LOCUS       NM_007611               2229 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus caspase 7 (Casp7), mRNA.
ACCESSION   NM_007611 XM_355169
VERSION     NM_007611.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Harvest,C.K., Abele,T.J., Yu,C., Beatty,C.J., Amason,M.E.,
            Billman,Z.P., DePrizio,M.A., Souza,F.W., Lacey,C.A., Maltez,V.I.,
            Larson,H.N., McGlaughon,B.D., Saban,D.R., Montgomery,S.A. and
            Miao,E.A.
  TITLE     An innate granuloma eradicates an environmental pathogen using
            Gsdmd and Nos2
  JOURNAL   Nat Commun 14 (1), 6686 (2023)
   PUBMED   37865673
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Li,X., Zhang,T., Kang,L., Xin,R., Sun,M., Chen,Q., Pei,J., Chen,Q.,
            Gao,X. and Lin,Z.
  TITLE     Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by
            GSDMB cleavage
  JOURNAL   Cell Death Differ 30 (9), 2120-2134 (2023)
   PUBMED   37591921
  REMARK    GeneRIF: Apoptotic caspase-7 activation inhibits non-canonical
            pyroptosis by GSDMB cleavage.
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   He,K., Wan,T., Wang,D., Hu,J., Zhou,T., Tao,W., Wei,Z., Lu,Q.,
            Zhou,R., Tian,Z., Flavell,R.A. and Zhu,S.
  TITLE     Gasdermin D licenses MHCII induction to maintain food tolerance in
            small intestine
  JOURNAL   Cell 186 (14), 3033-3048 (2023)
   PUBMED   37327784
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Barge,R.M., Willemze,R., Vandenabeele,P., Fiers,W. and Beyaert,R.
  TITLE     Differential involvement of caspases in apoptosis of myeloid
            leukemic cells induced by chemotherapy versus growth factor
            withdrawal
  JOURNAL   FEBS Lett 409 (2), 207-210 (1997)
   PUBMED   9202146
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Mukasa,T., Khoroku,Y., Tsukahara,T., Momoi,M.Y., Kimura,I. and
            Momoi,T.
  TITLE     Wortmannin enhances CPP32-like activity during neuronal
            differentiation of P19 embryonal carcinoma cells induced by
            retinoic acid
  JOURNAL   Biochem Biophys Res Commun 232 (1), 192-197 (1997)
   PUBMED   9125129
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Mukasa,T., Urase,K., Momoi,M.Y., Kimura,I. and Momoi,T.
  TITLE     Specific expression of CPP32 in sensory neurons of mouse embryos
            and activation of CPP32 in the apoptosis induced by a withdrawal of
            NGF
  JOURNAL   Biochem Biophys Res Commun 231 (3), 770-774 (1997)
   PUBMED   9070890
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Juan,T.S., McNiece,I.K., Argento,J.M., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Fletcher,F.A.
  TITLE     Identification and mapping of Casp7, a cysteine protease resembling
            CPP32 beta, interleukin-1 beta converting enzyme, and CED-3
  JOURNAL   Genomics 40 (1), 86-93 (1997)
   PUBMED   9070923
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Van de Craen,M., Vandenabeele,P., Declercq,W., Van den Brande,I.,
            Van Loo,G., Molemans,F., Schotte,P., Van Criekinge,W., Beyaert,R.
            and Fiers,W.
  TITLE     Characterization of seven murine caspase family members
  JOURNAL   FEBS Lett 403 (1), 61-69 (1997)
   PUBMED   9038361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115771.13 and AC166746.7.
