctcgggactt
      181 gtttctgata aggtgctatc ttgggtcttt tgctggcctg aaactctcca ggtagctcag
      241 gcagcctggc tggtgtttta aaaactccac attttaatgt gtgtgctttt ggaactactg
      301 agtgactggt tacagctctt ctacctcttg ataagaatgg atttccagag ttgtctttat
      361 gctattgctg aagaactggg cagtgaagac ctggctgccc tcaagttcct gtgcttggac
      421 tacatcccac acaagaagca ggagaccatc gaggatgccc agaagctatt tctgaggctg
      481 cgggaaaagg ggatgttgga ggaaggcaat ctgtctttcc tgaaagagct gcttttccac
      541 atcagtcggt gggacctgct ggtcaacttc ctagactgca accgagagga gatggtgaga
      601 gagctgcggg atccagacaa tgcccagatt tctccctaca gggtcatgct ctttaagctc
      661 tcagaagaag tgagcgagtt ggaattgaga tcttttaagt tccttttgaa caatgagatc
      721 cccaaatgta agctggaaga tgacttgagc ctgcttgaaa tttttgtaga aatggagaag
      781 aggaccatgc tggcagaaaa taacttggaa accctaaaat caatctgtga ccaggtcaac
      841 aagagcctgc tggggaagat cgaggattat gaaagatcaa gcacagagag aagaatgagc
      901 cttgaaggaa gggaagagtt gccaccttca gttttggatg agatgagcct caaaatggcg
      961 gaactgtgtg actcgccaag agaacaagac agtgagtcac ggacttcaga caaagtttac
     1021 caaatgaaga acaaacctcg gggatactgt ctgatcatca acaatcatga tttcagcaag
     1081 gcccgggaag acataaccca actccgaaaa atgaaggaca gaaaaggaac agactgtgat
     1141 aaagaggctc tgagtaagac ctttaaggag cttcattttg agatagtatc ttacgacgac
     1201 tgcactgcaa atgaaatcca cgagattcta gaaggctacc aaagcgcaga ccacaagaac
     1261 aaagactgct tcatctgctg tatcctatcc cacggtgaca agggtgtcgt ctatggaacg
     1321 gatgggaagg aggcctccat ctatgacctg acatcttact tcactggttc aaagtgccct
     1381 tccctgtctg ggaaacccaa gatctttttc attcaggctt gccaaggaag taacttccag
     1441 aaaggagtgc ctgatgaggc aggcttcgag caacagaacc acactttaga agtggattca
     1501 tcatctcaca agaactatat tccggatgag gcagactttc tgctgggaat ggctacggtg
     1561 aagaactgcg tttcctaccg agatcctgtg aatggaacct ggtatattca gtcactttgc
     1621 cagagcctga gggaaagatg tcctcaagga gatgacattc ttagcatcct gactggcgtg
     1681 aactatgacg tgagcaataa agacgacagg aggaacaagg gaaagcagat gccacagccc
     1741 accttcacac tacggaagaa gctcttcttc cctccctaat gatgtgtgct ctccacagtt
     1801 cacatggctt atctgtgcac ttttgtgtgg atgagtctaa tttatttttt agaatttctt
     1861 ttgcttttga atttacattt acataatttt cccttttctt ccctttaaac ccttctttgt
     1921 tatgttccaa tttcaaatac atggcctctt ttctcattaa ctgttgtaca cacacataca
     1981 tacacacaca cacacacaca cacacatttc taaatataac ctgtatacta tcacttgtat
     2041 gtatgttttg ttttgctttt tttaaaaaat ggagcgacct ttggtaggcc aatcacactc
     2101 caaggcaggt ccctctccca agaatagttg ggcaatacaa attggcttcc atgggttcac
     2161 ctttaatctc agcactctgg agacagaggc aggaggatct ctgagttcaa agccaacctg
     2221 ctctacatag caagttctga gatagccagg gctacacaga gaaagcttgt cttgaaaaaa
     2281 acaaaaaaga aaacttgaag atgcatgagt aagaaagcaa gactggagca tgaatctggt
     2341 taacagaatg ggtgaatgac gggagcaggg acctggggca agttaacaga gggggtgaat
     2401 gacgggagca gggacctggg gcaagttaac tgctgaaggt gagtcagcag aatggggtga
     2461 atatcatcag cattctctgc atgaaattct cagaggtaat aataatatta aacttttttc
     2521 tgtgcagt
//