            
            On Nov 16, 2022 this sequence version replaced NM_007611.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13088.1, BC005428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC115771.13        168038-168105
            69-178              AC115771.13        175204-175313
            179-315             AC115771.13        204030-204166
            316-444             AC115771.13        204590-204718
            445-620             AC115771.13        207015-207190
            621-750             AC115771.13        207507-207636
            751-2229            AC166746.7         20203-21681
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.84 cM"
     gene            1..2229
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /note="caspase 7"
                     /db_xref="GeneID:12369"
                     /db_xref="MGI:MGI:109383"
     exon            1..68
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..980
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /EC_number="3.4.22.60"
                     /note="CASP-7; cysteine protease LICE2; apoptotic protease
                     Mch-3"
                     /codon_start=1
                     /product="caspase-7 precursor"
                     /protein_id="NP_031637.1"
                     /db_xref="CCDS:CCDS29915.1"
                     /db_xref="GeneID:12369"
                     /db_xref="MGI:MGI:109383"
                     /translation="MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISSILLKKKRNAS
                     AGPVRTGRDRVPTYLYRMDFQKMGKCIIINNKNFDKATGMDVRNGTDKDAGALFKCFQ
                     NLGFEVTVHNDCSCAKMQDLLRKASEEDHSNSACFACVLLSHGEEDLIYGKDGVTPIK
                     DLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDIDANPRNKIPVEAD
                     FLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQ
                     SDDPRFNEKKQIPCMVSMLTKELYFSR"
     exon            69..178
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..315
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..444
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..620
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..750
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..2229
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /note="hexamer: ATTAAA"
     polyA_site      2229
                     /gene="Casp7"
                     /gene_synonym="caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3"
                     /note="major polyA site"
ORIGIN      
        1 caaagctgcc ctcgaccctt gcggaggacg gacgctgccg tgggctcctg gccgccgccg
       61 tgggaacgat gaccgatgat caggactgtg ctgcggagct ggaaaaggtg gattcttcca
      121 gcgaagacgg agttgacgcc aagccagacc gctcctctat catctcctct attctcttga
      181 agaagaagag aaatgcctct gcgggccccg tcaggaccgg ccgggaccga gtgcccactt
      241 atctgtaccg catggatttc cagaagatgg gtaaatgcat catcataaac aacaagaact
      301 tcgacaaagc gacaggtatg gacgtccgga atgggacgga caaagatgca ggggccctct
      361 tcaagtgctt ccaaaacctg ggttttgaag taaccgtcca caatgactgc tcttgtgcaa
      421 agatgcaaga tctgcttaga aaagcctctg aggaggacca cagcaactcg gcctgcttcg
      481 cctgcgtcct gctgagccac ggggaagagg acctgattta cgggaaagat ggcgtgacac
      541 ccataaagga tctgacagct cattttaggg gagaccgatg caaaaccctg ttagagaaac
      601 ccaaactctt cttcattcag gcatgccgag ggacggagct cgatgatgga atccaggctg
      661 actcggggcc catcaacgac attgacgcta atccccgcaa caagatcccg gtggaagccg
      721 acttcctctt tgcttactcc acggttccag gttattactc atggaggaac ccagggaaag
      781 gctcctggtt tgtgcaggcc ctctgctcca tcctgaatga gcatggcaag gacctcgaga
      841 tcatgcagat cctgaccagg gtgaacgaca gggtggccag gcacttcgag tcccagtctg
      901 atgatccacg cttcaacgag aagaagcaga tcccgtgtat ggtgtccatg ctcaccaaag
      961 agctgtactt cagccgttga ccacccttca gctgagaacc tgccgccgtt cgttgatgaa
     1021 tccagttttt attttatttt tgttccgatg ctctcaaaat atccagaaat gttgagggga
     1081 tttaatttca ggaaagtcta gatttttttt tttttgttta ataactttgt tcatctgatg
     1141 acttcatgct cttcctctaa ggttgatttc ctgtttctgt ttcttttttt ctttgtcgtc
     1201 tcgctgagtg catgctgtga gcatgacctc tggagaagac attggcaatg acgtctcagt
     1261 tgaacttggc aaagagaatc ccagctcttg atgaaagaat acagctgcga cacctgttgg
     1321 cctccattgg caaaggtggc tgctgagtgg ttgttctcag tggcttaggg cagattttta
     1381 agccgacctt cccaggtggc tgagagaaga cgacagttaa tattccagta tatagaaccc
     1441 aatccagaaa ataagccatc ctaggaatat cggtgcagaa gggtcaatac agggaattca
     1501 cttactcggg taattgagag acagtcaatc ccgttacctc acatgcctct gtggggctgt
     1561 aagaggactt cggttccctt gtcatcagta agaactgtgg cagggcagcc ttctagagac
     1621 tagaaccatg gaggactatg gtgattggag ccaggctcag gacaagccac tgcctgagat
     1681 ggaaaccaag ccagaactga gtcagacacc aaaggcctcc ccaggcctgt gcccatatcc
     1741 accagcgcct tataattcca aggtgcctga aagccaacta gtgagggcct agggaccatg
     1801 ctaccctgtg ctacagagca gaggaaggga tagcaaagca ggggtagtgg tgggggtaaa
     1861 cttggctcaa aatgtgaatt aaataaccat gtcctctggc gtgctacaat gtattcattc
     1921 actattcact gatttgtcag atcatccatc cacacaggtg ctgaagagta acccatttca
     1981 ctttgtatac aagataatgt ttttgtactt caaatacatc tggaattctt tcaaatattc
     2041 caagattttt tttttttctg aataatcttt ggttacctct ggttctacaa atgacaattt
     2101 aggcgaagat cttagcagtt tctttccaag gtatcatttt ctttggaatt cgttatacat
     2161 tcctgttttt cccacctaat aaatggttga cagatgttcc tatttattga ttaaaatgtg
     2221 tttcagaaa
//
